Experimental Evidence Shows Salubrinal, an eIF2α Dephosphorylation Inhibitor, Reduces Xenotoxicant-Induced Cellular Damage

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Experimental Evidence Shows Salubrinal, an eIF2α Dephosphorylation Inhibitor, Reduces Xenotoxicant-Induced Cellular Damage is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3390/IJMS160716275
P3181OpenCitations bibliographic resource ID4289462
P932PMC publication ID4519949
P698PubMed publication ID26193263
P5875ResearchGate publication ID281821518

P2093author name stringMasato Matsuoka
Yuta Komoike
P2860cites workRoles of CHOP/GADD153 in endoplasmic reticulum stressQ24302185
Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathwaysQ24309037
Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elementsQ24310021
Protection of Bcl-2 by salubrinalQ24608148
Endoplasmic reticulum stress and the inflammatory basis of metabolic diseaseQ24633352
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stressQ28306995
Regulated translation initiation controls stress-induced gene expression in mammalian cellsQ28506388
Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brainQ28572076
A trip to the ER: coping with stressQ29620455
Atypical, bidirectional regulation of cadmium-induced apoptosis via distinct signaling of unfolded protein response.Q51017044
Salubrinal protects against cigarette smoke extract-induced HBEpC apoptosis likely via regulating the activity of PERK-eIF2α signaling pathway.Q54477071
Amyloid β-induced FOXRED2 mediates neuronal cell death via inhibition of proteasome activityQ82037546
Therapeutical effects and mechanism of salubrinal combined with ulinastatin on treating paraquat poisoningQ87404398
Salubrinal, ER stress inhibitor, attenuates kainic acid-induced hippocampal cell deathQ87674849
Activation of PERK signaling attenuates Abeta-mediated ER stressQ33576967
Tripartite management of unfolded proteins in the endoplasmic reticulumQ33941135
The glucose-regulated proteins: stress induction and clinical applicationsQ34336908
Cadmium induces the expression of Grp78, an endoplasmic reticulum molecular chaperone, in LLC-PK1 renal epithelial cellsQ34687452
Critical role of proteostasis-imbalance in pathogenesis of COPD and severe emphysemaQ35083187
Calcium dynamics and endoplasmic reticular function in the regulation of protein synthesis: implications for cell growth and adaptabilityQ35196242
Mitogen-activated protein kinases in apoptosis regulationQ35743118
Salubrinal attenuates β-amyloid-induced neuronal death and microglial activation by inhibition of the NF-κB pathwayQ35803982
ER stress and the unfolded protein responseQ35986601
The impact of the unfolded protein response on human diseaseQ36062081
Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivoQ36289970
Endoplasmic reticulum stress as a progression factor for kidney injuryQ37666123
The oxidative stress: endoplasmic reticulum stress axis in cadmium toxicityQ37687181
The unfolded protein response triggered by environmental factorsQ38095787
Regulatory crosstalk within the mammalian unfolded protein responseQ38153592
Endoplasmic Reticulum Stress Plays a Key Role in Rotenone-Induced Apoptotic Death of NeuronsQ38446652
Salubrinal protects against rotenone-induced SH-SY5Y cell death via ATF4-parkin pathwayQ39034846
Arsenic trioxide induces unfolded protein response in vascular endothelial cellsQ39119312
Endoplasmic reticulum (ER) stress inhibitor salubrinal protects against ceramide-induced SH-SY5Y cell deathQ39288110
Endoplasmic reticulum stress modulates nicotine-induced extracellular matrix degradation in human periodontal ligament cells.Q39366985
Phosphorylation of the α-subunit of the eukaryotic initiation factor-2 (eIF2α) alleviates benzo[a]pyrene-7,8-diol-9,10-epoxide induced cell cycle arrest and apoptosis in human cellsQ39501284
Salubrinal, an eIF2α dephosphorylation inhibitor, enhances cisplatin-induced oxidative stress and nephrotoxicity in a mouse model.Q39535847
ASK1 overexpression accelerates paraquat-induced autophagy via endoplasmic reticulum stress.Q39647209
The role of endoplasmic reticulum stress-related unfolded protein response in the radiocontrast medium-induced renal tubular cell injuryQ39752405
Paraquat activates the IRE1/ASK1/JNK cascade associated with apoptosis in human neuroblastoma SH-SY5Y cellsQ39802567
Basal levels of eIF2alpha phosphorylation determine cellular antioxidant status by regulating ATF4 and xCT expressionQ39914990
Inhibition of endoplasmic reticulum stress counteracts neuronal cell death and protein aggregation caused by N-terminal mutant huntingtin proteinsQ40015897
Superoxide dismutase 1 mutants related to amyotrophic lateral sclerosis induce endoplasmic stress in neuro2a cellsQ40018929
Arsenite-induced cytotoxicity in dorsal root ganglion explantsQ40019739
The PERK-eIF2α signaling pathway is involved in TCDD-induced ER stress in PC12 cellsQ42705187
Effects of salubrinal on cadmium-induced apoptosis in HK-2 human renal proximal tubular cellsQ42728432
Salubrinal reduces expression and activity of MMP13 in chondrocytes.Q43432593
Autophagy protects renal tubular cells against cyclosporine toxicityQ45069349
Cyclosporine triggers endoplasmic reticulum stress in endothelial cells: a role for endothelial phenotypic changes and deathQ46262369
Cyclosporine-induced endoplasmic reticulum stress triggers tubular phenotypic changes and deathQ46373887
Structure-activity relationship studies of salubrinal lead to its active biotinylated derivativeQ46588403
Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicityQ46765805
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectureaQ48318
catalysisQ82264
organic chemistryQ11351
ribosomal proteinsQ3408228
carboxylic acidQ134856
SalubrinalQ7406268
pharmaceutical preparationQ66089252
P304page(s)16275-87
P577publication date2015-01-01
2015-07-17
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleExperimental Evidence Shows Salubrinal, an eIF2α Dephosphorylation Inhibitor, Reduces Xenotoxicant-Induced Cellular Damage
P478volume16

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cites work (P2860)
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Q41914993Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors.
Q51535977Salubrinal Suppresses IL-17-Induced Upregulation of MMP-13 and Extracellular Matrix Degradation Through the NF-kB Pathway in Human Nucleus Pulposus Cells.
Q39341900Sevoflurane-Induced Endoplasmic Reticulum Stress Contributes to Neuroapoptosis and BACE-1 Expression in the Developing Brain: The Role of eIF2α.
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Q37705909The involvement of endoplasmic reticulum stress response in immune dysfunction of dendritic cells after severe thermal injury in mice
Q37200271Vitamin E δ-tocotrienol triggers endoplasmic reticulum stress-mediated apoptosis in human melanoma cells

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