What Do We Know about the Role of miRNAs in Pediatric Sarcoma?

scientific article (publication date: 2015)

What Do We Know about the Role of miRNAs in Pediatric Sarcoma? is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.3390/IJMS160716593
P932PMC publication ID4519968
P698PubMed publication ID26204834
P5875ResearchGate publication ID281820062

P2093author name stringMaureen J O'Sullivan
Antonio Lázaro
Lorna C Kelly
P2860cites workComputational identification of Drosophila microRNA genesQ21092888
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The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblastsQ38287718
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Hsa-mir-145 is the top EWS-FLI1-repressed microRNA involved in a positive feedback loop in Ewing's sarcomaQ38338166
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The histone demethylase KDM3A is a microRNA-22-regulated tumor promoter in Ewing SarcomaQ39041044
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miRNA expression profile in human osteosarcoma: role of miR-1 and miR-133b in proliferation and cell cycle control.Q39228419
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Downregulation of microRNAs miR-1, -206 and -29 stabilizes PAX3 and CCND2 expression in rhabdomyosarcomaQ39397196
The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1Q24629399
Distinct roles for miR-1 and miR-133a in the proliferation and differentiation of rhabdomyosarcoma cellsQ24632284
Molecular profiling uncovers a p53-associated role for microRNA-31 in inhibiting the proliferation of serous ovarian carcinomas and other cancersQ24634248
MicroRNA-1/206 targets c-Met and inhibits rhabdomyosarcoma developmentQ24648202
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Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformationQ24658400
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The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegansQ27861103
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On protein synthesisQ28183644
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Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcomaQ28239992
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Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survivalQ28264400
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DICER1 mutations in embryonal rhabdomyosarcomas from children with and without familial PPB-tumor predisposition syndrome.Q37003048
Embryonal rhabdomyosarcoma of the uterine cervix: a report of 14 cases and a discussion of its unusual clinicopathological associations.Q37272571
The muscle-specific microRNA miR-206 blocks human rhabdomyosarcoma growth in xenotransplanted mice by promoting myogenic differentiationQ37286651
NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcomaQ37311506
Mir-214-dependent regulation of the polycomb protein Ezh2 in skeletal muscle and embryonic stem cellsQ37385808
miR-203, a tumor suppressor frequently down-regulated by promoter hypermethylation in rhabdomyosarcoma.Q37428692
Truncating mutations of hSNF5/INI1 in aggressive paediatric cancerQ28277002
Human RISC couples microRNA biogenesis and posttranscriptional gene silencingQ28280424
Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumorsQ28294240
Deregulated expression of miR-26a and Ezh2 in rhabdomyosarcomaQ28304953
The mirtron pathway generates microRNA-class regulatory RNAs in DrosophilaQ29615827
The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleusQ29617834
A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegansQ29618304
Distinct mechanisms for microRNA strand selection by Drosophila ArgonautesQ30886909
Comparing the MicroRNA spectrum between serum and plasmaQ31080442
Osteosarcoma incidence and survival rates from 1973 to 2004: data from the Surveillance, Epidemiology, and End Results ProgramQ33406382
Sorting of Drosophila small silencing RNAs partitions microRNA* strands into the RNA interference pathwayQ33572957
MiR-214 and N-ras regulatory loop suppresses rhabdomyosarcoma cell growth and xenograft tumorigenesisQ33688560
p53-Responsive micrornas 192 and 215 are capable of inducing cell cycle arrestQ33719450
Development of Ewing's sarcoma from primary bone marrow-derived mesenchymal progenitor cellsQ33992270
Let-7a is a direct EWS-FLI-1 target implicated in Ewing's sarcoma developmentQ33997274
Mesenchymal stem cell features of Ewing tumorsQ34003979
Upregulation of mir-221 and mir-222 in atypical teratoid/rhabdoid tumors: potential therapeutic targetsQ34088236
An inhibitory effect of miR-22 on cell migration and invasion in ovarian cancerQ34140013
microRNA-143, down-regulated in osteosarcoma, promotes apoptosis and suppresses tumorigenicity by targeting Bcl-2Q34140671
Micro-RNA profiles in osteosarcoma as a predictive tool for ifosfamide responseQ34143825
A cancer family syndrome in twenty-four kindredsQ34177945
Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcomaQ34228576
EWS/FLI1 regulates EYA3 in Ewing sarcoma via modulation of miRNA-708, resulting in increased cell survival and chemoresistance.Q34283431
Genomic and clinical analysis of amplification of the 13q31 chromosomal region in alveolar rhabdomyosarcoma: a report from the Children's Oncology GroupQ34694293
Growth-promoting role of the miR-106a~363 cluster in Ewing sarcomaQ34702270
Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcomaQ34793401
Localization- and mutation-dependent microRNA (miRNA) expression signatures in gastrointestinal stromal tumours (GISTs), with a cluster of co-expressed miRNAs located at 14q32.31.Q35004231
MiR-133b is down-regulated in human osteosarcoma and inhibits osteosarcoma cells proliferation, migration and invasion, and promotes apoptosisQ35082529
Treatment of Ewing sarcoma family of tumors: current status and outlook for the futureQ35090650
SS18-SSX-regulated miR-17 promotes tumor growth of synovial sarcoma by inhibiting p21WAF1/CIP1.Q35200425
miRNA signatures associate with pathogenesis and progression of osteosarcomaQ35894610
MicroRNA Involvement in OsteosarcomaQ35898407
Emerging functional and mechanistic paradigms of mammalian long non-coding RNAsQ36144721
Recent advances in the molecular pathogenesis of Ewing's sarcomaQ36562720
EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3.Q36701142
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectsarcomaQ223911
microRNAQ310899
tumor biomarkerQ66205818
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)16593-621
P577publication date2015-07-22
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleWhat Do We Know about the Role of miRNAs in Pediatric Sarcoma?
P478volume16

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cites work (P2860)
Q38964936Epigenetic and genetic changes in soft tissue sarcomas: a review
Q38768383MicroRNA expression patterns and signalling pathways in the development and progression of childhood solid tumours.

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