scholarly article | Q13442814 |
review article | Q7318358 |
P50 | author | Hiroko Tsutsui | Q57405615 |
P2093 | author name string | Shuhei Hayashi | |
Xianbin Cai | |||
P2860 | cites work | Fatty acid-induced mitochondrial uncoupling elicits inflammasome-independent IL-1α and sterile vascular inflammation in atherosclerosis | Q46323475 |
A possible role for interleukin 37 in the pathogenesis of Behcet's disease | Q46905913 | ||
The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells. | Q48234431 | ||
Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response | Q22008772 | ||
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines | Q24294720 | ||
The pan-caspase inhibitor Emricasan (IDN-6556) decreases liver injury and fibrosis in a murine model of non-alcoholic steatohepatitis. | Q50473358 | ||
Overview of the interleukin-1 family of ligands and receptors. | Q54536457 | ||
Caspase crosstalk: integration of apoptotic and innate immune signalling pathways. | Q55058744 | ||
A critical role of IL-33 in experimental allergic rhinitis | Q56897540 | ||
A newly defined interleukin-1? | Q59054402 | ||
The IL1-like cytokine IL33 and its receptor ST2 are abnormally expressed in the affected skin and visceral organs of patients with systemic sclerosis | Q61733657 | ||
Hepatic recruitment of the inflammatory Gr1+monocyte subset upon liver injury promotes hepatic fibrosis | Q62735118 | ||
Pit cell-hepatocyte contact in autoimmune hepatitis | Q70618941 | ||
Caspase-1-independent, Fas/Fas ligand-mediated IL-18 secretion from macrophages causes acute liver injury in mice | Q73065691 | ||
Elevated levels of interleukin-18 and tumor necrosis factor-alpha in serum of patients with type 2 diabetes mellitus: relationship with diabetic nephropathy | Q73420531 | ||
Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice | Q74817301 | ||
Human mast cell chymase cleaves pro-IL-18 and generates a novel and biologically active IL-18 fragment | Q79401048 | ||
ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules | Q80912569 | ||
Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system | Q81191920 | ||
IL-33 induces IL-13-dependent cutaneous fibrosis | Q82370239 | ||
Serum IL-33 levels are raised in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis | Q83233643 | ||
Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance | Q83864443 | ||
Fas-mediated inflammatory response in Listeria monocytogenes infection | Q86426529 | ||
Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome | Q24303046 | ||
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta | Q24305136 | ||
NLRs join TLRs as innate sensors of pathogens | Q24305830 | ||
Active caspase-1 is a regulator of unconventional protein secretion | Q24308770 | ||
Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes | Q24339219 | ||
Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells | Q24523640 | ||
Caspases: pharmacological manipulation of cell death | Q24536096 | ||
An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist | Q24606097 | ||
Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36α, IL-36β, and IL-36γ) or antagonist (IL-36Ra) activity | Q24630062 | ||
Meprins, membrane-bound and secreted astacin metalloproteinases | Q24646365 | ||
Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation | Q24676343 | ||
Regulation of hepatic innate immunity by hepatitis C virus | Q26824743 | ||
Elevation of interleukin-18 in chronic hepatitis C: implications for hepatitis C virus pathogenesis | Q27489815 | ||
The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism | Q27685465 | ||
Alcoholic liver disease: pathogenesis and new therapeutic targets | Q27690220 | ||
Artificial sweeteners induce glucose intolerance by altering the gut microbiota | Q27968228 | ||
Gout-associated uric acid crystals activate the NALP3 inflammasome | Q28131797 | ||
IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp | Q28141927 | ||
IL-13 effector functions | Q28180348 | ||
NALPs: a novel protein family involved in inflammation | Q28206764 | ||
Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs | Q28239808 | ||
Dietary modulation of the microbiome affects autoinflammatory disease | Q28249017 | ||
A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol | Q28254419 | ||
IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction | Q28258076 | ||
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf | Q28266417 | ||
Cloning of a new cytokine that induces IFN-gamma production by T cells | Q28283928 | ||
Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme | Q28287610 | ||
IL-37 is a fundamental inhibitor of innate immunity | Q28295265 | ||
Localization and functionality of the inflammasome in neutrophils | Q28305418 | ||
Non-canonical inflammasome activation targets caspase-11 | Q28506831 | ||
Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor | Q28507342 | ||
IL-33-mediated protection against experimental cerebral malaria is linked to induction of type 2 innate lymphoid cells, M2 macrophages and regulatory T cells | Q35557167 | ||
Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome | Q35570155 | ||
Innate lymphoid cells. Innate lymphoid cells: a new paradigm in immunology | Q35638915 | ||
Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases | Q35649473 | ||
Sterile inflammation of endothelial cell-derived apoptotic bodies is mediated by interleukin-1α | Q35651080 | ||
Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity | Q35660131 | ||
IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist | Q35779110 | ||
Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice | Q35807590 | ||
Contradictory functions (activation/termination) of neutrophil proteinase 3 enzyme (PR3) in interleukin-33 biological activity | Q35868166 | ||
Cell death and cell death responses in liver disease: mechanisms and clinical relevance | Q35938040 | ||
Induction of allergic inflammation by interleukin-18 in experimental animal models | Q35951814 | ||
T helper 1 cells stimulated with ovalbumin and IL-18 induce airway hyperresponsiveness and lung fibrosis by IFN-gamma and IL-13 production | Q35990342 | ||
Molecular mechanisms in genetically defined autoinflammatory diseases: disorders of amplified danger signaling | Q36041225 | ||
Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2 | Q36042132 | ||
The B-Raf(V600E) inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury | Q36179559 | ||
Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice | Q36243894 | ||
Transcription factor networks directing the development, function, and evolution of innate lymphoid effectors | Q36358937 | ||
Nonredundant roles for CD1d-restricted natural killer T cells and conventional CD4+ T cells in the induction of immunoglobulin E antibodies in response to interleukin 18 treatment of mice | Q36370669 | ||
Interleukin 18 acts on memory T helper cells type 1 to induce airway inflammation and hyperresponsiveness in a naive host mouse | Q36399270 | ||
Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis | Q36414956 | ||
Autoinflammatory disease reloaded: a clinical perspective | Q36520994 | ||
Antigen- and cytokine-driven accumulation of regulatory T cells in visceral adipose tissue of lean mice | Q36561831 | ||
The precursor form of IL-1alpha is an intracrine proinflammatory activator of transcription | Q36602261 | ||
The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis | Q36613779 | ||
Mechanisms of disease: inflammasome activation and the development of type 2 diabetes | Q36668052 | ||
Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages | Q36694157 | ||
Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury | Q36774034 | ||
Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases | Q36816872 | ||
Prointerleukin-18 is activated by meprin beta in vitro and in vivo in intestinal inflammation | Q36968427 | ||
Meprin A and meprin alpha generate biologically functional IL-1beta from pro-IL-1beta | Q36985463 | ||
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease | Q36994761 | ||
Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury | Q37031838 | ||
A missense mutation in pstpip2 is associated with the murine autoinflammatory disorder chronic multifocal osteomyelitis | Q37053052 | ||
Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. | Q37073714 | ||
RIP3: a molecular switch for necrosis and inflammation | Q37098143 | ||
Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease. | Q37123845 | ||
Converting enzyme-independent release of tumor necrosis factor alpha and IL-1beta from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3 | Q37203389 | ||
Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths. | Q37213084 | ||
Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice | Q37216910 | ||
Hepatitis C virus induces interleukin-1β (IL-1β)/IL-18 in circulatory and resident liver macrophages. | Q37254259 | ||
Interleukin-1 and tumor necrosis factor-α trigger restriction of hepatitis B virus infection via a cytidine deaminase activation-induced cytidine deaminase (AID) | Q37272140 | ||
Interleukin-33 overexpression is associated with liver fibrosis in mice and humans. | Q37311036 | ||
The Interleukin-1α Precursor is Biologically Active and is Likely a Key Alarmin in the IL-1 Family of Cytokines | Q37326965 | ||
Primed innate immunity leads to autoinflammatory disease in PSTPIP2-deficient cmo mice. | Q37352484 | ||
cDNA cloning of an intracellular form of the human interleukin 1 receptor antagonist associated with epithelium | Q37494553 | ||
Critical role for inflammasome-independent IL-1β production in osteomyelitis | Q37519575 | ||
Inflammasome-independent IL-1β mediates autoinflammatory disease in Pstpip2-deficient mice | Q37519648 | ||
TIR8/SIGIRR: an IL-1R/TLR family member with regulatory functions in inflammation and T cell polarization | Q37584645 | ||
Interleukin-33 potentiates bleomycin-induced lung injury | Q37596499 | ||
Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses. | Q37599811 | ||
FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes. | Q37601031 | ||
The sterile inflammatory response | Q37716003 | ||
Adipose tissue macrophages: their role in adipose tissue remodeling | Q37723181 | ||
Importance of IL-18-induced super Th1 cells for the development of allergic inflammation | Q37736214 | ||
Neutrophil serine proteases: mediators of innate immune responses | Q37806041 | ||
IL-36 in psoriasis. | Q37991473 | ||
The sterile immune response during hepatic ischemia/reperfusion | Q38011500 | ||
Immunotherapeutic applications of IL-18. | Q38067452 | ||
The immunology of fibrosis | Q38091697 | ||
Fat-resident Tregs: an emerging guard protecting from obesity-associated metabolic disorders | Q38093672 | ||
In search of novel highly active mitochondria-targeted antioxidants: thymoquinone and its cationic derivatives. | Q38105814 | ||
TH2, allergy and group 2 innate lymphoid cells | Q38107790 | ||
New Insights in the Immunobiology of IL-1 Family Members | Q38121074 | ||
Innate lymphoid cells and allergic inflammation | Q38133877 | ||
Inflammasomes and metabolic disease | Q38166027 | ||
Liver fibrosis and repair: immune regulation of wound healing in a solid organ | Q38190875 | ||
Importance of Both Innate Immunity and Acquired Immunity for Rapid Expulsion of S. venezuelensis. | Q38200089 | ||
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity | Q28512778 | ||
Psoriasiform dermatitis is driven by IL-36-mediated DC-keratinocyte crosstalk | Q28587108 | ||
Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis | Q28588383 | ||
Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme | Q28610362 | ||
Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death | Q28660873 | ||
Annotating genes with potential roles in the immune system: six new members of the IL-1 family | Q28679180 | ||
Pyroptosis: host cell death and inflammation | Q29615594 | ||
Activation and regulation of the inflammasomes | Q29615664 | ||
Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling | Q29616024 | ||
Inflammasomes in health and disease | Q29616356 | ||
Type 2 diabetes as an inflammatory disease | Q29617184 | ||
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function | Q29617462 | ||
Interleukin-1-receptor antagonist in type 2 diabetes mellitus | Q29619001 | ||
Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells | Q29619771 | ||
Mechanisms of fibrosis: therapeutic translation for fibrotic disease | Q29620307 | ||
Macrophage biology in development, homeostasis and disease | Q29620350 | ||
Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis. | Q30469652 | ||
Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice | Q30543593 | ||
HIV and HCV activate the inflammasome in monocytes and macrophages via endosomal Toll-like receptors without induction of type 1 interferon | Q33553764 | ||
An autoinflammatory disease due to homozygous deletion of the IL1RN locus | Q33577198 | ||
Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF-κB and MAPK signaling | Q33665643 | ||
Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation | Q33762651 | ||
Biliary repair and carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferation | Q33808159 | ||
Pathophysiological roles of interleukin-18 in inflammatory liver diseases | Q33916627 | ||
The TLR4/TRIF-Mediated Activation of NLRP3 Inflammasome Underlies Endotoxin-Induced Liver Injury in Mice | Q33996553 | ||
Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. | Q34031152 | ||
IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions | Q34038230 | ||
Inflammatory caspases are innate immune receptors for intracellular LPS. | Q34041730 | ||
MHCII-mediated dialog between group 2 innate lymphoid cells and CD4(+) T cells potentiates type 2 immunity and promotes parasitic helminth expulsion | Q34106637 | ||
Enhanced innate type 2 immune response in peripheral blood from patients with asthma | Q34111924 | ||
Cytotoxic and non-cytotoxic roles of the CTL/NK protease granzyme B. | Q34120058 | ||
A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis | Q34131187 | ||
IL-1 family nomenclature | Q34144622 | ||
Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human Diseases | Q34149948 | ||
Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells | Q34152594 | ||
Interleukin-18 regulates both Th1 and Th2 responses | Q34178165 | ||
Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu | Q34225141 | ||
Ischemia-reperfusion injury of the retina is linked to necroptosis via the ERK1/2-RIP3 pathway. | Q34229514 | ||
Downregulation of interleukin-18-mediated cell signaling and interferon gamma expression by the hepatitis B virus e antigen. | Q34262225 | ||
The interleukin-1 family: back to the future | Q34391415 | ||
Group 2 innate lymphoid cells facilitate sensitization to local, but not systemic, TH2-inducing allergen exposures | Q34412638 | ||
Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3. | Q34413744 | ||
Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases | Q34415551 | ||
Interleukin-33 induces protective effects in adipose tissue inflammation during obesity in mice | Q34626217 | ||
IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice | Q34647885 | ||
Contribution of IL-18 to atopic-dermatitis-like skin inflammation induced by Staphylococcus aureus product in mice | Q34695489 | ||
IL-1β production through the NLRP3 inflammasome by hepatic macrophages links hepatitis C virus infection with liver inflammation and disease | Q34697945 | ||
Cutting edge: IL-1α is a crucial danger signal triggering acute myocardial inflammation during myocardial infarction | Q34780382 | ||
Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets | Q34796756 | ||
Activated type 2 innate lymphoid cells regulate beige fat biogenesis | Q34979492 | ||
At the bench: understanding group 2 innate lymphoid cells in disease. | Q35115465 | ||
At the bedside: the emergence of group 2 innate lymphoid cells in human disease | Q35115486 | ||
Skin exposure promotes a Th2-dependent sensitization to peanut allergens | Q35139991 | ||
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease | Q35155012 | ||
Inflammasome is a central player in the induction of obesity and insulin resistance | Q35216914 | ||
Interleukin 37 expression protects mice from colitis | Q35289509 | ||
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. | Q35350543 | ||
Regulation of inflammasome activation | Q35456425 | ||
Th2 signals induce epithelial injury in mice and are compatible with the biliary atresia phenotype | Q35484899 | ||
IL-33 facilitates oncogene-induced cholangiocarcinoma in mice by an interleukin-6-sensitive mechanism | Q35528356 | ||
Innate-type and acquired-type allergy regulated by IL-33. | Q38210237 | ||
Mechanisms and functions of inflammasomes | Q38214128 | ||
The role of the IL-33/IL-1RL1 axis in mast cell and basophil activation in allergic disorders. | Q38228838 | ||
Macrophages, immunity, and metabolic disease | Q38230879 | ||
A long-awaited merger of the pathways mediating host defence and programmed cell death. | Q38242025 | ||
IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy. | Q38256319 | ||
Toll-like receptor 9 inhibition confers protection from liver ischemia-reperfusion injury | Q38278784 | ||
Inflammasome-independent regulation of IL-1-family cytokines | Q38286016 | ||
Curcumin targets multiple pathways to halt hepatic stellate cell activation: updated mechanisms in vitro and in vivo | Q38297265 | ||
The biology of innate lymphoid cells | Q38319907 | ||
Necroptosis and its role in inflammation | Q38319916 | ||
Regulation and function of interleukin-36 cytokines in homeostasis and pathological conditions | Q38352252 | ||
Lung ILC2s link innate and adaptive responses in allergic inflammation | Q38364043 | ||
Recent advancement of molecular mechanisms of liver fibrosis | Q38419194 | ||
Hepatitis regulation by the inflammasome signaling pathway | Q38423384 | ||
Negative regulation of the inflammasome: keeping inflammation under control. | Q38423405 | ||
Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis | Q39217108 | ||
IL36RN mutation causing generalized pustular psoriasis in a Palestinian patient | Q40204732 | ||
Release of interleukin-1α or interleukin-1β depends on mechanism of cell death | Q40369818 | ||
IL-33 Reverses an Obesity-Induced Deficit in Visceral Adipose Tissue ST2+ T Regulatory Cells and Ameliorates Adipose Tissue Inflammation and Insulin Resistance. | Q41077951 | ||
Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta | Q41457693 | ||
IL-37 requires IL-18Rα and SIGIRR/IL-1R8 to diminish allergic airway inflammation in mice | Q41628090 | ||
IL-18 with IL-2 protects against Strongyloides venezuelensis infection by activating mucosal mast cell-dependent type 2 innate immunity | Q41815590 | ||
Mutation of mouse Mayp/Pstpip2 causes a macrophage autoinflammatory disease. | Q41839767 | ||
Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis | Q41945735 | ||
Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation | Q42093185 | ||
Cutting edge: FAS (CD95) mediates noncanonical IL-1β and IL-18 maturation via caspase-8 in an RIP3-independent manner | Q42286900 | ||
Multiple interleukin-1beta-converting enzymes contribute to inflammatory arthritis | Q42875223 | ||
Neutrophil proteinase 3-mediated induction of bioactive IL-18 secretion by human oral epithelial cells | Q43803701 | ||
IL-1RL2 and its ligands contribute to the cytokine network in psoriasis. | Q43978795 | ||
Noncanonical inflammasome activation by intracellular LPS independent of TLR4. | Q44450840 | ||
Contribution of TIR domain-containing adapter inducing IFN-beta-mediated IL-18 release to LPS-induced liver injury in mice. | Q45980093 | ||
Granzyme B is a novel interleukin-18 converting enzyme. | Q45991320 | ||
P275 | copyright license | Creative Commons Attribution 3.0 Unported | Q14947546 |
P6216 | copyright status | copyrighted | Q50423863 |
P407 | language of work or name | English | Q1860 |
P921 | main subject | liver disease | Q929737 |
peptide | Q172847 | ||
interleukins | Q194908 | ||
cell biology | Q7141 | ||
P304 | page(s) | 630265 | |
P577 | publication date | 2015-01-01 | |
2015-10-15 | |||
P1433 | published in | Mediators of Inflammation | Q2144494 |
P1476 | title | Interleukin-1 Family Cytokines in Liver Diseases | |
P478 | volume | 2015 |
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