review article | Q7318358 |
scholarly article | Q13442814 |
P50 | author | Tâp Ha-Duong | Q58883403 |
P2093 | author name string | Philippe M Loiseau | |
Wei Mao | |||
Sébastien Pomel | |||
Christian Cavé | |||
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Recent developments and future prospects in the treatment of visceral leishmaniasis | Q26740563 | ||
Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase | Q27617894 | ||
Structure, mechanism and engineering of a nucleotidylyltransferase as a first step toward glycorandomization | Q27632060 | ||
Kinetic and crystallographic analyses support a sequential-ordered bi bi catalytic mechanism for Escherichia coli glucose-1-phosphate thymidylyltransferase | Q27636040 | ||
Structural Insights into the Catalytic Mechanism of Bacterial Guanosine-diphospho-D-mannose Pyrophosphorylase and Its Regulation by Divalent Ions | Q27662663 | ||
A quaternary mechanism enables the complex biological functions of octameric human UDP-glucose pyrophosphorylase, a key enzyme in cell metabolism | Q27700173 | ||
Disruption of mannose activation in Leishmania mexicana: GDP-mannose pyrophosphorylase is required for virulence, but not for viability | Q28343727 | ||
Purification and characterization of phosphomannose isomerase-guanosine diphospho-D-mannose pyrophosphorylase. A bifunctional enzyme in the alginate biosynthetic pathway of Pseudomonas aeruginosa | Q28493068 | ||
Cloning, expression and characterization of the pig liver GDP-mannose pyrophosphorylase. Evidence that GDP-mannose and GDP-Glc pyrophosphorylases are different proteins | Q28610118 | ||
Drug resistance in leishmaniasis | Q29616242 | ||
Inhibitors of Leishmania GDP-mannose pyrophosphorylase identified by high-throughput screening of small-molecule chemical library | Q33531622 | ||
Biochemical analysis of leishmanial and human GDP-Mannose Pyrophosphorylases and selection of inhibitors as new leads. | Q33677834 | ||
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Crystal structure of potato tuber ADP-glucose pyrophosphorylase | Q33868406 | ||
Efficacy of orally administered 2-substituted quinolines in experimental murine cutaneous and visceral leishmaniases | Q34228220 | ||
Glycolysis as a target for the design of new anti-trypanosome drugs. | Q34341037 | ||
Glycan-based interactions involving vertebrate sialic-acid-recognizing proteins | Q34623034 | ||
Genetic characterization of glucose transporter function in Leishmania mexicana | Q34918589 | ||
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Leishmaniasis--current chemotherapy and recent advances in the search for novel drugs | Q35569073 | ||
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Preliminary crystallographic analysis of ADP-glucose pyrophosphorylase from Agrobacterium tumefaciens | Q35950572 | ||
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The enemy within: Targeting host-parasite interaction for antileishmanial drug discovery | Q36395995 | ||
Mutations in GMPPA cause a glycosylation disorder characterized by intellectual disability and autonomic dysfunction | Q37217021 | ||
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Structural insights into the enzymes of the trypanothione pathway: targets for antileishmaniasis drugs. | Q38154346 | ||
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In silico analysis of a therapeutic target in Leishmania infantum: the guanosine-diphospho-D-mannose pyrophosphorylase | Q39362912 | ||
Leishmaniasis drug discovery: recent progress and challenges in assay development | Q39396336 | ||
Comparative study of structural models of Leishmania donovani and human GDP-mannose pyrophosphorylases | Q40327849 | ||
Characterisation of a Leishmania mexicana knockout lacking guanosine diphosphate-mannose pyrophosphorylase | Q40413373 | ||
Identification and characterization of a thermostable bifunctional enzyme with phosphomannose isomerase and sugar-1-phosphate nucleotidylyltransferase activities from a hyperthermophilic archaeon, Pyrococcus horikoshii OT3. | Q40625411 | ||
Molecular targets and pathways for the treatment of visceral leishmaniasis | Q41997195 | ||
In vitro activities of new 2-substituted quinolines against Leishmania donovani | Q42054263 | ||
Antileishmanial activity of a formulation of 2-n-propylquinoline by oral route in mice model | Q42147223 | ||
Functional characterization of GDP-mannose pyrophosphorylase from Leptospira interrogans serovar Copenhageni | Q43207628 | ||
GDP-mannose pyrophosphorylase is essential in the bloodstream form of Trypanosoma brucei | Q43240478 | ||
Bifunctional phosphomannose isomerase/GDP-D-mannose pyrophosphorylase is the point of control for GDP-D-mannose biosynthesis in Helicobacter pylori | Q44002040 | ||
Properties of GDP-mannose pyrophosphorylase, a critical enzyme and drug target in Leishmania mexicana | Q44725322 | ||
Design, synthesis, and evaluation of inhibitors of trypanosomal and leishmanial dihydrofolate reductase | Q46332821 | ||
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GDP-mannose pyrophosphorylase is essential for cell wall integrity, morphogenesis and viability of Aspergillus fumigatus | Q46403488 | ||
Functional analysis of the Burkholderia cenocepacia J2315 BceAJ protein with phosphomannose isomerase and GDP-D-mannose pyrophosphorylase activities | Q46454276 | ||
Simple and efficient synthesis of 5'-aryl-5'-deoxyguanosine analogs by azide-alkyne click reaction and their antileishmanial activities | Q47195828 | ||
The activity of 2-substituted quinoline alkaloids in BALB/c mice infected with Leishmania donovani. | Q47339496 | ||
A specialized pathway affecting virulence glycoconjugates of Leishmania | Q48070473 | ||
Glycosylation deficiency phenotypes resulting from depletion of GDP-mannose pyrophosphorylase in two yeast species. | Q50511620 | ||
Deciphering the kinetic mechanisms controlling selected plant ADP-glucose pyrophosphorylases. | Q51057244 | ||
Identification of amino acid residues involved in the activity of phosphomannose isomerase-guanosine 5'-diphospho-D-mannose pyrophosphorylase. A bifunctional enzyme in the alginate biosynthetic pathway of Pseudomonas aeruginosa. | Q54640047 | ||
Ornithine Decarboxylase Gene Deletion Mutants ofLeishmania donovani | Q58850167 | ||
Properties of uridine diphosphate glucose pyrophosphorylase from Golgi apparatus of liver | Q70183501 | ||
GDP-mannose pyrophosphorylase. Purification to homogeneity, properties, and utilization to prepare photoaffinity analogs | Q72090887 | ||
Purification and properties of mycobacterial GDP-mannose pyrophosphorylase | Q78171805 | ||
P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
P921 | main subject | leishmaniasis | Q331283 |
nucleotidyltransferase | Q408939 | ||
Leishmania | Q524818 | ||
antiprotozoal | Q582559 | ||
drug development | Q2198549 | ||
P304 | page(s) | 186 | |
P577 | publication date | 2019-05-31 | |
P1433 | published in | Frontiers in Cellular and Infection Microbiology | Q27724376 |
P1476 | title | GDP-Mannose Pyrophosphorylase: A Biologically Validated Target for Drug Development Against Leishmaniasis | |
P478 | volume | 9 |
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