An integrated analysis of miRNA and gene copy numbers in xenografts of Ewing's sarcoma

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An integrated analysis of miRNA and gene copy numbers in xenografts of Ewing's sarcoma is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1029889714
P356DOI10.1186/1756-9966-31-24
P3181OpenCitations bibliographic resource ID1968012
P932PMC publication ID3338077
P698PubMed publication ID22429812
P5875ResearchGate publication ID221722489

P50authorSuvi SavolaQ44178659
Antonio Llombart-BoschQ45924296
Silvia Calabuig-FariñasQ45924356
P2093author name stringJosé Antonio López-Guerrero
Katia Scotlandi
Sakari Knuutila
Mohamed Guled
Neda Mosakhani
Isidro Machado
Gayle Leen
Tarja Niini
P2860cites workDiscovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1Q21092854
Insulin-like growth factor-independent effects mediated by a C-terminal metal-binding domain of insulin-like growth factor binding protein-3Q24298366
microRNAs exhibit high frequency genomic alterations in human cancerQ24546369
Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancersQ24625794
A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasisQ24649156
Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cellsQ28245307
Many roads to maturity: microRNA biogenesis pathways and their regulationQ29615469
An analysis of human microRNA and disease associationsQ33377048
Modeling initiation of Ewing sarcoma in human neural crest cellsQ33894979
IGF-I receptor signalling in transformation and differentiationQ33918687
Development of Ewing's sarcoma from primary bone marrow-derived mesenchymal progenitor cellsQ33992270
Mesenchymal stem cell features of Ewing tumorsQ34003979
Does the GH-IGF axis play a role in cancer pathogenesis?Q34132256
Consistent genetic alterations in xenografts of proximal stomach and gastro-esophageal junction adenocarcinomasQ74027601
Prognostic impact of P53 status in Ewing sarcomaQ74199510
Genetic imbalances revealed by comparative genomic hybridization in Ewing tumorsQ74495598
A tissue microarray study of osteosarcoma: histopathologic and immunohistochemical validation of xenotransplanted tumors as preclinical modelsQ84144778
Ewing's sarcoma origin: from duel to dualityQ84386241
Molecular characterization of the pediatric preclinical testing panelQ34406965
CGH analysis of secondary genetic changes in Ewing tumors: correlation with metastatic disease in a series of 43 casesQ34416202
MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosisQ34835189
MicroRNAs: novel biomarkers for human cancerQ34952989
EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiationQ34963463
Mechanism of growth inhibition by MicroRNA 145: the role of the IGF-I receptor signaling pathwayQ34977594
Localization- and mutation-dependent microRNA (miRNA) expression signatures in gastrointestinal stromal tumours (GISTs), with a cluster of co-expressed miRNAs located at 14q32.31.Q35004231
Recurrent gains of 1q, 8 and 12 in the Ewing family of tumours by comparative genomic hybridizationQ36421638
EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3.Q36701142
Combined use of expression and CGH arrays pinpoints novel candidate genes in Ewing sarcoma family of tumorsQ37078506
MicroRNAsQ37095827
Hsa-mir-145 is the top EWS-FLI1-repressed microRNA involved in a positive feedback loop in Ewing's sarcomaQ38338166
Insulin-like growth factor (IGF)-binding protein-3 induces apoptosis and mediates the effects of transforming growth factor-beta1 on programmed cell death through a p53- and IGF-independent mechanismQ38346125
miR-34a predicts survival of Ewing's sarcoma patients and directly influences cell chemo-sensitivity and malignancyQ39465507
1q gain and CDT2 overexpression underlie an aggressive and highly proliferative form of Ewing sarcomaQ39493814
EWS-FLI-1 modulates miRNA145 and SOX2 expression to initiate mesenchymal stem cell reprogramming toward Ewing sarcoma cancer stem cellsQ39716224
Genetically defined EWS/FLI1 model system suggests mesenchymal origin of Ewing's family tumorsQ39931953
Credentialing preclinical pediatric xenograft models using gene expression and tissue microarray analysisQ40185427
Insulin-like growth factor 1 (IGF-1) receptors, IGF-1, and IGF-2 are expressed in primary human sarcomas.Q41392155
Transfection of the human insulin-like growth factor binding protein-3 gene into Balb/c fibroblasts inhibits cellular growthQ41572083
Lung cancer xenografting alters microRNA profile but not immunophenotypeQ42553888
Ewing sarcomas with p53 mutation or p16/p14ARF homozygous deletion: a highly lethal subset associated with poor chemoresponseQ45230556
Establishment of patient-derived non-small cell lung cancer xenografts as models for the identification of predictive biomarkers.Q46312574
Expression of the EWS/FLI-1 oncogene in murine primary bone-derived cells Results in EWS/FLI-1-dependent, ewing sarcoma-like tumorsQ47605320
Insulin-like growth factor-binding protein (IGFBP)-3 and IGFBP-5 share a common nuclear transport pathway in T47D human breast carcinoma cellsQ47859644
Prognostic impact of deletions at 1p36 and numerical aberrations in Ewing tumorsQ50756853
Array CGH and gene-expression profiling reveals distinct genomic instability patterns associated with DNA repair and cell-cycle checkpoint pathways in Ewing's sarcoma.Q53520709
Response and determinants of sensitivity to paclitaxel in human non-small cell lung cancer tumors heterotransplanted in nude mice.Q54023512
Clinicopathological significance of cell cycle regulation markers in a large series of genetically confirmed Ewing's Sarcoma Family of TumorsQ60050244
Allelotype of pancreatic adenocarcinoma using xenograft enrichmentQ71729160
Clinical correlations of genetic changes by comparative genomic hybridization in Ewing sarcoma and related tumorsQ73094960
Molecular cytogenetic parameters in Ewing sarcomaQ73147225
P53 mutations in Ewing's sarcomaQ73733603
Molecular analysis of the 9p21 locus and p53 genes in Ewing family tumorsQ74020557
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectxenograftQ64148587
P304page(s)24
P577publication date2012-01-01
P1433published inJournal of Experimental & Clinical Cancer ResearchQ13739415
P1476titleAn integrated analysis of miRNA and gene copy numbers in xenografts of Ewing's sarcoma
P478volume31

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cites work (P2860)
Q28543958A novel miRNA-based predictive model for biochemical failure following post-prostatectomy salvage radiation therapy
Q35131440Differentially expressed miRNAs in Ewing sarcoma compared to mesenchymal stem cells: low miR-31 expression with effects on proliferation and invasion.
Q51091546Differentiating soft tissue leiomyosarcoma and undifferentiated pleomorphic sarcoma: A miRNA analysis
Q38563638EWS/FLI1 Target Genes and Therapeutic Opportunities in Ewing Sarcoma.
Q96132782Elevated Levels of circRUNX1 in Colorectal Cancer Promote Cell Growth and Metastasis via miR-145-5p/IGF1 Signalling
Q36939163Ewing's Sarcoma: An Analysis of miRNA Expression Profiles and Target Genes in Paraffin-Embedded Primary Tumor Tissue.
Q40162309MiR-557 works as a tumor suppressor in human lung cancers by negatively regulating LEF1 expression
Q38296481MicroRNA expression and its clinical implications in Ewing's sarcoma
Q38038076MicroRNA-mediated gene regulations in human sarcomas
Q28087258MicroRNAs as potential target in human bone and soft tissue sarcoma therapeutics
Q35803040Role of microRNA-150 in solid tumors
Q39075856Stable microRNA expression enhances therapeutic antibody productivity of Chinese hamster ovary cells
Q35832308The SOX17/miR-371-5p/SOX2 axis inhibits EMT, stem cell properties and metastasis in colorectal cancer
Q90442872Translocations involving ETS family proteins in human cancer
Q26800124What Do We Know about the Role of miRNAs in Pediatric Sarcoma?
Q92617858miR-557 inhibits the proliferation and invasion of pancreatic cancer cells by targeting EGFR
Q55003738miR-598 acts as a tumor suppressor in human gastric cancer by targeting IGF-1R.

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