Sestrin2, a Regulator of Thermogenesis and Mitohormesis in Brown Adipose Tissue

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Sestrin2, a Regulator of Thermogenesis and Mitohormesis in Brown Adipose Tissue is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3389/FENDO.2015.00114
P932PMC publication ID4513567
P698PubMed publication ID26257706
P5875ResearchGate publication ID280909114

P2093author name stringJun Hee Lee
Allison Ho
Hwan-Woo Park
Seung-Hyun Ro
Ian Semple
P2860cites workLoss of MKP3 mediated by oxidative stress enhances tumorigenicity and chemoresistance of ovarian cancer cells.Q53319306
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Fatty acids acutely enhance insulin-induced oxidative stress and cause insulin resistance by increasing mitochondrial reactive oxygen species (ROS) generation and nuclear factor-κB inhibitor (IκB)-nuclear factor-κB (NFκB) activation in rat muscle, iQ82904528
Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinaseQ24294812
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Sestrins at the crossroad between stress and agingQ24633564
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Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpDQ28115105
Hepatoprotective role of Sestrin2 against chronic ER stressQ28115216
Sestrins inhibit mTORC1 kinase activation through the GATOR complexQ28115228
Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxinsQ28115923
Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damageQ28117084
p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signalingQ28117922
The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1Q28118221
Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signalingQ28118705
Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stressQ28251449
How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)Q28278053
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Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signalingQ28388989
Mitochondria-ros crosstalk in the control of cell death and agingQ28394689
Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obeseQ28510931
Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3Q28511498
Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signalingQ28513222
Selective activation of AMPK-PGC-1alpha or PKB-TSC2-mTOR signaling can explain specific adaptive responses to endurance or resistance training-like electrical muscle stimulationQ28582298
Sestrin as a feedback inhibitor of TOR that prevents age-related pathologiesQ28590387
NADPH oxidase: an updateQ28611494
A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicineQ29547303
Diet, lifestyle, and the risk of type 2 diabetes mellitus in womenQ29614196
Health benefits of physical activity: the evidenceQ29615134
ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasisQ29617340
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respirationQ29618751
beta-Adrenergic activation of p38 MAP kinase in adipocytes: cAMP induction of the uncoupling protein 1 (UCP1) gene requires p38 MAP kinaseQ33182037
p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 geneQ33199648
Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytesQ33217392
Antioxidant enzymes and their implications in pathophysiologic processes.Q33541272
Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen speciesQ33694643
Oxidative stress stimulates skeletal muscle glucose uptake through a phosphatidylinositol 3-kinase-dependent pathwayQ33901770
Sublethal mitochondrial stress with an attendant stoichiometric augmentation of reactive oxygen species may precipitate many of the beneficial alterations in cellular physiology produced by caloric restriction, intermittent fasting, exercise and dieQ33990893
Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force productionQ34016655
Regulation of mitochondrial biogenesisQ34119796
Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cellsQ34171596
Sestrins orchestrate cellular metabolism to attenuate agingQ34372569
Regulation of the uncoupling protein gene expressionQ41430138
Hormesis and the antiaging action of dietary restrictionQ41702982
Sestrin2 inhibits mTORC1 through modulation of GATOR complexesQ41896464
SESN-1 is a positive regulator of lifespan in Caenorhabditis elegansQ43755243
Caloric restriction augments ROS defense in S. cerevisiae, by a Sir2p independent mechanism.Q46473701
Unraveling the truth about antioxidants: mitohormesis explains ROS-induced health benefitsQ46869731
ROS production in brown adipose tissue mitochondria: the question of UCP1-dependence.Q46901228
Increased reactive oxygen species production in epicardial adipose tissues from coronary artery disease patients is associated with brown-to-white adipocyte trans-differentiation.Q46901366
p38 Mitogen-activated protein kinase is a critical component of the redox-sensitive signaling pathways activated by angiotensin II. Role in vascular smooth muscle cell hypertrophyQ48010552
Daily activity energy expenditure and mortality among older adultsQ48495312
The engineering of brown fat.Q51924548
The effect of dietary restriction on mitochondrial protein density and flight muscle mitochondrial morphology in Drosophila.Q52664637
Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegansQ34408851
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Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heartQ35039324
Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean?Q35047134
Mitochondria-mediated hormetic response in life span extension of calorie-restricted Saccharomyces cerevisiaeQ35080197
Unraveling the biological roles of reactive oxygen speciesQ35653213
The anti-tumor effects of calorie restriction are correlated with reduced oxidative stress in ENU-induced gliomasQ36159690
Diet, metabolism and lifespan in DrosophilaQ36246979
Oxidative and nitrative stress in neurodegenerationQ36326881
Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signalQ36835127
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Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extensionQ37279423
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Vascular rarefaction mediates whitening of brown fat in obesity.Q37726638
Stressin' Sestrins take an aging fightQ37794096
Multiple Functions of Peroxiredoxins: Peroxidases, Sensors and Regulators of the Intracellular Messenger H2O2, and Protein ChaperonesQ37797495
Brown adipose tissue and agingQ37810753
Exercise-induced oxidative stress in humans: cause and consequences.Q37822086
NADPH oxidase-mediated redox signaling: roles in cellular stress response, stress tolerance, and tissue repairQ37828016
Renaissance of brown adipose tissueQ37849516
Oxidative stress and vascular inflammation in aging.Q38121364
Antioxidant supplements and mortalityQ38163373
Peroxisomes sense and respond to environmental cues by regulating ROS and RNS signalling networksQ38526620
Oxidative stress in inherited mitochondrial diseasesQ38527423
Mitochondria are targets for peroxisome-derived oxidative stress in cultured mammalian cellsQ39103215
Lifespan extension by calorie restriction relies on the Sty1 MAP kinase stress pathwayQ39577594
Intracellular proteolytic systems may function as secondary antioxidant defenses: an hypothesisQ39765053
Sodium arsenite induces ROS generation, DNA oxidative damage, HO-1 and c-Myc proteins, NF-kappaB activation and cell proliferation in human breast cancer MCF-7 cells.Q39919711
The endogenous reactive oxygen species promote NF-kappaB activation by targeting on activation of NF-kappaB-inducing kinase in oral squamous carcinoma cellsQ40087559
Adaptive response and oxidative stressQ40500060
P407language of work or nameEnglishQ1860
P921main subjectthermogenesisQ965695
P304page(s)114
P577publication date2015-01-01
P1433published inFrontiers in EndocrinologyQ27723680
P1476titleSestrin2, a Regulator of Thermogenesis and Mitohormesis in Brown Adipose Tissue
P478volume6

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cites work (P2860)
Q90598383Arsenite exposure suppresses adipogenesis, mitochondrial biogenesis and thermogenesis via autophagy inhibition in brown adipose tissue
Q41738731Comparison of Diet versus Exercise on Metabolic Function and Gut Microbiota in Obese Rats.
Q51823732Influence of anaerobic and aerobic exercise on age-related pathways in skeletal muscle.
Q94561972Melatonin inhibits vascular smooth muscle cell proliferation and apoptosis through upregulation of Sestrin2
Q92188838Sestrin2: Its Potential Role and Regulatory Mechanism in Host Immune Response in Diseases

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