scholarly article | Q13442814 |
P50 | author | Andrea Ilari | Q43021315 |
Gianni Colotti | Q43433196 | ||
P2093 | author name string | Alberto Boffi | |
Annarita Fiorillo | |||
Paola Baiocco | |||
Elena Poser | |||
Francesco Di Chiaro | |||
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Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography | Q27671819 | ||
Synthesis and characterization of a pyridine-2-thiol N-oxide gold(I) complex with potent antiproliferative effect against Trypanosoma cruzi and Leishmania sp. insight into its mechanism of action | Q39861737 | ||
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Education is key to controlling visceral leishmaniasis | Q42942572 | ||
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Synthesis, inhibition potency, binding mode, and antiprotozoal activities of fluorescent inhibitors of trypanothione reductase based on mepacrine-conjugated diaryl sulfide scaffolds | Q43256895 | ||
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In vitro evaluation of the effectiveness and cytotoxicity of meglumine antimoniate microspheres produced by spray drying against Leishmania infantum | Q46751240 | ||
Evidence that the High Incidence of Treatment Failures in Indian Kala‐Azar Is Due to the Emergence of Antimony‐Resistant Strains ofLeishmania donovani | Q56781882 | ||
Improved Inhibitors of Trypanothione Reductase by Combination of Motifs: Synthesis, Inhibitory Potency, Binding Mode, and Antiprotozoal Activities | Q58848500 | ||
Rational design of selective ligands for trypanothione reductase fromtrypanosoma cruzStructural effects on the inhibition by dibenzazepines based on imipramine | Q58850207 | ||
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Crystal Structure of Reduced and of Oxidized Peroxiredoxin IV Enzyme Reveals a Stable Oxidized Decamer and a Non-disulfide-bonded Intermediate in the Catalytic Cycle | Q27675001 | ||
Inhibitory Effect of Silver Nanoparticles on Trypanothione Reductase Activity and Leishmania infantum Proliferation | Q27684102 | ||
Inhibition of Leishmania infantum trypanothione reductase by azole-based compounds: a comparative analysis with its physiological substrate by X-ray crystallography | Q27684748 | ||
Substrate binding and catalysis by glutathione reductase as derived from refined enzyme: substrate crystal structures at 2 A resolution | Q27700157 | ||
Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress | Q28144631 | ||
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Clinical pharmacology of gold | Q28282618 | ||
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Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids | Q28306157 | ||
Unresponsiveness to Glucantime treatment in Iranian cutaneous leishmaniasis due to drug-resistant Leishmania tropica parasites | Q28468760 | ||
Molecular dynamics reveal binding mode of glutathionylspermidine by trypanothione synthetase | Q28486718 | ||
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Comparative genomics of trypanosomatid parasitic protozoa | Q29617953 | ||
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Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate | Q30802015 | ||
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Kinetics and Redox-Sensitive Oligomerisation Reveal Negative Subunit Cooperativity in Tryparedoxin Peroxidase of Trypanosoma brucei brucei | Q30932104 | ||
Spread of vector-borne diseases and neglect of Leishmaniasis, Europe | Q31161304 | ||
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Targeting Trypanothione Metabolism in Trypanosomatid Human Parasites | Q37782110 | ||
The trypanothione system and the opportunities it offers to create drugs for the neglected kinetoplast diseases | Q37881219 | ||
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Cytotoxicity of (2,2':6',2''-terpyridine)platinum(II) complexes to Leishmania donovani, Trypanosoma cruzi, and Trypanosoma brucei | Q39191259 | ||
P433 | issue | 15 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | 1861-1875 | |
P577 | publication date | 2013-10-01 | |
P1433 | published in | Future Medicinal Chemistry | Q19280078 |
P1476 | title | Structural insights into the enzymes of the trypanothione pathway: targets for antileishmaniasis drugs | |
P478 | volume | 5 |
Q37546985 | Arginase Is Essential for Survival of Leishmania donovani Promastigotes but Not Intracellular Amastigotes |
Q39329032 | Foreword. Trypanosomatid disease drug discovery and target identification |
Q64249811 | Future Prospects in the Treatment of Parasitic Diseases: 2-Amino-1,3,4-Thiadiazoles in Leishmaniasis |
Q92864476 | GDP-Mannose Pyrophosphorylase: A Biologically Validated Target for Drug Development Against Leishmaniasis |
Q60312595 | Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening |
Q41627520 | Improved orthologous databases to ease protozoan targets inference |
Q36252376 | Inhibition of Leishmania infantum trypanothione reductase by diaryl sulfide derivatives |
Q93126792 | Leishmania mexicana Trypanothione Reductase Inhibitors: Computational and Biological Studies |
Q96304575 | Leishmanicidal Potential of Hardwickiic Acid Isolated From Croton sylvaticus |
Q36263511 | Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity |
Q38891993 | Novel Heteroaryl Selenocyanates and Diselenides as Potent Antileishmanial Agents. |
Q38783627 | Polyamine-trypanothione pathway: an update. |
Q27011766 | Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis |
Q27702048 | Structural insights into the novel inhibition mechanism of Trypanosoma cruzi spermidine synthase |
Q40396694 | Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking |
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