Immune responses and immunopathology in acute and chronic viral hepatitis

scientific article published on 4 July 2016

Immune responses and immunopathology in acute and chronic viral hepatitis is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1010444368
P356DOI10.1038/NRI.2016.69
P698PubMed publication ID27374637

P50authorEui-Cheol ShinQ79235655
P2093author name stringPil Soo Sung
Su-Hyung Park
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Memory CD8+ T cells are required for protection from persistent hepatitis C virus infectionQ27485119
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Successful vaccination induces multifunctional memory T-cell precursors associated with early control of hepatitis C virusQ36279345
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Distinct KIR/HLA compound genotypes affect the kinetics of human antiviral natural killer cell responsesQ36407362
Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell-mediated deletion.Q36547702
Hepatitis B Virus--Specific and Global T-Cell Dysfunction in Chronic Hepatitis B.Q36614504
Flying under the radar: the immunobiology of hepatitis C.Q36635544
The frequency of CD127(+) hepatitis C virus (HCV)-specific T cells but not the expression of exhaustion markers predicts the outcome of acute HCV infection.Q36760218
A pathogenic picornavirus acquires an envelope by hijacking cellular membranesQ36781367
Persistent LCMV infection is controlled by blockade of type I interferon signalingQ36808119
Innate immune responses in hepatitis C virus-exposed healthcare workers who do not develop acute infectionQ36944828
Immunobiology and pathogenesis of viral hepatitisQ37014739
Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1).Q37173264
Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cellsQ37333944
Interferon lambda 4 signals via the IFNλ receptor to regulate antiviral activity against HCV and coronavirusesQ37352688
The size of the viral inoculum contributes to the outcome of hepatitis B virus infectionQ37356013
Liver environment and HCV replication affect human T-cell phenotype and expression of inhibitory receptorsQ37625429
Pathological functions of interleukin-22 in chronic liver inflammation and fibrosis with hepatitis B virus infection by promoting T helper 17 cell recruitmentQ37673234
Simultaneous detection of hepatitis C virus and interferon stimulated gene expression in infected human liverQ37684887
Living in the liver: hepatic infectionsQ37987860
The impact of differential antiviral immunity in children and adultsQ38037339
Current progress in development of hepatitis C virus vaccinesQ38120201
Induction and suppression of innate antiviral responses by picornavirusesQ38236277
Reduced IFNλ4 activity is associated with improved HCV clearance and reduced expression of interferon-stimulated genesQ38926063
Natural killer cell phenotype modulation and natural killer/T-cell interplay in nucleos(t)ide analogue-treated hepatitis e antigen-negative patients with chronic hepatitis B.Q38964920
The ABCs of viral hepatitis that define biomarker signatures of acute viral hepatitisQ38979208
An effective interferon-gamma-mediated inhibition of hepatitis C virus replication by natural killer cells is associated with spontaneous clearance of acute hepatitis C in human immunodeficiency virus-positive patients.Q39037936
Melanoma Differentiation–Associated Gene 5 Senses Hepatitis B Virus and Activates Innate Immune Signaling To Suppress Virus ReplicationQ39113612
Hepatitis B Virus Polymerase Impairs Interferon-α–Induced STA Activation Through Inhibition of Importin-α5 and Protein Kinase C-δQ39274712
Preserved T-cell function in children and young adults with immune-tolerant chronic hepatitis B.Q39329221
Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 BlockadeQ27487939
Hepatitis C Virus E2 Envelope Glycoprotein Core StructureQ27680704
Analysis of successful immune responses in persons infected with hepatitis C virusQ27860698
Determinants of Viral Clearance and Persistence during Acute Hepatitis C Virus InfectionQ28131757
Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearanceQ28255243
Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIFQ29547901
IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapyQ29614896
Immunology of hepatitis B virus and hepatitis C virus infectionQ29618957
Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis CQ29619541
Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis CQ29620614
HCV Persistence and Immune Evasion in the Absence of Memory T Cell HelpQ29620766
Update on hepatitis E virology: Implications for clinical practiceQ30251804
Hepatitis C Virus-Induced Myeloid-Derived Suppressor Cells Suppress NK Cell IFN-γ Production by Altering Cellular Metabolism via Arginase-1.Q30277650
Hepatitis C virus promotes t-helper (Th)17 responses through thymic stromal lymphopoietin production by infected hepatocytesQ30414014
Myeloid Suppressor Cells Induced by Hepatitis C Virus Suppress T-Cell Responses Through the Production of Reactive Oxygen SpeciesQ30422587
Hepatic gene expression during treatment with peginterferon and ribavirin: Identifying molecular pathways for treatment responseQ33597579
Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiationQ33604835
Genomic analysis of the host response to hepatitis B virus infectionQ33696514
Clearance of hepatitis C infection is associated with the early appearance of broad neutralizing antibody responsesQ33707246
CD8(+) T-Cell Responses in Acute Hepatitis C Virus Infection.Q33718778
Blockade of immunosuppressive cytokines restores NK cell antiviral function in chronic hepatitis B virus infectionQ33781003
Natural killer cells are polarized toward cytotoxicity in chronic hepatitis C in an interferon-alfa-dependent mannerQ33822643
Dual function of the NK cell receptor 2B4 (CD244) in the regulation of HCV-specific CD8+ T cellsQ33916693
Interferon lambda alleles predict innate antiviral immune responses and hepatitis C virus permissivenessQ33922537
Pathogenesis of hepatitis B virus infectionQ33925491
Spontaneous control of primary hepatitis C virus infection and immunity against persistent reinfectionQ33929089
Selection pressure from neutralizing antibodies drives sequence evolution during acute infection with hepatitis C virusQ33955998
Disruption of TLR3 signaling due to cleavage of TRIF by the hepatitis A virus protease-polymerase processing intermediate, 3CD.Q34022995
Hepatitis C Virus Reveals a Novel Early Control in Acute Immune ResponseQ34055291
Hepatitis A virus 3C protease cleaves NEMO to impair induction of beta interferonQ34059504
T-Cell Dysfunction and Inhibitory Receptors in Hepatitis C Virus InfectionQ34127437
TGF-β1 Down-Regulation of NKG2D/DAP10 and 2B4/SAP Expression on Human NK Cells Contributes to HBV PersistenceQ34205905
Dysfunctional CD8+ T cells in hepatitis B and C are characterized by a lack of antigen-specific T-bet inductionQ34230513
HepG2 cells mount an effective antiviral interferon-lambda based innate immune response to hepatitis C virus infection.Q34250323
Increased degranulation of natural killer cells during acute HCV correlates with the magnitude of virus-specific T cell responsesQ34258994
Binding of Hepatitis A Virus to Its Cellular Receptor 1 Inhibits T-Regulatory Cell Functions in HumansQ39376854
The hepatitis B virus X protein disrupts innate immunity by downregulating mitochondrial antiviral signaling proteinQ39691872
Cleavage of mitochondrial antiviral signaling protein in the liver of patients with chronic hepatitis C correlates with a reduced activation of the endogenous interferon systemQ39756691
Characterization of CD8+ T-cell response in acute and resolved hepatitis A virus infectionQ39819888
Analysis of CD8+ T-cell-mediated inhibition of hepatitis C virus replication using a novel immunological modelQ39888672
Silencing of USP18 potentiates the antiviral activity of interferon against hepatitis C virus infectionQ40209074
Transcriptome analysis reveals a classical interferon signature induced by IFNλ4 in human primary cells.Q40844750
Virus-Specific CD4+ T Cells Have Functional and Phenotypic Characteristics of Follicular T-Helper Cells in Patients With Acute and Chronic HCV InfectionsQ40903773
Interferon-γ and Tumor Necrosis Factor-α Produced by T Cells Reduce the HBV Persistence Form, cccDNA, Without Cytolysis.Q40976544
Control of temporal activation of hepatitis C virus-induced interferon response by domain 2 of nonstructural protein 5A.Q41290555
Adaptation of the hepatitis B virus core protein to CD8(+) T-cell selection pressure.Q41462634
The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for hepatitis B virusQ41564761
A human vaccine strategy based on chimpanzee adenoviral and MVA vectors that primes, boosts, and sustains functional HCV-specific T cell memoryQ41672361
Blockade of chronic type I interferon signaling to control persistent LCMV infectionQ41807293
PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV.Q42017650
T-cell immunity and hepatitis C virus reinfection after cure of chronic hepatitis C with an interferon-free antiviral regimen in a chimpanzeeQ42061089
A heterogeneous hierarchy of co-regulatory receptors regulates exhaustion of HCV-specific CD8 T cells in patients with chronic hepatitis C.Q42199452
Restoration of HBV-specific CD8+ T cell function by PD-1 blockade in inactive carrier patients is linked to T cell differentiationQ42206594
Liver injury in acute hepatitis A is associated with decreased frequency of regulatory T cells caused by Fas-mediated apoptosisQ42206865
Restoration of HCV-specific CD8+ T cell function by interferon-free therapyQ42211746
Rapid and sustained autologous neutralizing response leading to early spontaneous recovery after HCV infectionQ42281089
Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control HBV infectionQ42284303
Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infectionQ42797242
Elevated CD4+/CD25+ T cell frequency and function during acute hepatitis C presage chronic evolution.Q42836169
Natural killer p46High expression defines a natural killer cell subset that is potentially involved in control of hepatitis C virus replication and modulation of liver fibrosis.Q42979699
Combined blockade of programmed death-1 and activation of CD137 increase responses of human liver T cells against HBV, but not HCV.Q42983710
HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infectionQ42986755
FOXP3 expression in hepatitis C virus-specific CD4+ T cells during acute hepatitis C.Q42989299
Abundant numbers of regulatory T cells localize to the liver of chronic hepatitis C infected patients and limit the extent of fibrosisQ42994516
A T-cell HCV vaccine eliciting effective immunity against heterologous virus challenge in chimpanzeesQ42998134
Discordant role of CD4 T-cell response relative to neutralizing antibody and CD8 T-cell responses in acute hepatitis C.Q43035496
Vaccine-induced early control of hepatitis C virus infection in chimpanzees fails to impact on hepatic PD-1 and chronicityQ43036305
Th17 cells are increased with severity of liver inflammation in patients with chronic hepatitis CQ43036898
Hepatitis C virus cell-cell transmission in hepatoma cells in the presence of neutralizing antibodiesQ43041465
Functional suppression by FoxP3+CD4+CD25(high) regulatory T cells during acute hepatitis C virus infectionQ43047846
Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challengeQ43048336
An immunomodulatory role for CD4(+)CD25(+) regulatory T lymphocytes in hepatitis C virus infection.Q43636357
Natural killer cell functional dichotomy in chronic hepatitis B and chronic hepatitis C virus infectionsQ43713361
Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection.Q44447870
Hepatitis B virus limits response of human hepatocytes to interferon-α in chimeric mice.Q45368507
Role of the coinhibitory receptor cytotoxic T lymphocyte antigen-4 on apoptosis-Prone CD8 T cells in persistent hepatitis B virus infectionQ45368686
The immunoregulatory role of CD244 in chronic hepatitis B infection and its inhibitory potential on virus-specific CD8+ T-cell functionQ45371390
Altered interferon-alpha-signaling in natural killer cells from patients with chronic hepatitis C virus infectionQ45375236
Temporal analysis of early immune responses in patients with acute hepatitis B virus infectionQ45382916
Interferon-induced gene expression is a stronger predictor of treatment response than IL28B genotype in patients with hepatitis C.Q50558076
Hepatic gene expression discriminates responders and nonresponders in treatment of chronic hepatitis C viral infectionQ50579007
Preferential loss of IL-2-secreting CD4+ T helper cells in chronic HCV infectionQ52563861
Viral Clearance Without Destruction of Infected Cells During Acute HBV InfectionQ56951258
Restored Function of HBV-Specific T Cells After Long-term Effective Therapy With Nucleos(t)ide AnaloguesQ58802756
Antiviral Intrahepatic T-Cell Responses Can Be Restored by Blocking Programmed Death-1 Pathway in Chronic Hepatitis BQ58802765
Protection against hepatitis C infection via NK cells in highly-exposed uninfected injecting drug usersQ59200459
Increased Th17 cells contribute to disease progression in patients with HBV‐associated liver cirrhosisQ84096204
Hepatitis B virus infectionQ88131866
Increased natural killer cell cytotoxicity and NKp30 expression protects against hepatitis C virus infection in high-risk individuals and inhibits replication in vitroQ34259130
IL-29 is the dominant type III interferon produced by hepatocytes during acute hepatitis C virus infectionQ34282251
Activation of natural killer cells during acute infection with hepatitis C virus.Q34283615
Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicityQ34364103
Interferon-stimulated genes: a complex web of host defensesQ34405609
Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection.Q34462234
CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infectionQ34462354
The Humoral Immune Response to HCV: Understanding is Key to Vaccine Development.Q34481429
Natural Killer Cells in Viral HepatitisQ34505690
IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B.Q34627115
The third signal cytokine IL-12 rescues the anti-viral function of exhausted HBV-specific CD8 T cellsQ34629141
CD27 engagement by a soluble CD70 protein enhances non-cytolytic antiviral activity of CD56bright natural killer cells by IFN-γ secretionQ34657312
A Randomized, Double-Blind, Placebo-Controlled Assessment of BMS-936558, a Fully Human Monoclonal Antibody to Programmed Death-1 (PD-1), in Patients with Chronic Hepatitis C Virus InfectionQ34744674
Galectin-9 and IL-21 mediate cross-regulation between Th17 and Treg cells during acute hepatitis C.Q34789276
Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammationQ35002436
Broadly neutralizing antibodies abrogate established hepatitis C virus infectionQ35032263
Acute hepatitis A virus infection is associated with a limited type I interferon response and persistence of intrahepatic viral RNA.Q35091008
Hepatitis B virus polymerase disrupts K63-linked ubiquitination of STING to block innate cytosolic DNA-sensing pathwaysQ35115583
Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virusQ35197999
Human pDCs preferentially sense enveloped hepatitis A virionsQ35242599
A proinflammatory role for interleukin-22 in the immune response to hepatitis B virusQ35420938
Vaccine-induced cross-genotype reactive neutralizing antibodies against hepatitis C virusQ35465926
Cross-genotype immunity to hepatitis C virusQ35543288
Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistenceQ35679577
Reassessing immune control of hepatitis A virusQ35685377
Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells.Q35690250
Activation of chemokine and inflammatory cytokine response in hepatitis C virus–infected hepatocytes depends on toll-like receptor 3 sensing of hepatitis C virus double-stranded RNA intermediatesQ35737678
Spontaneous clearance of chronic hepatitis C virus infection is associated with appearance of neutralizing antibodies and reversal of T-cell exhaustionQ35741969
CD39 Expression Identifies Terminally Exhausted CD8+ T CellsQ35814795
Activation of Type I and III Interferon Response by Mitochondrial and Peroxisomal MAVS and Inhibition by Hepatitis C VirusQ35847364
Early changes in interferon signaling define natural killer cell response and refractoriness to interferon-based therapy of hepatitis C patients.Q35964140
Neutralizing antibody response during acute and chronic hepatitis C virus infectionQ35971609
Delayed induction, not impaired recruitment, of specific CD8⁺ T cells causes the late onset of acute hepatitis CQ35986301
Roles of unphosphorylated ISGF3 in HCV infection and interferon responsiveness.Q35989977
P433issue8
P304page(s)509-523
P577publication date2016-07-04
P13046publication type of scholarly workreview articleQ7318358
P1433published inNature Reviews ImmunologyQ43355
P1476titleImmune responses and immunopathology in acute and chronic viral hepatitis
P478volume16

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