IL-18 attenuates experimental choroidal neovascularization as a potential therapy for wet age-related macular degeneration

scientific article (publication date: 2 April 2014)

IL-18 attenuates experimental choroidal neovascularization as a potential therapy for wet age-related macular degeneration is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1126/SCITRANSLMED.3007616
P3181OpenCitations bibliographic resource ID1710969
P698PubMed publication ID24695684
P5875ResearchGate publication ID261327698

P50authorPadraic G. FallonQ42944857
Emily HamsQ54378130
Arvydas MaminishkisQ55762128
Sean P. SaundersQ55948319
Sarah L DoyleQ55948328
Ed C. LavelleQ55948337
Clair GardinerQ61221569
Kelly MulfaulQ64428802
Kiva BrennanQ89449463
P2093author name stringMarian M Humphries
Matthew Campbell
Paul F Kenna
Peter Humphries
Ema Ozaki
Peter Adamson
Anna-Sophia Kiang
James Keaney
P2860cites workThe inflammasomesQ24304087
Ranibizumab and bevacizumab for neovascular age-related macular degenerationQ24616209
DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88Q24621930
Innate immune recognitionQ27860721
The family of five: TIR-domain-containing adaptors in Toll-like receptor signallingQ29615457
Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expressionQ29615589
P433issue230
P407language of work or nameEnglishQ1860
P921main subjectmacular degenerationQ27429789
neovascularizationQ1281049
P304page(s)230ra44
P577publication date2014-04-01
P1433published inScience Translational MedicineQ1573955
P1476titleIL-18 attenuates experimental choroidal neovascularization as a potential therapy for wet age-related macular degeneration
P478volume6

Reverse relations

cites work (P2860)
Q47427948Advances in Age-related Macular Degeneration Understanding and Therapy
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Q47123727An Induced Pluripotent Stem Cell Patient Specific Model of Complement Factor H (Y402H) Polymorphism Displays Characteristic Features of Age-Related Macular Degeneration and Indicates a Beneficial Role for UV Light Exposure.
Q37088454CFH Y402H polymorphism and the complement activation product C5a: effects on NF-κB activation and inflammasome gene regulation
Q30612009Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium
Q37731893Chronic, Systemic Interleukin-18 Does Not Promote Macular Degeneration or Choroidal Neovascularization
Q38819720Complement Component C5a Primes Retinal Pigment Epithelial Cells for Inflammasome Activation by Lipofuscin-mediated Photooxidative Damage
Q34526132DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration
Q36626060Defects in retinal pigment epithelial cell proteolysis and the pathology associated with age-related macular degeneration.
Q47202861Diverse roles of macrophages in intraocular neovascular diseases: a review.
Q38956279Doyne lecture 2016: intraocular health and the many faces of inflammation
Q90317718EASIX and mortality after allogeneic stem cell transplantation
Q47734998Evidence for the activation of pyroptotic and apoptotic pathways in RPE cells associated with NLRP3 inflammasome in the rodent eye.
Q87888119Eye diseases: a new use for interleukin-18 in sight
Q38851309Friend or Foe? Resident Microglia vs Bone Marrow-Derived Microglia and Their Roles in the Retinal Degeneration
Q91782625IL-1 Family Cytokine Regulation of Vascular Permeability and Angiogenesis
Q92404834IL-1 Family Members Mediate Cell Death, Inflammation and Angiogenesis in Retinal Degenerative Diseases
Q43009110IL-18 is not therapeutic for neovascular age-related macular degeneration
Q36569352IL-33 amplifies an innate immune response in the degenerating retina.
Q33673256Identification of small molecule inhibitors of Interleukin-18.
Q35161079Inflammasomes Induced by 7-Ketocholesterol and Other Stimuli in RPE and in Bone Marrow-Derived Cells Differ Markedly in Their Production of IL-1β and IL-18.
Q26768520Inflammation and its role in age-related macular degeneration
Q35755942Inflammatory Mechanisms of Age-related Macular Degeneration
Q100945794Inhibiting the NLRP3 inflammasome with MCC950 ameliorates retinal neovascularization and leakage by reversing the IL-1β/IL-18 activation pattern in an oxygen-induced ischemic retinopathy mouse model
Q39324207Interleukin-33 regulates tissue remodelling and inhibits angiogenesis in the eye.
Q41520482Melatonin antagonizes interleukin-18-mediated inhibition on neural stem cell proliferation and differentiation
Q26799766NLRP3 Inflammasome and Pathobiology in AMD
Q36512570NLRP3 Upregulation in Retinal Pigment Epithelium in Age-Related Macular Degeneration
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Q26995315NLRP3 inflammasome: activation and regulation in age-related macular degeneration
Q35582494Nod-like receptor protein-3 inflammasome plays an important role during early stages of wound healing
Q36940296Oxidative stress, innate immunity, and age-related macular degeneration
Q28818003PKR promotes choroidal neovascularization via upregulating the PI3K/Akt signaling pathway in VEGF expression
Q86184474Reply to IL-18 is not therapeutic for neovascular age-related macular degeneration
Q36595519Retinal Ganglion Cell Loss is Delayed Following Optic Nerve Crush in NLRP3 Knockout Mice.
Q59354960Role of IL-18 induced Amphiregulin expression on virus induced ocular lesions
Q47282467Social stress induces neurovascular pathology promoting depression
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Q38596848The NLRP3 Inflammasome and its Role in Age-Related Macular Degeneration
Q39024579The pathophysiology of geographic atrophy secondary to age-related macular degeneration and the complement pathway as a therapeutic target
Q35807878The peptidomimetic Vasotide targets two retinal VEGF receptors and reduces pathological angiogenesis in murine and nonhuman primate models of retinal disease

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