| scholarly article | Q13442814 |
| P2093 | author name string | R Luise Krauth-Siegel | |
| Florian Fueller | |||
| Joe D Lewis | |||
| Kerstin Putzker | |||
| Britta Jehle | |||
| P2860 | cites work | Identification and characterization of TRP14, a thioredoxin-related protein of 14 kDa. New insights into the specificity of thioredoxin function | Q24299385 |
| The high resolution crystal structure of recombinant Crithidia fasciculata tryparedoxin-I | Q27619480 | ||
| Structures of tryparedoxins revealing interaction with trypanothione | Q27631706 | ||
| Structural Basis for a Distinct Catalytic Mechanism in Trypanosoma brucei Tryparedoxin Peroxidase | Q27651439 | ||
| Structure ofMycobacterium tuberculosisthioredoxin in complex with quinol inhibitor PMX464 | Q27665406 | ||
| Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings | Q27861111 | ||
| Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress | Q28144631 | ||
| A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays | Q28145712 | ||
| Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism | Q28275518 | ||
| Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade | Q28472122 | ||
| Kinetics and Redox-Sensitive Oligomerisation Reveal Negative Subunit Cooperativity in Tryparedoxin Peroxidase of Trypanosoma brucei brucei | Q30932104 | ||
| Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase | Q31813150 | ||
| High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity | Q33267962 | ||
| Evaluation of different glutathione S-transferase-tagged protein captures for screening E6/E6AP interaction inhibitors using AlphaScreen | Q33283650 | ||
| Miniaturization and validation of the Ellman's reaction based acetylcholinesterase inhibitory assay into 384-well plate format and screening of a chemical library | Q33540815 | ||
| Metabolism and functions of trypanothione in the Kinetoplastida | Q33972467 | ||
| The resurgence of covalent drugs | Q34174891 | ||
| Dithiol proteins as guardians of the intracellular redox milieu in parasites: old and new drug targets in trypanosomes and malaria-causing plasmodia | Q36013371 | ||
| A cellular and molecular investigation of the action of PMX464, a putative thioredoxin inhibitor, in normal and colorectal cancer cell lines. | Q36358122 | ||
| Glycogen synthase kinase 3 is a potential drug target for African trypanosomiasis therapy | Q36932951 | ||
| Peroxidases of trypanosomatids | Q37170924 | ||
| New therapeutic targets for drug design against Trypanosoma cruzi, advances and perspectives. | Q37528501 | ||
| Elucidation of thioredoxin as a molecular target for antitumor quinols. | Q38326927 | ||
| Preparative enzymatic synthesis of trypanothione and trypanothione analogues. | Q38951340 | ||
| A unique cascade of oxidoreductases catalyses trypanothione-mediated peroxide metabolism in Crithidia fasciculata | Q39307673 | ||
| RNA interference identifies two hydroperoxide metabolizing enzymes that are essential to the bloodstream form of the african trypanosome. | Q39594334 | ||
| Work flow for multiplexing siRNA assays by solid-phase reverse transfection in multiwell plates | Q39965401 | ||
| Depletion of the thioredoxin homologue tryparedoxin impairs antioxidative defence in African trypanosomes | Q40220444 | ||
| Antitumor quinol PMX464 is a cytocidal anti-trypanosomal inhibitor targeting trypanothione metabolism | Q41781992 | ||
| Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity | Q41824183 | ||
| Catalytic mechanism of the glutathione peroxidase-type tryparedoxin peroxidase of Trypanosoma brucei | Q43075845 | ||
| Thienylhalomethylketones: Irreversible glycogen synthase kinase 3 inhibitors as useful pharmacological tools. | Q43277752 | ||
| A second class of peroxidases linked to the trypanothione metabolism | Q44238562 | ||
| Verification of the Interaction of a Tryparedoxin Peroxidase with Tryparedoxin by ESI-MS/MS | Q44600594 | ||
| Substrate specificity, localization, and essential role of the glutathione peroxidase-type tryparedoxin peroxidases in Trypanosoma brucei | Q45234385 | ||
| 1H, 13C, and 15N assignment of the oxidized and reduced forms of T. brucei glutathione peroxidase-type tryparedoxin peroxidase. | Q45918090 | ||
| Discovery of trypanocidal compounds by whole cell HTS of Trypanosoma brucei | Q46100258 | ||
| A tryparedoxin-dependent peroxidase protects African trypanosomes from membrane damage | Q46924016 | ||
| Trypanosoma brucei tryparedoxin, a thioredoxin-like protein in African trypanosomes. | Q48029133 | ||
| Cloning, sequencing, overproduction and purification of trypanothione reductase from Trypanosoma cruzi | Q48239353 | ||
| Trypanothione-dependent peroxide metabolism in Trypanosoma cruzi different stages. | Q52223166 | ||
| Functional characterization of methionine sulfoxide reductase A from Trypanosoma spp. | Q54377141 | ||
| Novel antitrypanosomal agents based on palladium nitrofurylthiosemicarbazone complexes: DNA and redox metabolism as potential therapeutic targets | Q58845288 | ||
| Improved Inhibitors of Trypanothione Reductase by Combination of Motifs: Synthesis, Inhibitory Potency, Binding Mode, and Antiprotozoal Activities | Q58848500 | ||
| Catalytic characteristics of tryparedoxin | Q61549828 | ||
| Rapid desalting of protein samples for on-line microflow electrospray ionization mass spectrometry | Q81855997 | ||
| P433 | issue | 12 | |
| P407 | language of work or name | English | Q1860 |
| P1104 | number of pages | 11 | |
| P304 | page(s) | 8792-8802 | |
| P577 | publication date | 2012-01-23 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | High throughput screening against the peroxidase cascade of African trypanosomes identifies antiparasitic compounds that inactivate tryparedoxin | |
| P478 | volume | 287 |
| Q88138209 | An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone. |
| Q34063670 | Antiparasitic compounds may potentially treat malaria and other parasitic diseases |
| Q38675854 | Backbone NMR assignments of tryparedoxin, the central protein in the hydroperoxide detoxification cascade of African trypanosomes, in the oxidized and reduced form |
| Q89662547 | Computational approaches for drug discovery against trypanosomatid-caused diseases |
| Q55092969 | Dipeptidyl Nitroalkenes as Potent Reversible Inhibitors of Cysteine Proteases Rhodesain and Cruzain. |
| Q38154344 | Drug discovery and human African trypanosomiasis: a disease less neglected? |
| Q33898663 | Essential multimeric enzymes in kinetoplastid parasites: A host of potentially druggable protein-protein interactions |
| Q92774155 | Gamma-glutamylcysteine synthetase and tryparedoxin 1 exert high control on the antioxidant system in Trypanosoma cruzi contributing to drug resistance and infectivity |
| Q28551301 | Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids |
| Q38783627 | Polyamine-trypanothione pathway: an update. |
| Q37086096 | Trypanosoma cruzi antioxidant enzymes as virulence factors in Chagas disease |
| Q28547882 | Trypanothione reductase: a target protein for a combined in vitro and in silico screening approach |
| Q56531120 | Tryparedoxin peroxidase-deficiency commits trypanosomes to ferroptosis-type cell death |
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