Systems biology approaches for studying the pathogenesis of non-alcoholic fatty liver disease

scientific article

Systems biology approaches for studying the pathogenesis of non-alcoholic fatty liver disease is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3748/WJG.V20.I41.15070
P932PMC publication ID4223240
P698PubMed publication ID25386055
P5875ResearchGate publication ID268230074

P50authorAndrzej M. KierzekQ41117993
Nick PlantQ42717895
J Bernadette MooreQ47158643
P2093author name stringCiarán P Fisher
P2860cites workComputational prediction of human metabolic pathways from the complete human genomeQ21092879
Finishing the euchromatic sequence of the human genomeQ22122488
A protocol for generating a high-quality genome-scale metabolic reconstructionQ24603373
GENCODE: the reference human genome annotation for The ENCODE ProjectQ24608743
Systems biology and the virtual physiological humanQ24653792
Global reconstruction of the human metabolic network based on genomic and bibliomic dataQ24677060
Tuberculosis presenting as immune thrombocytopenic purpuraQ24791974
Proteomics and Systems Biology: Current and Future Applications in the Nutritional SciencesQ26829598
Therapeutic approaches to non-alcoholic fatty liver disease: past achievements and future challengesQ27023893
The complete genome sequence of Escherichia coli K-12Q27860542
What is flux balance analysis?Q28275348
SurreyFBA: a command line tool and graphics user interface for constraint-based modeling of genome-scale metabolic reaction networksQ28300416
Optimization of stress response through the nuclear receptor-mediated cortisol signalling networkQ28397689
In silico elucidation of the molecular mechanism defining the adverse effect of selective estrogen receptor modulatorsQ28471679
The signaling petri net-based simulator: a non-parametric strategy for characterizing the dynamics of cell-specific signaling networksQ28472336
Context-specific metabolic networks are consistent with experimentsQ28472711
Drug Off-Target Effects Predicted Using Structural Analysis in the Context of a Metabolic Network ModelQ28475693
Building disease-specific drug-protein connectivity maps from molecular interaction networks and PubMed abstractsQ28475789
Reconstruction of genome-scale active metabolic networks for 69 human cell types and 16 cancer types using INITQ28483779
KEGG for integration and interpretation of large-scale molecular data setsQ29547277
Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination SurveyQ29614468
A community-driven global reconstruction of human metabolism.Q29614690
COPASI--a COmplex PAthway SImulatorQ29617467
Dynamic analysis of integrated signaling, metabolic, and regulatory networksQ30441717
Noninvasive investigations for non alcoholic fatty liver disease and liver fibrosisQ30479092
Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regenerationQ30495068
Nutritional systems biology modeling: from molecular mechanisms to physiologyQ30943969
New insights into functional aspects of liver morphologyQ30986309
Compartmentalization of the Edinburgh Human Metabolic NetworkQ30986319
Rapidly exploring structural and dynamic properties of signaling networks using PathwayOracleQ33361469
A detailed genome-wide reconstruction of mouse metabolism based on human Recon 1.Q33722800
iAB-RBC-283: A proteomically derived knowledge-base of erythrocyte metabolism that can be used to simulate its physiological and patho-physiological statesQ33958875
A multi-tissue type genome-scale metabolic network for analysis of whole-body systems physiologyQ34063123
Reconstruction and analysis of human heart-specific metabolic network based on transcriptome and proteome dataQ34068001
Regulation of Gene Expression in Flux Balance Models of MetabolismQ34101809
HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiologyQ34240836
Integration of clinical data with a genome-scale metabolic model of the human adipocyteQ34334051
Insight into human alveolar macrophage and M. tuberculosis interactions via metabolic reconstructionsQ34344292
Reconstruction of cellular signalling networks and analysis of their propertiesQ34385115
CardioNet: a human metabolic network suited for the study of cardiomyocyte metabolismQ34396816
Reconstruction of genome-scale metabolic models for 126 human tissues using mCADREQ34509501
Systems biology elucidates common pathogenic mechanisms between nonalcoholic and alcoholic-fatty liver diseaseQ34630137
Implications of the dominant role of transporters in drug uptake by cellsQ34939329
Modelling the heart: insights, failures and progressQ35007351
Diagnosing fatty liver disease: a comparative evaluation of metabolic markers, phenotypes, genotypes and established biomarkersQ35018573
Reconstruction and analysis of human kidney-specific metabolic network based on omics dataQ35040014
Large-scale in silico modeling of metabolic interactions between cell types in the human brainQ35117087
Pediatric nonalcoholic fatty liver disease, metabolic syndrome and cardiovascular riskQ35171570
New hepatocyte in vitro systems for drug metabolism: metabolic capacity and recommendations for application in basic research and drug development, standard operation proceduresQ35213378
Human fatty liver disease: old questions and new insightsQ35588477
A network-based, integrative study to identify core biological pathways that drive breast cancer clinical subtypesQ35832269
The Edinburgh human metabolic network reconstruction and its functional analysisQ36052649
Large-scale prediction and testing of drug activity on side-effect targetsQ36059863
The burden of overweight and obesity-related ill health in the UK.Q36918217
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Q37121662
Human metabolic network reconstruction and its impact on drug discovery and developmentQ37158701
Which in vitro models could be best used to study hepatocyte polarity?Q37189719
The virtual cell--a candidate co-ordinator for 'middle-out' modelling of biological systemsQ37416872
Nutritional systems biology: definitions and approachesQ37539998
Non-alcoholic fatty liver disease: the hepatic consequence of obesity and the metabolic syndromeQ37693238
From the metabolic syndrome to NAFLD or vice versa?Q37703968
Prevalence of non-alcoholic fatty liver disease and its association with cardiovascular disease in patients with type 1 diabetes.Q37771540
Current therapeutic strategies in non-alcoholic fatty liver disease.Q37859419
A systematic review of follow-up biopsies reveals disease progression in patients with non-alcoholic fatty liverQ38105838
Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general populationQ39693472
Comparative proteomic phenotyping of cell lines and primary cells to assess preservation of cell type-specific functionsQ39924973
Three-dimensional in vitro cell culture leads to a marked upregulation of cell function in human hepatocyte cell lines--an important tool for the development of a bioartificial liver machineQ40940480
Computational reconstruction of tissue‐specific metabolic models: application to human liver metabolismQ41846171
QSSPN: dynamic simulation of molecular interaction networks describing gene regulation, signalling and whole-cell metabolism in human cellsQ42862600
Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitisQ43174499
Integrating metabolic, transcriptional regulatory and signal transduction models in Escherichia coli.Q43575020
GEMSiRV: a software platform for GEnome-scale metabolic model simulation, reconstruction and visualizationQ43713406
On the reconstruction of the Mus musculus genome-scale metabolic network model.Q47853955
The reconstruction and analysis of tissue specific human metabolic networksQ48766685
Epidemiology of non-alcoholic fatty liver disease.Q51566234
GNU MCSim: Bayesian statistical inference for SBML-coded systems biology modelsQ51847870
Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathwaysQ51926243
The virtual liver: a multidisciplinary, multilevel challenge for systems biologyQ52890211
Emergence of the silicon human and network targeting drugsQ57393826
Snoopy--a unifying Petri net framework to investigate biomolecular networksQ63241826
Tuberculosis presenting as immune thrombocytopenic purpuraQ71595345
Differential gene expression in periportal and perivenous mouse hepatocytesQ79282635
Network-based prediction of human tissue-specific metabolismQ81798711
Genome-scale modeling and in silico analysis of mouse cell metabolic networkQ82298733
Maintaining hepatocyte differentiation in vitro through co-culture with hepatic stellate cellsQ83274871
Liver biopsyQ83395480
P433issue41
P407language of work or nameEnglishQ1860
P921main subjectsystems biologyQ815297
metabolic dysfunction–associated steatotic liver diseaseQ1546498
fatty liver diseaseQ6058862
non-alcoholic fatty liverQ66299798
P304page(s)15070-15078
P577publication date2014-11-01
P13046publication type of scholarly workreview articleQ7318358
P1433published inWorld Journal of GastroenterologyQ15708885
P1476titleSystems biology approaches for studying the pathogenesis of non-alcoholic fatty liver disease
P478volume20

Reverse relations

cites work (P2860)
Q47145823Computational Modeling in Liver Surgery
Q90601947Fagonia indica Repairs Hepatic Damage through Expression Regulation of Toll-Like Receptors in a Liver Injury Model
Q95940426From personalised nutrition to precision medicine: the rise of consumer genomics and digital health
Q92694745From sugar to liver fat and public health: systems biology driven studies in understanding non-alcoholic fatty liver disease pathogenesis
Q47158582Integration of Genome Scale Metabolic Networks and Gene Regulation of Metabolic Enzymes With Physiologically Based Pharmacokinetics
Q46443002Intermittent calorie restriction largely counteracts the adverse health effects of a moderate-fat diet in aging C57BL/6J mice
Q58417407Multi-scale, whole-system models of liver metabolic adaptation to fat and sugar in non-alcoholic fatty liver disease
Q36407635Synergistic interaction between lipid-loading and doxorubicin exposure in Huh7 hepatoma cells results in enhanced cytotoxicity and cellular oxidative stress: implications for acute and chronic care of obese cancer patients
Q27016052The role of dietary sugars and de novo lipogenesis in non-alcoholic fatty liver disease

Search more.