Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives

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Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives is …
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scholarly articleQ13442814
review articleQ7318358

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P356DOI10.2147/JIR.S51250
P932PMC publication ID4303395
P698PubMed publication ID25653548

P50authorSarah L DoyleQ55948328
P2093author name stringMatthew Campbell
Ema Ozaki
P2860cites workA frameshift mutation in NOD2 associated with susceptibility to Crohn's diseaseQ22251291
Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1Q24291293
Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndromeQ24291856
PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processingQ24297724
Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytesQ24298360
The inflammasomesQ24304087
Fine structure mapping of CIAS1: identification of an ancestral haplotype and a common FCAS mutation, L353P.Q40567772
Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosisQ40573796
Effect of interleukin-18 on mouse core body temperatureQ40588824
Phase I study of recombinant interleukin-1 beta in patients undergoing autologous bone marrow transplant for acute myelogenous leukemia.Q40699744
Interleukin-1: biological effects in human hematopoiesisQ40828953
An ‘Allergy’ to ColdQ40868379
IL-18 augments perforin-dependent cytotoxicity of liver NK-T cellsQ41011495
IFN-gamma-inducing factor/IL-18 administration mediates IFN-gamma- and IL-12-independent antitumor effects.Q41064602
The NLRP12 inflammasome recognizes Yersinia pestisQ41411108
Cryopyrin-associated autoinflammatory syndrome: a new mutationQ42410297
IL-converting enzyme/caspase-1 inhibitor VX-765 blocks the hypersensitive response to an inflammatory stimulus in monocytes from familial cold autoinflammatory syndrome patientsQ42482233
Efficacy and safety of CE-224,535, an antagonist of P2X7 receptor, in treatment of patients with rheumatoid arthritis inadequately controlled by methotrexateQ42720832
NLRP3 inflammasome blockade inhibits VEGF-A-induced age-related macular degeneration.Q42916834
Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's diseaseQ43770460
Immunochemical characterization of the antigen recognized by the murine monoclonal antibody A7 against human colorectal cancerQ43999558
Human astrocytes express a novel NLRP2 inflammasome.Q44760211
A novel CIAS1 mutation and plasma/cerebrospinal fluid cytokine profile in a German patient with neonatal-onset multisystem inflammatory disease responsive to methotrexate therapyQ44962168
Interleukin-18 in intestinal inflammation: friend and foe?Q45769281
Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defenceQ46064734
Interleukin 1 beta initially sensitizes and subsequently protects murine intestinal stem cells exposed to photon radiationQ46114464
Ethnopharmacology of Mexican asteraceae (Compositae).Q47761123
Emerging inflammasome effector mechanismsQ49071287
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-betaQ24305136
Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptorQ24306745
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorderQ24317771
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASCQ24319706
Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory responseQ24336216
De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseasesQ24337040
New mutations of CIAS1 that are responsible for Muckle-Wells syndrome and familial cold urticaria: a novel mutation underlies both syndromesQ24613164
DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88Q24621930
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilizationQ24631966
The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1Q24650268
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's diseaseQ27860821
A role for mitochondria in NLRP3 inflammasome activationQ28131794
Gout-associated uric acid crystals activate the NALP3 inflammasomeQ28131797
Inflamm-aging. An evolutionary perspective on immunosenescenceQ28141817
IL-18 attenuates experimental choroidal neovascularization as a potential therapy for wet age-related macular degenerationQ28237337
Inflammatory caspases and inflammasomes: master switches of inflammationQ28263855
Cryopyrin activates the inflammasome in response to toxins and ATPQ28291313
Interleukin 1 is a radioprotectorQ28299497
A phase I trial of recombinant human interleukin-1 beta alone and in combination with myelosuppressive doses of 5-fluorouracil in patients with gastrointestinal cancerQ28332949
The cytokine release inhibitory drug CRID3 targets ASC oligomerisation in the NLRP3 and AIM2 inflammasomesQ28478561
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via IpafQ28506503
Developmental control of the Nlrp6 inflammasome and a substrate, IL-18, in mammalian intestineQ28564168
Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxinQ28586508
In vivo antitumor effects of murine interferon-gamma-inducing factor/interleukin-18 in mice bearing syngeneic Meth A sarcoma malignant ascitesQ28586653
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophagesQ28594887
The mammalian PYHIN gene family: phylogeny, evolution and expressionQ28727434
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasomeQ29547419
Thioredoxin-interacting protein links oxidative stress to inflammasome activationQ29614471
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetesQ29615593
The NALP3 inflammasome is involved in the innate immune response to amyloid-betaQ29615595
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentrationQ29615596
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagyQ29615616
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystalsQ29615704
NLRP6 inflammasome regulates colonic microbial ecology and risk for colitisQ29616155
A case of Muckle-Wells syndrome caused by a novel H312P mutation in NALP3 (cryopyrin).Q50454078
Evidence of NLRP3-inflammasome activation in rheumatoid arthritis (RA); genetic variants within the NLRP3-inflammasome complex in relation to susceptibility to RA and response to anti-TNF treatment.Q50980583
Follow-up and quality of life of patients with cryopyrin-associated periodic syndromes treated with Anakinra.Q51908344
Clinical and genetic characterization of Italian patients affected by CINCA syndrome.Q51913494
Chemoimmunotherapy using pegylated liposomal Doxorubicin and interleukin-18 in recurrent ovarian cancer: a phase I dose-escalation study.Q53284273
Pannexin-1-Mediated Recognition of Bacterial Molecules Activates the Cryopyrin Inflammasome Independent of Toll-like Receptor SignalingQ57080628
Clinical evaluation of the efficacy of the P2X7purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazineQ57231903
IL-18 Induces PD-1-Dependent Immunosuppression in CancerQ57556330
A phase 2, randomized study of SB-485232, rhIL-18, in patients with previously untreated metastatic melanomaQ58024833
Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory CaspasesQ58061322
Cold hypersensitivityQ70746074
Loss of caspase-1 and caspase-3 protein expression in human prostate cancerQ73548885
Molecular regulation of granulocyte macrophage colony-stimulating factor in human lung epithelial cells by interleukin (IL)-1beta, IL-4, and IL-13 involves both transcriptional and post-transcriptional mechanismsQ73716291
Disease-associated CIAS1 mutations induce monocyte death, revealing low-level mosaicism in mutation-negative cryopyrin-associated periodic syndrome patientsQ80156768
Variant chronic infantile neurologic, cutaneous, articular syndrome due to a mutation within the leucine-rich repeat domain of CIAS1Q80502467
Neonatal-onset multisystem inflammatory disease (NOMID) due to a novel S331R mutation of the CIAS1 gene and response to interleukin-1 receptor antagonist treatmentQ82801857
Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistanceQ83864443
Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activationQ29617064
Immunological and inflammatory functions of the interleukin-1 familyQ29619669
NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasisQ30497993
NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen componentsQ30576000
Caspase-1 enhances the apoptotic response of prostate cancer cells to ionizing radiation.Q33205180
Clinical and biological effects of recombinant human interleukin-18 administered by intravenous infusion to patients with advanced cancerQ33372032
Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasomeQ33744674
The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancerQ33839949
ATP-sensitive potassium channelopathies: focus on insulin secretionQ33905803
Negative regulation of the NLRP3 inflammasome by A20 protects against arthritisQ34020795
Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1.Q34155136
Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibitionQ34262569
The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitisQ34313840
Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonistQ34367330
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteriaQ34640637
A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseasesQ35044923
The clinical continuum of cryopyrinopathies: novel CIAS1 mutations in North American patients and a new cryopyrin modelQ35064730
Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasomeQ35091448
The complex role of inflammasomes in the pathogenesis of Inflammatory Bowel Diseases - lessons learned from experimental models.Q35164159
Interleukin-18 has antipermeablity and antiangiogenic activities in the eye: reciprocal suppression with VEGF.Q35191520
Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signalingQ35808888
An NLRP7-containing inflammasome mediates recognition of microbial lipopeptides in human macrophagesQ35860827
Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activationQ36332983
NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degenerationQ36530569
Deubiquitinases regulate the activity of caspase-1 and interleukin-1β secretion via assembly of the inflammasomeQ36562107
Pharmacokinetic and pharmacodynamic profiling of a P2X7 receptor allosteric modulator GSK1482160 in healthy human subjectsQ36562495
Treating inflammation by blocking interleukin-1 in a broad spectrum of diseasesQ36816872
Induction of a chronic disease state in patients with smoldering or indolent multiple myeloma by targeting interleukin 1{beta}-induced interleukin 6 production and the myeloma proliferative componentQ37148370
Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1beta are differentially regulated in human blood mononuclear cells and mouse spleen cellsQ37179132
Interleukin-18 and IL-18 binding proteinQ37220336
Common variants in the NLRP3 region contribute to Crohn's disease susceptibilityQ37310504
Glyburide inhibits the Cryopyrin/Nalp3 inflammasomeQ37387873
Inflammasomes in cancer: a double-edged swordQ37610512
A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouseQ37692892
Anti-IL-1β therapiesQ37901516
Immunology in clinic review series; focus on autoinflammatory diseases: role of inflammasomes in autoinflammatory syndromesQ37979861
The autoinflammatory diseasesQ38020104
The NLRP3 inflammasome in Alzheimer's diseaseQ38107892
Inflammasome and cytokine blocking strategies in autoinflammatory disordersQ38108657
Anakinra for cryopyrin-associated periodic syndromeQ38168948
Interleukin-1 and hematopoiesisQ38257602
Cell volume regulation modulates NLRP3 inflammasome activationQ39278343
Familial cold urticariaQ39330730
Characterization of NLRP3 variants in Japanese cryopyrin-associated periodic syndrome patientsQ39423614
Chemical probing reveals insights into the signaling mechanism of inflammasome activationQ39653478
The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA.Q39861713
Identification of a key pathway required for the sterile inflammatory response triggered by dying cellsQ40119160
Long-term efficacy of the interleukin-1 receptor antagonist anakinra in ten patients with neonatal-onset multisystem inflammatory disease/chronic infantile neurologic, cutaneous, articular syndromeQ40370420
A dose-escalation study of recombinant human interleukin-18 using two different schedules of administration in patients with cancerQ40417751
Phenotype-genotype analysis of cryopyrin-associated periodic syndromes (CAPS): description of a rare non-exon 3 and a novel CIAS1 missense mutation.Q40432099
A variant Muckle-Wells syndrome with a novel mutation in CIAS1 gene responding to anakinra.Q40450521
Recovery from deafness in a patient with Muckle-Wells syndrome treated with anakinra.Q40480177
Anakinra therapy for CINCA syndrome with a novel mutation in exon 4 of the CIAS1 geneQ40487157
Clinical and genetic heterogeneity among Spanish patients with recurrent autoinflammatory syndromes associated with the CIAS1/PYPAF1/NALP3 gene.Q40519235
P275copyright licenseCreative Commons Attribution-NonCommercial 3.0 UnportedQ18810331
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectinflammationQ101991
inflammasome complexQ412405
P304page(s)15-27
P577publication date2015-01-16
P1433published inJournal of Inflammation ResearchQ6295349
P1476titleTargeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives
P478volume8

Reverse relations

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