| scholarly article | Q13442814 |
| P50 | author | Christine Clayton | Q40205995 |
| P2093 | author name string | A H Fairlamb | |
| R L Krauth-Siegel | |||
| M R Ariyanayagam | |||
| S Krieger | |||
| W Schwarz | |||
| P2860 | cites work | Tissue sulfhydryl groups | Q26778486 |
| Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids | Q28306157 | ||
| How do protozoan parasites survive inside macrophages? | Q33611111 | ||
| Genetic manipulation of kinetoplastida | Q33719348 | ||
| Trypanothione is the primary target for arsenical drugs against African trypanosomes | Q33849836 | ||
| Metabolism and functions of trypanothione in the Kinetoplastida | Q33972467 | ||
| Purification and characterization of trypanothione reductase from Crithidia fasciculata, a newly discovered member of the family of disulfide-containing flavoprotein reductases | Q34050552 | ||
| Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus | Q34067320 | ||
| Down-regulation of Leishmania donovani trypanothione reductase by heterologous expression of a trans-dominant mutant homologue: effect on parasite intracellular survival | Q36069752 | ||
| Production of homozygous mutant ES cells with a single targeting construct | Q36815597 | ||
| Isolation, expression, and regulation of the pgr1(+) gene encoding glutathione reductase absolutely required for the growth of Schizosaccharomyces pombe | Q36881310 | ||
| Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice | Q37303897 | ||
| A glutathione reductase mutant of yeast accumulates high levels of oxidized glutathione and requires thioredoxin for growth | Q37383386 | ||
| Site-directed mutagenesis of the redox-active cysteines of Trypanosoma cruzi trypanothione reductase. | Q38915055 | ||
| Arsenical-resistant trypanosomes lack an unusual adenosine transporter | Q38933302 | ||
| Mechanism of inhibition of trypanothione reductase and glutathione reductase by trivalent organic arsenicals | Q38957922 | ||
| Active site of trypanothione reductase. A target for rational drug design. | Q39088644 | ||
| Phenotype of recombinant Leishmania donovani and Trypanosoma cruzi which over-express trypanothione reductase. Sensitivity towards agents that are thought to induce oxidative stress. | Q39127504 | ||
| A unique cascade of oxidoreductases catalyses trypanothione-mediated peroxide metabolism in Crithidia fasciculata | Q39307673 | ||
| Extrachromosomal, homologous expression of trypanothione reductase and its complementary mRNA in Trypanosoma cruzi. | Q39531293 | ||
| Selection against the dihydrofolate reductase-thymidylate synthase (DHFR-TS) locus as a probe of genetic alterations in Leishmania major. | Q40020029 | ||
| Elongation and clustering of glycosomes in Trypanosoma brucei overexpressing the glycosomal Pex11p | Q41029230 | ||
| Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages. | Q42123859 | ||
| Microtubule polarity and dynamics in the control of organelle positioning, segregation, and cytokinesis in the trypanosome cell cycle | Q42490590 | ||
| Co-amplification of the gamma-glutamylcysteine synthetase gene gsh1 and of the ABC transporter gene pgpA in arsenite-resistant Leishmania tarentolae. | Q42619754 | ||
| Glutathione reductase-deficient erythrocytes as host cells of malarial parasites | Q47910599 | ||
| Trypanosoma brucei tryparedoxin, a thioredoxin-like protein in African trypanosomes. | Q48029133 | ||
| Differential sensitivity of Trypanosoma brucei rhodesiense isolates to in vitro lysis by arsenicals. | Q53863471 | ||
| Inducible gene expression in trypanosomes mediated by a prokaryotic repressor. | Q54172425 | ||
| Identification of a novel, thiol-containing co-factor essential for glutathione reductase enzyme activity in trypanosomatids. | Q54691023 | ||
| Trypanothione reductase from Trypanosoma cruzi. Purification and characterization of the crystalline enzyme. | Q54766074 | ||
| Trypanothione dependent peroxide metabolism in Crithidia fasciculata and Trypanosoma brucei | Q58850289 | ||
| P433 | issue | 3 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | virulence | Q1460232 |
| P304 | page(s) | 542-52 | |
| P577 | publication date | 2000-02-01 | |
| P1433 | published in | Molecular Microbiology | Q6895967 |
| P1476 | title | Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress | |
| P478 | volume | 35 |
| Q44560961 | 8-Methoxy-naphtho[2,3-b]thiophen-4,9-quinone, a non-competitive inhibitor of trypanothione reductase |
| Q33906314 | A 24-48 h fed Amblyomma americanum tick saliva immuno-proteome. |
| Q37401481 | A Comparative In Silico Study of the Antioxidant Defense Gene Repertoire of Distinct Lifestyle Trypanosomatid Species. |
| Q65002799 | A novel hydroxycinnamoyl transferase for synthesis of hydroxycinnamoyl spermine conjugates in plants. |
| Q46508906 | A potent trypanocidal component from the fungus Lentinus strigosus inhibits trypanothione reductase and modulates PBMC proliferation |
| Q44238562 | A second class of peroxidases linked to the trypanothione metabolism |
| Q34139347 | A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi |
| Q43106044 | ATP-dependent ligases in trypanothione biosynthesis--kinetics of catalysis and inhibition by phosphinic acid pseudopeptides |
| Q32062544 | Acyl-CoA binding protein is essential in bloodstream form Trypanosoma brucei |
| Q41781992 | Antitumor quinol PMX464 is a cytocidal anti-trypanosomal inhibitor targeting trypanothione metabolism |
| Q44539049 | Benzofuranyl 3,5-bis-polyamine derivatives as time-dependent inhibitors of trypanothione reductase |
| Q52602457 | Biological Evaluation and X-ray Co-crystal Structures of Cyclohexylpyrrolidine Ligands for Trypanothione Reductase, an Enzyme from the Redox Metabolism of Trypanosoma. |
| Q33187047 | Biosynthesis of trypanothione in Trypanosoma brucei brucei. |
| Q31142265 | Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi |
| Q41966973 | Characterization and developmentally regulated localization of the mitochondrial carrier protein homologue MCP6 from Trypanosoma brucei |
| Q42094447 | Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata |
| Q28139463 | Characterization of transsulfuration and cysteine biosynthetic pathways in the protozoan hemoflagellate, Trypanosoma cruzi. Isolation and molecular characterization of cystathionine beta-synthase and serine acetyltransferase from Trypanosoma |
| Q41835113 | Chemical and genetic validation of dihydrofolate reductase-thymidylate synthase as a drug target in African trypanosomes |
| Q24657204 | Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis |
| Q35569065 | Chemotherapy of human African trypanosomiasis: current and future prospects |
| Q40699796 | Cloning of Trypanosoma brucei and Leishmania major genes encoding the GlcNAc-phosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol biosynthesis that is essential to the African sleeping sickness parasite. |
| Q39507727 | Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of the mitochondrial tryparedoxin peroxidase from Leishmania braziliensis |
| Q28553426 | Comparative Transcriptome Profiling of Human Foreskin Fibroblasts Infected with the Sylvio and Y Strains of Trypanosoma cruzi |
| Q46041637 | Comparative molecular docking of antitrypanosomal natural products into multiple Trypanosoma brucei drug targets |
| Q27657406 | Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi |
| Q44225793 | Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum |
| Q92161098 | Current trends in the pharmacological management of Chagas disease |
| Q43833365 | Cysteine protease as a target for nitric oxide in parasitic organisms |
| Q36947873 | Cytosolic NADPH homeostasis in glucose-starved procyclic Trypanosoma brucei relies on malic enzyme and the pentose phosphate pathway fed by gluconeogenic flux. |
| Q37698643 | Deciphering the interplay between cysteine synthase and thiol cascade proteins in modulating Amphotericin B resistance and survival of Leishmania donovani under oxidative stress |
| Q35925923 | Deoxyhypusine Modification of Eukaryotic Translation Initiation Factor 5A (eIF5A) Is Essential for Trypanosoma brucei Growth and for Expression of Polyprolyl-containing Proteins |
| Q51294099 | Depletion of GIM5 causes cellular fragility, a decreased glycosome number, and reduced levels of ether-linked phospholipids in trypanosomes. |
| Q40220444 | Depletion of the thioredoxin homologue tryparedoxin impairs antioxidative defence in African trypanosomes |
| Q34097455 | Design, synthesis and biological evaluation of Trypanosoma brucei trypanothione synthetase inhibitors |
| Q38367858 | Detection of thiol-based redox switch processes in parasites - facts and future |
| Q36355665 | Developments in diagnosis and antileishmanial drugs |
| Q41479143 | Diglycosyl diselenides alter redox homeostasis and glucose consumption of infective African trypanosomes |
| Q27671819 | Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography |
| Q60919386 | Discovery and Genetic Validation of Chemotherapeutic Targets for Chagas' Disease |
| Q33267859 | Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening |
| Q42557517 | Dissecting the catalytic mechanism of Trypanosoma brucei trypanothione synthetase by kinetic analysis and computational modeling |
| Q24649110 | Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods |
| Q48051536 | Drug target validation of the trypanothione pathway enzymes through metabolic modelling |
| Q41813592 | Ebsulfur is a benzisothiazolone cytocidal inhibitor targeting the trypanothione reductase of Trypanosoma brucei. |
| Q41790538 | Ellman's-reagent-mediated regeneration of trypanothione in situ: substrate-economical microplate and time-dependent inhibition assays for trypanothione reductase |
| Q37540773 | Enzymes of the antioxidant network as novel determiners of Trypanosoma cruzi virulence |
| Q37267341 | Escherichia coli glutathionylspermidine synthetase/amidase: phylogeny and effect on regulation of gene expression |
| Q37310660 | Evidence that transport of iron from the lysosome to the cytosol in African trypanosomes is mediated by a mucolipin orthologue. |
| Q35813283 | Flavoprotein disulfide reductases: advances in chemistry and function |
| Q44569182 | Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei |
| Q35998332 | GMP synthase is essential for viability and infectivity of Trypanosoma brucei despite a redundant purine salvage pathway. |
| Q34027098 | Galactose metabolism is essential for the African sleeping sickness parasite Trypanosoma brucei |
| Q92774155 | Gamma-glutamylcysteine synthetase and tryparedoxin 1 exert high control on the antioxidant system in Trypanosoma cruzi contributing to drug resistance and infectivity |
| Q35180176 | Gene regulation by tetracyclines. Constraints of resistance regulation in bacteria shape TetR for application in eukaryotes |
| Q33766769 | Genetic validation of Trypanosoma brucei glutathione synthetase as an essential enzyme |
| Q35086396 | Genome sequence of the stramenopile Blastocystis, a human anaerobic parasite |
| Q33270008 | Glutathionylation of trypanosomal thiol redox proteins |
| Q31049371 | Glyoxalase II of African trypanosomes is trypanothione-dependent |
| Q42058134 | High throughput screening against the peroxidase cascade of African trypanosomes identifies antiparasitic compounds that inactivate tryparedoxin |
| Q33267962 | High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity |
| Q33474992 | Improved tricyclic inhibitors of trypanothione reductase by screening and chemical synthesis |
| Q39180209 | In silico structural characterization of protein targets for drug development against Trypanosoma cruzi |
| Q39617576 | In silico, in vitro, X-ray crystallography, and integrated strategies for discovering spermidine synthase inhibitors for Chagas disease. |
| Q28481512 | In-silico investigation of antitrypanosomal phytochemicals from Nigerian medicinal plants |
| Q38154345 | Indazoles: a new top seed structure in the search of efficient drugs against Trypanosoma cruzi. |
| Q31154737 | Information-based methods in the development of antiparasitic drugs |
| Q36252376 | Inhibition of Leishmania infantum trypanothione reductase by diaryl sulfide derivatives |
| Q39329009 | Inhibitors of Trypanosoma brucei trypanothione reductase: comparative molecular field analysis modeling and structural basis for selective inhibition. |
| Q30897674 | Investigation of trypanothione reductase as a drug target in Trypanosoma brucei |
| Q30932104 | Kinetics and Redox-Sensitive Oligomerisation Reveal Negative Subunit Cooperativity in Tryparedoxin Peroxidase of Trypanosoma brucei brucei |
| Q24655332 | Leishmania trypanothione synthetase-amidase structure reveals a basis for regulation of conflicting synthetic and hydrolytic activities |
| Q37217309 | Metabolic control analysis: a tool for designing strategies to manipulate metabolic pathways. |
| Q43719599 | Molecular characterisation of mitochondrial and cytosolic trypanothione-dependent tryparedoxin peroxidases in Trypanosoma brucei |
| Q39462850 | Molecular dynamics simulations of peptide inhibitors complexed with Trypanosoma cruzi trypanothione reductase. |
| Q41714322 | Molecular genetics evidence for the in vivo roles of the two major NADPH-dependent disulfide reductases in the malaria parasite |
| Q46453362 | Monothiol glutaredoxin-1 is an essential iron-sulfur protein in the mitochondrion of African trypanosomes |
| Q43600542 | NO donors inhibit Leishmania infantum cysteine proteinase activity |
| Q35112639 | Parasite-specific trypanothione reductase as a drug target molecule |
| Q58854359 | Pharmacological Metabolomics in Trypanosomes |
| Q24537133 | Phenotypic analysis of trypanothione synthetase knockdown in the African trypanosome |
| Q28732919 | Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities |
| Q37761657 | Polyamine metabolism in Leishmania: from arginine to trypanothione |
| Q38783627 | Polyamine-trypanothione pathway: an update. |
| Q58544813 | Polyamines in protozoan pathogens |
| Q44277644 | Probing the dimerization interface of Leishmania infantum trypanothione reductase with site-directed mutagenesis and short peptides |
| Q35037654 | Protozomics: trypanosomatid parasite genetics comes of age. |
| Q28553225 | Pyrimidine Salvage Enzymes Are Essential for De Novo Biosynthesis of Deoxypyrimidine Nucleotides in Trypanosoma brucei |
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| Q37191005 | RNA interference-mediated silencing of ornithine decarboxylase and spermidine synthase genes in Trypanosoma brucei provides insight into regulation of polyamine biosynthesis |
| Q36078889 | Reactive oxygen species-mediated immunity against Leishmania mexicana and Serratia marcescens in the sand phlebotomine fly Lutzomyia longipalpis. |
| Q91813186 | Reactive species and pathogen antioxidant networks during phagocytosis |
| Q98508491 | Recent Advancement in the Search of Innovative Antiprotozoal Agents Targeting Trypanothione Metabolism |
| Q28473800 | Regulated expression of an essential allosteric activator of polyamine biosynthesis in African trypanosomes |
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