Metabolic control analysis of glycolysis in trypanosomes as an approach to improve selectivity and effectiveness of drugs.

scientific article

Metabolic control analysis of glycolysis in trypanosomes as an approach to improve selectivity and effectiveness of drugs. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S0166-6851(99)00197-8
P698PubMed publication ID10743606

P50authorHans WesterhoffQ15989741
Barbara Marleen BakkerQ21551979
Fred OpperdoesQ55221768
P2093author name stringP A Michels
P2860cites workStructure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenaseQ27617894
Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitorsQ27618611
Crystal Structure of Glycosomal Glyceraldehyde-3-phosphate Dehydrogenase from Leishmania mexicana: Implications for Structure-Based Drug Design and a New Position for the Inorganic Phosphate Binding SiteQ27729721
A Linear Steady-State Treatment of Enzymatic Chains. General Properties, Control and Effector StrengthQ28246120
Sugar transporters from bacteria, parasites and mammals: structure-activity relationshipsQ28292451
An antibiotic, ascofuranone, specifically inhibits respiration and in vitro growth of long slender bloodstream forms of Trypanosoma brucei bruceiQ28306793
Structure-based drug design: progress, results and challengesQ30419784
Recent advances in identifying and validating drug targets in trypanosomes and leishmanias.Q33542293
Compartmentation of carbohydrate metabolism in trypanosomesQ34685609
Contribution of glucose transport to the control of the glycolytic flux in Trypanosoma bruceiQ35615506
Metabolic control analysis: a survey of its theoretical and experimental developmentQ35860764
Compartmentation of phosphoglycerate kinase in Trypanosoma brucei plays a critical role in parasite energy metabolismQ36314647
Structure, function, and biogenesis of glycosomes in kinetoplastidaQ39044849
Compartmentation of glycolysis in trypanosomes: a potential target for new trypanocidal drugsQ39249876
The inhibition of pyruvate transport across the plasma membrane of the bloodstream form of Trypanosoma brucei and its metabolic implications.Q39591858
Molecular mechanisms and therapeutic approaches to the treatment of African trypanosomiasisQ40437048
The control of flux.Q40481103
Inhibition of the glycolytic enzymes in the trypanosome: an approach in the development of new leads in the therapy of parasitic diseasesQ40667215
Regulation and control of compartmentalized glycolysis in bloodstream form Trypanosoma bruceiQ41040967
Purification, morphometric analysis, and characterization of the glycosomes (microbodies) of the protozoan hemoflagellate Trypanosoma bruceiQ41457278
Trypanosoma brucei: Trypanocidal effect of salicylhydroxamic acid plus glycerol in infected ratsQ41680538
Differential regulation of two distinct families of glucose transporter genes in Trypanosoma bruceiQ43181987
New approach to screening drugs for activity against African trypanosomesQ44983593
Inhibition of glyceraldehyde-3-phosphate dehydrogenase by pentalenolactone in Trypanosoma bruceiQ46211203
Glycolysis in bloodstream form Trypanosoma brucei can be understood in terms of the kinetics of the glycolytic enzymes.Q52274817
Selective tight binding inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase via structure-based drug design.Q53741874
What Controls Glycolysis in Bloodstream FormTrypanosoma brucei?Q57393902
Subcellular Compartmentation of Glycolytic Intermediates in Trypanosoma bruceiQ58843045
Specificity of glucose transport in Trypanosoma brucei. Effective inhibition by phloretin and cytochalasin BQ68036120
Prospects for antiparasitic drugs. The case of Trypanosoma brucei, the causative agent of African sleeping sicknessQ74263636
P433issue1
P304page(s)1-10
P577publication date2000-02-01
P1433published inMolecular and Biochemical ParasitologyQ15752756
P1476titleMetabolic control analysis of glycolysis in trypanosomes as an approach to improve selectivity and effectiveness of drugs
P478volume106

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