scholarly article | Q13442814 |
review article | Q7318358 |
P50 | author | Sarah L Doyle | Q55948328 |
P2093 | author name string | Matthew Campbell | |
Ema Ozaki | |||
P2860 | cites work | A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease | Q22251291 |
Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1 | Q24291293 | ||
Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome | Q24291856 | ||
PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing | Q24297724 | ||
Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes | Q24298360 | ||
The inflammasomes | Q24304087 | ||
Fine structure mapping of CIAS1: identification of an ancestral haplotype and a common FCAS mutation, L353P. | Q40567772 | ||
Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis | Q40573796 | ||
Effect of interleukin-18 on mouse core body temperature | Q40588824 | ||
Phase I study of recombinant interleukin-1 beta in patients undergoing autologous bone marrow transplant for acute myelogenous leukemia. | Q40699744 | ||
Interleukin-1: biological effects in human hematopoiesis | Q40828953 | ||
An ‘Allergy’ to Cold | Q40868379 | ||
IL-18 augments perforin-dependent cytotoxicity of liver NK-T cells | Q41011495 | ||
IFN-gamma-inducing factor/IL-18 administration mediates IFN-gamma- and IL-12-independent antitumor effects. | Q41064602 | ||
The NLRP12 inflammasome recognizes Yersinia pestis | Q41411108 | ||
Cryopyrin-associated autoinflammatory syndrome: a new mutation | Q42410297 | ||
IL-converting enzyme/caspase-1 inhibitor VX-765 blocks the hypersensitive response to an inflammatory stimulus in monocytes from familial cold autoinflammatory syndrome patients | Q42482233 | ||
Efficacy and safety of CE-224,535, an antagonist of P2X7 receptor, in treatment of patients with rheumatoid arthritis inadequately controlled by methotrexate | Q42720832 | ||
NLRP3 inflammasome blockade inhibits VEGF-A-induced age-related macular degeneration. | Q42916834 | ||
Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease | Q43770460 | ||
Immunochemical characterization of the antigen recognized by the murine monoclonal antibody A7 against human colorectal cancer | Q43999558 | ||
Human astrocytes express a novel NLRP2 inflammasome. | Q44760211 | ||
A novel CIAS1 mutation and plasma/cerebrospinal fluid cytokine profile in a German patient with neonatal-onset multisystem inflammatory disease responsive to methotrexate therapy | Q44962168 | ||
Interleukin-18 in intestinal inflammation: friend and foe? | Q45769281 | ||
Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence | Q46064734 | ||
Interleukin 1 beta initially sensitizes and subsequently protects murine intestinal stem cells exposed to photon radiation | Q46114464 | ||
Ethnopharmacology of Mexican asteraceae (Compositae). | Q47761123 | ||
Emerging inflammasome effector mechanisms | Q49071287 | ||
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta | Q24305136 | ||
Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor | Q24306745 | ||
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder | Q24317771 | ||
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC | Q24319706 | ||
Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response | Q24336216 | ||
De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases | Q24337040 | ||
New mutations of CIAS1 that are responsible for Muckle-Wells syndrome and familial cold urticaria: a novel mutation underlies both syndromes | Q24613164 | ||
DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88 | Q24621930 | ||
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization | Q24631966 | ||
The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1 | Q24650268 | ||
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease | Q27860821 | ||
A role for mitochondria in NLRP3 inflammasome activation | Q28131794 | ||
Gout-associated uric acid crystals activate the NALP3 inflammasome | Q28131797 | ||
Inflamm-aging. An evolutionary perspective on immunosenescence | Q28141817 | ||
IL-18 attenuates experimental choroidal neovascularization as a potential therapy for wet age-related macular degeneration | Q28237337 | ||
Inflammatory caspases and inflammasomes: master switches of inflammation | Q28263855 | ||
Cryopyrin activates the inflammasome in response to toxins and ATP | Q28291313 | ||
Interleukin 1 is a radioprotector | Q28299497 | ||
A phase I trial of recombinant human interleukin-1 beta alone and in combination with myelosuppressive doses of 5-fluorouracil in patients with gastrointestinal cancer | Q28332949 | ||
The cytokine release inhibitory drug CRID3 targets ASC oligomerisation in the NLRP3 and AIM2 inflammasomes | Q28478561 | ||
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf | Q28506503 | ||
Developmental control of the Nlrp6 inflammasome and a substrate, IL-18, in mammalian intestine | Q28564168 | ||
Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin | Q28586508 | ||
In vivo antitumor effects of murine interferon-gamma-inducing factor/interleukin-18 in mice bearing syngeneic Meth A sarcoma malignant ascites | Q28586653 | ||
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages | Q28594887 | ||
The mammalian PYHIN gene family: phylogeny, evolution and expression | Q28727434 | ||
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome | Q29547419 | ||
Thioredoxin-interacting protein links oxidative stress to inflammasome activation | Q29614471 | ||
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes | Q29615593 | ||
The NALP3 inflammasome is involved in the innate immune response to amyloid-beta | Q29615595 | ||
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration | Q29615596 | ||
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy | Q29615616 | ||
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals | Q29615704 | ||
NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis | Q29616155 | ||
A case of Muckle-Wells syndrome caused by a novel H312P mutation in NALP3 (cryopyrin). | Q50454078 | ||
Evidence of NLRP3-inflammasome activation in rheumatoid arthritis (RA); genetic variants within the NLRP3-inflammasome complex in relation to susceptibility to RA and response to anti-TNF treatment. | Q50980583 | ||
Follow-up and quality of life of patients with cryopyrin-associated periodic syndromes treated with Anakinra. | Q51908344 | ||
Clinical and genetic characterization of Italian patients affected by CINCA syndrome. | Q51913494 | ||
Chemoimmunotherapy using pegylated liposomal Doxorubicin and interleukin-18 in recurrent ovarian cancer: a phase I dose-escalation study. | Q53284273 | ||
Pannexin-1-Mediated Recognition of Bacterial Molecules Activates the Cryopyrin Inflammasome Independent of Toll-like Receptor Signaling | Q57080628 | ||
Clinical evaluation of the efficacy of the P2X7purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine | Q57231903 | ||
IL-18 Induces PD-1-Dependent Immunosuppression in Cancer | Q57556330 | ||
A phase 2, randomized study of SB-485232, rhIL-18, in patients with previously untreated metastatic melanoma | Q58024833 | ||
Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases | Q58061322 | ||
Cold hypersensitivity | Q70746074 | ||
Loss of caspase-1 and caspase-3 protein expression in human prostate cancer | Q73548885 | ||
Molecular regulation of granulocyte macrophage colony-stimulating factor in human lung epithelial cells by interleukin (IL)-1beta, IL-4, and IL-13 involves both transcriptional and post-transcriptional mechanisms | Q73716291 | ||
Disease-associated CIAS1 mutations induce monocyte death, revealing low-level mosaicism in mutation-negative cryopyrin-associated periodic syndrome patients | Q80156768 | ||
Variant chronic infantile neurologic, cutaneous, articular syndrome due to a mutation within the leucine-rich repeat domain of CIAS1 | Q80502467 | ||
Neonatal-onset multisystem inflammatory disease (NOMID) due to a novel S331R mutation of the CIAS1 gene and response to interleukin-1 receptor antagonist treatment | Q82801857 | ||
Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance | Q83864443 | ||
Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation | Q29617064 | ||
Immunological and inflammatory functions of the interleukin-1 family | Q29619669 | ||
NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis | Q30497993 | ||
NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components | Q30576000 | ||
Caspase-1 enhances the apoptotic response of prostate cancer cells to ionizing radiation. | Q33205180 | ||
Clinical and biological effects of recombinant human interleukin-18 administered by intravenous infusion to patients with advanced cancer | Q33372032 | ||
Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome | Q33744674 | ||
The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer | Q33839949 | ||
ATP-sensitive potassium channelopathies: focus on insulin secretion | Q33905803 | ||
Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis | Q34020795 | ||
Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1. | Q34155136 | ||
Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition | Q34262569 | ||
The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis | Q34313840 | ||
Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist | Q34367330 | ||
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria | Q34640637 | ||
A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases | Q35044923 | ||
The clinical continuum of cryopyrinopathies: novel CIAS1 mutations in North American patients and a new cryopyrin model | Q35064730 | ||
Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome | Q35091448 | ||
The complex role of inflammasomes in the pathogenesis of Inflammatory Bowel Diseases - lessons learned from experimental models. | Q35164159 | ||
Interleukin-18 has antipermeablity and antiangiogenic activities in the eye: reciprocal suppression with VEGF. | Q35191520 | ||
Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling | Q35808888 | ||
An NLRP7-containing inflammasome mediates recognition of microbial lipopeptides in human macrophages | Q35860827 | ||
Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation | Q36332983 | ||
NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degeneration | Q36530569 | ||
Deubiquitinases regulate the activity of caspase-1 and interleukin-1β secretion via assembly of the inflammasome | Q36562107 | ||
Pharmacokinetic and pharmacodynamic profiling of a P2X7 receptor allosteric modulator GSK1482160 in healthy human subjects | Q36562495 | ||
Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases | Q36816872 | ||
Induction of a chronic disease state in patients with smoldering or indolent multiple myeloma by targeting interleukin 1{beta}-induced interleukin 6 production and the myeloma proliferative component | Q37148370 | ||
Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1beta are differentially regulated in human blood mononuclear cells and mouse spleen cells | Q37179132 | ||
Interleukin-18 and IL-18 binding protein | Q37220336 | ||
Common variants in the NLRP3 region contribute to Crohn's disease susceptibility | Q37310504 | ||
Glyburide inhibits the Cryopyrin/Nalp3 inflammasome | Q37387873 | ||
Inflammasomes in cancer: a double-edged sword | Q37610512 | ||
A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouse | Q37692892 | ||
Anti-IL-1β therapies | Q37901516 | ||
Immunology in clinic review series; focus on autoinflammatory diseases: role of inflammasomes in autoinflammatory syndromes | Q37979861 | ||
The autoinflammatory diseases | Q38020104 | ||
The NLRP3 inflammasome in Alzheimer's disease | Q38107892 | ||
Inflammasome and cytokine blocking strategies in autoinflammatory disorders | Q38108657 | ||
Anakinra for cryopyrin-associated periodic syndrome | Q38168948 | ||
Interleukin-1 and hematopoiesis | Q38257602 | ||
Cell volume regulation modulates NLRP3 inflammasome activation | Q39278343 | ||
Familial cold urticaria | Q39330730 | ||
Characterization of NLRP3 variants in Japanese cryopyrin-associated periodic syndrome patients | Q39423614 | ||
Chemical probing reveals insights into the signaling mechanism of inflammasome activation | Q39653478 | ||
The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA. | Q39861713 | ||
Identification of a key pathway required for the sterile inflammatory response triggered by dying cells | Q40119160 | ||
Long-term efficacy of the interleukin-1 receptor antagonist anakinra in ten patients with neonatal-onset multisystem inflammatory disease/chronic infantile neurologic, cutaneous, articular syndrome | Q40370420 | ||
A dose-escalation study of recombinant human interleukin-18 using two different schedules of administration in patients with cancer | Q40417751 | ||
Phenotype-genotype analysis of cryopyrin-associated periodic syndromes (CAPS): description of a rare non-exon 3 and a novel CIAS1 missense mutation. | Q40432099 | ||
A variant Muckle-Wells syndrome with a novel mutation in CIAS1 gene responding to anakinra. | Q40450521 | ||
Recovery from deafness in a patient with Muckle-Wells syndrome treated with anakinra. | Q40480177 | ||
Anakinra therapy for CINCA syndrome with a novel mutation in exon 4 of the CIAS1 gene | Q40487157 | ||
Clinical and genetic heterogeneity among Spanish patients with recurrent autoinflammatory syndromes associated with the CIAS1/PYPAF1/NALP3 gene. | Q40519235 | ||
P275 | copyright license | Creative Commons Attribution-NonCommercial 3.0 Unported | Q18810331 |
P6216 | copyright status | copyrighted | Q50423863 |
P407 | language of work or name | English | Q1860 |
P921 | main subject | inflammation | Q101991 |
inflammasome complex | Q412405 | ||
P304 | page(s) | 15-27 | |
P577 | publication date | 2015-01-16 | |
P1433 | published in | Journal of Inflammation Research | Q6295349 |
P1476 | title | Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives | |
P478 | volume | 8 |
Q30276361 | A small molecule inhibitor of NFκB blocks ER stress and the NLRP3 inflammasome and prevents progression of pancreatitis |
Q36411522 | A20 overexpression alleviates pristine-induced lupus nephritis by inhibiting the NF-κB and NLRP3 inflammasome activation in macrophages of mice |
Q49437275 | Aberrant NLRP3 inflammasome associated with aryl hydrocarbon receptor potentially contributes to the imbalance of T-helper cells in patients with acute myeloid leukemia |
Q36128488 | Activation of Cannabinoid Receptor 2 Ameliorates DSS-Induced Colitis through Inhibiting NLRP3 Inflammasome in Macrophages |
Q47246776 | Anti-inflammatory effects of Lefty-1 in renal tubulointerstitial inflammation via regulation of the NF-κB pathway |
Q64235483 | Astragaloside IV Suppresses High Glucose-Induced NLRP3 Inflammasome Activation by Inhibiting TLR4/NF-B and CaSR |
Q33871018 | Canonical and Novel Non-Canonical Cholinergic Agonists Inhibit ATP-Induced Release of Monocytic Interleukin-1β via Different Combinations of Nicotinic Acetylcholine Receptor Subunits α7, α9 and α10. |
Q40035222 | Caspase-1, but Not Caspase-3, Promotes Diabetic Nephropathy |
Q47549875 | Cathepsin B aggravates coxsackievirus B3-induced myocarditis through activating the inflammasome and promoting pyroptosis. |
Q64245134 | Does Resveratrol Play a Role in Decreasing the Inflammation Associated with Contrast Induced Nephropathy in Rat Model? |
Q88768074 | Dopamine D2 receptor restricts astrocytic NLRP3 inflammasome activation via enhancing the interaction of β-arrestin2 and NLRP3 |
Q93090223 | Downregulation of NLRP2 inhibits HUVEC viability by inhibiting the MAPK signaling pathway |
Q64102636 | Dual Role of PTPN22 but Not NLRP3 Inflammasome Polymorphisms in Type 1 Diabetes and Celiac Disease in Children |
Q99578952 | Electroacupuncture Alleviates Osteoarthritis by Suppressing NLRP3 Inflammasome Activation in Guinea Pigs |
Q64230128 | Ghrelin attenuates UUO-induced renal fibrosis via attenuation of Nlrp3 inflammasome and endoplasmic reticulum stress |
Q64086078 | HSP70 is a negative regulator of NLRP3 inflammasome activation |
Q36856554 | Increased Expression of the NOD-like Receptor Family, Pyrin Domain Containing 3 Inflammasome in Dermatomyositis and Polymyositis is a Potential Contributor to Their Pathogenesis |
Q36546979 | Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt-induced hypertension in mice. |
Q47368616 | Inflammasomes, the eye and anti-inflammasome therapy. |
Q51093197 | Inflammatory Changes in Bone Marrow Microenvironment Associated with Declining B Lymphopoiesis. |
Q37729147 | Inhibition of NLRP3 Inflammasome Pathway by Butyrate Improves Corneal Wound Healing in Corneal Alkali Burn. |
Q51025124 | Inhibition of NLRP3 Inflammasome Prevents LPS-Induced Inflammatory Hyperalgesia in Mice: Contribution of NF-κB, Caspase-1/11, ASC, NOX, and NOS Isoforms. |
Q89884524 | Inhibition of microRNA-15 protects H9c2 cells against CVB3-induced myocardial injury by targeting NLRX1 to regulate the NLRP3 inflammasome |
Q26771260 | Innovative Target Therapies Are Able to Block the Inflammation Associated with Dysfunction of the Cholesterol Biosynthesis Pathway |
Q50648904 | Involvement of c-Abl Kinase in Microglial Activation of NLRP3 Inflammasome and Impairment in Autolysosomal System. |
Q60046417 | Kinase-Based Taming of Brain Microglia Toward Disease-Modifying Therapy |
Q37652182 | Mangiferin from Pueraria tuberosa reduces inflammation via inactivation of NLRP3 inflammasome |
Q58691527 | Mechanism of Action of Magnesium Lithospermate B against Aging and Obesity-Induced ER Stress, Insulin Resistance, and Inflammsome Formation in the Liver |
Q58764473 | Melatonin Ameliorates the Progression of Atherosclerosis via Mitophagy Activation and NLRP3 Inflammasome Inhibition |
Q36775656 | Mesenchymal stem cell transplantation inhibited high salt-induced activation of the NLRP3 inflammasome in the renal medulla in Dahl S rats |
Q46455327 | Mitochondria Protection after Acute Ischemia Prevents Prolonged Upregulation of IL-1β and IL-18 and Arrests CKD. |
Q26778556 | Molecular mechanisms regulating NLRP3 inflammasome activation |
Q33679029 | Multiple Immunosuppressive Effects of CpG-c41 on Intracellular TLR-Mediated Inflammation. |
Q37601852 | NLRP3 Inflammasome Expression and Signaling in Human Diabetic Wounds and in High Glucose Induced Macrophages. |
Q37698511 | NLRP3 inflammasome activation contributes to long-term behavioral alterations in mice injected with lipopolysaccharide |
Q41595173 | NLRP3 inflammasome activation promotes inflammation-induced carcinogenesis in head and neck squamous cell carcinoma. |
Q27023333 | NLRP3 inflammasome and its inhibitors: a review |
Q30252648 | Nanoparticle fullerol alleviates radiculopathy via NLRP3 inflammasome and neuropeptides |
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Q38705659 | Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies |
Q42279273 | Nonsaponin fractions of Korean Red Ginseng extracts prime activation of NLRP3 inflammasome |
Q40623445 | Ogg1-Dependent DNA Repair Regulates NLRP3 Inflammasome and Prevents Atherosclerosis |
Q57983387 | On PAMPs and DAMPs |
Q54260312 | Oxidative Stress and NLRP3-Inflammasome Activity as Significant Drivers of Diabetic Cardiovascular Complications: Therapeutic Implications. |
Q37545034 | Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury. |
Q91633999 | Quartz Dust Exposure Affects NLRP3 Inflammasome Activation and Plasma Levels of IL-18 and IL-1Ra in Iron Foundry Workers |
Q57471933 | REV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis |
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Q57483680 | Role of inflammatory signaling in atrial fibrillation |
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Q36399235 | Suppression of NLRP3 inflammasome by γ-tocotrienol ameliorates type 2 diabetes |
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