Interleukin-1 Family Cytokines in Liver Diseases

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Interleukin-1 Family Cytokines in Liver Diseases is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1155/2015/630265
P3181OpenCitations bibliographic resource ID1248973
P932PMC publication ID4624893
P698PubMed publication ID26549942
P5875ResearchGate publication ID283954755

P50authorHiroko TsutsuiQ57405615
P2093author name stringShuhei Hayashi
Xianbin Cai
P2860cites workFatty acid-induced mitochondrial uncoupling elicits inflammasome-independent IL-1α and sterile vascular inflammation in atherosclerosisQ46323475
A possible role for interleukin 37 in the pathogenesis of Behcet's diseaseQ46905913
The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells.Q48234431
Interleukin-18 binding protein: a novel modulator of the Th1 cytokine responseQ22008772
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokinesQ24294720
The pan-caspase inhibitor Emricasan (IDN-6556) decreases liver injury and fibrosis in a murine model of non-alcoholic steatohepatitis.Q50473358
Overview of the interleukin-1 family of ligands and receptors.Q54536457
Caspase crosstalk: integration of apoptotic and innate immune signalling pathways.Q55058744
A critical role of IL-33 in experimental allergic rhinitisQ56897540
A newly defined interleukin-1?Q59054402
The IL1-like cytokine IL33 and its receptor ST2 are abnormally expressed in the affected skin and visceral organs of patients with systemic sclerosisQ61733657
Hepatic recruitment of the inflammatory Gr1+monocyte subset upon liver injury promotes hepatic fibrosisQ62735118
Pit cell-hepatocyte contact in autoimmune hepatitisQ70618941
Caspase-1-independent, Fas/Fas ligand-mediated IL-18 secretion from macrophages causes acute liver injury in miceQ73065691
Elevated levels of interleukin-18 and tumor necrosis factor-alpha in serum of patients with type 2 diabetes mellitus: relationship with diabetic nephropathyQ73420531
Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in miceQ74817301
Human mast cell chymase cleaves pro-IL-18 and generates a novel and biologically active IL-18 fragmentQ79401048
ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor moleculesQ80912569
Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune systemQ81191920
IL-33 induces IL-13-dependent cutaneous fibrosisQ82370239
Serum IL-33 levels are raised in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosisQ83233643
Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistanceQ83864443
Fas-mediated inflammatory response in Listeria monocytogenes infectionQ86426529
Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasomeQ24303046
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-betaQ24305136
NLRs join TLRs as innate sensors of pathogensQ24305830
Active caspase-1 is a regulator of unconventional protein secretionQ24308770
Unified polymerization mechanism for the assembly of ASC-dependent inflammasomesQ24339219
Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cellsQ24523640
Caspases: pharmacological manipulation of cell deathQ24536096
An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonistQ24606097
Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36α, IL-36β, and IL-36γ) or antagonist (IL-36Ra) activityQ24630062
Meprins, membrane-bound and secreted astacin metalloproteinasesQ24646365
Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammationQ24676343
Regulation of hepatic innate immunity by hepatitis C virusQ26824743
Elevation of interleukin-18 in chronic hepatitis C: implications for hepatitis C virus pathogenesisQ27489815
The pseudokinase MLKL mediates necroptosis via a molecular switch mechanismQ27685465
Alcoholic liver disease: pathogenesis and new therapeutic targetsQ27690220
Artificial sweeteners induce glucose intolerance by altering the gut microbiotaQ27968228
Gout-associated uric acid crystals activate the NALP3 inflammasomeQ28131797
IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1RrpQ28141927
IL-13 effector functionsQ28180348
NALPs: a novel protein family involved in inflammationQ28206764
Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKsQ28239808
Dietary modulation of the microbiome affects autoinflammatory diseaseQ28249017
A human tRNA synthetase is a potent PARP1-activating effector target for resveratrolQ28254419
IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transductionQ28258076
Differential activation of the inflammasome by caspase-1 adaptors ASC and IpafQ28266417
Cloning of a new cytokine that induces IFN-gamma production by T cellsQ28283928
Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzymeQ28287610
IL-37 is a fundamental inhibitor of innate immunityQ28295265
Localization and functionality of the inflammasome in neutrophilsQ28305418
Non-canonical inflammasome activation targets caspase-11Q28506831
Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptorQ28507342
IL-33-mediated protection against experimental cerebral malaria is linked to induction of type 2 innate lymphoid cells, M2 macrophages and regulatory T cellsQ35557167
Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndromeQ35570155
Innate lymphoid cells. Innate lymphoid cells: a new paradigm in immunologyQ35638915
Common and unique mechanisms regulate fibrosis in various fibroproliferative diseasesQ35649473
Sterile inflammation of endothelial cell-derived apoptotic bodies is mediated by interleukin-1αQ35651080
Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesityQ35660131
IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonistQ35779110
Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected miceQ35807590
Contradictory functions (activation/termination) of neutrophil proteinase 3 enzyme (PR3) in interleukin-33 biological activityQ35868166
Cell death and cell death responses in liver disease: mechanisms and clinical relevanceQ35938040
Induction of allergic inflammation by interleukin-18 in experimental animal modelsQ35951814
T helper 1 cells stimulated with ovalbumin and IL-18 induce airway hyperresponsiveness and lung fibrosis by IFN-gamma and IL-13 productionQ35990342
Molecular mechanisms in genetically defined autoinflammatory diseases: disorders of amplified danger signalingQ36041225
Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2Q36042132
The B-Raf(V600E) inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injuryQ36179559
Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in miceQ36243894
Transcription factor networks directing the development, function, and evolution of innate lymphoid effectorsQ36358937
Nonredundant roles for CD1d-restricted natural killer T cells and conventional CD4+ T cells in the induction of immunoglobulin E antibodies in response to interleukin 18 treatment of miceQ36370669
Interleukin 18 acts on memory T helper cells type 1 to induce airway inflammation and hyperresponsiveness in a naive host mouseQ36399270
Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosisQ36414956
Autoinflammatory disease reloaded: a clinical perspectiveQ36520994
Antigen- and cytokine-driven accumulation of regulatory T cells in visceral adipose tissue of lean miceQ36561831
The precursor form of IL-1alpha is an intracrine proinflammatory activator of transcriptionQ36602261
The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosisQ36613779
Mechanisms of disease: inflammasome activation and the development of type 2 diabetesQ36668052
Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophagesQ36694157
Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injuryQ36774034
Treating inflammation by blocking interleukin-1 in a broad spectrum of diseasesQ36816872
Prointerleukin-18 is activated by meprin beta in vitro and in vivo in intestinal inflammationQ36968427
Meprin A and meprin alpha generate biologically functional IL-1beta from pro-IL-1betaQ36985463
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and DiseaseQ36994761
Two independent pathways of regulated necrosis mediate ischemia-reperfusion injuryQ37031838
A missense mutation in pstpip2 is associated with the murine autoinflammatory disorder chronic multifocal osteomyelitisQ37053052
Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome.Q37073714
RIP3: a molecular switch for necrosis and inflammationQ37098143
Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease.Q37123845
Converting enzyme-independent release of tumor necrosis factor alpha and IL-1beta from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3Q37203389
Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths.Q37213084
Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in miceQ37216910
Hepatitis C virus induces interleukin-1β (IL-1β)/IL-18 in circulatory and resident liver macrophages.Q37254259
Interleukin-1 and tumor necrosis factor-α trigger restriction of hepatitis B virus infection via a cytidine deaminase activation-induced cytidine deaminase (AID)Q37272140
Interleukin-33 overexpression is associated with liver fibrosis in mice and humans.Q37311036
The Interleukin-1α Precursor is Biologically Active and is Likely a Key Alarmin in the IL-1 Family of CytokinesQ37326965
Primed innate immunity leads to autoinflammatory disease in PSTPIP2-deficient cmo mice.Q37352484
cDNA cloning of an intracellular form of the human interleukin 1 receptor antagonist associated with epitheliumQ37494553
Critical role for inflammasome-independent IL-1β production in osteomyelitisQ37519575
Inflammasome-independent IL-1β mediates autoinflammatory disease in Pstpip2-deficient miceQ37519648
TIR8/SIGIRR: an IL-1R/TLR family member with regulatory functions in inflammation and T cell polarizationQ37584645
Interleukin-33 potentiates bleomycin-induced lung injuryQ37596499
Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses.Q37599811
FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes.Q37601031
The sterile inflammatory responseQ37716003
Adipose tissue macrophages: their role in adipose tissue remodelingQ37723181
Importance of IL-18-induced super Th1 cells for the development of allergic inflammationQ37736214
Neutrophil serine proteases: mediators of innate immune responsesQ37806041
IL-36 in psoriasis.Q37991473
The sterile immune response during hepatic ischemia/reperfusionQ38011500
Immunotherapeutic applications of IL-18.Q38067452
The immunology of fibrosisQ38091697
Fat-resident Tregs: an emerging guard protecting from obesity-associated metabolic disordersQ38093672
In search of novel highly active mitochondria-targeted antioxidants: thymoquinone and its cationic derivatives.Q38105814
TH2, allergy and group 2 innate lymphoid cellsQ38107790
New Insights in the Immunobiology of IL-1 Family MembersQ38121074
Innate lymphoid cells and allergic inflammationQ38133877
Inflammasomes and metabolic diseaseQ38166027
Liver fibrosis and repair: immune regulation of wound healing in a solid organQ38190875
Importance of Both Innate Immunity and Acquired Immunity for Rapid Expulsion of S. venezuelensis.Q38200089
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesityQ28512778
Psoriasiform dermatitis is driven by IL-36-mediated DC-keratinocyte crosstalkQ28587108
Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosisQ28588383
Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzymeQ28610362
Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell deathQ28660873
Annotating genes with potential roles in the immune system: six new members of the IL-1 familyQ28679180
Pyroptosis: host cell death and inflammationQ29615594
Activation and regulation of the inflammasomesQ29615664
Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signalingQ29616024
Inflammasomes in health and diseaseQ29616356
Type 2 diabetes as an inflammatory diseaseQ29617184
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated functionQ29617462
Interleukin-1-receptor antagonist in type 2 diabetes mellitusQ29619001
Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cellsQ29619771
Mechanisms of fibrosis: therapeutic translation for fibrotic diseaseQ29620307
Macrophage biology in development, homeostasis and diseaseQ29620350
Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis.Q30469652
Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in miceQ30543593
HIV and HCV activate the inflammasome in monocytes and macrophages via endosomal Toll-like receptors without induction of type 1 interferonQ33553764
An autoinflammatory disease due to homozygous deletion of the IL1RN locusQ33577198
Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF-κB and MAPK signalingQ33665643
Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammationQ33762651
Biliary repair and carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferationQ33808159
Pathophysiological roles of interleukin-18 in inflammatory liver diseasesQ33916627
The TLR4/TRIF-Mediated Activation of NLRP3 Inflammasome Underlies Endotoxin-Induced Liver Injury in MiceQ33996553
Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat.Q34031152
IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditionsQ34038230
Inflammatory caspases are innate immune receptors for intracellular LPS.Q34041730
MHCII-mediated dialog between group 2 innate lymphoid cells and CD4(+) T cells potentiates type 2 immunity and promotes parasitic helminth expulsionQ34106637
Enhanced innate type 2 immune response in peripheral blood from patients with asthmaQ34111924
Cytotoxic and non-cytotoxic roles of the CTL/NK protease granzyme B.Q34120058
A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitisQ34131187
IL-1 family nomenclatureQ34144622
Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human DiseasesQ34149948
Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cellsQ34152594
Interleukin-18 regulates both Th1 and Th2 responsesQ34178165
Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieuQ34225141
Ischemia-reperfusion injury of the retina is linked to necroptosis via the ERK1/2-RIP3 pathway.Q34229514
Downregulation of interleukin-18-mediated cell signaling and interferon gamma expression by the hepatitis B virus e antigen.Q34262225
The interleukin-1 family: back to the futureQ34391415
Group 2 innate lymphoid cells facilitate sensitization to local, but not systemic, TH2-inducing allergen exposuresQ34412638
Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3.Q34413744
Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPasesQ34415551
Interleukin-33 induces protective effects in adipose tissue inflammation during obesity in miceQ34626217
IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in miceQ34647885
Contribution of IL-18 to atopic-dermatitis-like skin inflammation induced by Staphylococcus aureus product in miceQ34695489
IL-1β production through the NLRP3 inflammasome by hepatic macrophages links hepatitis C virus infection with liver inflammation and diseaseQ34697945
Cutting edge: IL-1α is a crucial danger signal triggering acute myocardial inflammation during myocardial infarctionQ34780382
Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic isletsQ34796756
Activated type 2 innate lymphoid cells regulate beige fat biogenesisQ34979492
At the bench: understanding group 2 innate lymphoid cells in disease.Q35115465
At the bedside: the emergence of group 2 innate lymphoid cells in human diseaseQ35115486
Skin exposure promotes a Th2-dependent sensitization to peanut allergensQ35139991
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory diseaseQ35155012
Inflammasome is a central player in the induction of obesity and insulin resistanceQ35216914
Interleukin 37 expression protects mice from colitisQ35289509
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.Q35350543
Regulation of inflammasome activationQ35456425
Th2 signals induce epithelial injury in mice and are compatible with the biliary atresia phenotypeQ35484899
IL-33 facilitates oncogene-induced cholangiocarcinoma in mice by an interleukin-6-sensitive mechanismQ35528356
Innate-type and acquired-type allergy regulated by IL-33.Q38210237
Mechanisms and functions of inflammasomesQ38214128
The role of the IL-33/IL-1RL1 axis in mast cell and basophil activation in allergic disorders.Q38228838
Macrophages, immunity, and metabolic diseaseQ38230879
A long-awaited merger of the pathways mediating host defence and programmed cell death.Q38242025
IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy.Q38256319
Toll-like receptor 9 inhibition confers protection from liver ischemia-reperfusion injuryQ38278784
Inflammasome-independent regulation of IL-1-family cytokinesQ38286016
Curcumin targets multiple pathways to halt hepatic stellate cell activation: updated mechanisms in vitro and in vivoQ38297265
The biology of innate lymphoid cellsQ38319907
Necroptosis and its role in inflammationQ38319916
Regulation and function of interleukin-36 cytokines in homeostasis and pathological conditionsQ38352252
Lung ILC2s link innate and adaptive responses in allergic inflammationQ38364043
Recent advancement of molecular mechanisms of liver fibrosisQ38419194
Hepatitis regulation by the inflammasome signaling pathwayQ38423384
Negative regulation of the inflammasome: keeping inflammation under control.Q38423405
Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasisQ39217108
IL36RN mutation causing generalized pustular psoriasis in a Palestinian patientQ40204732
Release of interleukin-1α or interleukin-1β depends on mechanism of cell deathQ40369818
IL-33 Reverses an Obesity-Induced Deficit in Visceral Adipose Tissue ST2+ T Regulatory Cells and Ameliorates Adipose Tissue Inflammation and Insulin Resistance.Q41077951
Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1betaQ41457693
IL-37 requires IL-18Rα and SIGIRR/IL-1R8 to diminish allergic airway inflammation in miceQ41628090
IL-18 with IL-2 protects against Strongyloides venezuelensis infection by activating mucosal mast cell-dependent type 2 innate immunityQ41815590
Mutation of mouse Mayp/Pstpip2 causes a macrophage autoinflammatory disease.Q41839767
Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosisQ41945735
Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammationQ42093185
Cutting edge: FAS (CD95) mediates noncanonical IL-1β and IL-18 maturation via caspase-8 in an RIP3-independent mannerQ42286900
Multiple interleukin-1beta-converting enzymes contribute to inflammatory arthritisQ42875223
Neutrophil proteinase 3-mediated induction of bioactive IL-18 secretion by human oral epithelial cellsQ43803701
IL-1RL2 and its ligands contribute to the cytokine network in psoriasis.Q43978795
Noncanonical inflammasome activation by intracellular LPS independent of TLR4.Q44450840
Contribution of TIR domain-containing adapter inducing IFN-beta-mediated IL-18 release to LPS-induced liver injury in mice.Q45980093
Granzyme B is a novel interleukin-18 converting enzyme.Q45991320
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectliver diseaseQ929737
peptideQ172847
interleukinsQ194908
cell biologyQ7141
P304page(s)630265
P577publication date2015-01-01
2015-10-15
P1433published inMediators of InflammationQ2144494
P1476titleInterleukin-1 Family Cytokines in Liver Diseases
P478volume2015

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