Expandable megakaryocyte cell lines enable clinically applicable generation of platelets from human induced pluripotent stem cells

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Expandable megakaryocyte cell lines enable clinically applicable generation of platelets from human induced pluripotent stem cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.STEM.2014.01.011
P698PubMed publication ID24529595
P5875ResearchGate publication ID260217696

P50authorShinya YamanakaQ80917
Keisuke OkitaQ73389625
Koji EtoQ87047082
Shinji HirataQ114555975
Kiyosumi OchiQ114555977
P2093author name stringHiromitsu Nakauchi
Takeaki Dohda
Naoya Takayama
Satoshi Nishimura
Akira Watanabe
Ken-ichi Fujita
Akira Sawaguchi
Nobuyasu Takahashi
Sou Nakamura
Hiroshi Endo
Hideya Seo
Ken-ichi Harimoto
Tomo Koike
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Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cellsQ30483213
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Infusion of mature megakaryocytes into mice yields functional plateletsQ30497158
In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signalingQ30514057
A systems-biology analysis of isogenic megakaryocytic and granulocytic cultures identifies new molecular components of megakaryocytic apoptosisQ33303491
BclxL overexpression in megakaryocytes leads to impaired platelet fragmentationQ33343732
Metalloproteinase inhibitors improve the recovery and hemostatic function of in vitro-aged or -injured mouse plateletsQ33349386
The biogenesis of platelets from megakaryocyte proplateletsQ33369405
Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cellsQ33392928
Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce plateletsQ33397149
Congenital amegakaryocytic thrombocytopenia iPS cells exhibit defective MPL-mediated signalingQ33409483
Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living miceQ33789872
Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors.Q34030648
Characterization of stage progression in chronic myeloid leukemia by DNA microarray with purified hematopoietic stem cellsQ34108458
An efficient nonviral method to generate integration-free human-induced pluripotent stem cells from cord blood and peripheral blood cellsQ34314350
Immortalization of erythroblasts by c-MYC and BCL-XL enables large-scale erythrocyte production from human pluripotent stem cellsQ34394559
Diagnosis and management of refractoriness to platelet transfusionQ34494961
Transcriptional control of the core cell-death machineryQ35744897
Induction of functional platelets from mouse and human fibroblasts by p45NF-E2/MafQ36370865
Platelet receptor sheddingQ37963244
Challenges and promises for the development of donor-independent platelet transfusionsQ38074224
c-Myc functionally cooperates with Bax to induce apoptosisQ39675305
Gene expression analysis during platelet-like particle production in phorbol myristate acetate-treated MEG-01 cellsQ39878359
Efficient establishment of human embryonic stem cell lines and long-term maintenance with stable karyotype by enzymatic bulk passageQ40278874
Increased megakaryopoiesis in cultures of CD34-enriched cord blood cells maintained at 39 degrees C.Q40521527
Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient miceQ41779350
A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small moleculesQ42166429
Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearanceQ42382293
Establishment of a human leukaemic cell line (CMK) with megakaryocytic characteristics from a Down's syndrome patient with acute megakaryoblastic leukaemiaQ42814356
Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cellsQ45155046
A novel flow cytometry-based platelet aggregation assay.Q45792585
Dynamic Visualization of Thrombopoiesis Within Bone MarrowQ58450371
Role of platelet surface glycoprotein Ibalpha and P-selectin in the clearance of transfused platelet concentratesQ80596185
Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitorsQ81015137
Two differential flows in a bioreactor promoted platelet generation from human pluripotent stem cell-derived megakaryocytesQ86657049
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectHuman Induced Pluripotent Stem CellsQ88981775
P304page(s)535-548
P577publication date2014-02-13
P1433published inCell Stem CellQ2943975
P1476titleExpandable megakaryocyte cell lines enable clinically applicable generation of platelets from human induced pluripotent stem cells
P478volume14

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