Evasion of the Immune Response by Trypanosoma cruzi during Acute Infection

scientific article

Evasion of the Immune Response by Trypanosoma cruzi during Acute Infection is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.3389/FIMMU.2015.00659
P3181OpenCitations bibliographic resource ID3729949
P932PMC publication ID4716143
P698PubMed publication ID26834737
P5875ResearchGate publication ID290963095

P50authorDaniella Castanheira BartholomeuQ41905720
João Luís Reis-CunhaQ58873382
P2093author name stringMariana S Cardoso
P2860cites workThe Genome Sequence of Trypanosoma cruzi, Etiologic Agent of Chagas DiseaseQ22065799
A Toll-like receptor recognizes bacterial DNAQ24290668
A 9,000-year record of Chagas' diseaseQ24621555
Unveiling the intracellular survival gene kit of trypanosomatid parasitesQ27003077
Insufficient TLR activation contributes to the slow development of CD8+ T cell responses in Trypanosoma cruzi infectionQ39332973
Trypanosoma cruzi calreticulin inhibits the complement lectin pathway activation by direct interaction with L-FicolinQ39479713
LYT1 protein is required for efficient in vitro infection by Trypanosoma cruzi.Q39520750
Molecular mechanisms involved in the inactivation of the first component of human complement by Trypanosoma cruzi calreticulinQ39545681
The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin.Q39594349
TcGPXII, a glutathione-dependent Trypanosoma cruzi peroxidase with substrate specificity restricted to fatty acid and phospholipid hydroperoxides, is localized to the endoplasmic reticulumQ39594356
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruziQ39594361
Glycoinositolphospholipids from Trypanosoma cruzi interfere with macrophages and dendritic cell responses.Q39655557
Trypanosoma cruzi calreticulin: a novel virulence factor that binds complement C1 on the parasite surface and promotes infectivityQ39703575
Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position -7007 of the FPN1 promoterQ39736112
Biology of Trypanosoma cruziQ39879813
Recruitment and endo-lysosomal activation of TLR9 in dendritic cells infected with Trypanosoma cruzi.Q39964182
Trans-sialidase recombinant protein mixed with CpG motif-containing oligodeoxynucleotide induces protective mucosal and systemic trypanosoma cruzi immunity involving CD8+ CTL and B cell-mediated cross-priming.Q40157048
Differential use of TLR2 and TLR9 in the regulation of immune responses during the infection with Trypanosoma cruziQ40280437
Living dangerously: how Trypanosoma cruzi uses lysosomes to get inside host cells, and then escapes into the cytoplasm.Q40479781
Macrophage-derived peroxynitrite diffusion and toxicity to Trypanosoma cruziQ40492558
TLR9 signals after translocating from the ER to CpG DNA in the lysosomeQ40600429
Immediate/early response to Trypanosoma cruzi infection involves minimal modulation of host cell transcriptionQ40773508
Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasiteQ40797228
Dissecting the multifactorial causes of immunodominance in class I-restricted T cell responses to viruses.Q40901873
Identification of Trypanosoma cruzi trans-sialidase family members as targets of protective CD8+ TC1 responsesQ41049640
A T. cruzi-secreted protein immunologically related to the complement component C9: evidence for membrane pore-forming activity at low pH.Q41730283
Immunological dominance of Trypanosoma cruzi tandem repeat proteinsQ42406598
Epidemiology, control and surveillance of Chagas disease: 100 years after its discoveryQ43309611
Infection with Trypanosoma cruzi restricts the repertoire of parasite-specific CD8+ T cells leading to immunodominanceQ43486494
The ancient and divergent origins of the human pathogenic trypanosomes, Trypanosoma brucei and T. cruziQ43834978
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptorsQ27860900
Pathogen recognition and innate immunityQ27861084
Pattern recognition receptors and inflammationQ27861115
CD8+ T cells in Trypanosoma cruzi infectionQ28081766
Shotgun sequencing analysis of Trypanosoma cruzi I Sylvio X10/1 and comparison with T. cruzi VI CL BrenerQ28477359
The history of Chagas diseaseQ28655492
Membrane vesicles as conveyors of immune responsesQ29547765
Superoxide radical and superoxide dismutasesQ29614204
The biogenesis of lysosomesQ29617860
Epitope mapping of trans-sialidase from Trypanosoma cruzi reveals the presence of several cross-reactive determinantsQ30652825
CD8+ T-Cell responses to Trypanosoma cruzi are highly focused on strain-variant trans-sialidase epitopesQ33252349
Proteomic analysis of metacyclic trypomastigotes undergoing Trypanosoma cruzi metacyclogenesis.Q33303873
The neglected tropical diseases of Latin America and the Caribbean: a review of disease burden and distribution and a roadmap for control and eliminationQ33372349
HLA Class I-T cell epitopes from trans-sialidase proteins reveal functionally distinct subsets of CD8+ T cells in chronic Chagas diseaseQ33375075
Genomic organization and expression profile of the mucin-associated surface protein (masp) family of the human pathogen Trypanosoma cruziQ33425111
Inefficient complement system clearance of Trypanosoma cruzi metacyclic trypomastigotes enables resistant strains to invade eukaryotic cellsQ33543089
A partial cDNA clone of trypomastigote decay-accelerating factor (T-DAF), a developmentally regulated complement inhibitor of Trypanosoma cruzi, has genetic and functional similarities to the human complement inhibitor DAF.Q33607295
Specific humoral immunity versus polyclonal B cell activation in Trypanosoma cruzi infection of susceptible and resistant miceQ33631293
Immunodominance in major histocompatibility complex class I-restricted T lymphocyte responsesQ33652450
Stable transfection of Trypanosoma cruzi epimastigotes with the trypomastigote-specific complement regulatory protein cDNA confers complement resistanceQ33754261
Vaccination with trypomastigote surface antigen 1-encoding plasmid DNA confers protection against lethal Trypanosoma cruzi infectionQ33767207
Lymphocyte polyclonal activation: a pitfall for vaccine design against infectious agentsQ33826635
A B-cell mitogen from a pathogenic trypanosome is a eukaryotic proline racemaseQ33912838
Subdominant/cryptic CD8 T cell epitopes contribute to resistance against experimental infection with a human protozoan parasite.Q33968196
Analyses of 32 loci clarify phylogenetic relationships among Trypanosoma cruzi lineages and support a single hybridization prior to human contactQ33988951
Genomic analyses, gene expression and antigenic profile of the trans-sialidase superfamily of Trypanosoma cruzi reveal an undetected level of complexity.Q34062280
DNA and mRNA elements with complementary responses to hemin, antioxidant inducers, and iron control ferritin-L expressionQ34085026
Role of host lysosomal associated membrane protein (LAMP) in Trypanosoma cruzi invasion and intracellular developmentQ34108128
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruziQ34139347
Trypanosoma cruzi expresses a plant-like ascorbate-dependent hemoperoxidase localized to the endoplasmic reticulumQ34159631
Perpetual expression of PAMPs necessary for optimal immune control and clearance of a persistent pathogenQ34164082
Parasite polyclonal activators: new targets for vaccination approaches?Q34240147
The Trypanosoma cruzi trans-sialidase is a T cell-independent B cell mitogen and an inducer of non-specific Ig secretionQ43898130
Nitric oxide inhibits cruzipain, the major papain-like cysteine proteinase from Trypanosoma cruziQ44093805
Maximum-likelihood divergence date estimates based on rRNA gene sequences suggest two scenarios of Trypanosoma cruzi intraspecific evolutionQ44386235
Characterisation and properties of ectosomes released by human polymorphonuclear neutrophilsQ44410424
Novel PI 3-kinase-dependent mechanisms of trypanosome invasion and vacuole maturationQ44522457
Trypanosoma cruzi immune evasion mediated by host cell-derived microvesicles.Q44522735
The classical activation pathway of the human complement system is specifically inhibited by calreticulin from Trypanosoma cruziQ44772790
Susceptibility of beta 2-microglobulin-deficient mice to Trypanosoma cruzi infectionQ44832922
Complement C2 receptor inhibitor trispanning confers an increased ability to resist complement-mediated lysis in Trypanosoma cruziQ46581413
The Trypanosoma cruzi proteome.Q46601686
What has DNA sequencing revealed about the VSG expression sites of African trypanosomes?Q46673837
The Lipid Structure of the Glycosylphosphatidylinositol-anchored Mucin-like Sialic Acid Acceptors of Trypanosoma cruzi Changes during Parasite Differentiation from Epimastigotes to Infective Metacyclic Trypomastigote FormsQ47630684
Mortality due to Chagas disease in Brazil from 1979 to 2009: trends and regional differences.Q50111267
Trypanosoma cruzi infection induces a massive extrafollicular and follicular splenic B-cell response which is a high source of non-parasite-specific antibodies.Q50559773
Expression of trypomastigote trans-sialidase in metacyclic forms of Trypanosoma cruzi increases parasite escape from its parasitophorous vacuole.Q51806092
Expression of functional TLR4 confers proinflammatory responsiveness to Trypanosoma cruzi glycoinositolphospholipids and higher resistance to infection with T. cruzi.Q51822633
Biochemical characterization of a factor produced by trypomastigotes of Trypanosoma cruzi that accelerates the decay of complement C3 convertases.Q52250588
Characterization of a Trypanosoma cruzi C3 binding protein with functional and genetic similarities to the human complement regulatory protein, decay-accelerating factor.Q52445292
Studies in search of a suitable experimental insect model for xenodiagnosis of hosts with Chagas' disease. 4--The reflection of parasite stock in the responsiveness of different vector species to chronic infection with different Trypanosoma cruzi stQ52449377
Role of early lectin pathway activation in the complement-mediated killing of Trypanosoma cruzi.Q53368984
Impaired production of proinflammatory cytokines and host resistance to acute infection with Trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88.Q53905520
Mechanisms of TLR9 activation.Q54494727
A functional network of intramolecular cross-reacting epitopes delays the elicitation of neutralizing antibodies to Trypanosoma cruzi trans-sialidase.Q54541568
The evolution of Trypanosoma cruzi: the 'bat seeding' hypothesisQ56927701
Trypanosoma cruzi: parasite shed vesicles increase heart parasitism and generate an intense inflammatory responseQ57067411
Hexadecylpalmitoyglycerol or ceramide is linked to similar glycophosphoinositol anchor-like structures in Trypanosoma cruziQ57067563
Activation of human macrophages for the killing of intracellular Trypanosoma cruzi by TNF-α and IFN-γ through a nitric oxide-dependent mechanismQ57080133
Most B Cells in Acute Trypanosoma cruzi Infection Lack Parasite SpecificityQ57842433
Trypomastigotes and amastigotes of Trypanosoma cruzi induce apoptosis and STAT3 activation in cardiomyocytes in vitroQ58843283
PCR detection of Trypanosoma cruzi DNA in oesophageal tissues of patients with chronic digestive Chagas' diseaseQ58843303
Cutting edge: nucleotide-binding oligomerization domain 1-dependent responses account for murine resistance against Trypanosoma cruzi infectionQ58844182
Amplification of a Trypanosoma cruzi DNA sequence from inflammatory lesions in human chagasic cardiomyopathyQ58844325
Immunodominance: a new hypothesis to explain parasite escape and host/parasite equilibrium leading to the chronic phase of Chagas' disease?Q58844446
Trypanosoma cruzi: predominance of IgG2a in nonspecific humoral response during experimental Chagas' diseaseQ58844647
Cutting edge: TLR9 and TLR2 signaling together account for MyD88-dependent control of parasitemia in Trypanosoma cruzi infectionQ58845195
Depletion of CD8+ T cells increases susceptibility and reverses vaccine-induced immunity in mice infected with Trypanosoma cruziQ58845221
Phagocytosis: a defense mechanism against infection with Trypanosoma cruziQ58848531
The trans-sialidase of Trypanosoma cruzi is anchored by two different lipidsQ58855157
gp 58/68, a parasite component that contributes to the escape of the trypomastigote form of T. cruzi from damage by the human alternative complement pathwayQ70064606
The mechanisms of Trypanosoma cruzi invasion of mammalian cellsQ70899913
Structural variation in the glycoinositolphospholipids of different strains of Trypanosoma cruziQ71939521
Tc45, a dimorphic Trypanosoma cruzi immunogen with variable chromosomal localization, is calreticulinQ74076573
Proapoptotic activity of a Trypanosoma cruzi ceramide-containing glycolipid turned on in host macrophages by IFN-gammaQ77484030
Glycosylphosphatidylinositol-anchored mucin-like glycoproteins isolated from Trypanosoma cruzi trypomastigotes induce in vivo leukocyte recruitment dependent on MCP-1 production by IFN-gamma-primed-macrophagesQ78058095
Purification and biochemical characterization of four iron superoxide dismutases in Trypanosoma cruziQ81556847
Macrophage complement receptors and pathogen clearanceQ36859212
Immune system recognition of Trypanosoma cruziQ36891278
Trypanosoma cruzi infection from the view of CD8+ T cell immunity--an infection model for developing T cell vaccineQ36922758
Trypanosoma cruzi antioxidant enzymes as virulence factors in Chagas diseaseQ37086096
Peroxynitrite, a stealthy biological oxidantQ37168344
CD8+ T cells specific for immunodominant trans-sialidase epitopes contribute to control of Trypanosoma cruzi infection but are not required for resistanceQ37200211
Unleashing the therapeutic potential of NOD-like receptorsQ37502679
Glycobiology of Trypanosoma cruziQ37510071
Enzymes of the antioxidant network as novel determiners of Trypanosoma cruzi virulenceQ37540773
Fighting the oxidative assault: the Trypanosoma cruzi journey to infectionQ37555693
Antigenic variation in Giardia lambliaQ37587368
The effects of nitric oxide on the immune system during Trypanosoma cruzi infectionQ37597063
The role of parasite persistence in pathogenesis of Chagas heart diseaseQ37613774
Molecular mechanisms of host cell invasion by Trypanosoma cruziQ37769831
Insights into the role of Toll-like receptors in modulation of T cell responsesQ37777344
The endless race between Trypanosoma cruzi and host immunity: lessons for and beyond Chagas diseaseQ37788829
Molecular mechanisms underlying the control of antigenic variation in African trypanosomesQ37795350
Regulation of antigenic variation in Giardia lambliaQ37899177
Vesicles as carriers of virulence factors in parasitic protozoan diseasesQ38034618
Virulence factors of Trypanosoma cruzi: who is who?Q38046031
Mechanisms of complement lectin pathway activation and resistance by trypanosomatid parasitesQ38051898
Silence, activate, poise and switch! Mechanisms of antigenic variation in Plasmodium falciparum.Q38076799
Microvesicles and intercellular communication in the context of parasitism.Q38137085
Gene expression changes induced by Trypanosoma cruzi shed microvesicles in mammalian host cells: relevance of tRNA-derived halves.Q38987100
Isolation of Trypanosoma cruzi DNA in 4,000-year-old mummified human tissue from northern Chile.Q39035804
Correlation between Trypanosoma cruzi parasitism and myocardial inflammatory infiltrate in human chronic chagasic myocarditis: Light microscopy and immunohistochemical findingsQ39067405
Transfer of the chemokine receptor CCR5 between cells by membrane-derived microparticles: a mechanism for cellular human immunodeficiency virus 1 infectionQ39200565
???Q58648633
Control of VSG gene expression sitesQ34253288
A trypanosome-soluble factor induces IP3 formation, intracellular Ca2+ mobilization and microfilament rearrangement in host cellsQ34312703
Glycoinositolphospholipids, free and as anchors of proteins, in Trypanosoma cruziQ34319207
The MASP family of Trypanosoma cruzi: changes in gene expression and antigenic profile during the acute phase of experimental infectionQ34385087
Proinflammatory activity of glycosylphosphatidylinositol anchors derived from Trypanosoma cruzi: structural and functional analyses.Q34394414
Antigenic variation and allelic exclusionQ34602633
Intraphagosomal peroxynitrite as a macrophage-derived cytotoxin against internalized Trypanosoma cruzi: consequences for oxidative killing and role of microbial peroxiredoxins in infectivityQ34675951
Circulating microparticles: square the circleQ34680832
Antigenic variation in Giardia lamblia is regulated by RNA interferenceQ34902943
Mechanisms of cellular iron acquisition: another iron in the fireQ35015885
Requirement of UNC93B1 reveals a critical role for TLR7 in host resistance to primary infection with Trypanosoma cruziQ35147723
Exosomes: secreted vesicles and intercellular communicationsQ35161550
NADPH oxidase inhibition ameliorates Trypanosoma cruzi-induced myocarditis during Chagas diseaseQ35230292
Formation and remodeling of inositolphosphoceramide during differentiation of Trypanosoma cruzi from trypomastigote to amastigoteQ35612945
Glycoinositolphospholipid from Trypanosoma cruzi: structure, biosynthesis and immunobiology.Q35622904
Characterization of an immunodominant antigenic epitope from Trypanosoma cruzi as a biomarker of chronic Chagas' disease pathology.Q35739066
The Immune Response to Trypanosoma cruzi: Role of Toll-Like Receptors and Perspectives for Vaccine DevelopmentQ35838023
Antigenic variation in Trypanosoma brucei: facts, challenges and mysteriesQ35853298
Role of the Toll/interleukin-1 receptor signaling pathway in host resistance and pathogenesis during infection with protozoan parasites.Q35884180
Oxidative stress fuels Trypanosoma cruzi infection in miceQ36068270
Multigene families in Trypanosoma cruzi and their role in infectivityQ36156052
Desialylation of lysosomal membrane glycoproteins by Trypanosoma cruzi: a role for the surface neuraminidase in facilitating parasite entry into the host cell cytoplasm.Q36231609
Host cell invasion by trypanosomes requires lysosomes and microtubule/kinesin-mediated transportQ36237039
New approaches in vaccine development for parasitic infectionsQ36253622
The Trypanosoma cruzi-host-cell interplay: location, invasion, retentionQ36263007
North American import? Charting the origins of an enigmatic Trypanosoma cruzi domestic genotype.Q36348152
Role in host cell invasion of Trypanosoma cruzi-induced cytosolic-free Ca2+ transientsQ36362903
Lysosomal fusion is essential for the retention of Trypanosoma cruzi inside host cells.Q36399371
Trypanosoma cruzi surface mucins: host-dependent coat diversityQ36401388
Sequence diversity of the Trypanosoma cruzi complement regulatory protein familyQ36421495
Breaking the waves: improved detection of copy number variation from microarray-based comparative genomic hybridization.Q36465662
Protozoan encounters with Toll-like receptor signalling pathways: implications for host parasitism.Q36655907
Peroxiredoxins play a major role in protecting Trypanosoma cruzi against macrophage- and endogenously-derived peroxynitriteQ36740177
P407language of work or nameEnglishQ1860
P921main subjectTrypanosoma cruziQ150162
P304page(s)659
P577publication date2015-01-01
P1433published inFrontiers in ImmunologyQ27723748
P1476titleEvasion of the Immune Response by Trypanosoma cruzi during Acute Infection
P478volume6

Reverse relations

cites work (P2860)
Q39003990Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need
Q58799039Autoimmunity in Chronic Chagas Disease: A Road of Multiple Pathways to Cardiomyopathy?
Q39010376Biological factors that impinge on Chagas disease drug development
Q55364024CD86 Expression by Monocytes Influences an Immunomodulatory Profile in Asymptomatic Patients with Chronic Chagas Disease.
Q40110314Chagas disease: modulation of the inflammatory response by acetylcholinesterase in hematological cells and brain tissue.
Q91975356Circulating T Follicular Helper Cell Abnormalities Associated to Different Clinical Forms of Chronic Chagas Disease
Q99711499Comparative Analysis of the Secretome and Interactome of Trypanosoma cruzi and Trypanosoma rangeli Reveals Species Specific Immune Response Modulating Proteins
Q52364415Complement system contributes to modulate the infectivity of susceptible TcI strains of Trypanosoma cruzi.
Q93064937Cytosolic Fe-superoxide dismutase safeguards Trypanosoma cruzi from macrophage-derived superoxide radical
Q26740647Dendritic Cells: A Double-Edged Sword in Immune Responses during Chagas Disease
Q60047543Disease Tolerance and Pathogen Resistance Genes May Underlie Persistence and Differential Progression to Chagas Disease Cardiomyopathy
Q37256759Doxycycline and Benznidazole Reduce the Profile of Th1, Th2, and Th17 Chemokines and Chemokine Receptors in Cardiac Tissue from Chronic Trypanosoma cruzi-Infected Dogs
Q95933435Effect of the Tc13Tul antigen from Trypanosoma cruzi on splenocytes from naïve mice
Q89419160Evaluation of the immune response against Trypanosoma cruzi cytosolic tryparedoxin peroxidase in human natural infection
Q52660744Experimental Chagas disease-induced perturbations of the fecal microbiome and metabolome.
Q53683164Extracellular Vesicles Shed By Trypanosoma cruzi Potentiate Infection and Elicit Lipid Body Formation and PGE2 Production in Murine Macrophages.
Q55220925Extracellular Vesicles in Chagas Disease: A New Passenger for an Old Disease.
Q47138016Galectin-3: A Friend but Not a Foe during Trypanosoma cruzi Experimental Infection.
Q40429340Gene Expression Profiling and Functional Characterization of Macrophages in Response to Circulatory Microparticles Produced during Trypanosoma cruzi Infection and Chagas Disease.
Q40293929Immune complexes in chronic Chagas disease patients are formed by exovesicles from Trypanosoma cruzi carrying the conserved MASP N-terminal region
Q39325453Implication of Apoptosis for the Pathogenesis of Trypanosoma cruzi Infection
Q51148229Integrative Approaches to Understand the Mastery in Manipulation of Host Cytokine Networks by Protozoan Parasites with Emphasis on Plasmodium and Leishmania Species.
Q55188236Lipids From Trypanosoma cruzi Amastigotes of RA and K98 Strains Generate a Pro-inflammatory Response via TLR2/6.
Q58730645Molecular and cellular characterization of apoptosis in flat oyster a key mechanisms at the heart of host-parasite interactions
Q47381302Protective effect of aspirin treatment on mouse behavior in the acute phase of experimental infection with Trypanosoma cruzi.
Q37592659Protozoan Parasites and Type I IFNs
Q58865487Relevance of Trypanothione Reductase Inhibitors on Trypanosoma cruzi Infection: A Systematic Review, Meta-Analysis, and In Silico Integrated Approach
Q98465708The Interactions of Parasite Calreticulin With Initial Complement Components: Consequences in Immunity and Virulence
Q58705710The Unsolved Jigsaw Puzzle of the Immune Response in Chagas Disease
Q41619655Trypanosoma cruzi Evades the Complement System as an Efficient Strategy to Survive in the Mammalian Host: The Specific Roles of Host/Parasite Molecules and Trypanosoma cruzi Calreticulin
Q60932659Upregulation of Cardiac IL-10 and Downregulation of IFN- in Balb/c IL-4 in Acute Chagasic Myocarditis due to Colombian Strain of Trypanosoma cruzi

Search more.