Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance

scientific article published on 28 May 2006

Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/NM1415
P698PubMed publication ID16732281

P50authorCharles A. DinarelloQ834442
Jos W. M. van der MeerQ6279152
Mihai NeteaQ24517868
Bart Jan KullbergQ62560089
Leo A.B. JoostenQ89547374
P2093author name stringCees J Tack
Robert H Eckel
Shizuo Akira
Soo-Hyun Kim
Peter J Voshol
Han van Krieken
Fons A van de Loo
Dalan R Jensen
Ineke Verschueren
Wim van den Berg
Anton F Stalenhoef
Eli Lewis
Leslie Pulawa
P2860cites workInterleukin-18 binding protein: a novel modulator of the Th1 cytokine responseQ22008772
IL-18 activates STAT3 in the natural killer cell line 92, augments cytotoxic activity, and mediates IFN-gamma production by the stress kinase p38 and by the extracellular regulated kinases p44erk-1 and p42erk-21Q22254639
Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouseQ24564225
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform ExtractionQ25938986
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesityQ28506782
Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulationQ28594238
The role of SOCS-3 in leptin signaling and leptin resistanceQ28610032
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated functionQ29617462
Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking DgatQ33901239
Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative miceQ34142722
Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stressQ34154404
Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liverQ39740783
Role of insulin resistance in human disease (syndrome X): an expanded definitionQ40897897
Defective NK cell activity and Th1 response in IL-18-deficient miceQ43595287
In muscle-specific lipoprotein lipase-overexpressing mice, muscle triglyceride content is increased without inhibition of insulin-stimulated whole-body and muscle-specific glucose uptakeQ43778803
Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivoQ44723555
Serum interleukin-18 concentrations are increased in the polycystic ovary syndrome: relationship to insulin resistance and to obesity.Q44757152
Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout miceQ44934466
Central leptin acutely reverses diet-induced hepatic insulin resistanceQ46774723
Neutralization of IL-18 reduces neutrophil tissue accumulation and protects mice against lethal Escherichia coli and Salmonella typhimurium endotoxemiaQ50122257
Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma productionQ50335883
An IFN-gamma-independent proinflammatory role of IL-18 in murine streptococcal cell wall arthritisQ73209359
Elevated levels of interleukin-18 and tumor necrosis factor-alpha in serum of patients with type 2 diabetes mellitus: relationship with diabetic nephropathyQ73420531
IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 familyQ77807763
P433issue6
P921main subjectobesityQ12174
insulin resistanceQ1053470
P1104number of pages7
P304page(s)650-656
P577publication date2006-05-28
P1433published inNature MedicineQ1633234
P1476titleDeficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance
P478volume12

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cites work (P2860)
Q34141083A Common Haplotype in NAPEPLD Is Associated With Severe Obesity in a Norwegian Population‐Based Cohort (the HUNT Study)
Q35222170A locus on mouse Chromosome 9 (Adip5) affects the relative weight of the gonadal but not retroperitoneal adipose depot
Q40974696Activation of proteinase 3 contributes to Non-alcoholic Fatty Liver Disease (NAFLD) and insulin resistance
Q37347715Acute effect of infection by adipogenic human adenovirus Ad36.
Q37080092Acute reduction of lipolysis reduces adiponectin and IL-18: evidence from an intervention study with acipimox and insulin
Q30587153Adenosine through the A2A adenosine receptor increases IL-1β in the brain contributing to anxiety
Q29620456Adipokines in inflammation and metabolic disease
Q38139293Adipose tissue inflammation in glucose metabolism
Q91994660Analysis of genes linked to depressive-like behaviors in interleukin-18-deficient mice: Gene expression profiles in the brain
Q98613140Anti-inflammatory and anti-oxidant effects of aloe vera in rats with non-alcoholic steatohepatitis
Q47139364Are IL18RAP gene polymorphisms associated with body mass regulation? A cross-sectional study
Q36287002Association of interleukin-18 gene polymorphism with body mass index in women
Q37141763Autophagy deficiency in myeloid cells increases susceptibility to obesity-induced diabetes and experimental colitis
Q36381096Biomarkers of obesity and subsequent cardiovascular events
Q47661727COPs and POPs Patrol Inflammasome Activation
Q93007803CREBZF as a Key Regulator of STAT3 Pathway in the Control of Liver Regeneration in Mice
Q33595895Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging
Q90114942Caspase-1 as a regulatory molecule of lipid metabolism
Q38187337Caspases and inflammasomes in metabolic inflammation
Q35829203Central obesity, type 2 diabetes and insulin: exploring a pathway full of thorns
Q35861003Characterization of Visceral and Subcutaneous Adipose Tissue Transcriptome and Biological Pathways in Pregnant and Non-Pregnant Women: Evidence for Pregnancy-Related Regional-Specific Differences in Adipose Tissue
Q34573680Circulating interleukin-18: A specific biomarker for atherosclerosis-prone patients with metabolic syndrome
Q33652307Circulating levels of interleukin-1 family cytokines in overweight adolescents.
Q35968506Common STAT3 variants are not associated with obesity or insulin resistance in female twins
Q46367558Constitutive and LPS-regulated expression of interleukin-18 receptor beta variants in the mouse brain.
Q51745836Contribution of mesothelial cells in the expression of inflammatory-related factors in omental adipose tissue of obese subjects.
Q38100529Cytokine assays: an assessment of the preparation and treatment of blood and tissue samples
Q90678059Cytokines and inflammation in adipogenesis: an updated review
Q28480545Cytokinome profile of patients with type 2 diabetes and/or chronic hepatitis C infection
Q59330135Deficiency in interleukin-18 promotes differentiation of brown adipose tissue resulting in fat accumulation despite dyslipidemia
Q39898733Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance.
Q35900629Deficiency of lymphotoxin-α does not exacerbate high-fat diet-induced obesity but does enhance inflammation in mice
Q38294300Diet, behavior and immunity across the lifespan.
Q54731039Differential haplotypic expression of the interleukin-18 gene.
Q43136613Divergent responses to thermogenic stimuli in BAT and subcutaneous adipose tissue from interleukin 18 and interleukin 18 receptor 1-deficient mice
Q36692476Dysregulation of maternal serum adiponectin in preterm labor
Q85028058Edentulism associated with obesity: a study of four national surveys of 16 416 Swedes aged 55–84 years
Q36349767Effect of Weight-Reduction in Obese Mice Lacking Toll-Like Receptor 5 and C57BL/6 Mice Fed a Low-Fat Diet
Q33810797Effects of body weight and alcohol consumption on insulin sensitivity
Q35189080Endogenous interleukin 18 suppresses hyperglycemia and hyperinsulinemia during the acute phase of endotoxemia in mice.
Q30482887Endothelial dysfunction and the development of renal injury in spontaneously hypertensive rats fed a high-fat diet
Q36405704Endurance and Resistance Training Affect High Fat Diet-Induced Increase of Ceramides, Inflammasome Expression, and Systemic Inflammation in Mice
Q27321681Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis
Q33689422Evaluating the levels of interleukin-1 family cytokines in sporadic amyotrophic lateral sclerosis.
Q53691097Female sex hormones are necessary for the metabolic effects mediated by loss of Interleukin 18 signaling.
Q37143708Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes
Q35172378Genetic variation within IL18 is associated with insulin levels, insulin resistance and postprandial measures
Q34708047Historical insights into cytokines
Q39194536Hypothalamic neuronal toll-like receptor 2 protects against age-induced obesity
Q52582325IL-1 Family Cytokine Pathways Underlying NAFLD: Towards New Treatment Strategies.
Q36005876IL-1 family members in the pathogenesis and treatment of metabolic disease: Focus on adipose tissue inflammation and insulin resistance
Q34763727IL-18 is required for self-reactive T cell expansion in NOD mice
Q58802853IL-37 Expression Reduces Lean Body Mass in Mice by Reducing Food Intake
Q54325530IL-37 protects against obesity-induced inflammation and insulin resistance.
Q38192633Immune and inflammatory pathways in NASH.
Q44786716Immunological complications of obesity
Q42226733Immunomodulatory factors and infectious agents associated with the hepatic gene expression of the IGF system in nursery pigs
Q34024277Increased beta-cell mass by islet transplantation and PLAG1 overexpression causes hyperinsulinemic normoglycemia and hepatic insulin resistance in mice
Q37377709Increased cytokine production in interleukin-18 receptor alpha-deficient cells is associated with dysregulation of suppressors of cytokine signaling
Q35044541Increased expression of IL-18 in the serum and islets of type 1 diabetics
Q46506826Increased fat:carbohydrate oxidation ratio in Il1ra (-/-) mice on a high-fat diet is associated with increased sympathetic tone
Q35216914Inflammasome is a central player in the induction of obesity and insulin resistance
Q90701009Inflammasome signaling and regulation of interleukin-1 family cytokines
Q28512778Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
Q57492010Inflammasome: A Double-Edged Sword in Liver Diseases
Q28389531Inflammasomes and metabolic disorders: old genes in modern diseases
Q29616356Inflammasomes in health and disease
Q47593693Inflammasomes in neurological diseases: emerging pathogenic and therapeutic concepts
Q60303389Inflammasomes: Pandora's box for sepsis
Q37995069Inflammasomes: far beyond inflammation
Q27001186Inflammasomes: mechanism of action, role in disease, and therapeutics
Q37174503Inflammation during obesity is not all bad: evidence from animal and human studies
Q28066646Inflammatory Cytokines and Antipsychotic-Induced Weight Gain: Review and Clinical Implications
Q35838041Inflammatory and oxidative stress responses to high-carbohydrate and high-fat meals in healthy humans
Q36409227Inflammatory mechanisms in the regulation of insulin resistance
Q47149968Interleukin (IL)-18 Binding Protein Deficiency Disrupts Natural Killer Cell Maturation and Diminishes Circulating IL-18.
Q28771509Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter
Q34095673Interleukin 18 in the CNS.
Q26778553Interleukin-1 Family Cytokines in Liver Diseases
Q61911892Interleukin-15 Contributes to the Regulation of Murine Adipose Tissue and Human Adipocytes
Q37110553Interleukin-18 activates skeletal muscle AMPK and reduces weight gain and insulin resistance in mice
Q37220336Interleukin-18 and IL-18 binding protein
Q35865066Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency
Q42817301Interleukin-18 enhances glucose uptake in 3T3-L1 adipocytes
Q64275741Interleukin-18 in Health and Disease
Q42258755Interleukin-18 mediates cardiac dysfunction induced by western diet independent of obesity and hyperglycemia in the mouse
Q34450892Interleukin-18 null mutation increases weight and food intake and reduces energy expenditure and lipid substrate utilization in high-fat diet fed mice
Q38685111Interleukin-18 polymorphism as an inflammatory index in metabolic syndrome: A preliminary study.
Q81681379Interleukin-18 resistance in patients with obesity and type 2 diabetes mellitus
Q40720751Interleukin-18-deficient mice develop dyslipidemia resulting in nonalcoholic fatty liver disease and steatohepatitis.
Q47285927Interleukin-18: Biological properties and role in disease pathogenesis
Q34626217Interleukin-33 induces protective effects in adipose tissue inflammation during obesity in mice
Q93133573Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction
Q90101165Interleukin-37 treatment of mice with metabolic syndrome improves insulin sensitivity and reduces pro-inflammatory cytokine production in adipose tissue
Q60472237Interleukin-6 is a better metabolic biomarker than interleukin-18 in young healthy adults
Q36128155Interleukin-7 Plasma Levels in Human Differentiate Anorexia Nervosa, Constitutional Thinness and Healthy Obesity.
Q34328873Interleukin-7 regulates adipose tissue mass and insulin sensitivity in high-fat diet-fed mice through lymphocyte-dependent and independent mechanisms
Q33550810Interleukin-7, a new cytokine targeting the mouse hypothalamic arcuate nucleus: role in body weight and food intake regulation.
Q36854344Interplay of pro- and anti-inflammatory cytokines to determine lipid accretion in adipocytes
Q83379079Linking the inflammasome to obesity-related disease
Q36373163Lipidomic evidence that lowering the typical dietary palmitate to oleate ratio in humans decreases the leukocyte production of proinflammatory cytokines and muscle expression of redox-sensitive genes
Q56951980Liver repercussions of defective gut surveillance
Q41879714Long-term exposure to a high-fat diet results in the development of glucose intolerance and insulin resistance in interleukin-1 receptor I-deficient mice.
Q36119524Loss of Nlrp3 Does Not Protect Mice from Western Diet-Induced Adipose Tissue Inflammation and Glucose Intolerance
Q48226767Low expression of IL-18 and IL-18 receptor in human skeletal muscle is associated with systemic and intramuscular lipid metabolism-Role of HIV lipodystrophy
Q37695121Lower NLRP3 inflammasome activity in NAG-1 transgenic mice is linked to a resistance to obesity and increased insulin sensitivity
Q21144671Malnutrition and infection: complex mechanisms and global impacts
Q37350317Mapping of the full length and the truncated interleukin-18 receptor alpha in the mouse brain
Q42194619Matching experiments across species using expression values and textual information
Q42546120Membrane interleukin-18 revisits membrane IL-1α in T-helper type 1 responses
Q27336723Mice chronically fed high-fat diet have increased mortality and disturbed immune response in sepsis
Q34608360Mice deficient in the respiratory chain gene Cox6a2 are protected against high-fat diet-induced obesity and insulin resistance
Q91963050Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes
Q58316591Molecular Definition of Inflammasomes
Q60959905NLRP3 Inflammasome: A Possible Link Between Obesity-Associated Low-Grade Chronic Inflammation and Colorectal Cancer Development
Q90262460NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling
Q37212058Neuroendocrine and cardiac metabolic dysfunction and NLRP3 inflammasome activation in adipose tissue and pancreas following chronic spinal cord injury in the mouse
Q35641956Night eating and obesity in the EP3R-deficient mouse
Q90288099Nlrp1b1 negatively modulates obesity-induced inflammation by promoting IL-18 production
Q33580624Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease
Q50978244Obesity development in caspase-1-deficient mice.
Q22250939Obesity, Inflammation, and Insulin Resistance
Q47285878Overview of the IL-1 family in innate inflammation and acquired immunity
Q54260312Oxidative Stress and NLRP3-Inflammasome Activity as Significant Drivers of Diabetic Cardiovascular Complications: Therapeutic Implications.
Q35813603Panhistone deacetylase inhibitors inhibit proinflammatory signaling pathways to ameliorate interleukin-18-induced cardiac hypertrophy
Q50420493Physiological and molecular effects of interleukin-18 administration on the mouse kidney.
Q85184151Pitavastatin Reduces Elevated IL-18 Levels in Japanese Subjects with Hypercholesterolemia: Sub-analysis of Kansai Investigation of Statin for Hyperlipidemic Intervention in Metabolism and Endocrinology (KISHIMEN)
Q90244453Polyglycolic acid sutures embedded in abdominal acupoints for treatment of simple obesity in adults: a randomized control trial
Q33908725Programming of fetal insulin resistance in pregnancies with maternal obesity by ER stress and inflammation
Q90599568Pyroptosis in Liver Disease: New Insights into Disease Mechanisms
Q26739753Questions and controversies in innate immune research: what is the physiological role of NLRP3?
Q58692657Regulation of Energy Expenditure and Brown/Beige Thermogenic Activity by Interleukins: New Roles for Old Actors
Q95643265Remodeling adipose tissue inflammasome for type 2 diabetes mellitus treatment: Current perspective and translational strategies
Q36712641Role of caspase-1 in regulation of triglyceride metabolism.
Q28300967Role of the HIN domain in regulation of innate immune responses
Q37925073Sensing damage by the NLRP3 inflammasome
Q37505460Session on 'Obesity'. Adipose tissue development, nutrition in early life and its impact on later obesity.
Q36885097Signals generating anorexia during acute illness
Q40928068Sirtuin-1 is a nutrient-dependent modulator of inflammation
Q35001511Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives
Q35976791The ATP-P2X7 signaling axis is dispensable for obesity-associated inflammasome activation in adipose tissue
Q55401263The Effects of Sinapic Acid on the Development of Metabolic Disorders Induced by Estrogen Deficiency in Rats.
Q39793088The Proinflammatory Cytokine Interleukin 18 Regulates Feeding by Acting on the Bed Nucleus of the Stria Terminalis.
Q33861166The effect of chronic candesartan therapy on the metabolic profile and renal tissue cytokine levels in the obese Zucker rat.
Q34897067The effects of erythropoietin dose titration during high-fat diet-induced obesity
Q36686713The frequency of an IL-18-associated haplotype in Africans
Q36387304The hormonal control of food intake
Q36931760The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity
Q24613816The inflammasome: in memory of Dr. Jurg Tschopp
Q34391415The interleukin-1 family: back to the future
Q35017018The oral histone deacetylase inhibitor ITF2357 reduces cytokines and protects islet β cells in vivo and in vitro
Q26852901The role of adipokines in chronic inflammation
Q28730838The role of inflammatory pathway genetic variation on maternal metabolic phenotypes during pregnancy
Q33304007The role of interferon-gamma in the increased tuberculosis risk in type 2 diabetes mellitus
Q33804391The role of interleukin-18 in the metabolic syndrome
Q37462159The role of interleukins in insulin resistance and type 2 diabetes mellitus.
Q33331801The role of the small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J mice
Q24657048The role of the vgf gene and VGF-derived peptides in nutrition and metabolism
Q37796144Toll-like receptors: linking inflammation to metabolism
Q47589398Tuberculosis and host metabolism: ancient associations, fresh insights
Q59138098Verapamil Ameliorates Hepatic Metaflammation by Inhibiting Thioredoxin-Interacting Protein/NLRP3 Pathways
Q37286991Why is obesity associated with osteoarthritis? Insights from mouse models of obesity
Q42853651−607 C/A polymorphism in the promoter of IL-18 gene is associated with 2 h post-loading plasma glucose level in Chinese