| scholarly article | Q13442814 |
| P50 | author | Alan Fairlamb | Q4706598 |
| Emmanuel Tetaud | Q125319496 | ||
| Mark R Ariyanayagam | Q125319527 | ||
| Sandra L Oza | Q58464788 | ||
| P2093 | author name string | Stephanie S Warnon | |
| P2860 | cites work | DNA sequencing with chain-terminating inhibitors | Q22066207 |
| Purification of glutathionylspermidine and trypanothione synthetases from Crithidia fasciculata | Q24676196 | ||
| Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress | Q28144631 | ||
| Glutathione | Q28261279 | ||
| Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids | Q28306157 | ||
| Nucleotide sequences provide evidence of genetic exchange among distantly related lineages of Trypanosoma cruzi | Q28776155 | ||
| Polyamines | Q29615154 | ||
| Glutathione and trypanothione in parasitic hydroperoxide metabolism | Q33777935 | ||
| Metabolism and functions of trypanothione in the Kinetoplastida | Q33972467 | ||
| Purification and characterization of trypanothione reductase from Crithidia fasciculata, a newly discovered member of the family of disulfide-containing flavoprotein reductases | Q34050552 | ||
| Roles of the glutathione- and thioredoxin-dependent reduction systems in the Escherichia coli and saccharomyces cerevisiae responses to oxidative stress. | Q34052736 | ||
| Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus | Q34067320 | ||
| Glutathionylspermidine metabolism in Escherichia coli. Purification, cloning, overproduction, and characterization of a bifunctional glutathionylspermidine synthetase/amidase | Q34312691 | ||
| Trypanothione as a target in the design of antitrypanosomal and antileishmanial agents | Q34319189 | ||
| Regulation of a high-affinity diamine transport system in Trypanosoma cruzi epimastigotes | Q34733770 | ||
| Down-regulation of Leishmania donovani trypanothione reductase by heterologous expression of a trans-dominant mutant homologue: effect on parasite intracellular survival | Q36069752 | ||
| Diamine auxotrophy may be a universal feature of Trypanosoma cruzi epimastigotes | Q38879584 | ||
| Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi. | Q39088543 | ||
| Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi | Q39594361 | ||
| Biochemical characterization of a trypanosome enzyme with glutathione-dependent peroxidase activity | Q39594370 | ||
| Polyamines as targets for therapeutic intervention | Q40437004 | ||
| Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata | Q42094447 | ||
| Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages. | Q42123859 | ||
| Glutathione-dependent activities of Trypanosoma cruzi p52 makes it a new member of the thiol:disulphide oxidoreductase family | Q42269187 | ||
| Intracellular growth and metacyclogenesis defects in Trypanosoma cruzi carrying a targeted deletion of a Tc52 protein-encoding allele | Q42604370 | ||
| Evidence for a trypanothione-dependent peroxidase system in Trypanosoma cruzi | Q42623496 | ||
| Ovothiol and trypanothione as antioxidants in trypanosomatids | Q43648961 | ||
| Biosynthesis of the trypanosomatid metabolite trypanothione: purification and characterization of trypanothione synthetase from Crithidia fasciculata | Q44485901 | ||
| Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata | Q47792563 | ||
| Levels of polyamines, glutathione and glutathione-spermidine conjugates during growth of the insect trypanosomatid Crithidia fasciculata. | Q52460353 | ||
| The biosynthesis of trypanothione and N1-glutathionylspermidine in Crithidia fasciculata. | Q52465350 | ||
| Peroxynitrite affects Ca2+ transport in Trypanosoma cruzi. | Q52533979 | ||
| Identification of a novel, thiol-containing co-factor essential for glutathione reductase enzyme activity in trypanosomatids. | Q54691023 | ||
| In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei | Q58850283 | ||
| Glutathione as an endogenous sulphur source in the yeast Saccharomyces cerevisiae | Q68300331 | ||
| Solid-phase extraction and determination of dansyl derivatives of unconjugated and acetylated polyamines by reversed-phase liquid chromatography: improved separation systems for polyamines in cerebrospinal fluid, urine and tissue | Q69593259 | ||
| Dissection of glutathionylspermidine synthetase/amidase from Escherichia coli into autonomously folding and functional synthetase and amidase domains | Q71985246 | ||
| Activation of trypanosome surface glycoprotein genes involves a duplication-transposition leading to an altered 3' end | Q72417686 | ||
| Convenient isolation and kinetic mechanism of glutathionylspermidine synthetase from Crithidia fasciculata | Q73257855 | ||
| Evidence for a glutathionyl-enzyme intermediate in the amidase activity of the bifunctional glutathionylspermidine synthetase/amidase from Escherichia coli | Q73940303 | ||
| P433 | issue | 39 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | glutathione | Q116907 |
| Trypanosoma cruzi | Q150162 | ||
| aminopropylcadaverine | Q27133504 | ||
| P304 | page(s) | 35853-35861 | |
| P577 | publication date | 2002-07-16 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi | |
| P478 | volume | 277 |
| Q46147785 | A novel polyamine acyltransferase responsible for the accumulation of spermidine conjugates in Arabidopsis seed |
| Q89464714 | A tryparedoxin-coupled biosensor reveals a mitochondrial trypanothione metabolism in trypanosomes |
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| Q24657204 | Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis |
| Q45909806 | Cloning, expression, characterization and inhibition studies on trypanothione synthetase, a drug target enzyme, from Leishmania donovani. |
| Q21972828 | Comparative genomic analysis of three Leishmania species that cause diverse human disease |
| Q38845466 | Detection and treatment of Trypanosoma cruzi: a patent review (2011-2015). |
| Q42557517 | Dissecting the catalytic mechanism of Trypanosoma brucei trypanothione synthetase by kinetic analysis and computational modeling |
| Q24649110 | Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods |
| Q48051536 | Drug target validation of the trypanothione pathway enzymes through metabolic modelling |
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| Q26772721 | Evasion of the Immune Response by Trypanosoma cruzi during Acute Infection |
| Q89980583 | Evolution of metabolic capabilities and molecular features of diplonemids, kinetoplastids, and euglenids |
| Q92774155 | Gamma-glutamylcysteine synthetase and tryparedoxin 1 exert high control on the antioxidant system in Trypanosoma cruzi contributing to drug resistance and infectivity |
| Q28551301 | Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids |
| Q38154345 | Indazoles: a new top seed structure in the search of efficient drugs against Trypanosoma cruzi. |
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| Q57833404 | Molecular modeling of Trypanosoma cruzi glutamate cysteine ligase and investigation of its interactions with glutathione |
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| Q44388721 | Properties of phosphoenolpyruvate mutase, the first enzyme in the aminoethylphosphonate biosynthetic pathway in Trypanosoma cruzi |
| Q27662134 | Protein S-Thiolation by Glutathionylspermidine (Gsp): THE ROLE OF ESCHERICHIA COLI Gsp SYNTHETASE/AMIDASE IN REDOX REGULATION |
| Q91813186 | Reactive species and pathogen antioxidant networks during phagocytosis |
| Q92542179 | Redox Balance Keepers and Possible Cell Functions Managed by Redox Homeostasis in Trypanosoma cruzi |
| Q46985481 | Skl, a novel choline-binding N-acetylmuramoyl-L-alanine amidase of Streptococcus mitis SK137 containing a CHAP domain |
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| Q57802865 | Trypanothione synthetase confers growth, survival advantage and resistance to anti-protozoal drugs in Trypanosoma cruzi |
| Q44491242 | Trypanothione synthetase locus in Trypanosoma cruzi CL Brener strain shows an extensive allelic divergence |
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