| review article | Q7318358 |
| scholarly article | Q13442814 |
| P2093 | author name string | R Luise Krauth-Siegel | |
| Marcelo A Comini | |||
| P2860 | cites work | The Genome of the African Trypanosome Trypanosoma brucei | Q22065798 |
| The Genome Sequence of Trypanosoma cruzi, Etiologic Agent of Chagas Disease | Q22065799 | ||
| P433 | issue | 11 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | protozoa | Q101274 |
| Trypanosomatidae | Q132954 | ||
| P304 | page(s) | 1236-48 | |
| P577 | publication date | 2008-11-01 | |
| P1433 | published in | Biochimica et Biophysica Acta | Q864239 |
| P1476 | title | Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism | |
| P478 | volume | 1780 |
| Q39488275 | 1H, 13C and 15N resonance assignment of the cytosolic dithiol glutaredoxin 1 from the pathogen Trypanosoma brucei |
| Q57018793 | 1H, 13C and 15N resonance assignment of the mature form of monothiol glutaredoxin 1 from the pathogen Trypanosoma brucei |
| Q43105426 | A comparative study of methylglyoxal metabolism in trypanosomatids |
| Q50136692 | A glutaredoxin in the mitochondrial intermembrane space has stage-specific functions in the thermo-tolerance and proliferation of African trypanosomes. |
| Q38861387 | A systematic reconstruction and constraint-based analysis of Leishmania donovani metabolic network: identification of potential antileishmanial drug targets. |
| Q89464714 | A tryparedoxin-coupled biosensor reveals a mitochondrial trypanothione metabolism in trypanosomes |
| Q43106044 | ATP-dependent ligases in trypanothione biosynthesis--kinetics of catalysis and inhibition by phosphinic acid pseudopeptides |
| Q88138209 | An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone. |
| Q34727787 | Analysis of the peroxiredoxin family: using active-site structure and sequence information for global classification and residue analysis |
| Q45909806 | Cloning, expression, characterization and inhibition studies on trypanothione synthetase, a drug target enzyme, from Leishmania donovani. |
| Q38634845 | Conferring specificity in redox pathways by enzymatic thiol/disulfide exchange reactions. |
| Q35651454 | Contribution of Fdh3 and Glr1 to Glutathione Redox State, Stress Adaptation and Virulence in Candida albicans |
| Q28073426 | Current challenges in treatment options for visceral leishmaniasis in India: a public health perspective |
| Q36947873 | Cytosolic NADPH homeostasis in glucose-starved procyclic Trypanosoma brucei relies on malic enzyme and the pentose phosphate pathway fed by gluconeogenic flux. |
| Q37719798 | Dealing with environmental challenges: mechanisms of adaptation in Trypanosoma cruzi |
| Q37698643 | Deciphering the interplay between cysteine synthase and thiol cascade proteins in modulating Amphotericin B resistance and survival of Leishmania donovani under oxidative stress |
| Q39031418 | Deletion of Vitamin C biosynthesis enzyme, Arabino-1, 4-lactone oxidase in Leishmania donovani results in increased pro-inflammatory responses from host immune cells |
| Q38845466 | Detection and treatment of Trypanosoma cruzi: a patent review (2011-2015). |
| Q41479143 | Diglycosyl diselenides alter redox homeostasis and glucose consumption of infective African trypanosomes |
| Q27671819 | Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography |
| Q60919386 | Discovery and Genetic Validation of Chemotherapeutic Targets for Chagas' Disease |
| Q42557517 | Dissecting the catalytic mechanism of Trypanosoma brucei trypanothione synthetase by kinetic analysis and computational modeling |
| Q35666411 | Distinct Phenotypes Caused by Mutation of MSH2 in Trypanosome Insect and Mammalian Life Cycle Forms Are Associated with Parasite Adaptation to Oxidative Stress |
| Q38118386 | Drug resistance in vectorborne parasites: multiple actors and scenarios for an evolutionary arms race |
| Q48051536 | Drug target validation of the trypanothione pathway enzymes through metabolic modelling |
| Q38040818 | Drug-resistant microorganisms with a higher fitness--can medicines boost pathogens? |
| Q41813592 | Ebsulfur is a benzisothiazolone cytocidal inhibitor targeting the trypanothione reductase of Trypanosoma brucei. |
| Q46290224 | Efficacy of Leishmania donovani trypanothione reductase, identified as a potent Th1 stimulatory protein, for its immunogenicity and prophylactic potential against experimental visceral leishmaniasis |
| Q37540773 | Enzymes of the antioxidant network as novel determiners of Trypanosoma cruzi virulence |
| Q34498904 | Evaluation of Antitrypanosomal Dihydroquinolines for Hepatotoxicity, Mutagenicity, and Methemoglobin Formation In Vitro |
| Q84475148 | Evaluation of plumbagin and its derivative as potential modulators of redox thiol metabolism of Leishmania parasite |
| Q43857951 | Evaluation of selected antitumor agents as subversive substrate and potential inhibitor of trypanothione reductase: an alternative approach for chemotherapy of Leishmaniasis |
| Q55478711 | Flavonoids as a Natural Treatment Against Entamoeba histolytica. |
| Q55128382 | Footprinting of inhibitor interactions of in silico identified inhibitors of trypanothione reductase of Leishmania parasite. |
| Q50318718 | Functional Characterization of ABCC Proteins from Trypanosoma cruzi and Their Involvement with Thiol Transport. |
| Q92774155 | Gamma-glutamylcysteine synthetase and tryparedoxin 1 exert high control on the antioxidant system in Trypanosoma cruzi contributing to drug resistance and infectivity |
| Q28550531 | Genetic Manipulation of Leishmania donovani to Explore the Involvement of Argininosuccinate Synthase in Oxidative Stress Management |
| Q33766769 | Genetic validation of Trypanosoma brucei glutathione synthetase as an essential enzyme |
| Q35550761 | Genome evolution in trypanosomatid parasites |
| Q35740567 | Genome sequencing of the lizard parasite Leishmania tarentolae reveals loss of genes associated to the intracellular stage of human pathogenic species |
| Q42058134 | High throughput screening against the peroxidase cascade of African trypanosomes identifies antiparasitic compounds that inactivate tryparedoxin |
| Q28551301 | Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids |
| Q40261768 | In vitro antileishmanial activity of fisetin flavonoid via inhibition of glutathione biosynthesis and arginase activity in Leishmania infantum. |
| Q39200387 | In-silico analyses of sesquiterpene-related compounds on selected Leishmania enzyme-based targets. |
| Q38154345 | Indazoles: a new top seed structure in the search of efficient drugs against Trypanosoma cruzi. |
| Q35941223 | Induction of oxidative stress in Trypanosoma brucei by the antitrypanosomal dihydroquinoline OSU-40. |
| Q39329009 | Inhibitors of Trypanosoma brucei trypanothione reductase: comparative molecular field analysis modeling and structural basis for selective inhibition. |
| Q27684102 | Inhibitory Effect of Silver Nanoparticles on Trypanothione Reductase Activity and Leishmania infantum Proliferation |
| Q34675951 | Intraphagosomal peroxynitrite as a macrophage-derived cytotoxin against internalized Trypanosoma cruzi: consequences for oxidative killing and role of microbial peroxiredoxins in infectivity |
| Q27675564 | Iron–Sulfur Cluster Binding by Mitochondrial Monothiol Glutaredoxin-1 of Trypanosoma brucei : Molecular Basis of Iron–Sulfur Cluster Coordination and Relevance for Parasite Infectivity |
| Q30790484 | LC-MS metabolomics from study design to data-analysis - using a versatile pathogen as a test case |
| Q34181208 | Leishmania Subtilisin Is a Maturase for the Trypanothione Reductase System and Contributes to Disease Pathology |
| Q27670615 | Leishmania TDR1 structure, a unique trimeric glutathione transferase capable of deglutathionylation and antimonial prodrug activation |
| Q39429759 | Leishmania major protein disulfide isomerase as a drug target: enzymatic and functional characterization |
| Q28475170 | Linking in vitro and in vivo survival of clinical Leishmania donovani strains |
| Q36428337 | LmABCB3, an atypical mitochondrial ABC transporter essential for Leishmania major virulence, acts in heme and cytosolic iron/sulfur clusters biogenesis. |
| Q35105624 | Metabolic reprogramming during purine stress in the protozoan pathogen Leishmania donovani |
| Q91891817 | Metabolic syndrome agravates cardiovascular, oxidative and inflammatory dysfunction during the acute phase of Trypanosoma cruzi infection in mice |
| Q37839329 | Methylglyoxal metabolism in trypanosomes and leishmania |
| Q28475438 | Mitochondrial redox metabolism in trypanosomatids is independent of tryparedoxin activity |
| Q39462850 | Molecular dynamics simulations of peptide inhibitors complexed with Trypanosoma cruzi trypanothione reductase. |
| Q37573018 | Molecular mechanisms of in vitro betulin-induced apoptosis of Leishmania donovani |
| Q36318429 | Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophila. |
| Q38043539 | Mono- and dithiol glutaredoxins in the trypanothione-based redox metabolism of pathogenic trypanosomes. |
| Q38083314 | Mycothiol: a target for potentiation of rifampin and other antibiotics against Mycobacterium tuberculosis. |
| Q26781548 | New drug target in protozoan parasites: the role of thioredoxin reductase |
| Q46670964 | Novel Inhibitors of Ornithine Decarboxylase of Leishmania Parasite (LdODC): The Parasite Resists LdODC Inhibition by Overexpression of Spermidine Synthase |
| Q28253055 | Pentavalent antimonials: new perspectives for old drugs |
| Q38076471 | Pharmacological potential of biogenic amine-polyamine interactions beyond neurotransmission. |
| Q28732919 | Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities |
| Q37761657 | Polyamine metabolism in Leishmania: from arginine to trypanothione |
| Q38783627 | Polyamine-trypanothione pathway: an update. |
| Q58544813 | Polyamines in protozoan pathogens |
| Q34922108 | Probing the molecular mechanism of hypericin-induced parasite death provides insight into the role of spermidine beyond redox metabolism in Leishmania donovani. |
| Q37167161 | Product feedback regulation implicated in translational control of the Trypanosoma brucei S-adenosylmethionine decarboxylase regulatory subunit prozyme |
| Q33632160 | Proteomic analysis of Trypanosoma cruzi response to ionizing radiation stress |
| Q33699199 | Quiescin sulfhydryl oxidase from Trypanosoma brucei: catalytic activity and mechanism of a QSOX family member with a single thioredoxin domain. |
| Q38726904 | RAC2-P38 MAPK-dependent NADPH oxidase activity is associated with the resistance of quiescent cells to ionizing radiation. |
| Q98508491 | Recent Advancement in the Search of Innovative Antiprotozoal Agents Targeting Trypanothione Metabolism |
| Q39387702 | Redox biology of Leishmania and macrophage targeted nanoparticles for therapy. |
| Q58865487 | Relevance of Trypanothione Reductase Inhibitors on Trypanosoma cruzi Infection: A Systematic Review, Meta-Analysis, and In Silico Integrated Approach |
| Q38939544 | Repurposing as a strategy for the discovery of new anti-leishmanials: the-state-of-the-art |
| Q58854974 | Sleeping Sickness and Nagana Disease Caused by Trypanosoma brucei |
| Q28539382 | Stage-dependent expression and up-regulation of trypanothione synthetase in amphotericin B resistant Leishmania donovani |
| Q37852737 | State of the art in African trypanosome drug discovery |
| Q38880076 | Stress-Induced Protein S-Glutathionylation and S-Trypanothionylation in African Trypanosomes-A Quantitative Redox Proteome and Thiol Analysis |
| Q38154346 | Structural insights into the enzymes of the trypanothione pathway: targets for antileishmaniasis drugs. |
| Q27702048 | Structural insights into the novel inhibition mechanism of Trypanosoma cruzi spermidine synthase |
| Q27670578 | Structure ofLeishmania majorcysteine synthase |
| Q54348844 | Synthesis and evaluation of substrate analogue inhibitors of trypanothione reductase. |
| Q38974228 | Synthetic Medicinal Chemistry in Chagas' Disease: Compounds at The Final Stage of "Hit-To-Lead" Phase |
| Q38956970 | The Architecture of Thiol Antioxidant Systems among Invertebrate Parasites. |
| Q24651469 | The NADPH-dependent thioredoxin system constitutes a functional backup for cytosolic glutathione reductase in Arabidopsis |
| Q28546218 | The Trypanosoma cruzi vitamin C dependent peroxidase confers protection against oxidative stress but is not a determinant of virulence |
| Q26991843 | The basics of thiols and cysteines in redox biology and chemistry |
| Q43178100 | The conserved Cys76 plays a crucial role for the conformation of reduced glutathione peroxidase-type tryparedoxin peroxidase |
| Q46521791 | The cytosolic or the mitochondrial glutathione peroxidase-type tryparedoxin peroxidase is sufficient to protect procyclic Trypanosoma brucei from iron-mediated mitochondrial damage and lysis |
| Q42394562 | The dithiol glutaredoxins of african trypanosomes have distinct roles and are closely linked to the unique trypanothione metabolism |
| Q39383991 | The genome sequence of Leishmania (Leishmania) amazonensis: functional annotation and extended analysis of gene models |
| Q58611832 | The leishmanicidal activity of artemisinin is mediated by cleavage of the endoperoxide bridge and mitochondrial dysfunction |
| Q37160811 | The leishmanicidal activity of oleuropein is selectively regulated through inflammation- and oxidative stress-related genes |
| Q57018775 | The lineage-specific, intrinsically disordered N-terminal extension of monothiol glutaredoxin 1 from trypanosomes contains a regulatory region |
| Q27681897 | The narrow active-site cleft of O-acetylserine sulfhydrylase from Leishmania donovani allows complex formation with serine acetyltransferases with a range of C-terminal sequences |
| Q92765029 | The role of thiols in antioxidant systems |
| Q37742787 | The silicon trypanosome. |
| Q21092857 | The transferome of metabolic genes explored: analysis of the horizontal transfer of enzyme encoding genes in unicellular eukaryotes |
| Q37634945 | The trypanocidal activity of naphthoquinones: a review |
| Q28389739 | Thioredoxins, glutaredoxins, and peroxiredoxins--molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling |
| Q38901429 | Toward the development of dual-targeted glyceraldehyde-3-phosphate dehydrogenase/trypanothione reductase inhibitors against Trypanosoma brucei and Trypanosoma cruzi. |
| Q37734604 | Transsulfuration is an active pathway for cysteine biosynthesis in Trypanosoma rangeli |
| Q37623081 | Trypanocidal drugs: mechanisms, resistance and new targets |
| Q35976528 | Trypanosoma cruzi Needs a Signal Provided by Reactive Oxygen Species to Infect Macrophages |
| Q28547882 | Trypanothione reductase: a target protein for a combined in vitro and in silico screening approach |
| Q57802865 | Trypanothione synthetase confers growth, survival advantage and resistance to anti-protozoal drugs in Trypanosoma cruzi |
| Q56531120 | Tryparedoxin peroxidase-deficiency commits trypanosomes to ferroptosis-type cell death |
| Q46083528 | Two pathways for cysteine biosynthesis in Leishmania major |
| Q61799987 | Understanding the Cross-Talk of Redox Metabolism and Fe-S Cluster Biogenesis in Leishmania Through Systems Biology Approach |
| Q35860144 | Upregulation of Cysteine Synthase and Cystathionine β-Synthase Contributes to Leishmania braziliensis Survival under Oxidative Stress |
| Q35377767 | Use of antimony in the treatment of leishmaniasis: current status and future directions |
| Q46005772 | Use of clomipramine as chemotherapy of the chronic phase of Chagas disease. |
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