The gamma-glutamylcysteine synthetase gene of Leishmania is essential and involved in response to oxidants

scientific article published on 8 October 2009

The gamma-glutamylcysteine synthetase gene of Leishmania is essential and involved in response to oxidants is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1365-2958.2009.06907.X
P698PubMed publication ID19818018
P5875ResearchGate publication ID26883792

P50authorMarc OuelletteQ38546122
P2093author name stringAngana Mukherjee
Gaétan Roy
Chantal Guimond
P2860cites workTrypanothione overproduction and resistance to antimonials and arsenicals in LeishmaniaQ24595838
Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogensQ24630289
GlutathioneQ28261279
Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatidsQ28306157
The glutathione biosynthetic pathway of Plasmodium is essential for mosquito transmissionQ28474756
Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygousQ28508176
Glutathione synthesis is essential for mouse development but not for cell growth in cultureQ28511310
Drug resistance in leishmaniasisQ29616242
How do protozoan parasites survive inside macrophages?Q33611111
Glutathione and trypanothione in parasitic hydroperoxide metabolismQ33777935
Metabolism and functions of trypanothione in the KinetoplastidaQ33972467
Evidence that J-binding protein 2 is a thymidine hydroxylase catalyzing the first step in the biosynthesis of DNA base J.Q34015435
Target assessment for antiparasitic drug discoveryQ34301994
Leishmania major elongation factor 1B complex has trypanothione S-transferase and peroxidase activityQ34342417
Trypanothione biosynthesis in Leishmania majorQ34378267
Evasion of innate immunity by parasitic protozoaQ34983845
Leishmaniasis: drugs in the clinic, resistance and new developments.Q35943371
Plasticity in chromosome number and testing of essential genes in Leishmania by targetingQ36117098
Increased levels of thiols protect antimony unresponsive Leishmania donovani field isolates against reactive oxygen species generated by trivalent antimonyQ36133198
Inhibition of glutathione synthesis as a chemotherapeutic strategy for trypanosomiasisQ36344549
Peroxidases of trypanosomatidsQ37170924
Insights into the redox biology of Trypanosoma cruzi: Trypanothione metabolism and oxidant detoxificationQ37202974
Amplification of an alternate transporter gene suppresses the avirulent phenotype of glucose transporter null mutants in Leishmania mexicana.Q37310878
Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharideQ37555750
Substrate binding determinants of Trypanosoma brucei gamma-glutamylcysteine synthetaseQ38291935
Gene expression analysis of the mechanism of natural Sb(V) resistance in Leishmania donovani isolates from NepalQ38968281
DNA transformation of Leishmania infantum axenic amastigotes and their use in drug screeningQ39476913
The role of reduced pterins in resistance to reactive oxygen and nitrogen intermediates in the protozoan parasite LeishmaniaQ39913965
Roles of trypanothione S-transferase and tryparedoxin peroxidase in resistance to antimonialsQ40016515
Buthionine sulfoximine increases the toxicity of nifurtimox and benznidazole to Trypanosoma cruzi.Q40734322
Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages.Q42123859
Co-amplification of the gamma-glutamylcysteine synthetase gene gsh1 and of the ABC transporter gene pgpA in arsenite-resistant Leishmania tarentolae.Q42619754
Oxidative responses of human and murine macrophages during phagocytosis of Leishmania chagasiQ43664759
Gene knockdown of gamma-glutamylcysteine synthetase by RNAi in the parasitic protozoa Trypanosoma brucei demonstrates that it is an essential enzymeQ44530879
Disruption of gamma-glutamylcysteine synthetase results in absolute glutathione auxotrophy and apoptosis in Candida albicansQ44714781
Trypanosoma brucei and Trypanosoma cruzi tryparedoxin peroxidases catalytically detoxify peroxynitrite via oxidation of fast reacting thiols.Q44904831
Growth phase regulation of the main folate transporter of Leishmania infantum and its role in methotrexate resistanceQ45091641
Substrate specificity, localization, and essential role of the glutathione peroxidase-type tryparedoxin peroxidases in Trypanosoma bruceiQ45234385
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculataQ47792563
Identification and characterisation of a functional peroxidoxin from Leishmania majorQ48001860
Trypanosoma brucei tryparedoxin, a thioredoxin-like protein in African trypanosomes.Q48029133
Elevated levels of polyamines and trypanothione resulting from overexpression of the ornithine decarboxylase gene in arsenite-resistant Leishmania.Q54072274
Role of ABC transporter MRPA, gamma-glutamylcysteine synthetase and ornithine decarboxylase in natural antimony-resistant isolates of Leishmania donovani.Q54563374
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectgamma-glutamylcysteine synthetase, putativeQ61505629
gamma-glutamylcysteine synthetaseQ61573231
gamma-glutamylcysteine synthetase, putativeQ62253769
gamma-glutamylcysteine synthetase, putativeQ62422064
gamma-glutamylcysteine synthetaseQ62457188
P304page(s)914-927
P577publication date2009-10-08
P1433published inMolecular MicrobiologyQ6895967
P1476titleThe gamma-glutamylcysteine synthetase gene of Leishmania is essential and involved in response to oxidants
P478volume74

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cites work (P2860)
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Q90131592Ascorbate-Dependent Peroxidase (APX) from Leishmania amazonensis Is a Reactive Oxygen Species-Induced Essential Enzyme That Regulates Virulence
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Q50044336Compounds with potential activity against Mycobacterium tuberculosis.
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Q92774155Gamma-glutamylcysteine synthetase and tryparedoxin 1 exert high control on the antioxidant system in Trypanosoma cruzi contributing to drug resistance and infectivity
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Q52566647Genomic and transcriptomic alterations in Leishmania donovani lines experimentally resistant to antileishmanial drugs.
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Q28543469Intrachromosomal amplification, locus deletion and point mutation in the aquaglyceroporin AQP1 gene in antimony resistant Leishmania (Viannia) guyanensis
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