New drug target in protozoan parasites: the role of thioredoxin reductase

scientific article

New drug target in protozoan parasites: the role of thioredoxin reductase is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3389/FMICB.2015.00975
P3181OpenCitations bibliographic resource ID2781660
P932PMC publication ID4588103
P698PubMed publication ID26483758
P5875ResearchGate publication ID282840229

P2093author name stringSharon L Reed
Rosa M Andrade
P2860cites workThe genome of the kinetoplastid parasite, Leishmania majorQ22065797
The Genome of the African Trypanosome Trypanosoma bruceiQ22065798
The Genome Sequence of Trypanosoma cruzi, Etiologic Agent of Chagas DiseaseQ22065799
The genome of the protist parasite Entamoeba histolyticaQ22122475
Thioredoxin reductaseQ24531944
Biology of Giardia lambliaQ24550684
Drug targets and mechanisms of resistance in the anaerobic protozoaQ24550694
A high-throughput drug screen for Entamoeba histolytica identifies a new lead and targetQ24623736
Inhibition of Schistosoma mansoni thioredoxin-glutathione reductase by auranofin: structural and kinetic aspectsQ24652462
Reprofiled drug targets ancient protozoans: drug discovery for parasitic diarrheal diseasesQ27003233
Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruziQ27657406
A gold-containing drug against parasitic polyamine metabolism: the X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhibitionQ27671675
New uses for old drugs. Auranofin, a clinically established antiarthritic metallodrug, exhibits potent antimalarial effects in vitro: Mechanistic and pharmacological implicationsQ47861024
Differential inhibition of high and low Mr thioredoxin reductases of parasites by organotelluriums supports the concept that low Mr thioredoxin reductases are good drug targetsQ47886605
Cryptosporidiosis in Harare, Zimbabwe.Q50091062
Entamoeba histolytica thioredoxin reductase: molecular and functional characterization of its atypical properties.Q50241498
Thioredoxin-linked metabolism in Entamoeba histolytica.Q54442789
Trypanothione reductase from Trypanosoma cruzi. Purification and characterization of the crystalline enzyme.Q54766074
Expression of Trypanosoma congolense trypanothione reductase in Escherichia coli: overproduction, purification, and characterizationQ69529268
Auranofin: experience to dateQ70461337
Auranofin: a unique oral chrysotherapeutic agentQ70482149
Oxygen uptake in cysts and trophozoites of Giardia lambliaQ70752528
Characterization of the gene encoding serine acetyltransferase, a regulated enzyme of cysteine biosynthesis from the protist parasites Entamoeba histolytica and Entamoeba dispar. Regulation and possible function of the cysteine biosynthetic pathwayQ73133846
TREATMENT OF GIARDIA LAMBLIA INFECTIONQ76661002
Effects of stunting, diarrhoeal disease, and parasitic infection during infancy on cognition in late childhood: a follow-up studyQ77696967
Crystal structure of Escherichia coli thioredoxin reductase refined at 2 A resolution. Implications for a large conformational change during catalysisQ27731122
Compartmentation of redox metabolism in malaria parasitesQ27972605
Thioredoxin networks in the malarial parasite Plasmodium falciparumQ27972980
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolismQ28275518
Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatidsQ28306157
Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug targetQ28469234
Nitroimidazole action in Entamoeba histolytica: a central role for thioredoxin reductaseQ28469267
Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasisQ28543559
Molecular characterization of a 2-Cys peroxiredoxin from the human malaria parasite Plasmodium falciparumQ30047901
Identification of Entamoeba histolytica thiol-specific antioxidant as a GalNAc lectin-associated proteinQ30310731
The diversity and evolution of thioredoxin reductase: new perspectivesQ30716821
A comparison of the Giardia lamblia trophozoite and cyst transcriptome using microarraysQ33890040
Metabolism and functions of trypanothione in the KinetoplastidaQ33972467
Thioredoxin reductase two modes of catalysis have evolvedQ34049898
Thioredoxin reductase as a pathophysiological factor and drug targetQ34049902
Trypanothione Reductase from Leishmania donovani. Purification, Characterisation and Inhibition by Trivalent AntimonialsQ34058179
Anaerobic bacterial metabolism in the ancient eukaryote Giardia duodenalisQ34460598
A reprofiled drug, auranofin, is effective against metronidazole-resistant Giardia lambliaQ34583468
Comparative genomics of thiol oxidoreductases reveals widespread and essential functions of thiol-based redox control of cellular processesQ35604029
On the mechanism and rate of gold incorporation into thiol-dependent flavoreductasesQ36094494
Enteric protozoa in the developed world: a public health perspective.Q36156094
Giardia and Cryptosporidium join the 'Neglected Diseases Initiative'.Q36424454
Cryptosporidium species and subtypes and clinical manifestations in children, PeruQ37028494
Treatment of cryptosporidiosis: do we know what we think we know?Q37778260
Recombinant expression and biochemical characterization of an NADPH:flavin oxidoreductase from Entamoeba histolyticaQ38923639
Characterization of two E. histolytica proteins that inactivate reactive oxygen species.Q38923648
Trichomonas vaginalis: metronidazole and other nitroimidazole drugs are reduced by the flavin enzyme thioredoxin reductase and disrupt the cellular redox system. Implications for nitroimidazole toxicity and resistance.Q39169840
Entamoeba histolytica: identification of thioredoxin-targeted proteins and analysis of serine acetyltransferase-1 as a prototype example.Q39436857
Metronidazole resistance in the protozoan parasite Entamoeba histolytica is associated with increased expression of iron-containing superoxide dismutase and peroxiredoxin and decreased expression of ferredoxin 1 and flavin reductaseQ39580129
Platyhelminth mitochondrial and cytosolic redox homeostasis is controlled by a single thioredoxin glutathione reductase and dependent on selenium and glutathione.Q39599862
Selenium metabolism in Trypanosoma: characterization of selenoproteomes and identification of a Kinetoplastida-specific selenoproteinQ42019802
The amitochondriate eukaryote Trichomonas vaginalis contains a divergent thioredoxin-linked peroxiredoxin antioxidant system.Q44664089
Further trials of metronidazole in amoebic dysentery and amoebic liver abscessQ45012567
An unusual surface peroxiredoxin protects invasive Entamoeba histolytica from oxidant attack.Q46464785
Immunolocalization and enzymatic functional characterization of the thioredoxin system in Entamoeba histolytica.Q46660068
P407language of work or nameEnglishQ1860
P304page(s)975
P577publication date2015-01-01
P1433published inFrontiers in MicrobiologyQ27723481
P1476titleNew drug target in protozoan parasites: the role of thioredoxin reductase
P478volume6

Reverse relations

cites work (P2860)
Q64250608Activation Studies of the β-Carbonic Anhydrase from the Pathogenic Protozoan with Amino Acids and Amines
Q92697524Characterization of Entamoeba histolytica adenosine 5'-phosphosulfate (APS) kinase; validation as a target and provision of leads for the development of new drugs against amoebiasis
Q92290892Comparative Pathobiology of the Intestinal Protozoan Parasites Giardia lamblia, Entamoeba histolytica, and Cryptosporidium parvum
Q90585294Discrimination Experiments in Entamoeba and Evidence from Other Protists Suggest Pathogenic Amebas Cooperate with Kin to Colonize Hosts and Deter Rivals
Q92128951Drug repurposing for antimicrobial discovery
Q40046014Drug susceptibility testing in microaerophilic parasites: Cysteine strongly affects the effectivities of metronidazole and auranofin, a novel and promising antimicrobial
Q92946164Dynamic Basis for Auranofin Drug Recognition by Thiol-Reductases of Human Pathogens and Intermediate Coordinated Adduct Formation with Catalytic Cysteine Residues
Q36869493Epidemiology of Domestically Acquired Amebiasis in Japan, 2000-2013.
Q53134492Metal complexes of 3-(4-bromophenyl)-1-pyridin-2-ylprop-2-en-1-one thiosemicarbazone: cytotoxic activity and investigation on the mode of action of the gold(III) complex.
Q93186425Parasite-Produced MIF Cytokine: Role in Immune Evasion, Invasion, and Pathogenesis
Q28077685Recent advances in Entamoeba biology: RNA interference, drug discovery, and gut microbiome
Q60907797Sulfonamide Inhibition Studies of a New β-Carbonic Anhydrase from the Pathogenic Protozoan
Q88984609Viability Screen of LOPAC1280 Reveals Phosphorylation Inhibitor Auranofin as a Potent Inhibitor of Blastocystis Subtype 1, 4, and 7 Isolates

Search more.