MEF2 transcription factors: developmental regulators and emerging cancer genes

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MEF2 transcription factors: developmental regulators and emerging cancer genes is …
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scholarly articleQ13442814
review articleQ7318358

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P356DOI10.18632/ONCOTARGET.6223
P3181OpenCitations bibliographic resource ID4246128
P932PMC publication ID4823036
P698PubMed publication ID26506234

P50authorMarco MarraQ6757610
P2093author name stringJulia R Pon
P2860cites workRegulation of the MEF2 family of transcription factors by p38Q22008562
Exercise and MEF2-HDAC interactions.Q37024611
MEF2B mutations in non-Hodgkin lymphoma dysregulate cell migration by decreasing MEF2B target gene activationQ37031859
Genome-wide analysis of MEF2 transcriptional program reveals synaptic target genes and neuronal activity-dependent polyadenylation site selectionQ37070840
Contribution of myocyte enhancer factor 2 family transcription factors to BZLF1 expression in Epstein-Barr virus reactivation from latencyQ37123207
MEF2C Haploinsufficiency features consistent hyperkinesis, variable epilepsy, and has a role in dorsal and ventral neuronal developmental pathwaysQ37172192
MEF2 is an in vivo immune-metabolic switchQ37253703
Landscape of somatic mutations and clonal evolution in mantle cell lymphoma.Q37318226
Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure.Q37370471
Loss of MEF2D expression inhibits differentiation and contributes to oncogenesis in rhabdomyosarcoma cellsQ37427738
MicroRNA-155 controls RB phosphorylation in normal and malignant B lymphocytes via the noncanonical TGF-β1/SMAD5 signaling moduleQ37429726
Phosphorylation and alternative pre-mRNA splicing converge to regulate myocyte enhancer factor 2C activityQ37493082
Dysregulation of autophagy and Parkinson's disease: the MEF2D linkQ37694365
Regulating a master regulator: establishing tissue-specific gene expression in skeletal muscleQ37780648
The MEF2 family and the brain: from molecules to memoryQ38080479
Myocyte enhancer factor 2C in hematopoiesis and leukemiaQ38084093
Emerging roles for MEF2 transcription factors in memoryQ38116091
Understanding MYC-driven aggressive B-cell lymphomas: pathogenesis and classificationQ38134685
B-cell receptor signaling in lymphoid malignancies and autoimmunityQ38212804
Monitoring the interaction between DNA and a transcription factor (MEF2A) using fluorescence correlation spectroscopy.Q38318381
Requirements of myocyte-specific enhancer factor 2A in zebrafish cardiac contractilityQ38322027
Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factorQ28140525
Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2Q28143007
Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4Q28145073
Neuronal activity-dependent cell survival mediated by transcription factor MEF2Q28146016
Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2Q28146018
HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosisQ28204794
The Mef2c gene is a direct transcriptional target of myogenic bHLH and MEF2 proteins during skeletal muscle developmentQ28206113
Comprehensive molecular characterization of gastric adenocarcinomaQ28244985
MEF2: a central regulator of diverse developmental programsQ28254625
The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics dataQ28266682
Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteinsQ28272422
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortalQ28288215
Integrated genomic characterization of endometrial carcinomaQ28289962
Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteinsQ28294155
Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse numberQ28297899
Comprehensive molecular characterization of urothelial bladder carcinomaQ28306864
MEF2B-Nox1 signaling is critical for stretch-induced phenotypic modulation of vascular smooth muscle cellsQ28392513
MEF2C transcription factor controls chondrocyte hypertrophy and bone developmentQ28505927
MEF2B is a potent transactivator expressed in early myogenic lineagesQ28505977
Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10Q28509194
Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factorQ28510070
Requirement of the MADS-box transcription factor MEF2C for vascular developmentQ28510515
The cardiac transcription network modulated by Gata4, Mef2a, Nkx2.5, Srf, histone modifications, and microRNAsQ28512635
Regulation of skeletal muscle sarcomere integrity and postnatal muscle function by Mef2cQ28513098
Differentiation-dependent lysine 4 acetylation enhances MEF2C binding to DNA in skeletal muscle cellsQ28586759
Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulationQ28586846
A p38 MAPK-MEF2C pathway regulates B-cell proliferationQ28588781
Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2CQ28589290
Myocyte enhancer factor 2C as a neurogenic and antiapoptotic transcription factor in murine embryonic stem cellsQ28591351
MEF2B is a component of a smooth muscle-specific complex that binds an A/T-rich element important for smooth muscle myosin heavy chain gene expressionQ28592735
The positive transcription elongation factor b is an essential cofactor for the activation of transcription by myocyte enhancer factor 2Q28595060
MEF2 is a converging hub for histone deacetylase 4 and phosphatidylinositol 3-kinase/Akt-induced transformationQ30557593
Protein kinase A represses skeletal myogenesis by targeting myocyte enhancer factor 2D.Q30841374
Yin Yang-1 suppresses invasion and metastasis of pancreatic ductal adenocarcinoma by downregulating MMP10 in a MUC4/ErbB2/p38/MEF2C-dependent mechanismQ33717981
Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylasesQ24290235
Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5Q24290618
Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoRQ24292197
A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiationQ24305050
Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiationQ24307379
Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2Q24317299
Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modificationsQ24324035
Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activationQ24529566
Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosisQ24534050
HDAC4 deacetylase associates with and represses the MEF2 transcription factorQ24534407
GATA-dependent recruitment of MEF2 proteins to target promotersQ24599616
Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencingQ24612248
Targeting of SMAD5 links microRNA-155 to the TGF-beta pathway and lymphomagenesisQ24624863
Regulation of the human GLUT4 gene promoter: interaction between a transcriptional activator and myocyte enhancer factor 2AQ24630596
Frequent mutation of histone-modifying genes in non-Hodgkin lymphomaQ24630610
A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genesQ24631256
DECIPHER: Database of Chromosomal Imbalance and Phenotype in Humans Using Ensembl ResourcesQ24644530
Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivoQ24644531
Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2CQ24647260
Mutational analysis of the DNA binding, dimerization, and transcriptional activation domains of MEF2CQ24649105
Identifying autism loci and genes by tracing recent shared ancestryQ24655308
Mutation of MEF2A in an inherited disorder with features of coronary artery diseaseQ24669679
The transcription factor MEF2C is required for craniofacial developmentQ24672010
Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylasesQ24682791
Phosphorylation-facilitated sumoylation of MEF2C negatively regulates its transcriptional activityQ25256622
Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2Q27641007
Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assemblyQ27666773
Big mitogen-activated kinase regulates multiple members of the MEF2 protein familyQ28137985
Control of cardiac-specific transcription by p300 through myocyte enhancer factor-2DQ28138756
The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc.Q33744301
Vertebrate paralogous MEF2 genes: origin, conservation, and evolutionQ33843316
Ca(2+)-dependent gene expression mediated by MEF2 transcription factors.Q33885290
Myocyte enhancer factor 2A and 2D undergo phosphorylation and caspase-mediated degradation during apoptosis of rat cerebellar granule neurons.Q34087738
p38 MAPK signaling regulates recruitment of Ash2L-containing methyltransferase complexes to specific genes during differentiationQ34124906
Analysis of the coding genome of diffuse large B-cell lymphomaQ34205133
The MADS-box family of transcription factorsQ34310228
The epigenetics of epithelial-mesenchymal plasticity in cancerQ34310378
MEF2B mutations lead to deregulated expression of the oncogene BCL6 in diffuse large B cell lymphomaQ34366539
Phosphorylation of the MADS-Box transcription factor MEF2C enhances its DNA binding activity.Q34384721
TGF-beta signaling in cancer--a double-edged swordQ34421804
Transcriptional profiling of MEF2-regulated genes in human neural progenitor cells derived from embryonic stem cellsQ34452554
Characterization of myocyte enhancer factor 2 (MEF2) expression in B and T cells: MEF2C is a B cell-restricted transcription factor in lymphocytes.Q34478174
Pattern of MEF2B expression in lymphoid tissues and in malignant lymphomasQ34481343
Induction of the neural crest: a multigene processQ34664846
Alternative splicing of MEF2C pre-mRNA controls its activity in normal myogenesis and promotes tumorigenicity in rhabdomyosarcoma cellsQ34801443
Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart.Q34805195
Cocaine regulates MEF2 to control synaptic and behavioral plasticityQ34818266
MEF2 transcription factors regulate distinct gene programs in mammalian skeletal muscle differentiationQ34958598
Antiapoptotic role of the p38 mitogen-activated protein kinase-myocyte enhancer factor 2 transcription factor pathway during neuronal differentiationQ35163278
Myocyte enhancer factor 2C function in skeletal muscle is required for normal growth and glucose metabolism in mice.Q35190729
Histone modifiers in cancer: friends or foes?Q35216079
Cooperating cancer-gene identification through oncogenic-retrovirus-induced insertional mutagenesisQ35848246
Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylasesQ36141408
The MEF2D transcription factor mediates stress-dependent cardiac remodeling in miceQ36249548
Regulation of the Nur77 orphan steroid receptor in activation-induced apoptosisQ36555939
Genetic heterogeneity of diffuse large B-cell lymphomaQ36567845
The MEF2A 3' untranslated region functions as a cis-acting translational repressorQ36568257
Determination of the consensus binding site for MEF2 expressed in muscle and brain reveals tissue-specific sequence constraintsQ36681719
The N-terminal methionine is a major determinant of the DNA binding specificity of MEF-2C.Q38333096
High affinity binding of MEF-2C correlates with DNA bendingQ38340233
Homing and invasiveness of MLL/ENL leukemic cells is regulated by MEF2C.Q38352439
The control operated by the cell cycle machinery on MEF2 stability contributes to the downregulation of CDKN1A and entry into S phaseQ38904419
Destabilization of survival factor MEF2D mRNA by neurotoxin in models of Parkinson's diseaseQ38993032
Overexpression of the transcription factor MEF2D in hepatocellular carcinoma sustains malignant character by suppressing G2-M transition genes.Q39037282
A ChIP-seq-defined genome-wide map of MEF2C binding reveals inflammatory pathways associated with its role in bone density determination.Q39043467
The E3 ubiquitin ligase UBR5 is recurrently mutated in mantle cell lymphoma.Q39194965
Sequence features and chromatin structure around the genomic regions bound by 119 human transcription factorsQ39283917
Gli2 and MEF2C activate each other's expression and function synergistically during cardiomyogenesis in vitroQ39422264
Sclerostin expression is induced by BMPs in human Saos-2 osteosarcoma cells but not via direct effects on the sclerostin gene promoter or ECR5 elementQ39479811
Interaction between P-TEFb and the C-terminal domain of RNA polymerase II activates transcriptional elongation from sites upstream or downstream of target genesQ39676027
Alternative splicing of Mef2c promoted by Fox-1 during neural differentiation in P19 cellsQ39742083
Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcriptionQ39796090
Cabin1 represses MEF2 transcriptional activity by association with a methyltransferase, SUV39H1.Q40195503
Disruption of MEF2 activity in cardiomyoblasts inhibits cardiomyogenesisQ40227351
Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.Q40252270
Regulation of Muscle Differentiation by the MEF2 Family of MADS Box Transcription FactorsQ40432858
Myocyte enhancer factor 2 acetylation by p300 enhances its DNA binding activity, transcriptional activity, and myogenic differentiationQ40435172
MEF2-mediated recruitment of class II HDAC at the EBV immediate early gene BZLF1 links latency and chromatin remodelingQ40753970
MEF-2 regulates activity-dependent spine loss in striatopallidal medium spiny neurons.Q40817289
Myocyte enhancer factor-related B-MEF2 is developmentally expressed in B cells and regulates the immunoglobulin J chain promoterQ41006992
Cooperative transformation by MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins generated by the variant t(1;19) in acute lymphoblastic leukemiaQ42824153
MEF2 negatively regulates learning-induced structural plasticity and memory formationQ48411990
Anti-apoptotic wild-type Alzheimer amyloid precursor protein signaling involves the p38 mitogen-activated protein kinase/MEF2 pathwayQ48427045
Alternative pre-mRNA splicing governs expression of a conserved acidic transactivation domain in myocyte enhancer factor 2 factors of striated muscle and brainQ48925833
MEF2 transcription factors promotes EMT and invasiveness of hepatocellular carcinoma through TGF-β1 autoregulation circuitry.Q51064874
Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia.Q51549649
A novel genetic variant in the transcription factor Islet-1 exerts gain of function on myocyte enhancer factor 2C promoter activity.Q51756006
Mutations in MEF2C from the 5q14.3q15 microdeletion syndrome region are a frequent cause of severe mental retardation and diminish MECP2 and CDKL5 expression.Q51850375
Adenoviral ElA-associated protein p300 as a functional homologue of the transcriptional co-activator CBPQ59095054
Myocyte enhancer binding factor-2 expression and activity in vascular smooth muscle cells. Association with the activated phenotypeQ70934681
Phosphorylation motifs regulating the stability and function of myocyte enhancer factor 2AQ72999432
Overexpression of myocyte enhancer factor 2 and histone hyperacetylation in hepatocellular carcinomaQ80569126
A role for p38alpha mitogen-activated protein kinase in embryonic cardiac differentiationQ80805811
Control of MEF2 transcriptional activity by coordinated phosphorylation and sumoylationQ81631304
Myocyte enhancer factor 2C regulation of hepatocellular carcinoma via vascular endothelial growth factor and Wnt/β-catenin signalingQ85826288
P275copyright licenseCreative Commons Attribution 2.5 GenericQ18810333
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectcell differentiationQ210861
neoplasmQ1216998
neoplastic gene expression regulationQ66660300
developmental gene expression regulationQ70697639
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)2297-2312
P577publication date2016-01-01
2016-01-19
P1433published inOncotargetQ1573155
P1476titleMEF2 transcription factors: developmental regulators and emerging cancer genes
P478volume7

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