Buthionine sulfoximine is a multitarget inhibitor of trypanothione synthesis in Trypanosoma cruzi

scientific article published on 11 November 2017

Buthionine sulfoximine is a multitarget inhibitor of trypanothione synthesis in Trypanosoma cruzi is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/1873-3468.12904
P8608Fatcat IDrelease_vetr2kvgsnb4zf6doxramftdky
P698PubMed publication ID29127710

P50authorRafael Moreno-SanchezQ57574778
Emma SaavedraQ104904996
Citlali VázquezQ117254355
Zabdi González-ChávezQ117254358
Marlen Mejia-TlachiQ117254360
José Salud Rodríguez-ZavalaQ117254370
P2093author name stringAketzalli Silva
P2860cites workThe human serum metabolomeQ21135549
Leishmania trypanothione synthetase-amidase structure reveals a basis for regulation of conflicting synthetic and hydrolytic activitiesQ24655332
Protein production by auto-induction in high density shaking culturesQ27860514
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The importance of glutathione in human diseaseQ28180886
AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibilityQ29547658
A semiempirical free energy force field with charge-based desolvationQ29614316
Glutathione transport: a new role for PfCRT in chloroquine resistanceQ30041670
Protein structure homology modeling using SWISS-MODEL workspace.Q30374281
Genetic validation of Trypanosoma brucei glutathione synthetase as an essential enzymeQ33766769
Biologic and pharmacologic regulation of mammalian glutathione synthesisQ33777922
Activation of benznidazole by trypanosomal type I nitroreductases results in glyoxal formationQ34228648
Inhibition of glutathione synthesis as a chemotherapeutic strategy for trypanosomiasisQ36344549
Insights into the redox biology of Trypanosoma cruzi: Trypanothione metabolism and oxidant detoxificationQ37202974
Metabolic control analysis: a tool for designing strategies to manipulate metabolic pathways.Q37217309
Targeting Trypanothione Metabolism in Trypanosomatid Human ParasitesQ37782110
Glutathione transportersQ38064620
Key proteins in the polyamine-trypanothione pathway as drug targets against Trypanosoma cruziQ38164047
Thiol redox biology of trypanosomatids and potential targets for chemotherapyQ38642326
Identification of protein complex associated with LYT1 of Trypanosoma cruziQ39468283
Mitochondrial changes associated with glutathione deficiencyQ40437326
Buthionine sulfoximine increases the toxicity of nifurtimox and benznidazole to Trypanosoma cruzi.Q40734322
Functional analysis of the intergenic regions of TcP2beta gene loci allowed the construction of an improved Trypanosoma cruzi expression vectorQ40919671
Biological characterization and genetic diversity of Mexican isolates of Trypanosoma cruziQ41031344
Gene knockdown of gamma-glutamylcysteine synthetase by RNAi in the parasitic protozoa Trypanosoma brucei demonstrates that it is an essential enzymeQ44530879
Characterization of Trypanosoma cruzi L-cysteine transport mechanisms and their adaptive regulation.Q46143054
Drug target validation of the trypanothione pathway enzymes through metabolic modellingQ48051536
On the discovery of glutathione.Q52398273
Role of glutathione in the susceptibility of Trypanosoma cruzi to drugs.Q54367031
Glutathione and trypanothione in several strains of Trypanosoma cruzi: Effect of drugsQ58849682
P433issue23
P407language of work or nameEnglishQ1860
P921main subjectTrypanosoma cruziQ150162
P304page(s)3881-3894
P577publication date2017-11-11
P1433published inFEBS LettersQ1388051
P1476titleButhionine sulfoximine is a multitarget inhibitor of trypanothione synthesis in Trypanosoma cruzi
P478volume591

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cites work (P2860)
Q89662547Computational approaches for drug discovery against trypanosomatid-caused diseases
Q92774155Gamma-glutamylcysteine synthetase and tryparedoxin 1 exert high control on the antioxidant system in Trypanosoma cruzi contributing to drug resistance and infectivity

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