Complement Component C5a Primes Retinal Pigment Epithelial Cells for Inflammasome Activation by Lipofuscin-mediated Photooxidative Damage

scientific article published on 12 November 2015

Complement Component C5a Primes Retinal Pigment Epithelial Cells for Inflammasome Activation by Lipofuscin-mediated Photooxidative Damage is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.M115.671180
P932PMC publication ID4692241
P698PubMed publication ID26565031

P50authorTim U. KrohneQ41457656
Frank G HolzQ71014505
P2093author name stringCarolina Brandstetter
P2860cites workDrusen complement components C3a and C5a promote choroidal neovascularizationQ24303123
Photodamage to human RPE cells by A2-E, a retinoid component of lipofuscinQ73991053
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DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88Q24621930
Inflammasomes: too big to missQ24647337
Global data on visual impairment in the year 2002Q24650312
IL-18 attenuates experimental choroidal neovascularization as a potential therapy for wet age-related macular degenerationQ28237337
Systemic complement activation in age-related macular degenerationQ28285925
NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen componentsQ30576000
Lipid peroxidation products reduce lysosomal protease activities in human retinal pigment epithelial cells via two different mechanisms of actionQ33515441
The oxidative stress product carboxyethylpyrrole potentiates TLR2/TLR1 inflammatory signaling in macrophagesQ34128646
DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degenerationQ34526132
Complement component C5a activates ICAM-1 expression on human choroidal endothelial cellsQ34735128
A role for local inflammation in the formation of drusen in the aging eye.Q34809064
Interleukin-18 induces retinal pigment epithelium degeneration in mice.Q35263825
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.Q35350543
Interleukin-1β Level Is Increased in Vitreous of Patients with Neovascular Age-Related Macular Degeneration (nAMD) and Polypoidal Choroidal Vasculopathy (PCV).Q35610761
Vinpocetine inhibits amyloid-beta induced activation of NF-κB, NLRP3 inflammasome and cytokine production in retinal pigment epithelial cellsQ35705361
NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degenerationQ36530569
Cutting edge: the NLRP3 inflammasome links complement-mediated inflammation and IL-1β release.Q37031990
Critical functions of priming and lysosomal damage for NLRP3 activationQ37485683
Relationship between systemic cytokines and complement factor H Y402H polymorphism in patients with dry age-related macular degeneration.Q37626349
Cholesterol crystals induce complement-dependent inflammasome activation and cytokine releaseQ37700323
A2E induces IL-1ß production in retinal pigment epithelial cells via the NLRP3 inflammasomeQ39128040
Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells--implications for age-related macular degeneration (AMD).Q39331392
C5a contributes to intraocular inflammation by affecting retinal pigment epithelial cells and immune cellsQ39483173
Effects of lipid peroxidation products on lipofuscinogenesis and autophagy in human retinal pigment epithelial cellsQ39754366
C5a, but not C3a, increases VEGF secretion in ARPE-19 human retinal pigment epithelial cellsQ39890415
C5a receptor-mediated production of IL-8 by the human retinal pigment epithelial cell line, ARPE-19.Q40742862
Light induces NLRP3 inflammasome activation in retinal pigment epithelial cells via lipofuscin-mediated photooxidative damageQ41851269
Photocytotoxicity of lipofuscin in human retinal pigment epithelial cellsQ42506829
Effect of time, temperature and anticoagulants on in vitro complement activation: consequences for collection and preservation of samples to be examined for complement activationQ46412470
The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells.Q50511473
Blue light-induced reactivity of retinal age pigment. In vitro generation of oxygen-reactive species.Q50759187
Complement C5a potentiates uric acid crystal-induced IL-1β production.Q51697175
Effects of Inflammasome Activation on Secretion of Inflammatory Cytokines and Vascular Endothelial Growth Factor by Retinal Pigment Epithelial Cells.Q53665539
Age-related macular degenerationQ59446738
Interleukin 1 induces interleukin 1. II. Recombinant human interleukin 1 induces interleukin 1 production by adult human vascular endothelial cellsQ68827396
P433issue52
P407language of work or nameEnglishQ1860
P921main subjectinflammasome complexQ412405
P304page(s)31189-31198
P577publication date2015-11-12
P1433published inJournal of Biological ChemistryQ867727
P1476titleComplement Component C5a Primes Retinal Pigment Epithelial Cells for Inflammasome Activation by Lipofuscin-mediated Photooxidative Damage
P478volume290