An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone.

scientific article published on 26 September 2019

An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1371/JOURNAL.PPAT.1008065
P932PMC publication ID6783113
P698PubMed publication ID31557263
P4011Semantic Scholar paper IDa7c9a8b0efdf45211ec5510999b7f147e9889ad7

P50authorHaike AntelmannQ22035926
Lorenz AdrianQ43189718
Rachel B CurrierQ47484013
Yasar Luqman AhmedQ55030175
Kathrin UlrichQ56428096
Marcelo A CominiQ57247725
Mariana BonillaQ63352824
Matías DeambrosiQ88138186
Luise Krauth-SiegelQ88138193
Alejandro LerouxQ39632706
P2093author name stringUrsula Jakob
Natalie Dirdjaja
P2860cites workIron–Sulfur Cluster Binding by Mitochondrial Monothiol Glutaredoxin-1 of Trypanosoma brucei : Molecular Basis of Iron–Sulfur Cluster Coordination and Relevance for Parasite InfectivityQ27675564
Catalytic properties, localization, and in vivo role of Px IV, a novel tryparedoxin peroxidase of Trypanosoma bruceiQ39709757
Glutaredoxin-deficiency confers bloodstream Trypanosoma brucei with improved thermotoleranceQ40015601
Depletion of the thioredoxin homologue tryparedoxin impairs antioxidative defence in African trypanosomesQ40220444
Development of RNA interference revertants in Trypanosoma brucei cell lines generated with a double stranded RNA expression construct driven by two opposing promotersQ40666896
Thioredoxin catalyzes the reduction of insulin disulfides by dithiothreitol and dihydrolipoamideQ41107708
An Advanced System of the Mitochondrial Processing Peptidase and Core Protein Family in Trypanosoma brucei and Multiple Origins of the Core I Subunit in EukaryotesQ41581700
Mitochondrial protein import: biochemical and genetic evidence for interaction of matrix hsp70 and the inner membrane protein MIM44Q41969923
Chaperone properties of Escherichia coli thioredoxin and thioredoxin reductaseQ41982341
High throughput screening against the peroxidase cascade of African trypanosomes identifies antiparasitic compounds that inactivate tryparedoxinQ42058134
Francisella tularensis subsp. holarctica DsbA homologue: a thioredoxin-like protein with chaperone functionQ42248460
The dithiol glutaredoxins of african trypanosomes have distinct roles and are closely linked to the unique trypanothione metabolismQ42394562
Molecular characterisation of mitochondrial and cytosolic trypanothione-dependent tryparedoxin peroxidases in Trypanosoma bruceiQ43719599
Lipoamide dehydrogenase is essential for both bloodstream and procyclic Trypanosoma bruceiQ44219810
Silencing of the thioredoxin gene in Trypanosoma brucei bruceiQ44239927
Quantitative Ultrastructural Investigations of the Life Cycle ofTrypanosoma brucei:A Morphometric Analysis*Q44559410
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma bruceiQ44569182
Activation of the redox-regulated chaperone Hsp33 by domain unfolding.Q44801421
Substrate specificity, localization, and essential role of the glutathione peroxidase-type tryparedoxin peroxidases in Trypanosoma bruceiQ45234385
An unusual mode of iron-sulfur-cluster coordination in a teleost glutaredoxinQ45712611
Monothiol glutaredoxin-1 is an essential iron-sulfur protein in the mitochondrion of African trypanosomesQ46453362
A New Class of Thioredoxin-Related Protein Able to Bind Iron-Sulfur Clusters.Q46667788
Complex I is the major site of mitochondrial superoxide production by paraquatQ46881393
Polyamine-Based Thiols in Trypanosomatids: Evolution, Protein Structural Adaptations, and Biological Functions.Q47630513
Stress-Activated Chaperones: A First Line of Defense.Q47821726
A glutaredoxin in the mitochondrial intermembrane space has stage-specific functions in the thermo-tolerance and proliferation of African trypanosomes.Q50136692
4,4'-Bis[8-(phenylamino)naphthalene-1-sulfonate] binding to human thrombins: a sensitive exo site fluorescent affinity probe.Q50916543
The iron uptake repressor Fep1 in the fission yeast binds Fe-S cluster through conserved cysteines.Q51625709
Prokaryotic and eukaryotic monothiol glutaredoxins are able to perform the functions of Grx5 in the biogenesis of Fe/S clusters in yeast mitochondria.Q52022306
Trypanosomal mitochondrial intermediate peptidase does not behave as a classical mitochondrial processing peptidase.Q52308831
RNAit: an automated web-based tool for the selection of RNAi targets in Trypanosoma brucei.Q53863631
Tryparedoxin peroxidase-deficiency commits trypanosomes to ferroptosis-type cell deathQ56531120
Vectors for inducible expression of toxic gene products in bloodstream and procyclic Trypanosoma bruceiQ60181049
The Interface Between ER and Mitochondria: Molecular Compositions and FunctionsQ60958881
The Diverged Trypanosome MICOS Complex as a Hub for Mitochondrial Cristae Shaping and Protein ImportQ61486208
Chaperone activation and client binding of a 2-cysteine peroxiredoxinQ61797523
The Hsp70/J-protein machinery of the African trypanosome, Trypanosoma bruceiQ61923061
ENZYMATIC SYNTHESIS OF DEOXYRIBONUCLEOTIDES. IV. ISOLATION AND CHARACTERIZATION OF THIOREDOXIN, THE HYDROGEN DONOR FROM ESCHERICHIA COLI BQ77147031
External mitochondrial NADH-dependent reductase of redox cyclers: VDAC1 or Cyb5R3?Q88112510
Analysis of heat-induced protein aggregation in human mitochondriaQ89081054
Mitochondrial proteins: from biogenesis to functional networksQ90971081
Two-step processing of human frataxin by mitochondrial processing peptidase. Precursor and intermediate forms are cleaved at different ratesQ28140463
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolismQ28275518
Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatidsQ28306157
Cytosolic peroxidases protect the lysosome of bloodstream African trypanosomes from iron-mediated membrane damageQ28383831
Physiological functions of thioredoxin and thioredoxin reductaseQ29615600
Kinetics and Redox-Sensitive Oligomerisation Reveal Negative Subunit Cooperativity in Tryparedoxin Peroxidase of Trypanosoma brucei bruceiQ30932104
Persistent ER stress induces the spliced leader RNA silencing pathway (SLS), leading to programmed cell death in Trypanosoma brucei.Q30977264
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductaseQ31813150
Improved solubility of TEV protease by directed evolutionQ33222999
Genome-wide RNAi screens in bloodstream form trypanosomes identify drug transporters.Q33695578
Charting organellar importomes by quantitative mass spectrometry.Q33701986
High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosomeQ33833378
Trypanosoma brucei pteridine reductase 1 is essential for survival in vitro and for virulence in miceQ34044853
Leishmania mitochondrial peroxiredoxin plays a crucial peroxidase-unrelated role during infection: insight into its novel chaperone activityQ34064205
Identification of a redox-regulated chaperone networkQ34107320
Processing of mitochondrial presequencesQ34240956
A member of the Hsp70 family is localized in mitochondria and resembles Escherichia coli DnaKQ34311169
Validation of Trypanosoma brucei trypanothione synthetase as drug targetQ34316594
How does iron-sulfur cluster coordination regulate the activity of human glutaredoxin 2?Q34583043
A cytosolic thioredoxin acts as a molecular chaperone for peroxisome matrix proteins as well as antioxidant in peroxisomeQ35093796
Mitochondrial peroxiredoxin functions as crucial chaperone reservoir in Leishmania infantumQ35129032
Regulation of innate and acquired immunity in African trypanosomiasisQ36265002
Mitochondrial outer membrane proteome of Trypanosoma brucei reveals novel factors required to maintain mitochondrial morphologyQ36596866
Thioredoxins and glutaredoxins as facilitators of protein folding.Q37106759
Heat-shock dependent oligomeric status alters the function of a plant-specific thioredoxin-like protein, AtTDX.Q37153798
Low-molecular-mass antioxidants in parasites.Q37952777
Mono- and dithiol glutaredoxins in the trypanothione-based redox metabolism of pathogenic trypanosomes.Q38043539
Redox metabolism in mitochondria of trypanosomatidsQ38048340
Trypanothione: a unique bis-glutathionyl derivative in trypanosomatidsQ38080372
Selenoproteins of African trypanosomes are dispensable for parasite survival in a mammalian host.Q38786519
Single-locus targeting constructs for reliable regulated RNAi and transgene expression in Trypanosoma bruceiQ38870862
Identification and functional characterization of thioredoxin from Trypanosoma brucei brucei.Q39388499
RNA interference identifies two hydroperoxide metabolizing enzymes that are essential to the bloodstream form of the african trypanosome.Q39594334
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectTrypanosoma bruceiQ33244
P304page(s)e1008065
P577publication date2019-09-26
P1433published inPLOS PathogensQ283209
P1476titleAn essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone
P478volume15

Reverse relations

Q89464714A tryparedoxin-coupled biosensor reveals a mitochondrial trypanothione metabolism in trypanosomescites workP2860

Search more.