Antimalarial Drug Resistance: Literature Review and Activities and Findings of the ICEMR Network

scientific article

Antimalarial Drug Resistance: Literature Review and Activities and Findings of the ICEMR Network is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.4269/AJTMH.15-0007
P3181OpenCitations bibliographic resource ID796040
P932PMC publication ID4574275
P698PubMed publication ID26259943
P5875ResearchGate publication ID280968059

P50authorDaouda NdiayeQ28870686
Philip J RosenthalQ60060211
Liwang CuiQ60429811
Pradipsinh K. RathodQ88838215
P2093author name stringSungano Mharakurwa
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Malarone treatment failure not associated with previously described mutations in the cytochrome b geneQ21033786
Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, NigeriaQ21245928
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Evidence of Artemisinin-Resistant Malaria in Western CambodiaQ22061854
A molecular marker of artemisinin-resistant Plasmodium falciparum malariaQ22061872
Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal studyQ24598695
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Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trialQ24630683
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The interplay between drug resistance and fitness in malaria parasitesQ26998596
Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparumQ27861931
Disruption of a Plasmodium falciparum Multidrug Resistance-associated Protein (PfMRP) Alters Its Fitness and Transport of Antimalarial Drugs and GlutathioneQ27861935
Artemisinin and chloroquine: do mode of action and mechanism of resistance involve the same protagonists?Q36747313
In vitro sensitivities of Plasmodium falciparum isolates from the China-Myanmar border to piperaquine and association with polymorphisms in candidate genesQ36757694
K13-propeller polymorphisms in plasmodium falciparum parasites from sub-saharan AfricaQ36786733
Malaria chemoprophylaxis: strategies for risk groupsQ36803894
Apicoplast translation, transcription and genome replication: targets for antimalarial antibioticsQ37152316
Analysis of genetic mutations associated with anti-malarial drug resistance in Plasmodium falciparum from the Democratic Republic of East Timor.Q37166478
A systematic review and meta-analysis of evidence for correlation between molecular markers of parasite resistance and treatment outcome in falciparum malariaQ37190605
Plasmodium falciparum Na+/H+ exchanger 1 transporter is involved in reduced susceptibility to quinineQ37190763
Polymorphism in PfMRP1 (Plasmodium falciparum multidrug resistance protein 1) amino acid 1466 associated with resistance to sulfadoxine-pyrimethamine treatment.Q37204143
Chloroquine resistance before and after its withdrawal in KenyaQ37223629
Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studiesQ37240876
Effectiveness of quinine versus artemether-lumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomised trialQ37272095
In vivo selection of Plasmodium falciparum parasites carrying the chloroquine-susceptible pfcrt K76 allele after treatment with artemether-lumefantrine in AfricaQ37283105
Malaria and quinine resistance: a medical and scientific issue between Brazil and Germany (1907-19)Q37398997
Selection for chloroquine-sensitive Plasmodium falciparum by wild Anopheles arabiensis in Southern ZambiaQ37425838
Selection of parasites with diminished drug susceptibility by amodiaquine-containing antimalarial regimens in UgandaQ37436582
Four-year efficacy of RTS,S/AS01E and its interaction with malaria exposureQ37502907
Impaired fitness of drug-resistant malaria parasites: evidence and implication on drug-deployment policies.Q37503352
Prevalence of polymorphisms in antifolate drug resistance molecular marker genes pvdhfr and pvdhps in clinical isolates of Plasmodium vivax from Kolkata, IndiaQ37544364
Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr1 gene and cross-resistance to halofantrine and quinineQ37559063
Changes in drug sensitivity and anti-malarial drug resistance mutations over time among Plasmodium falciparum parasites in SenegalQ37583332
Validation of the ligase detection reaction fluorescent microsphere assay for the detection of Plasmodium falciparum resistance mediating polymorphisms in UgandaQ37731834
Transporters as mediators of drug resistance in Plasmodium falciparumQ37732867
The ABCs of multidrug resistance in malariaQ37764523
The role of antimalarial treatment in the elimination of malariaQ37939421
The P-glycoprotein multidrug transporter.Q37941756
Mapping 'partially resistant', 'fully resistant', and 'super resistant' malariaQ38136762
Combination therapy for uncomplicated falciparum malaria in Ugandan children: a randomized trialQ38397102
Artemether-lumefantrine versus amodiaquine plus sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Burkina Faso: a randomised non-inferiority trialQ38399521
Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malariaQ27861937
PfCRT and its role in antimalarial drug resistanceQ27861957
Probing the multifactorial basis of Plasmodium falciparum quinine resistance: Evidence for a strain-specific contribution of the sodium-proton exchanger PfNHEQ27861959
Polymorphisms in K13 and Falcipain-2 Associated with Artemisinin Resistance Are Not Prevalent in Plasmodium falciparum Isolated from Ugandan ChildrenQ27861962
Na(+) regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarialsQ27976482
Temporal changes in prevalence of molecular markers mediating antimalarial drug resistance in a high malaria transmission setting in UgandaQ28125904
Intermittent preventive treatment of malaria provides substantial protection against malaria in children already protected by an insecticide-treated bednet in Burkina Faso: a randomised, double-blind, placebo-controlled trialQ28477053
A head-to-head comparison of four artemisinin-based combinations for treating uncomplicated malaria in African children: a randomized trialQ28477853
Effect of transmission reduction by insecticide-treated bednets (ITNs) on antimalarial drug resistance in western KenyaQ28477925
Novel polymorphisms in Plasmodium falciparum ABC transporter genes are associated with major ACT antimalarial drug resistanceQ28478286
In vitro sensitivity of Plasmodium falciparum from China-Myanmar border area to major ACT drugs and polymorphisms in potential target genesQ28484068
Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparumQ28649962
Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistanceQ29615118
Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy numberQ29615128
A P-glycoprotein homologue of Plasmodium falciparum is localized on the digestive vacuoleQ30039339
The malaria parasite's chloroquine resistance transporter is a member of the drug/metabolite transporter superfamilyQ30041677
Absence of putative artemisinin resistance mutations among Plasmodium falciparum in Sub-Saharan Africa: a molecular epidemiologic studyQ30389796
A better resolution for integrating methods for monitoring Plasmodium falciparum resistance to antimalarial drugsQ30486953
Diverse chemotypes disrupt ion homeostasis in the Malaria parasiteQ30487225
(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium.Q30610467
Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trialQ33222370
Artemisinin combination therapies for treatment of uncomplicated malaria in UgandaQ33251914
Effect of sulfadoxine-pyrimethamine resistance on the efficacy of intermittent preventive therapy for malaria control during pregnancy: a systematic reviewQ33288230
Multidrug-resistant Plasmodium vivax associated with severe and fatal malaria: a prospective study in Papua, IndonesiaQ33344900
No seasonal accumulation of resistant P. falciparum when high-dose chloroquine is usedQ33498521
Seasonal distribution of anti-malarial drug resistance alleles on the island of Sumba, IndonesiaQ33507449
A non-radioactive DAPI-based high-throughput in vitro assay to assess Plasmodium falciparum responsiveness to antimalarials--increased sensitivity of P. falciparum to chloroquine in SenegalQ33617554
In vitro sensitivities of Plasmodium falciparum to different antimalarial drugs in UgandaQ33676088
Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparumQ33680054
Efficacy of amodiaquine, sulphadoxine-pyrimethamine and their combination for the treatment of uncomplicated Plasmodium falciparum malaria in children in Cameroon at the time of policy change to artemisinin-based combination therapyQ33702580
Association of microsatellite variations of Plasmodium falciparum Na+/H+ exchanger (Pfnhe-1) gene with reduced in vitro susceptibility to quinine: lack of confirmation in clinical isolates from AfricaQ33817484
Malaria antifolate resistance with contrasting Plasmodium falciparum dihydrofolate reductase (DHFR) polymorphisms in humans and Anopheles mosquitoesQ35558706
Impact of antimalarial treatment and chemoprevention on the drug sensitivity of malaria parasites isolated from ugandan childrenQ35607844
Amodiaquine and artemether-lumefantrine select distinct alleles of the Plasmodium falciparum mdr1 gene in Tanzanian children treated for uncomplicated malaria.Q35647706
Common origin and fixation of Plasmodium falciparum dhfr and dhps mutations associated with sulfadoxine-pyrimethamine resistance in a low-transmission area in South AmericaQ35840784
Resistance-mediating Plasmodium falciparum pfcrt and pfmdr1 alleles after treatment with artesunate-amodiaquine in UgandaQ35912645
A major genome region underlying artemisinin resistance in malariaQ35969854
Plasmodium falciparum transmission rate and selection for drug resistance: a vexed association or a key to successful control?Q35975158
The impact of antimalarial drug resistance mutations on parasite fitness, and its implications for the evolution of resistance.Q36153724
Mechanisms of in vitro resistance to dihydroartemisinin in Plasmodium falciparumQ36269058
Assessment of the molecular marker of Plasmodium falciparum chloroquine resistance (Pfcrt) in Senegal after several years of chloroquine withdrawalQ36450797
Clinical Efficacy of Dihydroartemisinin-Piperaquine for the Treatment of Uncomplicated Plasmodium falciparum Malaria at the China-Myanmar BorderQ36485224
Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast AsiaQ36512312
Reduced artemisinin susceptibility of Plasmodium falciparum ring stages in western CambodiaQ36558472
Selection of known Plasmodium falciparum resistance-mediating polymorphisms by artemether-lumefantrine and amodiaquine-sulfadoxine-pyrimethamine but not dihydroartemisinin-piperaquine in Burkina FasoQ33826359
Resistance to chloroquine unhinges vivax malaria therapeuticsQ33839067
Plasmodium falciparum multidrug resistance protein 1 (pfmrp1) gene and its association with in vitro drug susceptibility of parasite isolates from north-east MyanmarQ33910002
Comparative impacts over 5 years of artemisinin-based combination therapies on Plasmodium falciparum polymorphisms that modulate drug sensitivity in Ugandan childrenQ33947834
Independent origin of plasmodium falciparum antifolate super-resistance, Uganda, Tanzania, and EthiopiaQ33950981
Spiroindolone KAE609 for falciparum and vivax malariaQ34085717
In vitro sensitivity of Plasmodium falciparum clinical isolates from the China-Myanmar border area to quinine and association with polymorphism in the Na+/H+ exchangerQ34151002
Transporters involved in resistance to antimalarial drugs.Q34151405
Differential prevalence of transporter polymorphisms in symptomatic and asymptomatic falciparum malaria infections in UgandaQ34169765
Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutationsQ34198094
Compensatory mutations restore fitness during the evolution of dihydrofolate reductaseQ34310777
Different allele prevalence in the dihydrofolate reductase and dihydropteroate synthase genes in Plasmodium vivax populations from ChinaQ34341770
Plasmodium prevalence and artemisinin-resistant falciparum malaria in Preah Vihear Province, Cambodia: a cross-sectional population-based studyQ34354821
Piperaquine: a resurgent antimalarial drug.Q34378146
Anti-malarial drugs and the prevention of malaria in the population of malaria endemic areasQ34407217
Drug resistance. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistanceQ34453540
Limited ability of Plasmodium falciparum pfcrt, pfmdr1, and pfnhe1 polymorphisms to predict quinine in vitro sensitivity or clinical effectiveness in UgandaQ34529355
Artemisinin-based combination treatment of falciparum malaria.Q34731529
Burden of complicated malaria in a densely forested Bastar region of Chhattisgarh State (Central India).Q34757045
Molecular epidemiology of Plasmodium vivax anti-folate resistance in IndiaQ34995136
Multiple origins of Plasmodium falciparum dihydropteroate synthetase mutant alleles associated with sulfadoxine resistance in IndiaQ35005151
Discovery, mechanisms of action and combination therapy of artemisininQ35006418
Polymorphism of Plasmodium falciparum Na(+)/H(+) exchanger is indicative of a low in vitro quinine susceptibility in isolates from Viet Nam.Q35069374
High frequency of Plasmodium falciparum chloroquine resistance marker (pfcrt T76 mutation) in Yemen: an urgent need to re-examine malaria drug policyQ35074416
Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistanceQ35079297
Malaria drug-sensitivity testing: new assays, new perspectivesQ35104740
Therapeutic responses of Plasmodium vivax malaria to chloroquine and primaquine treatment in northeastern MyanmarQ35105826
Drug resistance. K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolatesQ35146682
Combining indoor residual spraying and insecticide-treated nets for malaria control in Africa: a review of possible outcomes and an outline of suggestions for the futureQ35163863
Prolonged selection of pfmdr1 polymorphisms after treatment of falciparum malaria with artemether-lumefantrine in UgandaQ35188480
Multidrug-resistant genotypes of Plasmodium falciparum, MyanmarQ35193462
Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular markerQ35217991
Structure and function of efflux pumps that confer resistance to drugsQ35294152
A thirteen-year analysis of Plasmodium falciparum populations reveals high conservation of the mutant pfcrt haplotype despite the withdrawal of chloroquine from national treatment guidelines in GabonQ35549781
Fansidar-resistant falciparum malaria in Papua New Guinea.Q54539949
Experiment to determine if a proguanil-resistant strain of P. falciparum would respond to large doses of pyrimethamine.Q55502424
Evolution of drug-resistance genes in Plasmodium falciparum in an area of seasonal malaria transmission in Eastern SudanQ38855059
Large differences in prevalence of Pfcrt and Pfmdr1 mutations between Mwanza, Tanzania and Iganga, Uganda-a reflection of differences in policies regarding withdrawal of chloroquine?Q38868907
Increased sensitivity to the antimalarials mefloquine and artemisinin is conferred by mutations in the pfmdr1 gene of Plasmodium falciparumQ38980049
The tyrosine-86 allele of the pfmdr1 gene of Plasmodium falciparum is associated with increased sensitivity to the anti-malarials mefloquine and artemisininQ38980054
Fitness costs of resistance to antimalarial drugsQ39001694
High prevalence of markers for sulfadoxine and pyrimethamine resistance in Plasmodium falciparum in the absence of drug pressure in the Ashanti region of GhanaQ39215959
Recovery of chloroquine sensitivity and low prevalence of the Plasmodium falciparum chloroquine resistance transporter gene mutation K76T following the discontinuance of chloroquine use in MalawiQ39254734
Seasonal carriage of pfcrt and pfmdr1 alleles in Gambian Plasmodium falciparum imply reduced fitness of chloroquine-resistant parasitesQ39326401
Prevalence of sulfadoxine-pyrimethamine resistance-associated mutations in dhfr and dhps genes of Plasmodium falciparum three years after SP withdrawal in Bahir Dar, Northwest EthiopiaQ39346727
Plasmodium falciparum pfmdr1 amplification, mefloquine resistance, and parasite fitnessQ39367622
Quinine in severe falciparum malaria: evidence of declining efficacy in ThailandQ39370966
Intercontinental spread of pyrimethamine-resistant malariaQ39408056
Mutations in Plasmodium falciparum cytochrome b that are associated with atovaquone resistance are located at a putative drug-binding siteQ39474607
Monitoring chloroquine resistance using Plasmodium falciparum parasites isolated from wild mosquitoes in Tanzania.Q39516937
Screening for mutations related to atovaquone/proguanil resistance in treatment failures and other imported isolates of Plasmodium falciparum in EuropeQ39591275
Resistance to antimalarials in Southeast Asia and genetic polymorphisms in pfmdr1.Q39792488
Response of Kampuchean strains of Plasmodium falciparum to antimalarials: in-vivo assessment of quinine and quinine plus tetracycline; multiple drug resistance in vitroQ40784576
Drug-resistant falciparum malaria among the Mayongong Indians in the Brazilian AmazonQ41103268
Decreased prevalence of Plasmodium falciparum resistance markers to amodiaquine despite its wide scale use as ACT partner drug in ZanzibarQ41827965
Deamplification of pfmdr1-containing amplicon on chromosome 5 in Plasmodium falciparum is associated with reduced resistance to artelinic acid in vitroQ41846791
pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparumQ41911870
A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance.Q41912137
Evidence of increased chloroquine sensitivity in Thai isolates of Plasmodium falciparumQ41912797
Dissecting the loci of low-level quinine resistance in malaria parasitesQ41914069
The principal chloroquine resistance protein of Plasmodium falciparum is a member of the drug/metabolite transporter superfamilyQ41914784
Multiple transporters associated with malaria parasite responses to chloroquine and quinineQ41915501
Reemergence of chloroquine-sensitive Plasmodium falciparum malaria after cessation of chloroquine use in MalawiQ41915777
Resistance of Plasmodium falciparum malaria to sulfadoxine-pyrimethamine ('Fansidar') in a refugee camp in ThailandQ41925042
Atovaquone, a broad spectrum antiparasitic drug, collapses mitochondrial membrane potential in a malarial parasiteQ41929069
Changes in genotypes of Plasmodium falciparum human malaria parasite following withdrawal of chloroquine in Tiwi, KenyaQ41929428
In vitro activities of quinine and other antimalarials and pfnhe polymorphisms in Plasmodium isolates from KenyaQ41935745
Sensitivity of Plasmodium vivax to chloroquine in Laza City, MyanmarQ41937411
In vitro activities of piperaquine, lumefantrine, and dihydroartemisinin in Kenyan Plasmodium falciparum isolates and polymorphisms in pfcrt and pfmdr1.Q41937598
Innate resistance to new antimalarial drugs in Plasmodium falciparum from NigeriaQ41940520
Selection of Plasmodium falciparum multidrug resistance gene 1 alleles in asexual stages and gametocytes by artemether-lumefantrine in Nigerian children with uncomplicated falciparum malariaQ41940547
Pyrimethamine-resistant dihydrofolate reductase enzymes of Plasmodium falciparum are not enzymatically compromised in vitroQ41943140
Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparumQ41943905
Amino acid mutations in Plasmodium vivax DHFR and DHPS from several geographical regions and susceptibility to antifolate drugsQ41944385
Decreasing pfmdr1 copy number in plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisininQ41944932
Association between the pfmdr1 gene and in vitro artemether and lumefantrine sensitivity in Thai isolates of Plasmodium falciparum.Q42072395
Border malaria associated with multidrug resistance on Thailand-Myanmar and Thailand-Cambodia borders: transmission dynamic, vulnerability, and surveillanceQ42181962
Structural features of Plasmodium cytochrome b that may underlie susceptibility to 8-aminoquinolines and hydroxynaphthoquinonesQ42620844
Plasmodium falciparum multidrug resistance protein 1 and artemisinin-based combination therapy in AfricaQ42635798
Intermittent preventive therapy for malaria in pregnancy: is sulfadoxine-pyrimethamine the right drug?Q43182467
Increasing prevalence of wildtypes in the dihydrofolate reductase gene of Plasmodium falciparum in an area with high levels of sulfadoxine/pyrimethamine resistance after introduction of treated bed netsQ43949108
In vivo selection of Plasmodium falciparum pfmdr1 86N coding alleles by artemether-lumefantrine (Coartem).Q45270651
Fansidar resistant falciparum malaria in IndonesiaQ47824731
Dihydroartemisinin-piperaquine failure in CambodiaQ47877123
Seasonal fluctuation of drug-resistant malaria parasites: a sign of fitness costQ47909648
Studies in human malaria. XXXIV. Acquired resistance to pyrimethamine (daraprim) by the Chesson strain of plasmodium vivaxQ47940624
Clinical atovaquone-proguanil resistance of Plasmodium falciparum associated with cytochrome b codon 268 mutationsQ48035243
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue3 Suppl
P407language of work or nameEnglishQ1860
P921main subjectantimalarialQ521616
malariaQ12156
drug resistanceQ12147416
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)57-68
P577publication date2015-09-01
P1433published inAmerican Journal of Tropical Medicine and HygieneQ15766943
P1476titleAntimalarial Drug Resistance: Literature Review and Activities and Findings of the ICEMR Network
P478volume93

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