GDP-Mannose Pyrophosphorylase: A Biologically Validated Target for Drug Development Against Leishmaniasis

scientific article published on 31 May 2019

GDP-Mannose Pyrophosphorylase: A Biologically Validated Target for Drug Development Against Leishmaniasis is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3389/FCIMB.2019.00186
P932PMC publication ID6554559
P698PubMed publication ID31214516

P50authorTâp Ha-DuongQ58883403
P2093author name stringPhilippe M Loiseau
Wei Mao
Sébastien Pomel
Christian Cavé
P2860cites workMutations in GDP-mannose pyrophosphorylase B cause congenital and limb-girdle muscular dystrophies associated with hypoglycosylation of α-dystroglycanQ24294992
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A quaternary mechanism enables the complex biological functions of octameric human UDP-glucose pyrophosphorylase, a key enzyme in cell metabolismQ27700173
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Purification and characterization of phosphomannose isomerase-guanosine diphospho-D-mannose pyrophosphorylase. A bifunctional enzyme in the alginate biosynthetic pathway of Pseudomonas aeruginosaQ28493068
Cloning, expression and characterization of the pig liver GDP-mannose pyrophosphorylase. Evidence that GDP-mannose and GDP-Glc pyrophosphorylases are different proteinsQ28610118
Drug resistance in leishmaniasisQ29616242
Inhibitors of Leishmania GDP-mannose pyrophosphorylase identified by high-throughput screening of small-molecule chemical libraryQ33531622
Biochemical analysis of leishmanial and human GDP-Mannose Pyrophosphorylases and selection of inhibitors as new leads.Q33677834
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Crystal structure of potato tuber ADP-glucose pyrophosphorylaseQ33868406
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Glycolysis as a target for the design of new anti-trypanosome drugs.Q34341037
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In vitro and in vivo antileishmanial efficacy of a new nitrilquinoline against Leishmania donovaniQ39292527
In silico analysis of a therapeutic target in Leishmania infantum: the guanosine-diphospho-D-mannose pyrophosphorylaseQ39362912
Leishmaniasis drug discovery: recent progress and challenges in assay developmentQ39396336
Comparative study of structural models of Leishmania donovani and human GDP-mannose pyrophosphorylasesQ40327849
Characterisation of a Leishmania mexicana knockout lacking guanosine diphosphate-mannose pyrophosphorylaseQ40413373
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Functional characterization of GDP-mannose pyrophosphorylase from Leptospira interrogans serovar CopenhageniQ43207628
GDP-mannose pyrophosphorylase is essential in the bloodstream form of Trypanosoma bruceiQ43240478
Bifunctional phosphomannose isomerase/GDP-D-mannose pyrophosphorylase is the point of control for GDP-D-mannose biosynthesis in Helicobacter pyloriQ44002040
Properties of GDP-mannose pyrophosphorylase, a critical enzyme and drug target in Leishmania mexicanaQ44725322
Design, synthesis, and evaluation of inhibitors of trypanosomal and leishmanial dihydrofolate reductaseQ46332821
Drug resistance and treatment failure in leishmaniasis: A 21st century challenge.Q46380663
GDP-mannose pyrophosphorylase is essential for cell wall integrity, morphogenesis and viability of Aspergillus fumigatusQ46403488
Functional analysis of the Burkholderia cenocepacia J2315 BceAJ protein with phosphomannose isomerase and GDP-D-mannose pyrophosphorylase activitiesQ46454276
Simple and efficient synthesis of 5'-aryl-5'-deoxyguanosine analogs by azide-alkyne click reaction and their antileishmanial activitiesQ47195828
The activity of 2-substituted quinoline alkaloids in BALB/c mice infected with Leishmania donovani.Q47339496
A specialized pathway affecting virulence glycoconjugates of LeishmaniaQ48070473
Glycosylation deficiency phenotypes resulting from depletion of GDP-mannose pyrophosphorylase in two yeast species.Q50511620
Deciphering the kinetic mechanisms controlling selected plant ADP-glucose pyrophosphorylases.Q51057244
Identification of amino acid residues involved in the activity of phosphomannose isomerase-guanosine 5'-diphospho-D-mannose pyrophosphorylase. A bifunctional enzyme in the alginate biosynthetic pathway of Pseudomonas aeruginosa.Q54640047
Ornithine Decarboxylase Gene Deletion Mutants ofLeishmania donovaniQ58850167
Properties of uridine diphosphate glucose pyrophosphorylase from Golgi apparatus of liverQ70183501
GDP-mannose pyrophosphorylase. Purification to homogeneity, properties, and utilization to prepare photoaffinity analogsQ72090887
Purification and properties of mycobacterial GDP-mannose pyrophosphorylaseQ78171805
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P921main subjectleishmaniasisQ331283
nucleotidyltransferaseQ408939
LeishmaniaQ524818
antiprotozoalQ582559
drug developmentQ2198549
P304page(s)186
P577publication date2019-05-31
P1433published inFrontiers in Cellular and Infection MicrobiologyQ27724376
P1476titleGDP-Mannose Pyrophosphorylase: A Biologically Validated Target for Drug Development Against Leishmaniasis
P478volume9

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