| scholarly article | Q13442814 |
| P50 | author | Donald Metcalf | Q1240162 |
| Emma C Josefsson | Q59647756 | ||
| Andrew W. Roberts | Q43445505 | ||
| Michael J. White | Q46040334 | ||
| Kylie D. Mason | Q46040354 | ||
| Benjamin T. Kile | Q46040375 | ||
| Sarah Ellis | Q54107325 | ||
| Kelly L. Rogers | Q55180008 | ||
| P2093 | author name string | David C S Huang | |
| Paquita Nurden | |||
| Lorraine A O'Reilly | |||
| Mark R Dowling | |||
| Rachael M Lane | |||
| Katya J Henley | |||
| Chloé James | |||
| Elizabeth A Kruse | |||
| Marlyse A Debrincat | |||
| P2860 | cites work | Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak | Q24296478 |
| Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1 | Q24302166 | ||
| Inhibition of ADP/ATP exchange in receptor-interacting protein-mediated necrosis | Q24306119 | ||
| In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains | Q24315787 | ||
| No death without life: vital functions of apoptotic effectors | Q24319057 | ||
| Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development | Q24321429 | ||
| Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death | Q24336389 | ||
| Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009 | Q24653924 | ||
| Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy | Q28131727 | ||
| Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity | Q28138855 | ||
| BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis | Q28189945 | ||
| FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex | Q28283294 | ||
| Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death | Q28363890 | ||
| The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues | Q28512628 | ||
| Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis | Q28512797 | ||
| Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease | Q28513752 | ||
| Bax-deficient mice with lymphoid hyperplasia and male germ cell death | Q28589360 | ||
| The BCL-2 protein family: opposing activities that mediate cell death | Q29547380 | ||
| An inhibitor of Bcl-2 family proteins induces regression of solid tumours | Q29547595 | ||
| ATR: an essential regulator of genome integrity | Q29547883 | ||
| The pathophysiology of mitochondrial cell death | Q29547893 | ||
| Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis. | Q30554728 | ||
| Approaches to managing carboplatin-induced thrombocytopenia: focus on the role of amifostine. | Q33328960 | ||
| Pathophysiology of thrombocytopenia and anemia in mice lacking transcription factor NF-E2. | Q33330558 | ||
| BclxL overexpression in megakaryocytes leads to impaired platelet fragmentation | Q33343732 | ||
| Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro | Q33347325 | ||
| Ultrastructural study shows morphologic features of apoptosis and para-apoptosis in megakaryocytes from patients with idiopathic thrombocytopenic purpura | Q33349911 | ||
| PLATELET SEQUESTRATION IN MAN. I. METHODS. | Q33355155 | ||
| The effect of antiplatelet autoantibodies on megakaryocytopoiesis | Q33365374 | ||
| The biogenesis of platelets from megakaryocyte proplatelets | Q33369405 | ||
| Programmed anuclear cell death delimits platelet life span. | Q33374664 | ||
| Chemotherapy-induced thrombocytopenia derives from the selective death of megakaryocyte progenitors and can be rescued by stem cell factor | Q33375296 | ||
| Roles of focal adhesion kinase (FAK) in megakaryopoiesis and platelet function: studies using a megakaryocyte lineage specific FAK knockout | Q33376946 | ||
| Caspase activation is involved in early megakaryocyte differentiation but not in platelet production from megakaryocytes | Q33383251 | ||
| Management of chemotherapy-induced thrombocytopenia: current status of thrombopoietic agents | Q33383470 | ||
| Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage | Q33385721 | ||
| Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets. | Q33388172 | ||
| Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR | Q33392029 | ||
| Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity | Q33392920 | ||
| BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: molecular requisites for the mitochondrial pathway to apoptosis in platelets | Q33394363 | ||
| Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease | Q33398808 | ||
| Structural changes in the megakaryocytes of patients infected with the human immune deficiency virus (HIV-1). | Q33434918 | ||
| Mechanisms of thrombocytopenia in chronic autoimmune thrombocytopenic purpura. Evidence of both impaired platelet production and increased platelet clearance | Q33454343 | ||
| Re-examining the role of cytochrome c in cell death | Q57220115 | ||
| Dynamic Visualization of Thrombopoiesis Within Bone Marrow | Q58450371 | ||
| Bcl-2 has a cell cycle inhibitory function separable from its enhancement of cell survival | Q59607019 | ||
| Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice | Q72600081 | ||
| Biotinylated platelets: a new approach to the measurement of platelet life span | Q72695639 | ||
| Effects of cytokines on platelet production from blood and marrow CD34+ cells | Q74106130 | ||
| Bcl-x is a regulatory factor of apoptosis and differentiation in megakaryocytic lineage cells | Q74314712 | ||
| Broad-spectrum caspase inhibitors: from myth to reality? | Q79157631 | ||
| Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo | Q79220440 | ||
| Impaired survival of bone marrow GPIIb/IIa+ megakaryocytic cells as an additional pathogenetic mechanism of HIV-1-related thrombocytopenia | Q33495589 | ||
| Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl | Q33495712 | ||
| Mice lacking transcription factor NF-E2 provide in vivo validation of the proplatelet model of thrombocytopoiesis and show a platelet production defect that is intrinsic to megakaryocytes | Q33503448 | ||
| Whole blood analysis of reticulated platelets: improvements of detection and assay stability. | Q33504395 | ||
| zVAD-induced necroptosis in L929 cells depends on autocrine production of TNFα mediated by the PKC-MAPKs-AP-1 pathway. | Q35092587 | ||
| Role of apoptotic processes in platelet biogenesis | Q35596713 | ||
| Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes | Q36313419 | ||
| Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death | Q36324970 | ||
| Apoptosis: a basic biological phenomenon with wide-ranging implications in human disease | Q36325036 | ||
| bcl-x prevents apoptotic cell death of both primitive and definitive erythrocytes at the end of maturation | Q36368245 | ||
| Caspases at the crossroads of immune-cell life and death | Q36430147 | ||
| Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival | Q36776853 | ||
| Drugs targeting Bcl-2 family members as an emerging strategy in cancer | Q37786022 | ||
| BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program | Q38269004 | ||
| Continuous expression of Bcl-xL protein during megakaryopoiesis is post-translationally regulated by thrombopoietin-mediated Akt activation, which prevents the cleavage of Bcl-xL. | Q40153818 | ||
| Antiapoptotic protein Bcl-x(L) is up-regulated during megakaryocytic differentiation of CD34(+) progenitors but is absent from senescent megakaryocytes. | Q40802790 | ||
| Thrombopoietin signal transduction in purified murine megakaryocytes | Q41134439 | ||
| P1 aspartate-based peptide alpha-((2,6-dichlorobenzoyl)oxy)methyl ketones as potent time-dependent inhibitors of interleukin-1 beta-converting enzyme | Q41481455 | ||
| DNA damage as a basis for 4'-demethylepipodophyllotoxin-9-(4,6-O-ethylidene-beta-D-glucopyranoside) (etoposide) cytotoxicity. | Q41605393 | ||
| p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis | Q42140565 | ||
| Immunohistochemical analysis of in vivo patterns of Bcl-X expression | Q42491717 | ||
| Platelet senescence is regulated by an internal timer, not damage inflicted by hits | Q43041905 | ||
| Platelet formation is the consequence of caspase activation within megakaryocytes | Q44083637 | ||
| Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties | Q44483506 | ||
| The macrophage alphaMbeta2 integrin alphaM lectin domain mediates the phagocytosis of chilled platelets | Q45291316 | ||
| Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function. | Q46040273 | ||
| Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis. | Q52547440 | ||
| Observation of Antigen-Dependent CD8+ T-Cell/ Dendritic Cell Interactions in Vivo | Q56922092 | ||
| P433 | issue | 10 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | apoptotic process | Q14599311 |
| P304 | page(s) | 2017-2031 | |
| P577 | publication date | 2011-09-12 | |
| P1433 | published in | Journal of Experimental Medicine | Q3186912 |
| P1476 | title | Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets | |
| P478 | volume | 208 |
| Q33402025 | A megakaryocyte with no platelets: anti-platelet antibodies, apoptosis, and platelet production |
| Q35679582 | A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2. |
| Q35416666 | Actin inhibition increases megakaryocyte proplatelet formation through an apoptosis-dependent mechanism |
| Q33407110 | Advances in megakaryocytopoiesis and thrombopoiesis: from bench to bedside. |
| Q53650348 | Aging platelets stimulate TPO production. |
| Q36535484 | Alzheimer disease and platelets: how's that relevant |
| Q47155664 | Anti-apoptotic BCL-2 family members in development |
| Q33422077 | BCL-2 is dispensable for thrombopoiesis and platelet survival |
| Q92453289 | BCL-XL expression is essential for human erythropoiesis and engraftment of hematopoietic stem cells |
| Q93166015 | BMP2K dysregulation promotes abnormal megakaryopoiesis in acute megakaryoblastic leukemia |
| Q33403953 | Bacteria differentially induce degradation of Bcl-xL, a survival protein, by human platelets |
| Q38735628 | Bcl-2 proteins in development, health, and disease of the hematopoietic system. |
| Q36596892 | CCL5 derived from platelets increases megakaryocyte proplatelet formation |
| Q33433254 | CD8(+) T cells induce platelet clearance in the liver via platelet desialylation in immune thrombocytopenia |
| Q50048420 | Developmental Stage-Specific Manifestations of Absent TPO/c-MPL Signalling in Newborn Mice |
| Q39052443 | Differential regulation of the apoptotic machinery during megakaryocyte differentiation and platelet production by inhibitor of apoptosis protein Livin |
| Q46265048 | Dopamine induces platelet production from megakaryocytes via oxidative stress-mediated signaling pathways |
| Q42227148 | Dysregulation of the intrinsic apoptotic pathway mediates megakaryocytic hyperplasia in myeloproliferative neoplasms. |
| Q33417148 | Effect of thrombopoietin receptor agonists on the apoptotic profile of platelets in patients with chronic immune thrombocytopenia |
| Q47288480 | Effects of vascular endothelial growth factors and their receptors on megakaryocytes and platelets and related diseases |
| Q38398064 | Emerging understanding of Bcl-2 biology: Implications for neoplastic progression and treatment. |
| Q38187494 | Ex vivo production of platelets from stem cells |
| Q33413336 | Expandable megakaryocyte cell lines enable clinically applicable generation of platelets from human induced pluripotent stem cells |
| Q33413694 | Expansion of the neonatal platelet mass is achieved via an extension of platelet lifespan |
| Q36358673 | Identifying and enriching platelet-producing human stem cell-derived megakaryocytes using factor V uptake. |
| Q33414241 | Impaired proplatelet formation in immune thrombocytopenia: a novel mechanism contributing to decreased platelet count |
| Q90733820 | Induction of differentiation of human stem cells ex vivo: Toward large-scale platelet production |
| Q33431116 | Inherited thrombocytopenia: novel insights into megakaryocyte maturation, proplatelet formation and platelet lifespan |
| Q33413168 | Interpreting the developmental dance of the megakaryocyte: a review of the cellular and molecular processes mediating platelet formation |
| Q33423736 | Interspecies Variation in the Functional Consequences of Mutation of Cytochrome c |
| Q33435991 | Investigation of platelet apoptosis in adult patients with chronic immune thrombocytopenia |
| Q38307680 | Lessons from gain- and loss-of-function models of pro-survival Bcl2 family proteins: implications for targeted therapy |
| Q33413048 | Lessons in platelet production from inherited thrombocytopenias |
| Q26770863 | Linkage between the mechanisms of thrombocytopenia and thrombopoiesis |
| Q33412907 | Loss of Bak enhances lymphocytosis but does not ameliorate thrombocytopaenia in BCL-2 transgenic mice. |
| Q42133744 | Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice |
| Q33432478 | Loss of PUMA (BBC3) does not prevent thrombocytopenia caused by the loss of BCL-XL (BCL2L1). |
| Q34611158 | MCMV-mediated inhibition of the pro-apoptotic Bak protein is required for optimal in vivo replication |
| Q48168170 | Magnetic nanoparticles for drug targeting: from design to insights into systemic toxicity. Preclinical evaluation of hematological, vascular and neurobehavioral toxicology. |
| Q33424186 | Manipulating megakaryocytes to manufacture platelets ex vivo |
| Q33402322 | Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistages |
| Q54677212 | Mechanisms of platelet clearance and translation to improve platelet storage. |
| Q90282070 | Megakaryocytes contain extranuclear histones and may be a source of platelet-associated histones during sepsis |
| Q48144174 | Megakaryocytic hyperplasia in myeloproliferative neoplasms is driven by disordered proliferative, apoptotic and epigenetic mechanisms. |
| Q28088519 | Megakaryopoiesis and platelet production: insight into hematopoietic stem cell proliferation and differentiation |
| Q92756639 | Mesenchymal stromal cells lower platelet activation and assist in platelet formation in vitro |
| Q26741708 | Mitochondria, cholesterol and cancer cell metabolism |
| Q38367962 | Mitochondrial apoptosis: killing cancer using the enemy within. |
| Q33441740 | Mouse RUNX1C regulates premegakaryocytic/erythroid output and maintains survival of megakaryocyte progenitors |
| Q33405191 | Multiploid CD61+ cells are the pre-dominant cell lineage infected during acute dengue virus infection in bone marrow |
| Q39241674 | Navitoclax augments the activity of carboplatin and paclitaxel combinations in ovarian cancer cells |
| Q47760265 | Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia. |
| Q39140591 | Non-apoptotic functions of caspases in myeloid cell differentiation. |
| Q33424241 | Novel mechanisms of platelet clearance and thrombopoietin regulation |
| Q33430602 | P53 activation inhibits all types of hematopoietic progenitors and all stages of megakaryopoiesis. |
| Q36218842 | PSAP induces a unique Apaf-1 and Smac-dependent mitochondrial apoptotic pathway independent of Bcl-2 family proteins |
| Q58692179 | Pharmacological characterization of hetrombopag, a novel orally active human thrombopoietin receptor agonist |
| Q36955957 | Physiological restraint of Bak by Bcl-xL is essential for cell survival |
| Q33413970 | Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways |
| Q36616993 | Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease |
| Q38764769 | Proplatelet formation in megakaryocytes is associated with endoplasmic reticulum stress |
| Q36169258 | Regulating billions of blood platelets: glycans and beyond. |
| Q33431667 | Regulation of platelet lifespan by apoptosis |
| Q33433417 | Regulation of platelet lifespan in the presence and absence of thrombopoietin signaling. |
| Q38919547 | Regulation of platelet membrane protein shedding in health and disease |
| Q26749232 | Role of autophagy in megakaryocyte differentiation and platelet formation |
| Q58720234 | Role of p53 and transcription-independent p53-induced apoptosis in shear-stimulated megakaryocytic maturation, particle generation, and platelet biogenesis |
| Q42662112 | Separation of in-vitro-derived megakaryocytes and platelets using spinning-membrane filtration |
| Q34293014 | Shear enhances thrombopoiesis and formation of microparticles that induce megakaryocytic differentiation of stem cells. |
| Q27684453 | Structure-guided design of a selective BCL-X(L) inhibitor |
| Q33419210 | The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling |
| Q33412943 | The role of apoptosis in megakaryocytes and platelets |
| Q27015841 | Transcription factors in late megakaryopoiesis and related platelet disorders |
| Q26770860 | Understanding platelet generation from megakaryocytes: implications for in vitro-derived platelets |
| Q59333353 | VDAC2 enables BAX to mediate apoptosis and limit tumor development |
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