Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death

scientific article

Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1083/JCB.200210111
P932PMC publication ID2173731
P698PubMed publication ID12591916
P5875ResearchGate publication ID10895621

P50authorMurray ClarkeQ63919085
David B. JonesQ110229241
P2093author name stringSimon B Brown
John Savill
Brendon S Noble
P2860cites workCaspase activation is required for terminal erythroid differentiationQ24290854
Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome cQ24309066
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascadeQ24311006
Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blockedQ24318845
Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue KineticsQ24564912
alpha-Toxin is a mediator of Staphylococcus aureus-induced cell death and activates caspases via the intrinsic death pathway independently of death receptor signalingQ24653351
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunityQ28138855
Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activationQ28263551
The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosisQ29616513
Actin reorganization and proplatelet formation in murine megakaryocytes: the role of protein kinase calphaQ31775053
Establishment and characterization of a new human megakaryoblastic cell line (SET-2) that spontaneously matures to megakaryocytes and produces platelet-like particlesQ33331222
Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunityQ33488225
Clinical, immunological, and pathological consequences of Fas-deficient conditionsQ33496872
Direct cleavage by the calcium-activated protease calpain can lead to inactivation of caspasesQ33889747
Induction of platelet formation from megakaryocytoid cells by nitric oxideQ33951944
Regulation of neutrophil apoptosis: a role for protein kinase C and phosphatidylinositol-3-kinase.Q34188902
Mechanisms of platelet production.Q34499028
Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophagesQ34561816
Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosisQ36235778
Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytesQ36313419
Mitochondrial permeability transition is a central coordinating event of apoptosisQ36367290
Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survivalQ36776853
Localization of megakaryocytes in the bone marrowQ38613783
Antiapoptotic protein Bcl-x(L) is up-regulated during megakaryocytic differentiation of CD34(+) progenitors but is absent from senescent megakaryocytes.Q40802790
Platelet-like particle formation in the human megakaryoblastic leukaemia cell lines, MEG-01 and MEG-01sQ41062224
JC-1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess delta psi changes in intact cells: implications for studies on mitochondrial functionality during apoptosisQ41099996
Thrombopoietin signal transduction in purified murine megakaryocytesQ41134439
Actin is cleaved during constitutive apoptosisQ41968458
Effects of gangliosides on cell maturation of murine megakaryocytes in a liquid culture system.Q42124196
Energy-dependent expression of platelet-von Willebrand factor on the surface of unstimulated and stimulated plateletsQ42447842
Neutrophil priming and apoptosis in anti-neutrophil cytoplasmic autoantibody-associated vasculitisQ42503324
Inhibition of human caspases by peptide-based and macromolecular inhibitorsQ42538024
Establishment of a novel human megakaryoblastic leukemia cell line, MEG-01, with positive Philadelphia chromosomeQ42819189
Platelet shape change induced by the peptide YFLLRNP.Q43735020
Platelet formation is the consequence of caspase activation within megakaryocytesQ44083637
Three stages of erythropoietic progenitor cell differentiation distinguished by a number of physical and biologic propertiesQ67263236
Morphological aspects of glucocorticoid-induced cell death in human lymphoblastoid cellsQ67443294
Energy metabolism in human platelets: interrelationship between glycolysis and oxidative metabolismQ71456197
Fate of senescent megakaryocytes in the bone marrowQ71651202
Hypoxia alters the energy metabolism and aggregation of washed human plateletsQ71818415
Ultrastructure of platelet formation by human megakaryocytes cultured with the Mpl ligandQ73260630
Constitutive death of platelets leading to scavenger receptor-mediated phagocytosis. A caspase-independent cell clearance programQ73463044
In vitro senescence and apoptotic cell death of human megakaryocytesQ73731985
Activation of calpain I converts excitotoxic neuron death into a caspase-independent cell deathQ73827485
Bcl-x is a regulatory factor of apoptosis and differentiation in megakaryocytic lineage cellsQ74314712
Constitutive apoptosis in human neutrophils requires synergy between calpains and the proteasome downstream of caspasesQ77520993
Calpain functions in a caspase-independent manner to promote apoptosis-like events during platelet activationQ78225184
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)577-587
P577publication date2003-02-01
P1433published inJournal of Cell BiologyQ1524550
P1476titleCompartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death
P478volume160

Reverse relations

cites work (P2860)
Q3338095115-deoxy-delta12,14-PGJ2 enhances platelet production from megakaryocytes
Q33402025A megakaryocyte with no platelets: anti-platelet antibodies, apoptosis, and platelet production
Q30478057A novel role for microtubules in apoptotic chromatin dynamics and cellular fragmentation
Q33303491A systems-biology analysis of isogenic megakaryocytic and granulocytic cultures identifies new molecular components of megakaryocytic apoptosis
Q33299579A ubiquitin ligase complex regulates caspase activation during sperm differentiation in Drosophila
Q35416666Actin inhibition increases megakaryocyte proplatelet formation through an apoptosis-dependent mechanism
Q38695213Anaplasma phagocytophilum infection modulates expression of megakaryocyte cell cycle genes through phosphatidylinositol-3-kinase signaling
Q27016041Apoptosis: role in myeloid cell development
Q53581386Bcl-2 family proteins are essential for platelet survival.
Q40387246CD46 plays a key role in tailoring innate immune recognition of apoptotic and necrotic cells
Q33377273CD8+ T cells suppress autologous megakaryocyte apoptosis in idiopathic thrombocytopenic purpura
Q33383251Caspase activation is involved in early megakaryocyte differentiation but not in platelet production from megakaryocytes
Q37848054Cell death assays for drug discovery
Q33391076Contributions of TRAIL-mediated megakaryocyte apoptosis to impaired megakaryocyte and platelet production in immune thrombocytopenia
Q34331948Determination of apoptotic and necrotic cell death in vitro and in vivo.
Q39052443Differential regulation of the apoptotic machinery during megakaryocyte differentiation and platelet production by inhibitor of apoptosis protein Livin
Q37417290Dynamic Regulation of a Ribosome Rescue Pathway in Erythroid Cells and Platelets
Q40408299Enforced expression of KDR receptor promotes proliferation, survival and megakaryocytic differentiation of TF1 progenitor cell line.
Q38187494Ex vivo production of platelets from stem cells
Q54642108Heat-shock protein 60 translocates to the surface of apoptotic cells and differentiated megakaryocytes and stimulates phagocytosis.
Q88921642How to Avoid False-Negative and False-Positive Diagnoses of Platelet Apoptosis: Illustrative Experimental and Clinically Relevant Cases
Q27310713IL-1α induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs
Q36358673Identifying and enriching platelet-producing human stem cell-derived megakaryocytes using factor V uptake.
Q37644828In vitro megakaryocyte production and platelet biogenesis: state of the art
Q36090943In vivo platelet production from mature megakaryocytes: does platelet release occur via proplatelets?
Q33413168Interpreting the developmental dance of the megakaryocyte: a review of the cellular and molecular processes mediating platelet formation
Q33423736Interspecies Variation in the Functional Consequences of Mutation of Cytochrome c
Q30479625Mechanisms of organelle transport and capture along proplatelets during platelet production
Q36075300Megakaryocyte apoptosis: sorting out the signals
Q90282070Megakaryocytes contain extranuclear histones and may be a source of platelet-associated histones during sepsis
Q33397149Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets
Q36778744Megakaryocytic Maturation in Response to Shear Flow Is Mediated by the Activator Protein 1 (AP-1) Transcription Factor via Mitogen-activated Protein Kinase (MAPK) Mechanotransduction
Q28088519Megakaryopoiesis and platelet production: insight into hematopoietic stem cell proliferation and differentiation
Q30483213Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells
Q33416435Mitoquinone restores platelet production in irradiation-induced thrombocytopenia
Q24319057No death without life: vital functions of apoptotic effectors
Q39140591Non-apoptotic functions of caspases in myeloid cell differentiation.
Q81028266Platelet biology for the clinician-scientist: an evolution of understanding
Q33413970Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways
Q37196840Platelets: developmental biology, physiology, and translatable platforms for preclinical investigation and drug development.
Q38764769Proplatelet formation in megakaryocytes is associated with endoplasmic reticulum stress
Q33938189Proplatelet formation of megakaryocytes is triggered by autocrine-synthesized estradiol
Q36185474Proposed megakaryocytic regulon of p53: the genes engaged to control cell cycle and apoptosis during megakaryocytic differentiation
Q39428071Regulation of fas/fas ligand-mediated apoptosis by nuclear factor of activated T cells in megakaryocytes
Q33431667Regulation of platelet lifespan by apoptosis
Q58720234Role of p53 and transcription-independent p53-induced apoptosis in shear-stimulated megakaryocytic maturation, particle generation, and platelet biogenesis
Q37126477Sepsis alters the megakaryocyte-platelet transcriptional axis resulting in granzyme B-mediated lymphotoxicity.
Q34293014Shear enhances thrombopoiesis and formation of microparticles that induce megakaryocytic differentiation of stem cells.
Q33615612Slowed decay of mRNAs enhances platelet specific translation
Q41834899Systems analysis of effector caspase activation and its control by X-linked inhibitor of apoptosis protein
Q64109244The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin
Q34851384The Feverfew plant-derived compound, parthenolide enhances platelet production and attenuates platelet activation through NF-κB inhibition
Q50355706The Plant Hormone Abscisic Acid Is a Prosurvival Factor in Human and Murine Megakaryocytes
Q33369405The biogenesis of platelets from megakaryocyte proplatelets
Q36262585The bone marrow vascular niche: home of HSC differentiation and mobilization
Q37455021The ins and outs of phospholipid asymmetry in the plasma membrane: roles in health and disease
Q43120475The regulation of proplatelet production
Q33412943The role of apoptosis in megakaryocytes and platelets
Q38779334Thrombin Maybe Plays an Important Role in MK Differentiation into Platelets
Q27015841Transcription factors in late megakaryopoiesis and related platelet disorders

Search more.