| scholarly article | Q13442814 |
| P50 | author | Margaret A. Phillips | Q87687432 |
| P2093 | author name string | Suong Nguyen | |
| Chelsea Pratt | |||
| P2860 | cites work | SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis | Q21144510 |
| Structure and mechanism of spermidine synthases | Q24313105 | ||
| Phenotypic analysis of trypanothione synthetase knockdown in the African trypanosome | Q24537133 | ||
| Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods | Q24649110 | ||
| Regulation of glutathione synthesis | Q24655260 | ||
| Trypanosoma brucei gamma-glutamylcysteine synthetase. Characterization of the kinetic mechanism and the role of Cys-319 in cystamine inactivation. | Q38332894 | ||
| Characterization of Trypanosoma brucei gamma-glutamylcysteine synthetase, an essential enzyme in the biosynthesis of trypanothione (diglutathionylspermidine). | Q38355194 | ||
| Fully automated assay for total homocysteine, cysteine, cysteinylglycine, glutathione, cysteamine, and 2-mercaptopropionylglycine in plasma and urine. | Q42543216 | ||
| The role of the glycine triad in human glutathione synthetase | Q42704684 | ||
| Continuous cultivation of Trypanosoma brucei blood stream forms in a medium containing a low concentration of serum protein without feeder cell layers | Q43435078 | ||
| Genetic analysis of spermidine synthase from Leishmania donovani | Q43648965 | ||
| Overexpression of the putative thiol conjugate transporter TbMRPA causes melarsoprol resistance in Trypanosoma brucei | Q43936767 | ||
| Gene knockdown of gamma-glutamylcysteine synthetase by RNAi in the parasitic protozoa Trypanosoma brucei demonstrates that it is an essential enzyme | Q44530879 | ||
| Function of conserved residues of human glutathione synthetase: implications for the ATP-grasp enzymes | Q44780535 | ||
| An RNA ligase essential for RNA editing and survival of the bloodstream form of Trypanosoma brucei | Q46859677 | ||
| Drug target validation of the trypanothione pathway enzymes through metabolic modelling | Q48051536 | ||
| In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei | Q58850283 | ||
| Inhibition of Trypanosoma brucei gene expression by RNA interference using an integratable vector with opposing T7 promoters | Q73025256 | ||
| Leishmania trypanothione synthetase-amidase structure reveals a basis for regulation of conflicting synthetic and hydrolytic activities | Q24655332 | ||
| Structure of Trypanosoma brucei glutathione synthetase: Domain and loop alterations in the catalytic cycle of a highly conserved enzyme | Q27658837 | ||
| Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography | Q27671819 | ||
| Hgt1p, a high affinity glutathione transporter from the yeast Saccharomyces cerevisiae. | Q27933589 | ||
| The spermidine synthase of the malaria parasite Plasmodium falciparum: molecular and biochemical characterisation of the polyamine synthesis enzyme | Q27974262 | ||
| Allosteric activation of trypanosomatid deoxyhypusine synthase by a catalytically dead paralog | Q28119052 | ||
| Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress | Q28144631 | ||
| Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism | Q28275518 | ||
| Aminopropyltransferases: function, structure and genetics | Q28293007 | ||
| Reaction mechanism of glutathione synthetase from Arabidopsis thaliana: site-directed mutagenesis of active site residues | Q28298991 | ||
| Regulated expression of an essential allosteric activator of polyamine biosynthesis in African trypanosomes | Q28473800 | ||
| Diverse effects on mitochondrial and nuclear functions elicited by drugs and genetic knockdowns in bloodstream stage Trypanosoma brucei | Q28473842 | ||
| A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei | Q29617358 | ||
| Investigation of trypanothione reductase as a drug target in Trypanosoma brucei | Q30897674 | ||
| Functional significance of eIF5A and its hypusine modification in eukaryotes | Q33691772 | ||
| Serum glutathione in adolescent males predicts parental coronary heart disease | Q33881955 | ||
| Galactose metabolism is essential for the African sleeping sickness parasite Trypanosoma brucei | Q34027098 | ||
| Design, synthesis and biological evaluation of Trypanosoma brucei trypanothione synthetase inhibitors | Q34097455 | ||
| Clinical features, diagnosis, and treatment of human African trypanosomiasis (sleeping sickness). | Q34319076 | ||
| Allosteric regulation of an essential trypanosome polyamine biosynthetic enzyme by a catalytically dead homolog | Q35850113 | ||
| Plasticity in chromosome number and testing of essential genes in Leishmania by targeting | Q36117098 | ||
| Kinetoplastids: related protozoan pathogens, different diseases | Q36513308 | ||
| Trypanosoma brucei S-adenosylmethionine decarboxylase N terminus is essential for allosteric activation by the regulatory subunit prozyme | Q36620918 | ||
| Current status of the polyamine research field | Q36838564 | ||
| Product feedback regulation implicated in translational control of the Trypanosoma brucei S-adenosylmethionine decarboxylase regulatory subunit prozyme | Q37167161 | ||
| RNA interference-mediated silencing of ornithine decarboxylase and spermidine synthase genes in Trypanosoma brucei provides insight into regulation of polyamine biosynthesis | Q37191005 | ||
| Mammalian polyamine metabolism and function | Q37365983 | ||
| Polyamine catabolism and disease | Q37372519 | ||
| Radioprotection by glutathione ester: transport of glutathione ester into human lymphoid cells and fibroblasts | Q37560726 | ||
| Targeting Trypanothione Metabolism in Trypanosomatid Human Parasites | Q37782110 | ||
| Potential new drugs for human African trypanosomiasis: some progress at last | Q37789134 | ||
| State of the art in African trypanosome drug discovery | Q37852737 | ||
| Regulation and function of polyamines in African trypanosomes | Q37970853 | ||
| Lysine-69 plays a key role in catalysis by ornithine decarboxylase through acceleration of the Schiff base formation, decarboxylation, and product release steps | Q38319755 | ||
| P4510 | describes a project that uses | ImageJ | Q1659584 |
| P433 | issue | 5 | |
| P921 | main subject | Trypanosoma brucei | Q33244 |
| P304 | page(s) | 614-624 | |
| P577 | publication date | 2014-03-07 | |
| P1433 | published in | Eukaryotic Cell | Q5408685 |
| P1476 | title | Genetic validation of Trypanosoma brucei glutathione synthetase as an essential enzyme | |
| P478 | volume | 13 |
| Q47414193 | Buthionine sulfoximine is a multitarget inhibitor of trypanothione synthesis in Trypanosoma cruzi |
| Q35925923 | Deoxyhypusine Modification of Eukaryotic Translation Initiation Factor 5A (eIF5A) Is Essential for Trypanosoma brucei Growth and for Expression of Polyprolyl-containing Proteins |
| Q33898663 | Essential multimeric enzymes in kinetoplastid parasites: A host of potentially druggable protein-protein interactions |
| Q35998332 | GMP synthase is essential for viability and infectivity of Trypanosoma brucei despite a redundant purine salvage pathway. |
| Q40275251 | Identification of Trypanosoma brucei AdoMetDC Inhibitors Using a High-Throughput Mass Spectrometry-Based Assay. |
| Q58544813 | Polyamines in protozoan pathogens |
| Q28553225 | Pyrimidine Salvage Enzymes Are Essential for De Novo Biosynthesis of Deoxypyrimidine Nucleotides in Trypanosoma brucei |
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