IL-18 is required for self-reactive T cell expansion in NOD mice

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IL-18 is required for self-reactive T cell expansion in NOD mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.JAUT.2011.02.005
P932PMC publication ID4275030
P698PubMed publication ID21414755

P2093author name stringAnnette M Marleau
Nora E Sarvetnick
P2860cites workReduction in insulitis following administration of IFN-gamma and TNF-alpha in the NOD mouseQ67996898
IFN-gamma and tumor necrosis factor-alpha. Cytotoxicity to murine islets of LangerhansQ70405590
Following a diabetogenic T cell from genesis through pathogenesisQ70488192
Crosses of NOD mice with the related NON strain. A polygenic model for IDDMQ71736914
Interferon-gamma receptor signaling is dispensable in the development of autoimmune type 1 diabetes in NOD miceQ73299448
Systemic Production of Interferon-Gamma Inducing Factor (IGIF) Versus Local IFN-γ Expression Involved in the Development of Th1 Insulitis in NOD MiceQ73501283
A mechanism underlying synergy between IL-12 and IFN-gamma-inducing factor in enhanced production of IFN-gammaQ73648057
An IFN-gamma-dependent pathway controls stimulation of memory phenotype CD8+ T cell turnover in vivo by IL-12, IL-18, and IFN-gammaQ73850507
IL-18 directs autoreactive T cells and promotes autodestruction in the central nervous system via induction of IFN-gamma by NK cellsQ74279845
IFN-gamma affects homing of diabetogenic T cellsQ77198737
IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma productionQ77367658
IL-18 inhibits diabetes development in nonobese diabetic mice by counterregulation of Th1-dependent destructive insulitisQ78025358
Pancreas-infiltrating Th1 cells and diabetes develop in IL-12-deficient nonobese diabetic miceQ78145332
Gamma interferon paradoxically inhibits the development of diabetes in the NOD mouseQ78482270
Th1 and Th2 pancreatic inflammation differentially affects homing of islet-reactive CD4 cells in nonobese diabetic miceQ78946090
Systemic administration of IL-18 promotes diabetes development in young nonobese diabetic miceQ79317471
Serum interleukin-18 levels are increased and closely associated with various soluble adhesion molecule levels in type 1 diabetic patientsQ79455847
Naive CD4+ T lymphocytes circulate through lymphoid organs to interact with endogenous antigens and upregulate their functionQ83375925
Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistanceQ83864443
IL-18 produced by thymic epithelial cells induces development of dendritic cells with CD11b in the fetal thymusQ83986359
Lymphopenia-induced spontaneous T-cell proliferation as a cofactor for autoimmune disease developmentQ84136013
Two subsets of memory T lymphocytes with distinct homing potentials and effector functionsQ28146072
Cloning of a new cytokine that induces IFN-gamma production by T cellsQ28283928
An IFN-gamma-IL-18 signaling loop accelerates memory CD8+ T cell proliferationQ33342847
The inflammasomes.Q33521252
IL-12-induced IFN-gamma is dependent on caspase-1 processing of the IL-18 precursorQ33853915
Homeostatic expansion of T cells during immune insufficiency generates autoimmunity.Q33977505
Responses of IL-18- and IL-18 receptor-deficient pancreatic islets with convergence of positive and negative signals for the IL-18 receptorQ35130769
Resistance of the target islet tissue to autoimmune destruction contributes to genetic susceptibility in Type 1 diabetesQ35634096
Regulation of interleukin (IL)-18 receptor alpha chain expression on CD4(+) T cells during T helper (Th)1/Th2 differentiation. Critical downregulatory role of IL-4Q36369407
Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic miceQ36380895
Homeostasis of memory T cellsQ36528980
Interleukin-18 and the pathogenesis of inflammatory diseasesQ36750958
Spontaneous proliferation, a response of naive CD4 T cells determined by the diversity of the memory cell repertoire.Q37095109
Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient miceQ37111353
Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1beta are differentially regulated in human blood mononuclear cells and mouse spleen cellsQ37179132
Inhibition of Th17 cells regulates autoimmune diabetes in NOD mice.Q37193763
Active stage of autoimmune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2.Q37363100
Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells.Q37370178
Following the fate of individual T cells throughout activation and clonal expansion. Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative responseQ37376774
IFN-gamma/TNF-alpha synergism as the final effector in autoimmune diabetes: a key role for STAT1/IFN regulatory factor-1 pathway in pancreatic beta cell deathQ38303234
Bystander activation of CD8+ T cells contributes to the rapid production of IFN-gamma in response to bacterial pathogensQ39171860
Identification of IL-18 and Th17 cells in salivary glands of patients with Sjögren's syndrome, and amplification of IL-17-mediated secretion of inflammatory cytokines from salivary gland cells by IL-18.Q39953212
Functional IL-18 Is produced by primary pancreatic mouse islets and NIT-1 beta cells and participates in the progression towards destructive insulitisQ40732633
Turnover of naive- and memory-phenotype T cellsQ41475935
"Bystander polarization" of CD4+ T cells: activation with high-dose IL-2 renders naive T cells responsive to IL-12 and/or IL-18 in the absence of TCR ligationQ44481494
Essential pathogenic role of endogenous IL-18 in murine diabetes induced by multiple low doses of streptozotocin. Prevention of hyperglycemia and insulitis by a recombinant IL-18-binding protein: Fc constructQ44528111
Caspase-1 is not required for type 1 diabetes in the NOD mouseQ44704977
Activation of virus-specific CD8+ T cells by lipopolysaccharide-induced IL-12 and IL-18.Q45548915
Increased atherosclerotic lesions and Th17 in interleukin-18 deficient apolipoprotein E-knockout mice fed high-fat dietQ46129274
Genetic absence of gamma-interferon delays but does not prevent diabetes in NOD miceQ46314387
IL-12 administration accelerates autoimmune diabetes in both wild-type and IFN-gamma-deficient nonobese diabetic mice, revealing pathogenic and protective effects of IL-12-induced IFN-gammaQ47897970
IL-18 binding protein fusion construct delays the development of diabetes in adoptive transfer and cyclophosphamide-induced diabetes in NOD mouseQ48550682
Division-linked differentiation can account for CD8+ T-cell phenotype in vivo.Q51857017
Synergistic effect of IL-2, IL-12, and IL-18 on thymocyte apoptosis and Th1/Th2 cytokine expression.Q52973794
P433issue3-4
P304page(s)263-277
P577publication date2011-03-16
P1433published inJournal of AutoimmunityQ15716783
P1476titleIL-18 is required for self-reactive T cell expansion in NOD mice
P478volume36

Reverse relations

cites work (P2860)
Q38124723IL-18 in inflammatory and autoimmune disease
Q35044541Increased expression of IL-18 in the serum and islets of type 1 diabetics
Q92711317Interleukin-18 Expression Increases in the Aorta and Plasma of Patients with Acute Aortic Dissection
Q36056835NLRP3 deficiency protects from type 1 diabetes through the regulation of chemotaxis into the pancreatic islets.
Q39302816The immunobiology of apotransferrin in type 1 diabetes

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