Tim-3 and Tim-4 as the potential targets for antitumor therapy

scientific article (publication date: 2015)

Tim-3 and Tim-4 as the potential targets for antitumor therapy is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1080/21645515.2015.1056953
P932PMC publication ID4635934
P698PubMed publication ID26211834

P2093author name stringZhihua Ruan
Lin Cheng
P2860cites workTIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells.Q24657708
The blockade of immune checkpoints in cancer immunotherapyQ27860852
CEACAM1 regulates TIM-3-mediated tolerance and exhaustionQ28115443
Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1Q28116224
Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene familyQ28207890
T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient miceQ30494990
Identification of Tim4 as a phosphatidylserine receptorQ33303850
Reversal of NK-cell exhaustion in advanced melanoma by Tim-3 blockadeQ33714165
RepSox slows decay of CD34+ acute myeloid leukemia cells and decreases T cell immunoglobulin mucin-3 expressionQ33816240
Autophagy inhibition enhances vorinostat-induced apoptosis via ubiquitinated protein accumulationQ33937865
Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunityQ34161493
Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+ T cell dysfunction in melanoma patientsQ34161579
Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escapeQ34241893
Tim-3 expression in cervical cancer promotes tumor metastasisQ34555771
Decreased galectin-9 and increased Tim-3 expression are related to poor prognosis in gastric cancerQ35067641
CD8(+) T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1.Q35783166
Tim-3 is an inducible human natural killer cell receptor that enhances interferon gamma production in response to galectin-9Q35876978
Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicityQ35909663
Upregulation of TIM-3 and PD-1 on CD4+ and CD8+ T Cells Associated with Dysfunction of Cell-Mediated Immunity after Colorectal Cancer OperationQ37055901
Combined TIM-3 blockade and CD137 activation affords the long-term protection in a murine model of ovarian cancerQ37368087
TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunityQ37763998
Autophagy as a target for anticancer therapyQ37876679
Tim-3, a negative regulator of anti-tumor immunityQ37973887
TIM-3 as a therapeutic target for malignant stem cells in acute myelogenous leukemiaQ38035447
The T-cell immunoglobulin and mucin domain (Tim) gene family in asthma, allergy, and autoimmunityQ38081296
TIM-3 as a novel therapeutic target for eradicating acute myelogenous leukemia stem cellsQ38138901
PD-1 and Tim-3 regulate the expansion of tumor antigen-specific CD8⁺ T cells induced by melanoma vaccinesQ38264346
Tim-3 fosters HCC development by enhancing TGF-β-mediated alternative activation of macrophages.Q38917897
Blocked autophagy sensitizes resistant carcinoma cells to radiation therapyQ40006232
Macroautophagy inhibition sensitizes tamoxifen-resistant breast cancer cells and enhances mitochondrial depolarizationQ40028670
Tumor-induced senescent T cells promote the secretion of pro-inflammatory cytokines and angiogenic factors by human monocytes/macrophages through a mechanism that involves Tim-3 and CD40L.Q41904511
Tim-3 expression in tumour-associated macrophages: a new player in HCC progressionQ42161787
The expression of Tim-3 in peripheral blood of ovarian cancerQ42272038
Genetic variations of PD1 and TIM3 are differentially and interactively associated with the development of cirrhosis and HCC in patients with chronic HBV infectionQ42280004
Prognostic value of T cell immunoglobulin mucin-3 in prostate cancerQ42281463
Tumor immunity times out: TIM-3 and HMGB1.Q43141630
Ectopic expression of TIM-3 in lung cancers: a potential independent prognostic factor for patients with NSCLC.Q43529147
TIM-4 glycoprotein-mediated degradation of dying tumor cells by autophagy leads to reduced antigen presentation and increased immune toleranceQ44110792
T-cell immunoglobulin- and mucin-domain-containing molecule 3 gene polymorphisms and prognosis of non-small-cell lung cancerQ44642609
TIM-3 is a promising target to selectively kill acute myeloid leukemia stem cellsQ45077632
Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma.Q45358316
Combined blockade of TIM-3 and TIM-4 augments cancer vaccine efficacy against established melanomas.Q45988106
T cell immunoglobulin- and mucin-domain-containing molecule 3 gene polymorphisms and susceptibility to pancreatic cancer.Q54303561
T-cell immunoglobulin- and mucin-domain-containing molecule 3 gene polymorphisms and renal cell carcinomaQ83799126
Genetic variations and haplotypes in TIM-3 gene and the risk of gastric cancerQ84974532
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)2458-62
P577publication date2015-01-01
P1433published inHuman Vaccines & ImmunotherapeuticsQ21072749
P1476titleTim-3 and Tim-4 as the potential targets for antitumor therapy
P478volume11

Reverse relations

cites work (P2860)
Q48614611Concordant bone marrow involvement of diffuse large B-cell lymphoma represents a distinct clinical and biological entity in the era of immunotherapy.
Q92783939Development of a protein-based system for transient epigenetic repression of immune checkpoint molecule and enhancement of antitumour activity of natural killer cells
Q41672129Effects of Tim-3 silencing on the viability of fibroblast-like synoviocytes and lipopolysaccharide-induced inflammatory reactions
Q26769884Novel cancer antigens for personalized immunotherapies: latest evidence and clinical potential
Q89685712T lymphocyte-targeted immune checkpoint modulation in glioma
Q58558279TIM-3, a promising target for cancer immunotherapy
Q90725991TLR-3 Stimulation Skews M2 Macrophages to M1 Through IFN-αβ Signaling and Restricts Tumor Progression
Q50119256The Potential Role of Inhibitory Receptors in the Treatment of Psoriasis
Q38699771The significance of TIMD4 expression in clear cell renal cell carcinoma
Q40137306Tim-3 as a diagnostic and prognostic biomarker of osteosarcoma
Q92001030Tim-4 in Health and Disease: Friend or Foe?
Q50698174[Effect of inhibiting TIM-4 function in Kupffer cells on liver graft rejection in mice].

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