COPASI--a COmplex PAthway SImulator

scientific article (publication date: 15 December 2006)

COPASI--a COmplex PAthway SImulator is …
instance of (P31):
scholarly articleQ13442814

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P8978DBLP publication IDjournals/bioinformatics/HoopsSGLPSSXMK06
P356DOI10.1093/BIOINFORMATICS/BTL485
P3181OpenCitations bibliographic resource ID131936
P698PubMed publication ID17032683
P5875ResearchGate publication ID6761935

P50authorJürgen PahleQ57574724
Pedro MendesQ7159862
P2093author name stringLiang Xu
Mudita Singhal
Christine Lee
Stefan Hoops
Ursula Kummer
Sven Sahle
Ralph Gauges
Natalia Simus
P2860cites workThe systems biology markup language (SBML): a medium for representation and exchange of biochemical network modelsQ28212902
P433issue24
P407language of work or nameEnglishQ1860
P921main subjectcomputational mathematicsQ1122491
P304page(s)3067-3074
P577publication date2006-10-10
P1433published inBioinformaticsQ4914910
P1476titleCOPASI--a COmplex PAthway SImulator
P478volume22

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Q90640172In silico Metabolic Pathway Analysis Identifying Target Against Leishmaniasis - A Kinetic Modeling Approach
Q33772734In silico modeling of the effects of alpha-synuclein oligomerization on dopaminergic neuronal homeostasis.
Q36962711Increasing extracellular H2O2 produces a bi-phasic response in intracellular H2O2, with peroxiredoxin hyperoxidation only triggered once the cellular H2O2-buffering capacity is overwhelmed
Q38905586Inferring Mechanistic Parameters from Amyloid Formation Kinetics by Approximate Bayesian Computation
Q54585320Influence of kinetics of drug binding on EGFR signaling: a comparative study of three EGFR signaling pathway models.
Q37277390Inhibition of Non-flux-Controlling Enzymes Deters Cancer Glycolysis by Accumulation of Regulatory Metabolites of Controlling Steps
Q46815661Insights into Zn2+ homeostasis in neurons from experimental and modeling studies
Q30480219Integrated network reconstruction, visualization and analysis using YANAsquare.
Q38119873Integrating pathways of Parkinson's disease in a molecular interaction map.
Q28740525Integrating systems biology models and biomedical ontologies
Q28534507Integration of biochemical and electrical signaling-multiscale model of the medium spiny neuron of the striatum
Q91712018Integrative Computational Framework for Understanding Metabolic Modulation in Leishmania
Q35536427Interleukin-1β enhances FasL-induced caspase-3/-7 activity without increasing apoptosis in primary mouse hepatocytes
Q90567475Intrinsic Dynamics of a Human Gene Reveal the Basis of Expression Heterogeneity
Q36563109Intrinsic regulation of FIC-domain AMP-transferases by oligomerization and automodification
Q46130452Introduction of a new platform for parameter estimation of kinetically complex environmental systems
Q41886452Invariants and other structural properties of biochemical models as a constraint satisfaction problem.
Q35009820Investigating interventions in Alzheimer's disease with computer simulation models
Q91864503JigCell Model Connector: building large molecular network models from components
Q35878537JigCell Run Manager (JC-RM): a tool for managing large sets of biochemical model parametrizations
Q90337547K-FIT: An accelerated kinetic parameterization algorithm using steady-state fluxomic data
Q28651992KiMoSys: a web-based repository of experimental data for KInetic MOdels of biological SYStems
Q39277115Kinetic Analysis and Probing with Substrate Analogues of the Reaction Pathway of the Nitrile Reductase QueF from Escherichia coli.
Q58693980Kinetic mechanism of coupled binding in sodium-aspartate symporter GltPh
Q65000956Kinetic modeling of Stickland reactions-coupled methanogenesis for a methanogenic culture.
Q33881486Kinetic modeling of biological systems
Q28482687Kinetic modelling of GlmU reactions - prioritization of reaction for therapeutic application
Q38205653Kinetic models in industrial biotechnology - Improving cell factory performance
Q51697204Kinetics and model development for enzymatic synthesis of fructo-oligosaccharides using fructosyltransferase.
Q37723601Kinetics of extracellular ATP in mastoparan 7-activated human erythrocytes
Q43995167Kinetics of sucrose conversion to fructo-oligosaccharides using enzyme (invertase) under free condition
Q29994733LASSIE: simulating large-scale models of biochemical systems on GPUs.
Q89980566LK-DFBA: a linear programming-based modeling strategy for capturing dynamics and metabolite-dependent regulation in metabolism
Q56913847Large Scale Dynamic Model Reconstruction for the Central Carbon Metabolism of Escherichia coli
Q30544055Lattice Microbes: high-performance stochastic simulation method for the reaction-diffusion master equation
Q31061814Learning stochastic process-based models of dynamical systems from knowledge and data
Q64233922Length-independent telomere damage drives post-mitotic cardiomyocyte senescence
Q42181605Leveraging modeling approaches: reaction networks and rules
Q28539118Leveraging systems biology approaches in clinical pharmacology
Q34420422LibKiSAO: a Java library for Querying KiSAO.
Q35550638Ligand-dependent opening of the multiple AMPA receptor conductance states: a concerted model
Q34496057Light-enhanced catalysis by pyridoxal phosphate-dependent aspartate aminotransferase
Q47114235Linking physiologically-based pharmacokinetic and genome-scale metabolic networks to understand estradiol biology
Q36215331Living on the edge: substrate competition explains loss of robustness in mitochondrial fatty-acid oxidation disorders.
Q34484814Logic modeling and the ridiculome under the rug.
Q47305365MAMMOTh: A new database for curated mathematical models of biomolecular systems
Q108126729MASSpy: Building, simulating, and visualizing dynamic biological models in Python using mass action kinetics
Q92837425MCell-R: A Particle-Resolution Network-Free Spatial Modeling Framework
Q33806474MEMOSys: Bioinformatics platform for genome-scale metabolic models
Q38671211MUFINS: multi-formalism interaction network simulator.
Q26801210Macroscopic modeling of mammalian cell growth and metabolism
Q33818583Mass conservation and inference of metabolic networks from high-throughput mass spectrometry data
Q42213727Massive exploration of perturbed conditions of the blood coagulation cascade through GPU parallelization
Q49804607Mathematical Modelling of Nitric Oxide/Cyclic GMP/Cyclic AMP Signalling in Platelets.
Q38809377Mathematical Models for Immunology: Current State of the Art and Future Research Directions
Q38921582Mathematical analysis of the influence of brain metabolism on the BOLD signal in Alzheimer's disease
Q28082151Mathematical and computational modeling in biology at multiple scales
Q35161056Mathematical descriptions of biochemical networks: stability, stochasticity, evolution
Q36638792Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system
Q34531633Mathematical modeling of sustainable synaptogenesis by repetitive stimuli suggests signaling mechanisms in vivo
Q51089841Mathematical modelling of arsenic transport, distribution and detoxification processes in yeast.
Q38448975Mathematical modelling of metabolic regulation in aging
Q36828180Mathematical models for the Notch and Wnt signaling pathways and the crosstalk between them during somitogenesis
Q34776635Mathematical models in biology: from molecules to life
Q46346574Measuring CO2 and HCO3- permeabilities of isolated chloroplasts using a MIMS-18O approach
Q91663379Mechanism of Catalytic O2 Reduction by Iron Tetraphenylporphyrin
Q28550745Mechanism of Focal Adhesion Kinase Mechanosensing
Q37145133Mechanism of synergistic activation of Arp2/3 complex by cortactin and N-WASP
Q42157338Mechanisms of regulation of olfactory transduction and adaptation in the olfactory cilium.
Q42275459Mechanistic Kinetic Modeling of Thiol-Michael Addition Photopolymerizations via Photocaged "Superbase" Generators: An Analytical Approach
Q38769967Mechanosensing of shear by Pseudomonas aeruginosa leads to increased levels of the cyclic-di-GMP signal initiating biofilm development
Q90678591Membrane Tension Orchestrates Rear Retraction in Matrix-Directed Cell Migration
Q30483077Membrane identity and GTPase cascades regulated by toggle and cut-out switches
Q39970633MetaCrop 2.0: managing and exploring information about crop plant metabolism.
Q42082854MetaCrop: a detailed database of crop plant metabolism.
Q36276893Metabolic regulation is sufficient for global and robust coordination of glucose uptake, catabolism, energy production and growth in Escherichia coli.
Q42925318Metabolica: a statistical research tool for analyzing metabolic networks
Q56974486Metabolomic biomarkers: search, discovery and validation
Q27144251Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery
Q38665803Methods of Model Reduction for Large-Scale Biological Systems: A Survey of Current Methods and Trends.
Q43956692Methylerythritol phosphate pathway to isoprenoids: kinetic modeling and in silico enzyme inhibitions in Plasmodium falciparum
Q33830181Microarray data can predict diurnal changes of starch content in the picoalga Ostreococcus
Q42320855Minimum-noise production of translation factor eIF4G maps to a mechanistically determined optimal rate control window for protein synthesis
Q41511168Mixed mechanisms of multi-site phosphorylation
Q37426285ModeLang: a new approach for experts-friendly viral infections modeling
Q34587158Model composition through model reduction: a combined model of CD95 and NF-κB signaling pathways
Q40820351Model of colonic inflammation: immune modulatory mechanisms in inflammatory bowel disease
Q30678210Model of tryptophan metabolism, readily scalable using tissue-specific gene expression data
Q46850321Model-assisted analysis of sugar metabolism throughout tomato fruit development reveals enzyme and carrier properties in relation to vacuole expansion
Q38892442Modeling Intercellular Communication as a Survival Strategy of Cancer Cells: An In Silico Approach on a Flexible Bioinformatics Framework
Q34344753Modeling and experimental analyses reveals signaling plasticity in a bi-modular assembly of CD40 receptor activated kinases
Q41281433Modeling and simulation of biological systems using SPICE language
Q33280162Modeling biochemical transformation processes and information processing with Narrator
Q51080469Modeling cancer glycolysis under hypoglycemia, and the role played by the differential expression of glycolytic isoforms.
Q58751607Modeling clock-related metabolic syndrome due to conflicting light and food cues
Q64269457Modeling genotypes in their microenvironment to predict single- and multi-cellular behavior
Q24651812Modeling metabolic networks in C. glutamicum: a comparison of rate laws in combination with various parameter optimization strategies
Q46249708Modeling of the jasmonate signaling pathway in Arabidopsis thaliana with respect to pathophysiology of Alternaria blight in Brassica
Q21145352Modeling structure-function relationships in synthetic DNA sequences using attribute grammars
Q41861941Modeling temperature entrainment of circadian clocks using the Arrhenius equation and a reconstructed model from Chlamydomonas reinhardtii
Q34066290Modeling the Calvin-Benson cycle
Q34494038Modeling the Regulatory Mechanisms by Which NLRX1 Modulates Innate Immune Responses to Helicobacter pylori Infection
Q36217991Modeling the Role of Lanthionine Synthetase C-Like 2 (LANCL2) in the Modulation of Immune Responses to Helicobacter pylori Infection
Q35900690Modeling the ascorbate-glutathione cycle in chloroplasts under light/dark conditions
Q36375897Modeling the dynamics of mouse iron body distribution: hepcidin is necessary but not sufficient
Q30424551Modeling the role of peroxisome proliferator-activated receptor γ and microRNA-146 in mucosal immune responses to Clostridium difficile
Q26766623Modeling-Enabled Systems Nutritional Immunology
Q42249980Modelling and experimental analysis of hormonal crosstalk in Arabidopsis
Q37952605Modelling complex biological systems using an agent-based approach
Q35238701Modelling coupled oscillations in the Notch, Wnt, and FGF signaling pathways during somitogenesis: a comprehensive mathematical model
Q33390476Modelling phagosomal lipid networks that regulate actin assembly
Q42431432Modelling reveals novel roles of two parallel signalling pathways and homeostatic feedbacks in yeast
Q40292403Modelling the regulation of thermal adaptation in Candida albicans, a major fungal pathogen of humans
Q33612153Modelling the response of FOXO transcription factors to multiple post-translational modifications made by ageing-related signalling pathways
Q33968220Modelling the role of the Hsp70/Hsp90 system in the maintenance of protein homeostasis
Q36678678Models and Simulations as a Service: Exploring the Use of Galaxy for Delivering Computational Models.
Q34346565Modular, rule-based modeling for the design of eukaryotic synthetic gene circuits
Q64256132Molecular crypsis by pathogenic fungi using human factor H. A numerical model
Q30513833Molecular thermodynamics for cell biology as taught with boxes
Q34657714MonaLisa--visualization and analysis of functional modules in biochemical networks
Q37419056Monitoring of multiple sclerosis immunotherapy: from single candidates to biomarker networks.
Q35264385Multi-level kinetic model of mRNA delivery via transfection of lipoplexes
Q37826628Multi-scale modelling and simulation in systems biology
Q58417407Multi-scale, whole-system models of liver metabolic adaptation to fat and sugar in non-alcoholic fatty liver disease
Q18145441Multi-state modeling of biomolecules
Q104064550Multiplicity of carotene patterns derives from competition between phytoene desaturase diversification and biological environments
Q92824558Multiscale Process Modelling in Translational Systems Biology of Leishmania major: A Holistic view
Q28752388Multiscale modeling for biologists
Q35761666Multiscale modeling of mucosal immune responses
Q44731939Multiscale modelling approach combining a kinetic model of glutathione metabolism with PBPK models of paracetamol and the potential glutathione-depletion biomarkers ophthalmic acid and 5-oxoproline in humans and rats
Q90103694Multisite rate control analysis identifies ribosomal scanning as the sole high-capacity/low-flux-control step in mRNA translation
Q28652052Multistate Model Builder (MSMB): a flexible editor for compact biochemical models
Q35001166Multivalency in the inhibition of oxidative protein folding by arsenic(III) species
Q96303813NMR and MS-based Stable Isotope-Resolved Metabolomics and Applications in Cancer Metabolism
Q37406084Nested autoinhibitory feedbacks alter the resistance of homeostatic adaptive biochemical networks.
Q34198065Network motif comparison rationalizes Sec1/Munc18-SNARE regulation mechanism in exocytosis
Q91941572Network pharmacology modeling identifies synergistic Aurora B and ZAK interaction in triple-negative breast cancer
Q89678898Neurogranin stimulates Ca2+/calmodulin-dependent kinase II by suppressing calcineurin activity at specific calcium spike frequencies
Q26823013New types of experimental data shape the use of enzyme kinetics for dynamic network modeling
Q39063396No Evidence That Protein Noise-Induced Epigenetic Epistasis Constrains Gene Expression Evolution
Q34505131Non Linear Programming (NLP) formulation for quantitative modeling of protein signal transduction pathways
Q35836933Non-canonical Activation of Akt in Serum-Stimulated Fibroblasts, Revealed by Comparative Modeling of Pathway Dynamics
Q38811523Notions of similarity for systems biology models
Q34257351Novel ATP-independent RNA annealing activity of the dengue virus NS3 helicase
Q57981903Numerical Simulation of ODE Models
Q27028202Nutritional protective mechanisms against gut inflammation
Q57981907ODE Models for Systems Biological Networks
Q47798116ODE-Based Modeling of Complex Regulatory Circuits
Q51342628Observation conflict resolution in steady-state metabolic network dynamics analysis.
Q33575122Odefy--from discrete to continuous models.
Q30639272On an infrastructure to support sharing and aggregating pre- and post-publication systems biology research data.
Q33635208On reverse engineering of gene interaction networks using time course data with repeated measurements
Q43985483On the killing of mycobacteria by macrophages
Q28661919On the need for mechanistic models in computational genomics and metagenomics
Q35765830On the translocation of bacteria and their lipopolysaccharides between blood and peripheral locations in chronic, inflammatory diseases: the central roles of LPS and LPS-induced cell death
Q58052287Optimization in Biology Parameter Estimation and the Associated Optimization Problem
Q28397689Optimization of stress response through the nuclear receptor-mediated cortisol signalling network
Q28535193Organism-adapted specificity of the allosteric regulation of pyruvate kinase in lactic acid bacteria
Q33883302Origin of bistability underlying mammalian cell cycle entry
Q51165855Origins of heterogeneity in Streptococcus mutans competence: interpreting an environment-sensitive signaling pathway.
Q34303057Oscillations in MAPK cascade triggered by two distinct designs of coupled positive and negative feedback loops
Q38406442Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage.
Q38236912Oxidative protein folding: from thiol-disulfide exchange reactions to the redox poise of the endoplasmic reticulum
Q33897013Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis
Q50947147PKC-mediated inhibitory feedback of the cholecystokinin 1 receptor controls the shape of oscillatory Ca²⁺ signals.
Q47100426PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K.
Q38468279Palladium-catalyzed aerobic dehydrogenation of substituted cyclohexanones to phenols
Q57981911Parameter Identification in ODE Models
Q39045810Parameter estimation for dynamical systems with discrete events and logical operations
Q28751984Pathway databases and tools for their exploitation: benefits, current limitations and challenges
Q38626560Performance of objective functions and optimisation procedures for parameter estimation in system biology models
Q33849372Perspectives for computer modeling in the study of T cell activation
Q60323404Photo-Induced Depletion of Binding Sites in DNA-PAINT Microscopy.
Q52688323PhysiCell: An open source physics-based cell simulator for 3-D multicellular systems.
Q39429444Physical Routes to Primitive Cells: An Experimental Model Based on the Spontaneous Entrapment of Enzymes inside Micrometer-Sized Liposomes.
Q40085573Piecewise parameter estimation for stochastic models in COPASI.
Q26852422Plant metabolic modeling: achieving new insight into metabolism and metabolic engineering
Q35199634Plant stress biomarkers from biosimulations: the Transcriptome-To-Metabolome (TTM) technology - effects of drought stress on rice.
Q38199642Plant systems biology: insights, advances and challenges.
Q60213945Polarized displacement by transcription activator-like effectors for regulatory circuits
Q58608601Polypyrimidine tract-binding protein blocks miRNA-124 biogenesis to enforce its neuronal-specific expression in the mouse
Q41331576Postsynaptic signal transduction models for long-term potentiation and depression
Q36351777Predictive Modeling of Drug Treatment in the Area of Personalized Medicine
Q34988965Predictive computational modeling of the mucosal immune responses during Helicobacter pylori infection
Q50028742Probing biological activity through structural modelling of ligand-receptor interactions of 2,4-disubstituted thiazole retinoids.
Q40965673Probing reversible chemistry in coenzyme B12 -dependent ethanolamine ammonia lyase with kinetic isotope effects
Q38731492Probing the origin of degenerate metathesis selectivity via characterization and dynamics of ruthenacyclobutanes containing variable NHCs
Q34328597Programming biological models in Python using PySB
Q48313939Progress toward reaction monitoring at variable temperatures: a new stopped-flow NMR probe design
Q99346653Promiscuous phosphoketolase and metabolic rewiring enables novel non-oxidative glycolysis in yeast for high-yield production of acetyl-CoA derived products
Q35420913Proteasomal degradation from internal sites favors partial proteolysis via remote domain stabilization
Q83229489Proteostasis collapse, a hallmark of aging, hinders the chaperone-Start network and arrests cells in G1
Q51898580Proximate parameter tuning for biochemical networks with uncertain kinetic parameters.
Q44610032Push-Pull and Feedback Mechanisms Can Align Signaling System Outputs with Inputs
Q90110751PyBioNetFit and the Biological Property Specification Language
Q61982458PyCoTools: a Python toolbox for COPASI
Q28727231Qualitative translation of relations from BioPAX to SBML qual
Q42318220Quantifying Fenton reaction pathways driven by self-generated H2O2 on pyrite surfaces.
Q92422904Quantitative Analyses of the Yeast Oxidative Protein Folding Pathway In Vitro and In Vivo
Q48050591Quantitative DFT modeling of product concentration in organometallic reactions: Cu-mediated pentafluoroethylation of benzoic acid chlorides as a case study
Q34205663Quantitative analysis of cellular metabolic dissipative, self-organized structures
Q39008508Quantitative and integrative analysis of paracrine hepatocyte activation by nonparenchymal cells upon lipopolysaccharide induction
Q28083248Quantitative and logic modelling of molecular and gene networks
Q38680217Quantitative computational models of molecular self-assembly in systems biology
Q64106754Quantitative dynamics of reversible platelet aggregation: mathematical modelling and experiments
Q41009828Quantitative interactome of a membrane Bcl-2 network identifies a hierarchy of complexes for apoptosis regulation.
Q27313334Quantitative super-resolution imaging with qPAINT.
Q64240805Quantitative systems pharmacology of interferon alpha administration: A multi-scale approach
Q43976166Querying metabolism under different physiological constraints
Q33285703RMBNToolbox: random models for biochemical networks
Q40310761RNAi revised--target mRNA-dependent enhancement of gene silencing
Q33361469Rapidly exploring structural and dynamic properties of signaling networks using PathwayOracle
Q42028214Rate and extent of protein localization is controlled by peptide-binding domain association kinetics and morphology
Q56927576Rational engineering of Candida antarctica lipase B for selective monoacylation of diols
Q90448390Rational selection of co-catalysts for the deaminative hydrogenation of amides
Q43116515Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway
Q28608563Reactome pathway analysis to enrich biological discovery in proteomics data sets
Q28082443Recent Advances and Emerging Applications in Text and Data Mining for Biomedical Discovery
Q47819372Recent Advances in the Systems Biology of Aging
Q38525312Recent advances in elementary flux modes and yield space analysis as useful tools in metabolic network studies.
Q38700387Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition
Q31126762Reconstruction of the Fatty Acid Biosynthetic Pathway of Exiguobacterium antarcticum B7 Based on Genomic and Bibliomic Data
Q30465511Reduction of dynamical biochemical reactions networks in computational biology
Q35874448Regulated clearance of histone deacetylase 3 protects independent formation of nuclear receptor corepressor complexes.
Q41752115Regulation of release factor expression using a translational negative feedback loop: a systems analysis
Q41058068Regulatory dynamics of network architecture and function in tristable genetic circuit of Leishmania: a mathematical biology approach
Q92619960Repository of proposed pathways and protein-protein interaction networks in age-related macular degeneration
Q56988947Reproducible Research Using Biomodels
Q21202776Reproducible computational biology experiments with SED-ML--the Simulation Experiment Description Markup Language
Q57014509Reproducible model development in the cardiac electrophysiology Web Lab
Q41370456Retinitis pigmentosa: rapid neurodegeneration is governed by slow cell death mechanisms
Q34840961Revealing neuronal function through microelectrode array recordings
Q55192761Reversible Control of Nanoparticle Functionalization and Physicochemical Properties by Dynamic Covalent Exchange.
Q39958002Reversible control of nanoparticle functionalization and physicochemical properties by dynamic covalent exchange.
Q33793614Revision history aware repositories of computational models of biological systems.
Q33645846Rhodium-catalyzed C-C bond formation via heteroatom-directed C-H bond activation
Q28538077Robustness analysis of stochastic biochemical systems
Q46085877Rods progressively escape saturation to drive visual responses in daylight conditions.
Q38762692Role of DNA binding sites and slow unbinding kinetics in titration-based oscillators.
Q34488992Role of a GAG hinge in the nucleotide-induced conformational change governing nucleotide specificity by T7 DNA polymerase
Q34253620Role of phosphate in the central metabolism of two lactic acid bacteria--a comparative systems biology approach
Q93069869Room Temperature Acceptorless Alkane Dehydrogenation from Molecular σ-Alkane Complexes
Q37626541Rule-based modeling: a computational approach for studying biomolecular site dynamics in cell signaling systems.
Q57038543Rule-based modelling of iron homeostasis in tuberculosis
Q43447225SAGPAR: structural grammar-based automated pathway reconstruction
Q38534028SBML and CellML translation in antimony and JSim.
Q51604954SBML-PET-MPI: a parallel parameter estimation tool for Systems Biology Markup Language based models.
Q33360434SBML-SAT: a systems biology markup language (SBML) based sensitivity analysis tool
Q90641625SBMLSimulator: A Java Tool for Model Simulation and Parameter Estimation in Systems Biology
Q38430285SBMLmod: a Python-based web application and web service for efficient data integration and model simulation
Q35802135SBMLsqueezer 2: context-sensitive creation of kinetic equations in biochemical networks
Q27499005SBMLsqueezer: A CellDesigner plug-in to generate kinetic rate equations for biochemical networks
Q113227862SBMLtoODEpy: A software program for converting SBML models into ODE models in Python
Q36342436SBpipe: a collection of pipelines for automating repetitive simulation and analysis tasks
Q52765469SED-ML web tools: generate, modify and export standard-compliant simulation studies.
Q47313302SELANSI: a toolbox for Simulation of Stochastic Gene Regulatory Networks
Q42669808SGNS2: a compartmentalized stochastic chemical kinetics simulator for dynamic cell populations.
Q34762128SPEDRE: a web server for estimating rate parameters for cell signaling dynamics in data-rich environments
Q28818540Scalable Parameter Estimation for Genome-Scale Biochemical Reaction Networks
Q41841882Selection on metabolic pathway function in the presence of mutation-selection-drift balance leads to rate-limiting steps that are not evolutionarily stable
Q50544066Selective control of up-regulated and down-regulated genes by temporal patterns and doses of insulin.
Q37265068Selective trapping of SNO-BSA and GSNO by benzenesulfinic acid sodium salt: mechanistic study of thiosulphonate formation and feasibility as a protein S-nitrosothiol detection strategy
Q41691396Self-organization of signal transduction
Q42911961SensA: web-based sensitivity analysis of SBML models
Q33412397Signaling logic of activity-triggered dendritic protein synthesis: an mTOR gate but not a feedback switch
Q34184822Simplification of biochemical models: a general approach based on the analysis of the impact of individual species and reactions on the systems dynamics
Q36995768Simulated Interventions to Ameliorate Age-Related Bone Loss Indicate the Importance of Timing
Q36791279Simulated de novo assembly of golgi compartments by selective cargo capture during vesicle budding and targeted vesicle fusion
Q82715439Simulating plant metabolic pathways with enzyme-kinetic models
Q64096181Simulation and inference algorithms for stochastic biochemical reaction networks: from basic concepts to state-of-the-art
Q41884304Single-molecule multiparameter fluorescence spectroscopy reveals directional MutS binding to mismatched bases in DNA
Q42260449Slippery substrates impair ATP-dependent protease function by slowing unfolding
Q38650224Snoopy's hybrid simulator: a tool to construct and simulate hybrid biological models.
Q38059081Software applications toward quantitative metabolic flux analysis and modeling
Q37952114Software for systems biology: from tools to integrated platforms
Q33757969Software that goes with the flow in systems biology
Q38692647SpaceScanner: COPASI wrapper for automated management of global stochastic optimization experiments.
Q53444471Spatially extended hybrid methods: a review.
Q30421795Steady-state NTPase activity of Dengue virus NS3: number of catalytic sites, nucleotide specificity and activation by ssRNA.
Q51401049Steady-state parameter sensitivity in stochastic modeling via trajectory reweighting.
Q35048361StochPy: a comprehensive, user-friendly tool for simulating stochastic biological processes
Q28554812Stochastic Simulation Service: Bridging the Gap between the Computational Expert and the Biologist
Q34669804Stochastic simulation in systems biology
Q33459140Stochasticity in protein levels drives colinearity of gene order in metabolic operons of Escherichia coli
Q48196284Stoichiometric network analysis of spontaneous mirror symmetry breaking in chemical reactions
Q42951494Stopped-Flow NMR: Determining the Kinetics of [rac-(C2H4(1-indenyl)2)ZrMe][MeB(C6F5)3]-Catalyzed Polymerization of 1-Hexene by Direct Observation
Q28478949Structural analysis and stochastic modelling suggest a mechanism for calmodulin trapping by CaMKII
Q43196957Studies on the Claisen rearrangements in the indolo[2,3-b]quinoline system
Q47650745Study Quiescence Heterogeneity by Coupling Single-Cell Measurements and Computer Modeling
Q36074198Substrate Ubiquitination Controls the Unfolding Ability of the Proteasome
Q91711303Substrate complex competition is a regulatory motif that allows NFκB RelA to license but not amplify NFκB RelB
Q40574683Supervised learning methods in modeling of CD4+ T cell heterogeneity
Q34001312SynBioSS designer: a web-based tool for the automated generation of kinetic models for synthetic biological constructs
Q28601294SynBioSS-aided design of synthetic biological constructs
Q45062978Synchronized DNA cycling across a bacterial population
Q43055273Synergy-COPD: a systems approach for understanding and managing chronic diseases
Q56981797Syntax-Guided Optimal Synthesis for Chemical Reaction Networks
Q38433859Synthesis of cyclic enones via direct palladium-catalyzed aerobic dehydrogenation of ketones
Q34673301Synthesis of dihydropyridines and pyridines from imines and alkynes via C-H activation
Q35931254Synthetic Transcription Amplifier System for Orthogonal Control of Gene Expression in Saccharomyces cerevisiae
Q36711501Synthetic circuit of inositol phosphorylceramide synthase in Leishmania : a chemical biology approach
Q35063614Systematic construction of kinetic models from genome-scale metabolic networks
Q27496467Systematic integration of experimental data and models in systems biology
Q35729663Systems Modeling of Interactions between Mucosal Immunity and the Gut Microbiome during Clostridium difficile Infection
Q34467142Systems biology approaches for studying the pathogenesis of non-alcoholic fatty liver disease
Q35189593Systems biology in immunology: a computational modeling perspective.
Q61810619Systems biology reveals how altered TGFβ signalling with age reduces protection against pro-inflammatory stimuli
Q38008573Systems biology tools for toxicology
Q35559681Systems glycobiology: biochemical reaction networks regulating glycan structure and function.
Q37691412Systems metabolic engineering: genome-scale models and beyond
Q34671782Systems modeling of molecular mechanisms controlling cytokine-driven CD4+ T cell differentiation and phenotype plasticity
Q39429367Systems modelling ageing: from single senescent cells to simple multi-cellular models
Q38152375Systems-based understanding of pharmacological responses with combinations of multidisciplinary methodologies
Q92883776TGF-β family ligands exhibit distinct signalling dynamics that are driven by receptor localisation
Q33511365TIde: a software for the systematic scanning of drug targets in kinetic network models
Q28829341Tailored parameter optimization methods for ordinary differential equation models with steady-state constraints
Q54483777Taming Living Logic Using Formal Methods
Q33334544Tandem driven dynamic combinatorial resolution via Henry-iminolactone rearrangement
Q28468608Targeting pathogen metabolism without collateral damage to the host
Q55510151Tellurium notebooks-An environment for reproducible dynamical modeling in systems biology.
Q28083385Temporal aspects of copper homeostasis and its crosstalk with hormones
Q91858392The FRiND Model: A Mathematical Model for Representing Macrophage Plasticity in Muscular Dystrophy Pathogenesis
Q24294979The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1
Q41971759The Peculiar Glycolytic Pathway in Hyperthermophylic Archaea: Understanding Its Whims by Experimentation In Silico.
Q31110953The Perseus computational platform for comprehensive analysis of (prote)omics data
Q89978340The Potential of Computational Modeling to Predict Disease Course and Treatment Response in Patients with Relapsing Multiple Sclerosis
Q57838183The extended catalysis of glutathione transferase
Q38875156The feasibility of genome-scale biological network inference using Graphics Processing Units
Q36634086The game theory of Candida albicans colonization dynamics reveals host status-responsive gene expression
Q36526717The interplay of multiple feedback loops with post-translational kinetics results in bistability of mycobacterial stress response
Q42181307The logic of kinetic regulation in the thioredoxin system.
Q56598688The molecular basis of the interactions between synthetic retinoic acid analogues and the retinoic acid receptors
Q36211863The pattern of growth observed for Clostridium botulinum type A1 strain ATCC 19397 is influenced by nutritional status and quorum sensing: a modelling perspective.
Q28077650The promises of quantitative systems pharmacology modelling for drug development
Q38327408The proteins of exocytosis: lessons from the sperm model
Q35849058The relationship between stochastic and deterministic quasi-steady state approximations
Q89120203The role of glycolysis-derived hexose phosphates in the induction of the Crabtree effect
Q34798508The systems biology simulation core algorithm
Q27700192The use of ene adducts to study and engineer enoyl-thioester reductases
Q64054054Time-dependent antagonist-agonist switching in receptor tyrosine kinase-mediated signaling
Q64443969Time-resolved interaction proteomics of the GIGANTEA protein under diurnal cycles in Arabidopsis
Q38580042To senesce or not to senesce: how primary human fibroblasts decide their cell fate after DNA damage
Q27675273Tolerance of Protein Folding to a Circular Permutation in a PDZ Domain
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Q24289511Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples
Q47436857Towards dynamic genome-scale models.
Q41668377Toxicity of an α-pore-forming toxin depends on the assembly mechanism on the target membrane as revealed by single molecule imaging
Q34842023Transcriptome-wide analysis of trypanosome mRNA decay reveals complex degradation kinetics and suggests a role for co-transcriptional degradation in determining mRNA levels
Q38776953Translation initiation events on structured eukaryotic mRNAs generate gene expression noise.
Q34170516Two component systems: physiological effect of a third component.
Q28755845Understanding diseases by mouse click: the promise and potential of computational approaches in Systems Biology
Q33846654Understanding dynamics using sensitivity analysis: caveat and solution
Q61799987Understanding the Cross-Talk of Redox Metabolism and Fe-S Cluster Biogenesis in Leishmania Through Systems Biology Approach
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Q41554289Understanding the regulation of aspartate metabolism using a model based on measured kinetic parameters
Q36691249Unravelling the complex drug-drug interactions of the cardiovascular drugs, verapamil and digoxin, with P-glycoprotein
Q33381173Update of KDBI: Kinetic Data of Bio-molecular Interaction database.
Q37689710Use of logic theory in understanding regulatory pathway signaling in response to infection
Q58577889Using Systems Biology and Mathematical Modeling Approaches in the Discovery of Therapeutic Targets for Spinal Muscular Atrophy
Q42031465Using computer simulation models to investigate the most promising microRNAs to improve muscle regeneration during ageing
Q33418932Version control of pathway models using XML patches
Q26796849Visualizing genome and systems biology: technologies, tools, implementation techniques and trends, past, present and future
Q30587418Visualizing time-related data in biology, a review
Q37200103Water-soluble cavitands promote hydrolyses of long-chain diesters
Q37089705Web-based applications for building, managing and analysing kinetic models of biological systems
Q28535142What can we learn from global sensitivity analysis of biochemical systems?
Q24655513Writing DNA with GenoCAD
Q37544638Yeast GPCR signaling reflects the fraction of occupied receptors, not the number
Q28541383cuTauLeaping: a GPU-powered tau-leaping stochastic simulator for massive parallel analyses of biological systems
Q35101465iVUN: interactive Visualization of Uncertain biochemical reaction Networks
Q35666806libRoadRunner: a high performance SBML simulation and analysis library
Q47189773pSSAlib: The partial-propensity stochastic chemical network simulator.
Q36172772phraSED-ML: A paraphrased, human-readable adaptation of SED-ML.
Q108126775pyFOOMB: Python framework for object oriented modeling of bioprocesses
Q28678389yApoptosis: yeast apoptosis database
Q113307259yaml2sbml: Human-readable and -writable specification of ODE models and their conversion to SBML
Q33971161α-SNAP prevents docking of the acrosome during sperm exocytosis because it sequesters monomeric syntaxin

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