Hepcidin and Host Defense against Infectious Diseases

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Hepcidin and Host Defense against Infectious Diseases is …
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review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.1004998
P3181OpenCitations bibliographic resource ID1381483
P932PMC publication ID4546197
P698PubMed publication ID26291319
P5875ResearchGate publication ID281171235

P50authorTomas GanzQ15059118
Kathryn MichelsQ56488049
Borna MehradQ41554549
P2093author name stringElizabeta Nemeth
P2860cites workHepcidin protects against lipopolysaccharide-induced liver injury in a mouse model of obstructive jaundice.Q54338584
Molecular mechanism of hepcidin-mediated ferroportin internalization requires ferroportin lysines, not tyrosines or JAK-STAT.Q54505590
Hepcidin regulation by innate immune and infectious stimuliQ59401841
C282Y mutation and hepatic iron status in hepatitis C and cryptogenic cirrhosisQ73191778
Intraphagosomal Mycobacterium tuberculosis acquires iron from both extracellular transferrin and intracellular iron pools. Impact of interferon-gamma and hemochromatosisQ78425267
Hepatitis C, iron status, and disease severity: relationship with HFE mutationsQ78854372
Hereditary hemochromatosis results in decreased iron acquisition and growth by Mycobacterium tuberculosis within human macrophagesQ79234100
Increased hepcidin expression and hypoferraemia associated with an acute phase response are not affected by inactivation of HFEQ80348512
The origin and spread of the HFE-C282Y haemochromatosis mutationQ80409591
Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPSQ81734651
Hepcidin expression and iron transport in alveolar macrophagesQ83221889
LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activityQ24290410
Hepcidin, a urinary antimicrobial peptide synthesized in the liverQ24290609
Interleukin-6 induces hepcidin expression through STAT3Q24296906
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalizationQ24310115
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expressionQ24316099
The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulationQ24338877
Severe iron deficiency anemia in transgenic mice expressing liver hepcidinQ24536163
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidinQ24568204
Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in miceQ24617847
Iron, anemia and hepcidin in malariaQ26828803
Fungal iron availability during deep seated candidiasis is defined by a complex interplay involving systemic and local eventsQ27332296
Hepcidin expression in the liver: relatively low level in patients with chronic hepatitis CQ27478403
The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosisQ27639413
Multicentric origin of hemochromatosis gene (HFE) mutationsQ28139525
Associations of iron overload in Africa with hepatocellular carcinoma and tuberculosis: Strachan's 1929 thesis revisited.Q51036431
Blunted hepcidin response to inflammation in the absence of Hfe and transferrin receptor 2.Q52607006
A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overloadQ28139987
Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase proteinQ28214986
Identification of erythroferrone as an erythroid regulator of iron metabolismQ28240988
HLA haplotype map of river valley populations with hemochromatosis traced through five centuries in Central SwedenQ28273833
The serine protease TMPRSS6 is required to sense iron deficiencyQ28278593
Suppression of hepcidin expression and iron overload mediate Salmonella susceptibility in ankyrin 1 ENU-induced mutantQ28505375
Targeted disruption of hepcidin in the liver recapitulates the hemochromatotic phenotypeQ28510894
Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout miceQ28586797
A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidinQ28590264
Balancing acts: molecular control of mammalian iron metabolismQ29620380
The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammationQ29620394
The battle for iron between bacterial pathogens and their vertebrate hostsQ33658687
Iron metabolism in pathogenic bacteria.Q33920195
Epidemic pathogenic selection: an explanation for hereditary hemochromatosis?Q33961191
Effects of iron overload on the immune systemQ34068469
Distinct patterns of hepcidin and iron regulation during HIV-1, HBV, and HCV infectionsQ34082628
Low hepcidin accounts for the proinflammatory status associated with iron deficiency.Q34188665
BMP type II receptors have redundant roles in the regulation of hepatic hepcidin gene expression and iron metabolismQ34293026
HFE gene and hereditary hemochromatosis: a HuGE review. Human Genome EpidemiologyQ34322947
Host-mediated regulation of superinfection in malariaQ34356504
Hepcidin regulation by BMP signaling in macrophages is lipopolysaccharide dependent.Q34427185
Silencing airway epithelial cell-derived hepcidin exacerbates sepsis induced acute lung injuryQ34570105
Iron availability and infectionQ34803576
Targeting iron acquisition blocks infection with the fungal pathogens Aspergillus fumigatus and Fusarium oxysporumQ34819468
Iron levels in hepatocytes and portal tract cells predict progression and outcomes of patients with advanced chronic hepatitis C.Q34851479
A strong anti-inflammatory signature revealed by liver transcription profiling of Tmprss6-/- mice.Q34903557
Interleukin-10 regulates hepcidin in Plasmodium falciparum malariaQ35092820
The IL-6- and lipopolysaccharide-induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta 2-microglobulin-deficient hepatocytesQ35316703
Inflammation-induced hepcidin-25 is associated with the development of anemia in septic patients: an observational studyQ35567161
Iron deficiency protects against severe Plasmodium falciparum malaria and death in young childrenQ35845332
Hepcidin demonstrates a biphasic association with anemia in acute Plasmodium falciparum malariaQ36366599
Iron depletion limits intracellular bacterial growth in macrophagesQ36787471
The effect of the host's iron status on tuberculosisQ36816940
The iron export protein ferroportin 1 is differentially expressed in mouse macrophage populations and is present in the mycobacterial-containing phagosome.Q36838527
Association of hemochromatosis with infectious diseases: expanding spectrumQ36864775
Survival advantage of the hemochromatosis C282Y mutationQ37056091
Reduced serum hepcidin levels in patients with chronic hepatitis C.Q37387659
Absence of functional Hfe protects mice from invasive Salmonella enterica serovar Typhimurium infection via induction of lipocalin-2.Q37398323
Leishmania-mediated inhibition of iron export promotes parasite replication in macrophages.Q37534221
Hepcidin induction by pathogens and pathogen-derived molecules is strongly dependent on interleukin-6Q37546397
Beyond anemia: hepcidin, monocytes and inflammationQ38073620
Dual stimulation with bacterial and viral components increases the expression of hepcidin in human monocytesQ38304822
Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infantsQ39244633
Bacterial cell wall constituents induce hepcidin expression in macrophages through MyD88 signalingQ39356682
Role of Ferroportin in Macrophage-Mediated ImmunityQ39656348
Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD.Q39881846
Attenuated inflammatory responses in hemochromatosis reveal a role for iron in the regulation of macrophage cytokine translationQ39953240
Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activityQ39955308
Expression and localization of hepcidin in macrophages: a role in host defense against tuberculosis.Q40112013
The iron efflux protein ferroportin regulates the intracellular growth of Salmonella entericaQ40290550
Assessment of urinary concentrations of hepcidin provides novel insight into disturbances in iron homeostasis during malarial infectionQ40404046
The effects on malaria of treatment of iron-deficiency anaemia with oral iron in Gambian childrenQ40777786
Distinct requirements for Hfe in basal and induced hepcidin levels in iron overload and inflammation.Q41370453
Hepcidin-induced hypoferremia is a critical host defense mechanism against the siderophilic bacterium Vibrio vulnificusQ41543544
Hepatic hepcidin protects against polymicrobial sepsis in mice by regulating host iron statusQ41723603
BMP6 is a key endogenous regulator of hepcidin expression and iron metabolismQ41871982
Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trialQ42170063
Inverse agonist of estrogen-related receptor γ controls Salmonella typhimurium infection by modulating host iron homeostasisQ42222690
TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogensQ42741793
Increased susceptibility to Mycobacterium avium in hemochromatosis protein HFE-deficient mice.Q42754682
Antimicrobial activity of human hepcidin 20 and 25 against clinically relevant bacterial strains: effect of copper and acidic pH.Q42936287
Hepatitis C virus core protein compromises iron-induced activation of antioxidants in mice and HepG2 cellsQ42995764
Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcriptionQ43047877
Decreased susceptibility to Plasmodium falciparum infection in pregnant women with iron deficiencyQ43944520
Low-dose daily iron supplementation for 12 months does not increase the prevalence of malarial infection or density of parasites in young Zanzibari childrenQ43948407
Iron supplementation increases prevalence and effects of malaria: report on clinical studies in Papua New GuineaQ44700727
Liver hepcidin mRNA correlates with iron stores, but not inflammation, in patients with chronic hepatitis C.Q45187496
The effect of hepatitis B virus infection on hepcidin expression in hepatitis B patientsQ45351134
Iron deficiency and malaria among children living on the coast of KenyaQ46411719
Iron deficiency influences the course of malaria in Plasmodium berghei infected mice.Q47830788
Plasmodium falciparum infected erythrocytes induce hepcidin (HAMP) mRNA synthesis by peripheral blood mononuclear cellsQ47913673
A critical role for phagocytosis in resistance to malaria in iron-deficient miceQ47977032
Hepcidin is regulated during blood-stage malaria and plays a protective role in malaria infectionQ47994913
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectinfectionQ166231
iron-responsive element-binding proteinQ3408230
membrane proteinQ423042
infectious diseaseQ18123741
antimicrobial cationic peptidesQ78188513
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)e1004998
P577publication date2015-08-01
2015-08-20
P1433published inPLOS PathogensQ283209
P1476titleHepcidin and Host Defense against Infectious Diseases
P478volume11