Inhibitors of Trypanosoma brucei trypanothione reductase: comparative molecular field analysis modeling and structural basis for selective inhibition.

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Inhibitors of Trypanosoma brucei trypanothione reductase: comparative molecular field analysis modeling and structural basis for selective inhibition. is …
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scholarly articleQ13442814

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P356DOI10.4155/FMC.13.140
P698PubMed publication ID24144411

P50authorLeonardo G FerreiraQ83166751
P2093author name stringAdriano D Andricopulo
P2860cites workRedox-active antiparasitic drugsQ37961952
Update on field use of the available drugs for the chemotherapy of human African trypanosomiasisQ37981773
The trypanothione system and its implications in the therapy of trypanosomatid diseasesQ38034314
Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activityQ41824183
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An alternative form of melarsoprol in sleeping sicknessQ46219228
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Synthesis and evaluation of substrate analogue inhibitors of trypanothione reductase.Q54348844
Principles of QSAR models validation: internal and externalQ56432346
Development and use of quantum mechanical molecular models. 76. AM1: a new general purpose quantum mechanical molecular modelQ26778456
Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein CrystallographyQ27671819
The bacterial redox signaller pyocyanin as an antiplasmodial agent: comparisons with its thioanalog methylene blueQ27672885
Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stressQ28144631
The global burden of neglected tropical diseasesQ28259482
Neglected tropical diseasesQ28267545
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolismQ28275518
Dyes, trypanosomiasis and DNA: a historical and critical reviewQ28298491
Best Practices for QSAR Model Development, Validation, and ExploitationQ28649930
Investigation of trypanothione reductase as a drug target in Trypanosoma bruceiQ30897674
Insights into the redox biology of Trypanosoma cruzi: Trypanothione metabolism and oxidant detoxificationQ37202974
Chemotherapy against human African trypanosomiasis: is there a road to success?Q37801690
State of the art in African trypanosome drug discoveryQ37852737
Human African trypanosomiasis: a review of non-endemic cases in the past 20 years.Q37891323
Drug resistance in human African trypanosomiasisQ37940573
P433issue15
P921main subjectTrypanosoma bruceiQ33244
P304page(s)1753-1762
P577publication date2013-10-01
P1433published inFuture Medicinal ChemistryQ19280078
P1476titleInhibitors of Trypanosoma brucei trypanothione reductase: comparative molecular field analysis modeling and structural basis for selective inhibition
P478volume5

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cites work (P2860)
Q38668657Combined HQSAR, topomer CoMFA, homology modeling and docking studies on triazole derivatives as SGLT2 inhibitors
Q45943914Development of Predictive QSAR Models of 4-Thiazolidinones Antitrypanosomal Activity using Modern Machine Learning Algorithms.
Q39329032Foreword. Trypanosomatid disease drug discovery and target identification

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