scholarly article | Q13442814 |
P50 | author | Marc Ouellette | Q38546122 |
P2093 | author name string | Angana Mukherjee | |
Gaétan Roy | |||
Chantal Guimond | |||
P2860 | cites work | Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania | Q24595838 |
Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens | Q24630289 | ||
Glutathione | Q28261279 | ||
Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids | Q28306157 | ||
The glutathione biosynthetic pathway of Plasmodium is essential for mosquito transmission | Q28474756 | ||
Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous | Q28508176 | ||
Glutathione synthesis is essential for mouse development but not for cell growth in culture | Q28511310 | ||
Drug resistance in leishmaniasis | Q29616242 | ||
How do protozoan parasites survive inside macrophages? | Q33611111 | ||
Glutathione and trypanothione in parasitic hydroperoxide metabolism | Q33777935 | ||
Metabolism and functions of trypanothione in the Kinetoplastida | Q33972467 | ||
Evidence that J-binding protein 2 is a thymidine hydroxylase catalyzing the first step in the biosynthesis of DNA base J. | Q34015435 | ||
Target assessment for antiparasitic drug discovery | Q34301994 | ||
Leishmania major elongation factor 1B complex has trypanothione S-transferase and peroxidase activity | Q34342417 | ||
Trypanothione biosynthesis in Leishmania major | Q34378267 | ||
Evasion of innate immunity by parasitic protozoa | Q34983845 | ||
Leishmaniasis: drugs in the clinic, resistance and new developments. | Q35943371 | ||
Plasticity in chromosome number and testing of essential genes in Leishmania by targeting | Q36117098 | ||
Increased levels of thiols protect antimony unresponsive Leishmania donovani field isolates against reactive oxygen species generated by trivalent antimony | Q36133198 | ||
Inhibition of glutathione synthesis as a chemotherapeutic strategy for trypanosomiasis | Q36344549 | ||
Peroxidases of trypanosomatids | Q37170924 | ||
Insights into the redox biology of Trypanosoma cruzi: Trypanothione metabolism and oxidant detoxification | Q37202974 | ||
Amplification of an alternate transporter gene suppresses the avirulent phenotype of glucose transporter null mutants in Leishmania mexicana. | Q37310878 | ||
Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide | Q37555750 | ||
Substrate binding determinants of Trypanosoma brucei gamma-glutamylcysteine synthetase | Q38291935 | ||
Gene expression analysis of the mechanism of natural Sb(V) resistance in Leishmania donovani isolates from Nepal | Q38968281 | ||
DNA transformation of Leishmania infantum axenic amastigotes and their use in drug screening | Q39476913 | ||
The role of reduced pterins in resistance to reactive oxygen and nitrogen intermediates in the protozoan parasite Leishmania | Q39913965 | ||
Roles of trypanothione S-transferase and tryparedoxin peroxidase in resistance to antimonials | Q40016515 | ||
Buthionine sulfoximine increases the toxicity of nifurtimox and benznidazole to Trypanosoma cruzi. | Q40734322 | ||
Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages. | Q42123859 | ||
Co-amplification of the gamma-glutamylcysteine synthetase gene gsh1 and of the ABC transporter gene pgpA in arsenite-resistant Leishmania tarentolae. | Q42619754 | ||
Oxidative responses of human and murine macrophages during phagocytosis of Leishmania chagasi | Q43664759 | ||
Gene knockdown of gamma-glutamylcysteine synthetase by RNAi in the parasitic protozoa Trypanosoma brucei demonstrates that it is an essential enzyme | Q44530879 | ||
Disruption of gamma-glutamylcysteine synthetase results in absolute glutathione auxotrophy and apoptosis in Candida albicans | Q44714781 | ||
Trypanosoma brucei and Trypanosoma cruzi tryparedoxin peroxidases catalytically detoxify peroxynitrite via oxidation of fast reacting thiols. | Q44904831 | ||
Growth phase regulation of the main folate transporter of Leishmania infantum and its role in methotrexate resistance | Q45091641 | ||
Substrate specificity, localization, and essential role of the glutathione peroxidase-type tryparedoxin peroxidases in Trypanosoma brucei | Q45234385 | ||
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata | Q47792563 | ||
Identification and characterisation of a functional peroxidoxin from Leishmania major | Q48001860 | ||
Trypanosoma brucei tryparedoxin, a thioredoxin-like protein in African trypanosomes. | Q48029133 | ||
Elevated levels of polyamines and trypanothione resulting from overexpression of the ornithine decarboxylase gene in arsenite-resistant Leishmania. | Q54072274 | ||
Role of ABC transporter MRPA, gamma-glutamylcysteine synthetase and ornithine decarboxylase in natural antimony-resistant isolates of Leishmania donovani. | Q54563374 | ||
P433 | issue | 4 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | gamma-glutamylcysteine synthetase, putative | Q61505629 |
gamma-glutamylcysteine synthetase | Q61573231 | ||
gamma-glutamylcysteine synthetase, putative | Q62253769 | ||
gamma-glutamylcysteine synthetase, putative | Q62422064 | ||
gamma-glutamylcysteine synthetase | Q62457188 | ||
P304 | page(s) | 914-927 | |
P577 | publication date | 2009-10-08 | |
P1433 | published in | Molecular Microbiology | Q6895967 |
P1476 | title | The gamma-glutamylcysteine synthetase gene of Leishmania is essential and involved in response to oxidants | |
P478 | volume | 74 |
Q34479541 | A rapid, efficient and economical method for generating leishmanial gene targeting constructs |
Q53723808 | ABCI3 Is a New Mitochondrial ABC Transporter from Leishmania major Involved in Susceptibility to Antimonials and Infectivity. |
Q90131592 | Ascorbate-Dependent Peroxidase (APX) from Leishmania amazonensis Is a Reactive Oxygen Species-Induced Essential Enzyme That Regulates Virulence |
Q41682691 | Biochemical and biophysical characterization of Leishmania donovani gamma-glutamylcysteine synthetase |
Q54325937 | Biomarkers of antimony resistance: need for expression analysis of multiple genes to distinguish resistance phenotype in clinical isolates of Leishmania donovani. |
Q50044336 | Compounds with potential activity against Mycobacterium tuberculosis. |
Q48051536 | Drug target validation of the trypanothione pathway enzymes through metabolic modelling |
Q92774155 | Gamma-glutamylcysteine synthetase and tryparedoxin 1 exert high control on the antioxidant system in Trypanosoma cruzi contributing to drug resistance and infectivity |
Q58699473 | Generation and characterization of thiol-deficient Mycobacterium tuberculosis mutants |
Q52566647 | Genomic and transcriptomic alterations in Leishmania donovani lines experimentally resistant to antileishmanial drugs. |
Q52431178 | High-throughput Cos-Seq screen with intracellular Leishmania infantum for the discovery of novel drug-resistance mechanisms. |
Q28539098 | Induction of a stringent metabolic response in intracellular stages of Leishmania mexicana leads to increased dependence on mitochondrial metabolism |
Q24622502 | Interactions between BRCA2 and RAD51 for promoting homologous recombination in Leishmania infantum |
Q40381739 | Interplay between a cytosolic and a cell surface carbonic anhydrase in pH homeostasis and acid tolerance of Leishmania. |
Q28543469 | Intrachromosomal amplification, locus deletion and point mutation in the aquaglyceroporin AQP1 gene in antimony resistant Leishmania (Viannia) guyanensis |
Q38535267 | Intrachromosomal tandem duplication and repeat expansion during attempts to inactivate the subtelomeric essential gene GSH1 in Leishmania |
Q34598358 | Leishmania major methionine sulfoxide reductase A is required for resistance to oxidative stress and efficient replication in macrophages. |
Q96304575 | Leishmanicidal Potential of Hardwickiic Acid Isolated From Croton sylvaticus |
Q28480626 | Multiple mutations in heterogeneous miltefosine-resistant Leishmania major population as determined by whole genome sequencing |
Q38783627 | Polyamine-trypanothione pathway: an update. |
Q42219032 | Probing druggability and biological function of essential proteins in Leishmania combining facilitated null mutant and plasmid shuffle analyses. |
Q28535444 | Proteomic and genomic analyses of antimony resistant Leishmania infantum mutant |
Q39387702 | Redox biology of Leishmania and macrophage targeted nanoparticles for therapy. |
Q35171613 | Roles of Rad51 paralogs for promoting homologous recombination in Leishmania infantum. |
Q28539382 | Stage-dependent expression and up-regulation of trypanothione synthetase in amphotericin B resistant Leishmania donovani |
Q45851384 | Sulfur mustard causes oxidative stress and depletion of antioxidants in muscles, livers, and kidneys of Wistar rats |
Q27671551 | The Leishmania nicotinamidase is essential for NAD+ production and parasite proliferation |
Q35623857 | The genetic toolbox for Leishmania parasites |
Q37160811 | The leishmanicidal activity of oleuropein is selectively regulated through inflammation- and oxidative stress-related genes |
Q92461310 | The role of low molecular weight thiols in Mycobacterium tuberculosis |
Q38626366 | Tolerance to drug-induced cell death favours the acquisition of multidrug resistance in Leishmania |
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