| scholarly article | Q13442814 |
| P50 | author | Alan Fairlamb | Q4706598 |
| Sandra L Oza | Q58464788 | ||
| William Nigel Hunter | Q68041284 | ||
| P2093 | author name string | Paul K Fyfe | |
| P2860 | cites work | Genomic analysis of the eukaryotic protein kinase superfamily: a perspective | Q21092887 |
| Phenotypic analysis of trypanothione synthetase knockdown in the African trypanosome | Q24537133 | ||
| A diverse superfamily of enzymes with ATP-dependent carboxylate-amine/thiol ligase activity | Q24673557 | ||
| Purification of glutathionylspermidine and trypanothione synthetases from Crithidia fasciculata | Q24676196 | ||
| Evolutionary history, structural features and biochemical diversity of the NlpC/P60 superfamily of enzymes | Q24804620 | ||
| PROCHECK: a program to check the stereochemical quality of protein structures | Q26778411 | ||
| Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors | Q27618611 | ||
| The high resolution crystal structure of recombinant Crithidia fasciculata tryparedoxin-I | Q27619480 | ||
| The structure of reduced tryparedoxin peroxidase reveals a decamer and insight into reactivity of 2Cys-peroxiredoxins | Q27625327 | ||
| Large conformational changes in the catalytic cycle of glutathione synthase | Q27640106 | ||
| Tryparedoxins from Crithidia fasciculata and Trypanosoma brucei: photoreduction of the redox disulfide using synchrotron radiation and evidence for a conformational switch implicated in function | Q27641042 | ||
| A pseudo-michaelis quaternary complex in the reverse reaction of a ligase: structure of Escherichia coli B glutathione synthetase complexed with ADP, glutathione, and sulfate at 2.0 A resolution | Q27733431 | ||
| Maximum-likelihood density modification | Q27860478 | ||
| Use of TLS parameters to model anisotropic displacements in macromolecular refinement | Q27860499 | ||
| Coot: model-building tools for molecular graphics | Q27860505 | ||
| Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions | Q27860532 | ||
| Structure validation by Calpha geometry: phi,psi and Cbeta deviation | Q27860657 | ||
| Efficient anisotropic refinement of macromolecular structures using FFT | Q27861028 | ||
| The CCP4 suite: programs for protein crystallography | Q27861090 | ||
| Scaling and assessment of data quality | Q27861107 | ||
| Automated MAD and MIR structure solution | Q27861114 | ||
| Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress | Q28144631 | ||
| Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants | Q29546524 | ||
| Drug resistance in leishmaniasis | Q29616242 | ||
| MOLREP: an Automated Program for Molecular Replacement | Q29642797 | ||
| Amidase domains from bacterial and phage autolysins define a family of gamma-D,L-glutamate-specific amidohydrolases | Q33187139 | ||
| Metabolism and functions of trypanothione in the Kinetoplastida | Q33972467 | ||
| A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi | Q34139347 | ||
| The CHAP domain: a large family of amidases including GSP amidase and peptidoglycan hydrolases | Q34199699 | ||
| Glutathionylspermidine metabolism in Escherichia coli. Purification, cloning, overproduction, and characterization of a bifunctional glutathionylspermidine synthetase/amidase | Q34312691 | ||
| Validation of Trypanosoma brucei trypanothione synthetase as drug target | Q34316594 | ||
| Trypanothione synthesis in crithidia revisited. | Q34366818 | ||
| Trypanothione biosynthesis in Leishmania major | Q34378267 | ||
| Mapping the functional synthetase domain of trypanothione synthetase from Leishmania major | Q34536654 | ||
| Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis | Q34645824 | ||
| Polyamine metabolism as chemotherapeutic target in protozoan parasites | Q34948330 | ||
| Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase | Q35222226 | ||
| Dithiol proteins as guardians of the intracellular redox milieu in parasites: old and new drug targets in trypanosomes and malaria-causing plasmodia | Q36013371 | ||
| Enzyme inhibitors as chemical tools to study enzyme catalysis: rational design, synthesis, and applications | Q36206000 | ||
| Human African trypanosomiasis: pharmacological re-engagement with a neglected disease. | Q36740553 | ||
| Drugs and drug resistance in African trypanosomiasis | Q36780369 | ||
| Polyamines as targets for therapeutic intervention | Q40437004 | ||
| Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata | Q42094447 | ||
| High-resolution complex of papain with remnants of a cysteine protease inhibitor derived from Trypanosoma brucei. | Q43044261 | ||
| Biosynthesis of the trypanosomatid metabolite trypanothione: purification and characterization of trypanothione synthetase from Crithidia fasciculata | Q44485901 | ||
| Properties of trypanothione synthetase from Trypanosoma brucei | Q44580579 | ||
| Function of conserved residues of human glutathione synthetase: implications for the ATP-grasp enzymes | Q44780535 | ||
| A solution for the best rotation to relate two sets of vectors | Q45034417 | ||
| Design, synthesis, and biological evaluation of phosphinopeptides against Trypanosoma cruzi targeting trypanothione biosynthesis. | Q46879325 | ||
| Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata | Q47792563 | ||
| A comprehensive and non-redundant database of protein domain movements. | Q48493291 | ||
| Protozoan genomics for drug discovery. | Q55041205 | ||
| Protein Identification and Analysis Tools on the ExPASy Server | Q56880448 | ||
| Dissection of glutathionylspermidine synthetase/amidase from Escherichia coli into autonomously folding and functional synthetase and amidase domains | Q71985246 | ||
| Catalytic mechanism in papain family of cysteine peptidases | Q72519392 | ||
| Cutaneous leishmaniasis | Q80832717 | ||
| P4510 | describes a project that uses | PyMOL | Q1373457 |
| P433 | issue | 25 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | cell biology | Q7141 |
| P304 | page(s) | 17672-17680 | |
| P577 | publication date | 2008-04-17 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Leishmania trypanothione synthetase-amidase structure reveals a basis for regulation of conflicting synthetic and hydrolytic activities | |
| P478 | volume | 283 |
| Q43106044 | ATP-dependent ligases in trypanothione biosynthesis--kinetics of catalysis and inhibition by phosphinic acid pseudopeptides |
| Q38883627 | An Improved Model of the Trypanosoma brucei CTP Synthetase Glutaminase Domain-Acivicin Complex |
| Q47414193 | Buthionine sulfoximine is a multitarget inhibitor of trypanothione synthesis in Trypanosoma cruzi |
| Q24657204 | Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis |
| Q45909806 | Cloning, expression, characterization and inhibition studies on trypanothione synthetase, a drug target enzyme, from Leishmania donovani. |
| Q34097455 | Design, synthesis and biological evaluation of Trypanosoma brucei trypanothione synthetase inhibitors |
| Q42557517 | Dissecting the catalytic mechanism of Trypanosoma brucei trypanothione synthetase by kinetic analysis and computational modeling |
| Q24649110 | Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods |
| Q64249811 | Future Prospects in the Treatment of Parasitic Diseases: 2-Amino-1,3,4-Thiadiazoles in Leishmaniasis |
| Q33766769 | Genetic validation of Trypanosoma brucei glutathione synthetase as an essential enzyme |
| Q28551301 | Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids |
| Q39200387 | In-silico analyses of sesquiterpene-related compounds on selected Leishmania enzyme-based targets. |
| Q28485261 | Mathematical modelling of polyamine metabolism in bloodstream-form Trypanosoma brucei: an application to drug target identification |
| Q28486718 | Molecular dynamics reveal binding mode of glutathionylspermidine by trypanothione synthetase |
| Q37524043 | Optimized CGenFF force-field parameters for acylphosphate and N-phosphonosulfonimidoyl functional groups |
| Q28732919 | Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities |
| Q37761657 | Polyamine metabolism in Leishmania: from arginine to trypanothione |
| Q38783627 | Polyamine-trypanothione pathway: an update. |
| Q58544813 | Polyamines in protozoan pathogens |
| Q27662134 | Protein S-Thiolation by Glutathionylspermidine (Gsp): THE ROLE OF ESCHERICHIA COLI Gsp SYNTHETASE/AMIDASE IN REDOX REGULATION |
| Q37191005 | RNA interference-mediated silencing of ornithine decarboxylase and spermidine synthase genes in Trypanosoma brucei provides insight into regulation of polyamine biosynthesis |
| Q98508491 | Recent Advancement in the Search of Innovative Antiprotozoal Agents Targeting Trypanothione Metabolism |
| Q27011766 | Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis |
| Q28473800 | Regulated expression of an essential allosteric activator of polyamine biosynthesis in African trypanosomes |
| Q27657995 | Specificity and Mechanism ofAcinetobacter baumaniiNicotinamidase: Implications for Activation of the Front-Line Tuberculosis Drug Pyrazinamide |
| Q28539382 | Stage-dependent expression and up-regulation of trypanothione synthetase in amphotericin B resistant Leishmania donovani |
| Q38880076 | Stress-Induced Protein S-Glutathionylation and S-Trypanothionylation in African Trypanosomes-A Quantitative Redox Proteome and Thiol Analysis |
| Q27658384 | Structural Basis for Evolution of Product Diversity in Soybean Glutathione Biosynthesis |
| Q27653800 | Structural Basis of Murein Peptide Specificity of a γ-D-Glutamyl-L-Diamino Acid Endopeptidase |
| Q28538904 | Structural and biochemical characterization reveals LysGH15 as an unprecedented "EF-hand-like" calcium-binding phage lysin |
| Q27680772 | Structural basis for type VI secreted peptidoglycanDL-endopeptidase function, specificity and neutralization inSerratia marcescens |
| Q38154346 | Structural insights into the enzymes of the trypanothione pathway: targets for antileishmaniasis drugs. |
| Q27666555 | Structure and mechanism ofEscherichia coliglutathionylspermidine amidase belonging to the family of cysteine; histidine-dependent amidohydrolases/peptidases |
| Q27658837 | Structure of Trypanosoma brucei glutathione synthetase: Domain and loop alterations in the catalytic cycle of a highly conserved enzyme |
| Q27684385 | Structures of bacterial kynurenine formamidase reveal a crowded binuclear zinc catalytic site primed to generate a potent nucleophile |
| Q93042430 | Tetraazamacrocyclic derivatives and their metal complexes as antileishmanial leads |
Search more.