| scholarly article | Q13442814 |
| P50 | author | Paul A.M. Michels | Q57211701 |
| Rafael Moreno-Sanchez | Q57574778 | ||
| Sara Rodríguez-Enríquez | Q57574909 | ||
| Emma Saavedra | Q104904996 | ||
| Rusely Encalada | Q117254349 | ||
| Citlali Vázquez | Q117254355 | ||
| Zabdi González-Chávez | Q117254358 | ||
| Marlen Mejia-Tlachi | Q117254360 | ||
| P2093 | author name string | Rebeca Manning-Cela | |
| Claudia Márquez-Dueñas | |||
| P2860 | cites work | Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress | Q28144631 |
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| Enzymes or redox couples? The kinetics of thioredoxin and glutaredoxin reactions in a systems biology context | Q28290522 | ||
| Benznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomics | Q28539047 | ||
| COPASI--a COmplex PAthway SImulator | Q29617467 | ||
| The redox status of cystinotic fibroblasts | Q33729597 | ||
| Metabolic control analysis of glycolysis in trypanosomes as an approach to improve selectivity and effectiveness of drugs. | Q33879099 | ||
| Trypanothione synthetase confers growth, survival advantage and resistance to anti-protozoal drugs in Trypanosoma cruzi | Q57802865 | ||
| Chagas disease | Q58842312 | ||
| Chagas disease in Latin America: an epidemiological update based on 2010 estimates | Q58842739 | ||
| Metabolic control analysis of the Trypanosoma cruzi peroxide detoxification pathway identifies tryparedoxin as a suitable drug target | Q58842743 | ||
| Differential expression of Trypanosoma cruzi I associated with clinical forms of Chagas disease: overexpression of oxidative stress proteins in acute patient isolate | Q58843696 | ||
| Peroxiredoxins from Trypanosoma cruzi: virulence factors and drug targets for treatment of Chagas disease? | Q58844767 | ||
| Possible role of cAMP in the differentiation of Trypanosoma cruzi | Q70162771 | ||
| Molecular characterization and interactome analysis of Trypanosoma cruzi tryparedoxin 1 | Q84026650 | ||
| Stress-Induced Proliferation and Cell Cycle Plasticity of Intracellular Trypanosoma cruzi Amastigotes | Q89507365 | ||
| Kinetic studies reveal a key role of a redox-active glutaredoxin in the evolution of the thiol-redox metabolism of trypanosomatid parasites | Q90796660 | ||
| Drug Target Selection for Trypanosoma cruzi Metabolism by Metabolic Control Analysis and Kinetic Modeling | Q91477065 | ||
| A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi | Q34139347 | ||
| GEPASI: a software package for modelling the dynamics, steady states and control of biochemical and other systems | Q34348589 | ||
| Mode of action of natural and synthetic drugs against Trypanosoma cruzi and their interaction with the mammalian host. | Q34515509 | ||
| Ecoepidemiology, short history and control of Chagas disease in the endemic countries and the new challenge for non-endemic countries | Q34975844 | ||
| Peroxiredoxins play a major role in protecting Trypanosoma cruzi against macrophage- and endogenously-derived peroxynitrite | Q36740177 | ||
| Insights into the redox biology of Trypanosoma cruzi: Trypanothione metabolism and oxidant detoxification | Q37202974 | ||
| Metabolic control analysis: a tool for designing strategies to manipulate metabolic pathways. | Q37217309 | ||
| Enzymes of the antioxidant network as novel determiners of Trypanosoma cruzi virulence | Q37540773 | ||
| Targeting Trypanothione Metabolism in Trypanosomatid Human Parasites | Q37782110 | ||
| The trypanothione system and the opportunities it offers to create drugs for the neglected kinetoplast diseases | Q37881219 | ||
| Trypanothione: a unique bis-glutathionyl derivative in trypanosomatids | Q38080372 | ||
| Thiol redox biology of trypanosomatids and potential targets for chemotherapy | Q38642326 | ||
| How Trypanosoma cruzi deals with oxidative stress: Antioxidant defence and DNA repair pathways | Q38795673 | ||
| Challenges in Chagas Disease Drug Discovery: A Review | Q38880814 | ||
| Trypanothione Reductase and Superoxide Dismutase as Current Drug Targets for Trypanosoma cruzi: An Overview of Compounds with Activity against Chagas Disease. | Q38901567 | ||
| Preparative enzymatic synthesis of trypanothione and trypanothione analogues. | Q38951340 | ||
| Targets and Patented Drugs for Chemotherapy of Chagas Disease in the Last 15 Years-Period | Q38991613 | ||
| Phenotype of recombinant Leishmania donovani and Trypanosoma cruzi which over-express trypanothione reductase. Sensitivity towards agents that are thought to induce oxidative stress. | Q39127504 | ||
| In silico structural characterization of protein targets for drug development against Trypanosoma cruzi | Q39180209 | ||
| Trypanothione Reductase: A Target for the Development of Anti- Trypanosoma cruzi Drugs. | Q39182489 | ||
| A unique cascade of oxidoreductases catalyses trypanothione-mediated peroxide metabolism in Crithidia fasciculata | Q39307673 | ||
| LYT1 protein is required for efficient in vitro infection by Trypanosoma cruzi. | Q39520750 | ||
| RNA interference identifies two hydroperoxide metabolizing enzymes that are essential to the bloodstream form of the african trypanosome. | Q39594334 | ||
| The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin. | Q39594349 | ||
| Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi | Q39594361 | ||
| The overexpression of genes of thiol metabolism contribute to drug resistance in clinical isolates of visceral leishmaniasis (kala azar) in India | Q40177604 | ||
| Depletion of the thioredoxin homologue tryparedoxin impairs antioxidative defence in African trypanosomes | Q40220444 | ||
| Functional analysis of the intergenic regions of TcP2beta gene loci allowed the construction of an improved Trypanosoma cruzi expression vector | Q40919671 | ||
| Biological characterization and genetic diversity of Mexican isolates of Trypanosoma cruzi | Q41031344 | ||
| High throughput screening against the peroxidase cascade of African trypanosomes identifies antiparasitic compounds that inactivate tryparedoxin | Q42058134 | ||
| The gamma-glutamylcysteine synthetase gene of Leishmania is essential and involved in response to oxidants | Q43264412 | ||
| Interaction of benznidazole reactive metabolites with nuclear and kinetoplastic DNA, proteins and lipids from Trypanosoma cruzi | Q43488469 | ||
| Characterization of Trypanosoma cruzi L-cysteine transport mechanisms and their adaptive regulation. | Q46143054 | ||
| A tryparedoxin-dependent peroxidase protects African trypanosomes from membrane damage | Q46924016 | ||
| Buthionine sulfoximine is a multitarget inhibitor of trypanothione synthesis in Trypanosoma cruzi | Q47414193 | ||
| Drug target validation of the trypanothione pathway enzymes through metabolic modelling | Q48051536 | ||
| The sum of the control coefficients of all enzymes on the flux through a group-transfer pathway can be as high as two. | Q50165022 | ||
| Trypanothione-dependent peroxide metabolism in Trypanosoma cruzi different stages. | Q52223166 | ||
| A 'top-down' approach to the determination of control coefficients in metabolic control theory. | Q52491318 | ||
| Role of ABC transporter MRPA, gamma-glutamylcysteine synthetase and ornithine decarboxylase in natural antimony-resistant isolates of Leishmania donovani. | Q54563374 | ||
| P921 | main subject | Trypanosoma cruzi | Q150162 |
| infectivity | Q1662346 | ||
| P304 | page(s) | 101231 | |
| P577 | publication date | 2019-05-28 | |
| P1433 | published in | Redox Biology | Q27724751 |
| P1476 | title | Gamma-glutamylcysteine synthetase and tryparedoxin 1 exert high control on the antioxidant system in Trypanosoma cruzi contributing to drug resistance and infectivity | |
| P478 | volume | 26 |
| Q100307202 | Motility patterns of Trypanosoma cruzi trypomastigotes correlate with the efficiency of parasite invasion in vitro |
| Q93200202 | Physiological Role of Glutamate Dehydrogenase in Cancer Cells |
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