Trypanothione synthetase confers growth, survival advantage and resistance to anti-protozoal drugs in Trypanosoma cruzi

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Trypanothione synthetase confers growth, survival advantage and resistance to anti-protozoal drugs in Trypanosoma cruzi is …
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scholarly articleQ13442814

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P356DOI10.1016/J.FREERADBIOMED.2018.10.436
P932PMC publication ID6331241
P698PubMed publication ID30359758

P50authorMarcelo A CominiQ57247725
Cecilia Perez BrandanQ58889622
Carlos RobelloQ68078353
P2093author name stringConrad Kunick
M Paola Zago
Nisha J Garg
Diego G Arias
Natalia Sasoni
Andrea C Mesías
Oliver C F Orban
P2860cites workMetabolic control analysis of the Trypanosoma cruzi peroxide detoxification pathway identifies tryparedoxin as a suitable drug targetQ58842743
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Integration of expression vectors into the ribosomal locus of Trypanosoma cruziQ73513765
A colorimetric method for the assay of ADP-glucose pyrophosphorylaseQ83014950
Phenotypic analysis of trypanothione synthetase knockdown in the African trypanosomeQ24537133
Trypanothione overproduction and resistance to antimonials and arsenicals in LeishmaniaQ24595838
Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methodsQ24649110
A critical review on Chagas disease chemotherapyQ28216601
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolismQ28275518
Benznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomicsQ28539047
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductaseQ31813150
Proteomic analysis of metacyclic trypomastigotes undergoing Trypanosoma cruzi metacyclogenesis.Q33303873
Progressive chronic Chagas heart disease ten years after treatment with anti-Trypanosoma cruzi nitroderivatives.Q33949549
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruziQ34139347
Validation of Trypanosoma brucei trypanothione synthetase as drug targetQ34316594
TcI Isolates of Trypanosoma cruzi Exploit the Antioxidant Network for Enhanced Intracellular Survival in Macrophages and Virulence in Mice.Q35986511
Universal minicircle sequence binding protein of Leishmania donovani regulates pathogenicity by controlling expression of cytochrome-b.Q36588170
Trypanosoma cruzi antioxidant enzymes as virulence factors in Chagas diseaseQ37086096
Insights into the redox biology of Trypanosoma cruzi: Trypanothione metabolism and oxidant detoxificationQ37202974
Enzymes of the antioxidant network as novel determiners of Trypanosoma cruzi virulenceQ37540773
Fighting the oxidative assault: the Trypanosoma cruzi journey to infectionQ37555693
Rhodnius prolixus: from physiology by Wigglesworth to recent studies of immune system modulation by Trypanosoma cruzi and Trypanosoma rangeli.Q38793097
Randomized Trial of Benznidazole for Chronic Chagas' CardiomyopathyQ39269382
Redox potential regulates binding of universal minicircle sequence binding protein at the kinetoplast DNA replication originQ39325265
5-Substituted 3-chlorokenpaullone derivatives are potent inhibitors of Trypanosoma brucei bloodstream formsQ39326358
Nifurtimox activation by trypanosomal type I nitroreductases generates cytotoxic nitrile metabolites.Q39587113
Depletion of the thioredoxin homologue tryparedoxin impairs antioxidative defence in African trypanosomesQ40220444
Functional analysis of the intergenic regions of TcP2beta gene loci allowed the construction of an improved Trypanosoma cruzi expression vectorQ40919671
In vitro metacyclogenesis of Trypanosoma cruzi induced by starvation correlates with a transient adenylyl cyclase stimulation as well as with a constitutive upregulation of adenylyl cyclase expression.Q41013683
Mode of action of nifurtimox and N-oxide-containing heterocycles against Trypanosoma cruzi: is oxidative stress involved?Q43152757
Biological aspects of the Dm 28c clone of Trypanosoma cruzi after metacyclogenesis in chemically defined mediaQ44071500
Trypanosoma cruzi response to the oxidative stress generated by hydrogen peroxide.Q44688124
The Trypanosoma cruzi proteome.Q46601686
Genetic and chemical analyses reveal that trypanothione synthetase but not glutathionylspermidine synthetase is essential for Leishmania infantumQ46891068
Comparative genomics analysis of triatomines reveals common first line and inducible immunity-related genes and the absence of Imd canonical components among hemimetabolous arthropods.Q49176314
Redox metabolism in Trypanosoma cruzi: functional characterization of tryparedoxins revisited.Q51001361
Trypanothione-dependent peroxide metabolism in Trypanosoma cruzi different stages.Q52223166
Trypanosoma cruzi: differentiation after interaction of epimastigotes and Triatoma infestans intestinal homogenate.Q52457794
Differentiation of Trypanosoma cruzi epimastigotes: metacyclogenesis and adhesion to substrate are triggered by nutritional stress.Q52585911
Epidemiology of Chagas disease in non-endemic countries: the role of international migration.Q52684308
Life and death of Trypanosoma cruzi in presence of metals.Q54326587
P407language of work or nameEnglishQ1860
P921main subjectTrypanosoma cruziQ150162
P304page(s)23-34
P577publication date2018-10-23
P1433published inFree Radical Biology and MedicineQ5500023
P1476titleTrypanothione synthetase confers growth, survival advantage and resistance to anti-protozoal drugs in Trypanosoma cruzi
P478volume130

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cites work (P2860)
Q92774155Gamma-glutamylcysteine synthetase and tryparedoxin 1 exert high control on the antioxidant system in Trypanosoma cruzi contributing to drug resistance and infectivity
Q98508491Recent Advancement in the Search of Innovative Antiprotozoal Agents Targeting Trypanothione Metabolism
Q92542179Redox Balance Keepers and Possible Cell Functions Managed by Redox Homeostasis in Trypanosoma cruzi

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