Upregulation of TIM-3 and PD-1 on CD4+ and CD8+ T Cells Associated with Dysfunction of Cell-Mediated Immunity after Colorectal Cancer Operation

scientific article published on March 2012

Upregulation of TIM-3 and PD-1 on CD4+ and CD8+ T Cells Associated with Dysfunction of Cell-Mediated Immunity after Colorectal Cancer Operation is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID3727487
P698PubMed publication ID24031134

P2093author name stringHiroaki Saito
Yosuke Arai
Masahide Ikeguchi
P2860cites workNegative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cellsQ37333944
The perioperative period is an underutilized window of therapeutic opportunity in patients with colorectal cancerQ37456058
Detection of disseminated colorectal cancer cells in lymph nodes, blood and bone marrow.Q40803208
Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trialQ42656476
The long-term results of a randomized clinical trial of laparoscopy-assisted versus open surgery for colon cancerQ42660407
Downregulation of T helper type 1 immune response and altered pro-inflammatory and anti-inflammatory T cell cytokine balance following conventional but not laparoscopic surgeryQ42692798
Role of circulating tumour cells in predicting recurrence after excision of primary colorectal carcinomaQ48650456
Surgical stress induces a shift in the type-1/type-2 T-helper cell balance, suggesting down-regulation of cell-mediated and up-regulation of antibody-mediated immunity commensurate to the traumaQ50167363
Altered helper and suppressor lymphocyte populations in surgical patients. A measure of postoperative immunosuppressionQ50183810
Detection of hematogenous tumor cell dissemination predicts tumor relapse in patients undergoing surgical resection of colorectal liver metastases.Q54685064
Intra-abdominal activation of a local inflammatory response within the human muscularis externa during laparotomy.Q54786399
B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progressionQ57997549
Laparoscopic surgery versus open surgery for colon cancer: short-term outcomes of a randomised trialQ61866769
Depression of cellular immunity after major injury. Its association with posttraumatic complications and its reversal with immunomodulationQ69585266
The significance of changes in blood lymphocyte populations following surgical operationsQ72812153
Suppression of cellular immunity by surgical stressQ73545815
Immunological effects of laparoscopic vs open colorectal surgery: a prospective clinical studyQ80389307
Dysregulated T cell expression of TIM3 in multiple sclerosisQ24676780
Global cancer statistics, 2002Q27860562
The B7 family revisitedQ28240070
The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunityQ28281686
Restoring function in exhausted CD8 T cells during chronic viral infectionQ28289222
Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral toleranceQ28511160
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progressionQ29618956
Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune diseaseQ34112417
Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunityQ34161493
Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+ T cell dysfunction in melanoma patientsQ34161579
Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance.Q34269503
Effect of laparoscopy on immune functionQ34385769
Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunctionQ34570127
PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infectionQ34570624
Immunologic changes during minimally invasive surgeryQ35033586
Detection of disseminated tumour cells in the liver of cancer patientsQ36242505
The PD-1-PD-L pathway in immunological toleranceQ36405777
Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infectionQ36979967
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectcolorectal cancerQ188874
colorectal carcinomaQ25493920
P304page(s)1-9
P577publication date2012-03-01
P1433published inYonago Acta MedicaQ15765174
P1476titleUpregulation of TIM-3 and PD-1 on CD4+ and CD8+ T Cells Associated with Dysfunction of Cell-Mediated Immunity after Colorectal Cancer Operation
P478volume55

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cites work (P2860)
Q58787920Addressing the Adult Soft Tissue Sarcoma Microenvironment with Intratumoral Immunotherapy
Q36193004Apoptosis of tumor infiltrating effector TIM-3+CD8+ T cells in colon cancer
Q36299762Circulating and tumor-infiltrating Tim-3 in patients with colorectal cancer
Q39079676Functional impairment of infiltrating T cells in human colorectal cancer
Q26775578Immune Checkpoint Modulation in Colorectal Cancer: What's New and What to Expect
Q34283708PD-1(+) CD8(+) T cells are exhausted in tumours and functional in draining lymph nodes of colorectal cancer patients.
Q90621894Rapamycin Prevents Surgery-Induced Immune Dysfunction in Patients with Bladder Cancer
Q27345519Surgical Stress Abrogates Pre-Existing Protective T Cell Mediated Anti-Tumor Immunity Leading to Postoperative Cancer Recurrence
Q58558279TIM-3, a promising target for cancer immunotherapy
Q26799502Tim-3 and Tim-4 as the potential targets for antitumor therapy
Q36014245Up-regulation of Tim-3 is associated with poor prognosis of patients with colon cancer

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