Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells

scientific article published on 08 July 2009

Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.00639-09
P932PMC publication ID2738247
P698PubMed publication ID19587053

P50authorLucy Golden-MasonQ47412530
Vijay KuchrooQ87889159
P2093author name stringBrent E Palmer
Hugo R Rosen
Lucy Golden-Mason
Brian J McMahon
Nasim Kassam
David R Gretch
Lisa Townshend-Bulson
Nicole Castelblanco
Stephen Livingston
P2860cites workSustained Dysfunction of Antiviral CD8+ T Lymphocytes after Infection with Hepatitis C VirusQ27469800
PD-1 Expression in Acute Hepatitis C Virus (HCV) Infection Is Associated with HCV-Specific CD8 ExhaustionQ27477628
Liver-Infiltrating Lymphocytes in Chronic Human Hepatitis C Virus Infection Display an Exhausted Phenotype with High Levels of PD-1 and Low Levels of CD127 ExpressionQ27478366
Upregulation of PD-1 Expression on Circulating and Intrahepatic Hepatitis C Virus-Specific CD8+ T Cells Associated with Reversible Immune DysfunctionQ27481027
Global epidemiology of hepatitis C virus infectionQ27860799
Two subsets of memory T lymphocytes with distinct homing potentials and effector functionsQ28146072
The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunityQ28281686
Three-color flow cytometry detection of intracellular cytokines in peripheral blood mononuclear cells: comparative analysis of phorbol myristate acetate-ionomycin and phytohemagglutinin stimulationQ28359797
Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cellsQ28754733
Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infectionQ29620795
Understanding dendritic cell and T-lymphocyte traffic through the analysis of chemokine receptor expressionQ34118755
PD-1 and its ligands in T-cell immunityQ36791446
Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infectionQ36979967
Novel strategies to eliminate persistent viral infectionsQ37079434
Blockade of Tim-3 pathway ameliorates interferon-gamma production from hepatic CD8+ T cells in a mouse model of hepatitis B virus infectionQ37728408
TIMs: central regulators of immune responsesQ42287215
Cutting edge: programmed death-1 expression is increased on immunocytes in chronic hepatitis C virus and predicts failure of response to antiviral therapy: race-dependent differencesQ42977043
Pervasive influence of hepatitis C virus on the phenotype of antiviral CD8+ T cellsQ42982580
Differential antigenic hierarchy associated with spontaneous recovery from hepatitis C virus infection: implications for vaccine designQ43001324
Loss of IL-7 receptor alpha-chain (CD127) expression in acute HCV infection associated with viral persistenceQ43032677
Frequencies of HCV-specific effector CD4+ T cells by flow cytometry: correlation with clinical disease stagesQ43036009
Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infectionsQ45733084
Identification and characterization of galectin-9, a novel beta-galactoside-binding mammalian lectinQ48053615
Prospective analysis of effector and regulatory CD4+ T cells in chronic HCV patients undergoing combination antiviral therapy.Q50568011
Programmed death 1 expression on HIV-specific CD4+ T cells is driven by viral replication and associated with T cell dysfunctionQ80641790
P433issue18
P407language of work or nameEnglishQ1860
P921main subjectvirusQ808
Hepatitis C virusQ708693
hepatitis CQ154869
overexpressionQ61643320
P304page(s)9122-9130
P577publication date2009-07-08
P1433published inJournal of VirologyQ1251128
P1476titleNegative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells
P478volume83

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