Lost in translation: pluripotent stem cell-derived hematopoiesis

scientific article (publication date: November 2015)

Lost in translation: pluripotent stem cell-derived hematopoiesis is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.15252/EMMM.201505301
P3181OpenCitations bibliographic resource ID2684729
P932PMC publication ID4644373
P698PubMed publication ID26174486
P5875ResearchGate publication ID280062449

P50authorJan-Henning KlusmannQ42231158
Nico LachmannQ42245309
P2093author name stringMania Ackermann
Steffi Liebhaber
P2860cites workHematopoietic specification from human pluripotent stem cells: current advances and challenges toward de novo generation of hematopoietic stem cellsQ26851475
Adenosine signaling promotes hematopoietic stem and progenitor cell emergenceQ27308862
The RUNX1 +24 enhancer and P1 promoter identify a unique subpopulation of hematopoietic progenitor cells derived from human pluripotent stem cellsQ27329605
A novel serum-free monolayer culture for orderly hematopoietic differentiation of human pluripotent cells via mesodermal progenitorsQ27331986
Induced pluripotent stem cell lines derived from human somatic cellsQ27860597
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Induction of pluripotent stem cells from adult human fibroblasts by defined factorsQ27860967
Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signalingQ28118040
Wnt-3a is required for somite specification along the anteroposterior axis of the mouse embryo and for regulation of cdx-1 expressionQ73832810
Suppression of hematopoietic activity in tenascin-C-deficient miceQ74576884
Differential expression of Hox, Meis1, and Pbx1 genes in primitive cells throughout murine hematopoietic ontogenyQ77583284
Hemogenic and nonhemogenic endothelium can be distinguished by the activity of fetal liver kinase (Flk)-1 promoter/enhancer during mouse embryogenesisQ78410585
Promotion of hematopoietic differentiation from mouse induced pluripotent stem cells by transient HoxB4 transductionQ82034877
Inducing definitive hematopoiesis in a dishQ88043486
Differentiation of human embryonic stem cells into hematopoietic cells by coculture with human fetal liver cells recapitulates the globin switch that occurs early in development.Q40341874
Human embryonic stem cell-derived NK cells acquire functional receptors and cytolytic activityQ40364711
Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cellsQ40654271
Receptor for macrophage colony-stimulating factor transduces a signal decreasing erythroid potential in the multipotent hematopoietic EML cell lineQ40849693
Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivoQ41325322
Clonal Dominance With Retroviral Vector Insertions Near the ANGPT1 and ANGPT2 Genes in a Human Xenotransplant Mouse ModelQ42184255
Large-scale hematopoietic differentiation of human induced pluripotent stem cells provides granulocytes or macrophages for cell replacement therapiesQ42245259
Direct reprogramming of murine fibroblasts to hematopoietic progenitor cellsQ42265766
Generation of hematopoietic repopulating cells from human embryonic stem cells independent of ectopic HOXB4 expressionQ42972247
Scalable generation of universal platelets from human induced pluripotent stem cells.Q43010381
Hematopoietic repopulating ability of CD34⁺ progenitor cells ex vivo expanded with different cytokine combinationsQ44473871
In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 proteinQ44714937
Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokinesQ45046201
Interaction of Wnt and caudal-related genes in zebrafish posterior body formationQ45263246
Lymphomyeloid contribution of an immune-restricted progenitor emerging prior to definitive hematopoietic stem cellsQ45856689
Gene correction of human induced pluripotent stem cells repairs the cellular phenotype in pulmonary alveolar proteinosis.Q45858446
Pulmonary transplantation of macrophage progenitors as effective and long-lasting therapy for hereditary pulmonary alveolar proteinosisQ45867818
The hemangioblast: a state of competence.Q45903542
Retinoic acid signaling is essential for embryonic hematopoietic stem cell developmentQ46331596
The caudal-related homeobox genes cdx1a and cdx4 act redundantly to regulate hox gene expression and the formation of putative hematopoietic stem cells during zebrafish embryogenesisQ46927100
Vascular endothelial growth factor (VEGF) and VEGF receptor 2 (flk-1) are expressed during vasculogenesis and vascular differentiation in the quail embryo.Q48073084
HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulationQ49033123
Generation of T cells from human embryonic stem cell-derived hematopoietic zonesQ49134707
Requirement for Wnt3 in vertebrate axis formationQ28141064
Preliminary note on the differentiation of angioblasts and the method by which they produce blood-vessels, blood-plasma and red blood-cells as seen in the living chick. 1917Q28201647
A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouseQ28238399
Meet the tenascins: multifunctional and mysteriousQ28254352
Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouseQ28296363
SOX7 transcription factor: sequence, chromosomal localisation, expression, transactivation and interference with Wnt signallingQ28640827
A common precursor for primitive erythropoiesis and definitive haematopoiesisQ29027802
Expression of angiotensin-converting enzyme (CD143) identifies and regulates primitive hemangioblasts derived from human pluripotent stem cellsQ29394497
Abnormal blood vessel development and lethality in embryos lacking a single VEGF alleleQ29547733
Efficient and rapid generation of induced pluripotent stem cells from human keratinocytesQ29614341
An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrowQ29615498
Haemangioblast commitment is initiated in the primitive streak of the mouse embryoQ30054525
Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cellsQ30410059
Identification of the hemogenic endothelial progenitor and its direct precursor in human pluripotent stem cell differentiation cultures.Q30525434
BMP-mediated specification of the erythroid lineage suppresses endothelial development in blood island precursorsQ30558849
Expandable megakaryocyte cell lines enable clinically applicable generation of platelets from human induced pluripotent stem cellsQ33413336
The expression of Sox17 identifies and regulates haemogenic endotheliumQ33572058
Development and function of human innate immune cells in a humanized mouse modelQ33596915
Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factorsQ33768149
Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living miceQ33789872
Cooperative interaction of Etv2 and Gata2 regulates the development of endothelial and hematopoietic lineagesQ33906266
Direct induction of haematoendothelial programs in human pluripotent stem cells by transcriptional regulators.Q33935685
In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells.Q34034653
Generation of engraftable hematopoietic stem cells from induced pluripotent stem cells by way of teratoma formation.Q34036700
Kit regulates HSC engraftment across the human-mouse species barrierQ34041440
Wnt signaling controls the specification of definitive and primitive hematopoiesis from human pluripotent stem cellsQ34124971
Runx1 expression marks long-term repopulating hematopoietic stem cells in the midgestation mouse embryoQ34131812
Direct conversion of human fibroblasts to multilineage blood progenitors.Q34148584
Reprogramming human endothelial cells to haematopoietic cells requires vascular inductionQ34157738
Embryonic stem cell-derived hematopoietic stem cellsQ34244938
A direct measurement of the radiation sensitivity of normal mouse bone marrow cellsQ34249472
Supralethal whole body irradiation and isologous marrow transplantation in man.Q34250866
Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cellsQ34253556
THE DISTRIBUTION OF COLONY-FORMING CELLS AMONG SPLEEN COLONIES.Q34255950
T lymphocyte potential marks the emergence of definitive hematopoietic progenitors in human pluripotent stem cell differentiation cultures.Q34316024
Of lineage and legacy: the development of mammalian hematopoietic stem cellsQ37060270
Homogeneous monocytes and macrophages from human embryonic stem cells following coculture-free differentiation in M-CSF and IL-3.Q37083114
Enhanced hemangioblast generation and improved vascular repair and regeneration from embryonic stem cells by defined transcription factorsQ37133650
Generation of mature human myelomonocytic cells through expansion and differentiation of pluripotent stem cell-derived lin-CD34+CD43+CD45+ progenitorsQ37328520
Runx1 is required for the endothelial to haematopoietic cell transition but not thereafterQ37347018
Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursorsQ37462880
Use of induced pluripotent stem cells to recapitulate pulmonary alveolar proteinosis pathogenesisQ37698322
Maternal and zygotic control of zebrafish dorsoventral axial patterningQ37937575
Instruction of hematopoietic lineage choice by cytokine signaling.Q38232236
Role of SOX17 in hematopoietic development from human embryonic stem cellsQ38319819
Induction of a hemogenic program in mouse fibroblastsQ39401906
Generation of dendritic cells and macrophages from human induced pluripotent stem cells aiming at cell therapyQ39571768
Direct comparison of Dll1- and Dll4-mediated Notch activation levels shows differential lymphomyeloid lineage commitment outcomes.Q39693040
A feeder-free and efficient production of functional neutrophils from human embryonic stem cellsQ39930657
Generation of induced pluripotent stem cells from human cord blood.Q39942465
Large-scale production of embryonic red blood cells from human embryonic stem cells.Q40198963
Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation culturesQ40200355
Human ESC-derived hemogenic endothelial cells undergo distinct waves of endothelial to hematopoietic transition.Q50548116
Human induced pluripotent stem cell-derived B lymphocytes express sIgM and can be generated via a hemogenic endothelium intermediate.Q50614235
BMP and Wnt specify hematopoietic fate by activation of the Cdx-Hox pathway.Q50640813
Differentiation of human embryonic stem cells in serum-free medium reveals distinct roles for bone morphogenetic protein 4, vascular endothelial growth factor, stem cell factor, and fibroblast growth factor 2 in hematopoiesis.Q50984450
Thymopentin enhances the generation of T-cell lineage derived from human embryonic stem cells in vitro.Q51018835
Manipulation of the angiopoietic/hemangiopoietic commitment in the avian embryo.Q51092344
Derivation of functional mature neutrophils from human embryonic stem cells.Q51750810
WNT and BMP signaling are both required for hematopoietic cell development from human ES cells.Q51930571
Differentiation of human embryonic stem cells into immunostimulatory dendritic cells under feeder-free culture conditions.Q51948437
Cdx4 is a direct target of the canonical Wnt pathway.Q52033246
HOXB4-induced expansion of adult hematopoietic stem cells ex vivo.Q52121269
HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors.Q52121270
Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo.Q52136574
Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 alpha, beta and gamma genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm.Q52222142
RADIATION EFFECTS ON THE DIVISION CYCLE OF MAMMALIAN CELLS IN VITRO*Q56246887
Efficient differentiation and function of human macrophages in humanized CSF-1 miceQ57201659
The orderly allocation of mesodermal cells to the extraembryonic structures and the anteroposterior axis during gastrulation of the mouse embryoQ60982889
Immunological reconstitution of sex-linked lymphopenic immunological deficiencyQ70099373
Extracellular matrix production by the adherent cells of long-term murine bone marrow culturesQ70425630
HOXB gene expression and function in differentiating purified hematopoietic progenitorsQ71562650
Identification and characterization of a bipotent (erythroid and megakaryocytic) cell precursor from the spleen of phenylhydrazine-treated miceQ73642949
Conversion of human fibroblasts into monocyte-like progenitor cellsQ34345247
Immortalization of erythroblasts by c-MYC and BCL-XL enables large-scale erythrocyte production from human pluripotent stem cellsQ34394559
Hedgehog signaling is required for adult blood stem cell formation in zebrafish embryosQ34398804
A requirement for Flk1 in primitive and definitive hematopoiesis and vasculogenesisQ34430479
Hematopoietic stem cell fate is established by the Notch-Runx pathwayQ34451310
A common precursor for hematopoietic and endothelial cells.Q34452940
Axis development and early asymmetry in mammalsQ34492466
Pulmonary macrophage transplantation therapyQ34539736
Generation of megakaryocytic progenitors from human embryonic stem cells in a feeder- and serum-free medium.Q34592667
Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genesQ34653693
Hematopoietic cytokines, transcription factors and lineage commitmentQ34658525
Tenascin C promotes hematoendothelial development and T lymphoid commitment from human pluripotent stem cells in chemically defined conditionsQ34684059
An expandable, inducible hemangioblast state regulated by fibroblast growth factorQ34684558
Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotencyQ34771507
Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factorsQ34791180
Erythroid differentiation of human induced pluripotent stem cells is independent of donor cell type of origin.Q34797997
Chemically defined conditions for human iPSC derivation and cultureQ34890309
Efficient, long term production of monocyte-derived macrophages from human pluripotent stem cells under partly-defined and fully-defined conditionsQ34948733
Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endotheliumQ35126252
Generation of red blood cells from human induced pluripotent stem cellsQ35179358
SCL/TAL1-mediated transcriptional network enhances megakaryocytic specification of human embryonic stem cellsQ35591443
Definitive-like erythroid cells derived from human embryonic stem cells coexpress high levels of embryonic and fetal globins with little or no adult globinQ35848983
Dynamic HoxB4-regulatory network during embryonic stem cell differentiation to hematopoietic cells.Q35995253
Autonomous murine T-cell progenitor production in the extra-embryonic yolk sac before HSC emergence.Q36057573
Blood island formation: longstanding observations and modern interpretationsQ36248237
Functional characterization of B lymphocytes generated in vitro from embryonic stem cells.Q36434592
Challenges and strategies for generating therapeutic patient-specific hemangioblasts and hematopoietic stem cells from human pluripotent stem cellsQ36436582
Hematopoietic stem-cell transplantationQ36461248
All primitive and definitive hematopoietic progenitor cells emerging before E10 in the mouse embryo are products of the yolk sac.Q36508856
In vitro human embryonic stem cell hematopoiesis mimics MYB-independent yolk sac hematopoiesisQ36715938
Deciphering the hierarchy of angiohematopoietic progenitors from human pluripotent stem cellsQ36724256
RUNX1a enhances hematopoietic lineage commitment from human embryonic stem cells and inducible pluripotent stem cellsQ36761531
Generation of functional erythrocytes from human embryonic stem cell-derived definitive hematopoiesisQ36854698
Serum- and stromal cell-free hypoxic generation of embryonic stem cell-derived hematopoietic cells in vitro, capable of multilineage repopulation of immunocompetent miceQ36861646
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue11
P407language of work or nameEnglishQ1860
P921main subjecthemopoiesisQ919283
pluripotencyQ1894941
cellQ7868
P304page(s)1388-1402
P577publication date2015-11-01
P1433published inEMBO Molecular MedicineQ15817279
P1476titleLost in translation: pluripotent stem cell-derived hematopoiesis
P478volume7

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