Systems modeling of molecular mechanisms controlling cytokine-driven CD4+ T cell differentiation and phenotype plasticity

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Systems modeling of molecular mechanisms controlling cytokine-driven CD4+ T cell differentiation and phenotype plasticity is …
instance of (P31):
scholarly articleQ13442814

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P8978DBLP publication IDjournals/ploscb/CarboHKVPLPHMEBWJMB13
P356DOI10.1371/JOURNAL.PCBI.1003027
P932PMC publication ID3617204
P698PubMed publication ID23592971
P5875ResearchGate publication ID236207342

P50authorBarbara KronsteinerQ41047888
Stephen EubankQ41047902
Abdul JarrahQ57193520
Pinyi LuQ59677379
Josep Bassaganya-RieraQ62066149
Madhav MaratheQ63015429
Katherine WendelsdorfQ66305652
Keith BissetQ66305655
Raquel HontecillasQ66305659
Monica ViladomiuQ66305665
Adria CarboQ66305670
Casandra W. PhilipsonQ67103830
Mireia PedragosaQ67123597
Stefan HoopsQ30303478
P2093author name stringYongguo Mei
P2860cites workSingle-cell quantification of IL-2 response by effector and regulatory T cells reveals critical plasticity in immune responseQ41472662
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Peroxisome proliferator-activated receptor gamma is required for regulatory CD4+ T cell-mediated protection against colitisQ44927266
IFN-gamma suppresses STAT6 phosphorylation by inhibiting its recruitment to the IL-4 receptorQ45231996
T-regulatory 1 cells: a novel subset of CD4 T cells with immunoregulatory properties.Q45869113
Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cellsQ46490320
IL-17+ regulatory T cells in the microenvironments of chronic inflammation and cancer.Q46885750
Sequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin-12.Q47898451
Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions.Q50711339
Human T helper (Th) cell lineage commitment is not directly linked to the secretion of IFN-gamma or IL-4: characterization of Th cells isolated by FACS based on IFN-gamma and IL-4 secretion.Q50959583
Human tumor-infiltrating Th17 cells have the capacity to differentiate into IFN-γ+ and FOXP3+ T cells with potent suppressive function.Q51887184
The nuclear receptor PPAR gamma and immunoregulation: PPAR gamma mediates inhibition of helper T cell responsesQ73368153
Peroxisome proliferator-activated receptor gamma (PPARgamma) and immunoregulation: enhancement of regulatory T cells through PPARgamma-dependent and -independent mechanismsQ79984782
A network model for the control of the differentiation process in Th cellsQ82137174
Inhibition of interleukin-17 promotes differentiation of CD25⁻ cells into stable T regulatory cells in patients with autoimmune hepatitisQ83566115
CD28 co-stimulation down regulates Th17 developmentQ21143804
TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat functionQ24314628
Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseasesQ24607561
A whole-cell computational model predicts phenotype from genotypeQ24622101
The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammatQ24648890
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cellsQ27860460
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cellsQ27860620
The control of fluxQ28237216
A Linear Steady-State Treatment of Enzymatic Chains. General Properties, Control and Effector StrengthQ28246120
COPASI--a COmplex PAthway SImulatorQ29617467
Molecular antagonism and plasticity of regulatory and inflammatory T cell programsQ29619478
The role of peroxisome proliferator-activated receptor γ in immune responses to enteroaggregative Escherichia coli infectionQ30422017
Modeling the role of peroxisome proliferator-activated receptor γ and microRNA-146 in mucosal immune responses to Clostridium difficileQ30424551
Peroxisome proliferator-activated receptor α and γ agonists together with TGF-β convert human CD4+CD25- T cells into functional Foxp3+ regulatory T cellsQ33740542
Plasticity of human Th17 cells and iTregs is orchestrated by different subsets of myeloid cellsQ33873201
A mathematical model for the reciprocal differentiation of T helper 17 cells and induced regulatory T cellsQ33987374
All-trans retinoic acid promotes TGF-β-induced Tregs via histone modification but not DNA demethylation on Foxp3 gene locusQ34023732
Immune response to Bifidobacterium bifidum strains support Treg/Th17 plasticityQ34037796
Cutting edge: CTLA-4--B7 interaction suppresses Th17 cell differentiationQ34041965
Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environmentQ34093086
TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathologyQ34712326
Plasticity of CD4+ T cell lineage differentiation.Q34982725
Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligandQ35143424
Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activityQ35210669
Quantifying crosstalk among interferon-γ, interleukin-12, and tumor necrosis factor signaling pathways within a TH1 cell modelQ36027002
Dynamics of CD4(+) T cell responses against Listeria monocytogenesQ36417402
The Hill equation: a review of its capabilities in pharmacological modellingQ37339368
The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunityQ37377446
IL-9: basic biology, signaling pathways in CD4+ T cells and implications for autoimmunityQ37658504
Interleukin-23 and T helper 17-type responses in intestinal inflammation: from cytokines to T-cell plasticityQ37883457
Late developmental plasticity in the T helper 17 lineageQ39265291
FoxP3+RORgammat+ T helper intermediates display suppressive function against autoimmune diabetesQ39752246
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectphenotypeQ104053
phenotypic plasticityQ295130
cell differentiationQ210861
P304page(s)e1003027
P577publication date2013-04-04
P1433published inPLOS Computational BiologyQ2635829
P1476titleSystems modeling of molecular mechanisms controlling cytokine-driven CD4+ T cell differentiation and phenotype plasticity
P478volume9

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