Lower NLRP3 inflammasome activity in NAG-1 transgenic mice is linked to a resistance to obesity and increased insulin sensitivity

scientific article published on 05 December 2013

Lower NLRP3 inflammasome activity in NAG-1 transgenic mice is linked to a resistance to obesity and increased insulin sensitivity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/OBY.20638
P932PMC publication ID3981958
P698PubMed publication ID24124102
P5875ResearchGate publication ID257756305

P2093author name stringJustin Kosak
Thomas E Eling
Xingya Wang
Kali Chrysovergis
P2860cites workObesity is associated with macrophage accumulation in adipose tissueQ27860976
MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesityQ29614283
Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signalingQ29616024
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistanceQ29616026
Type 2 diabetes as an inflammatory diseaseQ29617184
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetesQ33918445
Single-cell analysis of insulin-regulated fatty acid uptake in adipocytesQ34149544
Association of adiponectin and resistin with adipose tissue compartments, insulin resistance and dyslipidaemia.Q34426322
Interaction of osteopontin with IL-18 in obese individuals: implications for insulin resistance.Q34723169
Lack of interleukin-1 receptor I (IL-1RI) protects mice from high-fat diet-induced adipose tissue inflammation coincident with improved glucose homeostasis.Q35043422
Inflammasome is a central player in the induction of obesity and insulin resistanceQ35216914
The H6D variant of NAG-1/GDF15 inhibits prostate xenograft growth in vivoQ35531969
The diverse roles of nonsteroidal anti-inflammatory drug activated gene (NAG-1/GDF15) in cancerQ36592451
Mechanisms of disease: inflammasome activation and the development of type 2 diabetesQ36668052
NAG-1/GDF15 transgenic mouse has less white adipose tissue and a reduced inflammatory responseQ36869509
The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivityQ36931760
Interleukin-18 activates skeletal muscle AMPK and reduces weight gain and insulin resistance in miceQ37110553
The NLRP3 inflammasome: a sensor for metabolic danger?Q37675505
Inflammation links excess fat to insulin resistance: the role of the interleukin-1 familyQ38034273
Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1.Q40056643
Caspase-1 deficiency in mice reduces intestinal triglyceride absorption and hepatic triglyceride secretionQ41585297
Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expressionQ41862754
Identification of macrophage inhibitory cytokine-1 in adipose tissue and its secretion as an adipokine by human adipocytesQ42805165
Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans.Q43414241
Increased serum concentrations of macrophage inhibitory cytokine-1 in patients with obesity and type 2 diabetes mellitus: the influence of very low calorie diet.Q45974276
Differential expression of NLRP3 among hematopoietic cells.Q50528108
Hyperinsulinemia acutely increases serum macrophage inhibitory cytokine-1 concentration in anorexia nervosa and obesity.Q51372416
Adiponectin, insulin resistance and clinical expression of the metabolic syndrome in patients with Type 2 diabetes.Q51496934
The Relationship between Insulin Resistance and the Cardiovascular Biomarker Growth Differentiation Factor-15 in Obese PatientsQ58788278
Adipose tissue as an endocrine organQ79189502
Nonsteroidal anti-inflammatory drug-activated gene-1 over expression in transgenic mice suppresses intestinal neoplasiaQ79353945
Linking the inflammasome to obesity-related diseaseQ83379079
Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistanceQ83864443
The inflammasome and caspase-1 activation: a new mechanism underlying increased inflammatory activity in human visceral adipose tissueQ84813098
P433issue5
P921main subjectobesityQ12174
inflammasome complexQ412405
preproinsulinQ7240673
P304page(s)1256-1263
P577publication date2013-12-05
P1433published inObesityQ15763232
P1476titleLower NLRP3 inflammasome activity in NAG-1 transgenic mice is linked to a resistance to obesity and increased insulin sensitivity
P478volume22

Reverse relations

cites work (P2860)
Q38380755Acute rhabdomyolysis and inflammation
Q89967548Contribution of TGF-Beta-Mediated NLRP3-HMGB1 Activation to Tubulointerstitial Fibrosis in Rat With Angiotensin II-Induced Chronic Kidney Disease
Q92385169Elevated Plasma Growth and Differentiation Factor 15 Is Associated With Slower Gait Speed and Lower Physical Performance in Healthy Community-Dwelling Adults
Q28552243Expression of Human NSAID Activated Gene 1 in Mice Leads to Altered Mammary Gland Differentiation and Impaired Lactation
Q35126861Letter: GDF15 Is a Novel Biomarker for Impaired Fasting Glucose (Diabetes Metab J 2014;38:472-9)
Q45057004NLRP3 inflammasome as a novel target for docosahexaenoic acid metabolites to abrogate glomerular injury
Q45323971Over-production of growth differentiation factor 15 (GDF15) promotes human rhinovirus infection and virus-induced inflammation in the lung.
Q37062591Protective Action of Anandamide and Its COX-2 Metabolite against l-Homocysteine-Induced NLRP3 Inflammasome Activation and Injury in Podocytes
Q53693528Reduced oxidative capacity in macrophages results in systemic insulin resistance.
Q35909717Sodium butyrate alleviates adipocyte inflammation by inhibiting NLRP3 pathway
Q48574810Treatment with the TGF-b superfamily cytokine MIC-1/GDF15 reduces the adiposity and corrects the metabolic dysfunction of mice with diet-induced obesity
Q34217628hNAG-1 increases lifespan by regulating energy metabolism and insulin/IGF-1/mTOR signaling

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