| scholarly article | Q13442814 |
| review article | Q7318358 |
| P50 | author | Cedric Ghevaert | Q60000569 |
| P2093 | author name string | M R Tijssen | |
| P2860 | cites work | A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis | Q24292976 |
| Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development | Q24321429 | ||
| Mutation of the beta1-tubulin gene associated with congenital macrothrombocytopenia affecting microtubule assembly | Q24321712 | ||
| FLI1 monoallelic expression combined with its hemizygous loss underlies Paris-Trousseau/Jacobsen thrombopenia | Q24563302 | ||
| Cyclin D-Cdk4 is regulated by GATA-1 and required for megakaryocyte growth and polyploidization | Q24674862 | ||
| Transcription of eukaryotic protein-coding genes | Q28138540 | ||
| Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity | Q28138855 | ||
| EVI1 is expressed in megakaryocyte cell lineage and enforced expression of EVI1 in UT-7/GM cells induces megakaryocyte differentiation | Q28211329 | ||
| The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells | Q28281239 | ||
| Identification of a mutation in a GATA binding site of the platelet glycoprotein Ibbeta promoter resulting in the Bernard-Soulier syndrome | Q28284551 | ||
| Maturation stage-specific regulation of megakaryopoiesis by pointed-domain Ets proteins | Q28505042 | ||
| Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis | Q28505080 | ||
| Tie2Cre-mediated gene ablation defines the stem-cell leukemia gene (SCL/tal1)-dependent window during hematopoietic stem-cell development | Q28507279 | ||
| Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis | Q28585695 | ||
| The transcription factor Srf regulates hematopoietic stem cell adhesion | Q28590745 | ||
| SCL and associated proteins distinguish active from repressive GATA transcription factor complexes | Q28591576 | ||
| A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development | Q28591602 | ||
| Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function | Q28592055 | ||
| ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cells | Q28754852 | ||
| The long-range interaction landscape of gene promoters | Q29615403 | ||
| Gene regulatory networks and the evolution of animal body plans | Q29618587 | ||
| Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein | Q29620253 | ||
| Primary megakaryocytes reveal a role for transcription factor NF-E2 in integrin alpha IIb beta 3 signaling | Q30442042 | ||
| Expression analysis of primary mouse megakaryocyte differentiation and its application in identifying stage-specific molecular markers and a novel transcriptional target of NF-E2. | Q30478947 | ||
| Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes | Q30479626 | ||
| The role of megakaryocyte growth and development factor in terminal stages of thrombopoiesis. | Q46029813 | ||
| Mammalian target of rapamycin (mTOR) regulates both proliferation of megakaryocyte progenitors and late stages of megakaryocyte differentiation. | Q46799750 | ||
| Different sequence requirements for expression in erythroid and megakaryocytic cells within a regulatory element upstream of the GATA-1 gene. | Q47962866 | ||
| Single-cell level analysis of megakaryocyte growth and development | Q48798178 | ||
| NF-E2-mediated enhancement of megakaryocytic differentiation and platelet production in vitro and in vivo. | Q50662222 | ||
| Interrelation between polyploidization and megakaryocyte differentiation: a gene profiling approach. | Q51999245 | ||
| FLT3-mediated p38-MAPK activation participates in the control of megakaryopoiesis in primary myelofibrosis. | Q54597002 | ||
| Megakaryocyte polyploidization is associated with a functional gene amplification | Q57082825 | ||
| Proplatelet formation is regulated by the Rho/ROCK pathway | Q58125582 | ||
| Dynamic Visualization of Thrombopoiesis Within Bone Marrow | Q58450371 | ||
| Cyclin D3 and megakaryocyte development: Exploration of a transgenic phenotype | Q58486864 | ||
| A role for Rab27b in NF-E2-dependent pathways of platelet formation | Q63362266 | ||
| What are the molecular ties that maintain genomic loops? | Q64938361 | ||
| Regulation of megakaryocytopoiesis | Q69529280 | ||
| Recombinant human c-Mpl ligand is not a direct stimulator of proplatelet formation in mature human megakaryocytes | Q71403942 | ||
| Different ploidy levels of megakaryocytes generated from peripheral or cord blood CD34+ cells are correlated with different levels of platelet release | Q77535996 | ||
| Latent myeloproliferative disorder revealed by the JAK2-V617F mutation and endogenous megakaryocytic colonies in patients with splanchnic vein thrombosis | Q79288688 | ||
| Incidence of the JAK2 V617F mutation among patients with splanchnic or cerebral venous thrombosis and without overt chronic myeloproliferative disorders | Q79690448 | ||
| Differential regulation of actin stress fiber assembly and proplatelet formation by alpha2beta1 integrin and GPVI in human megakaryocytes | Q80362900 | ||
| Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors | Q81015137 | ||
| The effect of oestrogen on megakaryocyte differentiation and platelet counts in vivo | Q81015987 | ||
| VEGFR1 stimulates a CXCR4-dependent translocation of megakaryocytes to the vascular niche, enhancing platelet production in mice | Q84268501 | ||
| Dysmegakaryopoiesis of FPD/AML pedigrees with constitutional RUNX1 mutations is linked to myosin II deregulated expression | Q84812579 | ||
| A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis | Q30528487 | ||
| Paris-Trousseau syndrome : clinical, hematological, molecular data of ten new cases | Q30883473 | ||
| Outside-in signalling generated by a constitutively activated integrin αIIbβ3 impairs proplatelet formation in human megakaryocytes | Q31059222 | ||
| Existence of a differentiation blockage at the stage of a megakaryocyte precursor in the thrombocytopenia and absent radii (TAR) syndrome | Q33331581 | ||
| Comparative analyses of megakaryocytes derived from cord blood and bone marrow | Q33332055 | ||
| Hematopoietic-specific beta 1 tubulin participates in a pathway of platelet biogenesis dependent on the transcription factor NF-E2. | Q33333603 | ||
| A lineage-restricted and divergent beta-tubulin isoform is essential for the biogenesis, structure and function of blood platelets | Q33337405 | ||
| BclxL overexpression in megakaryocytes leads to impaired platelet fragmentation | Q33343732 | ||
| Mechanisms and implications of platelet discoid shape | Q33346525 | ||
| Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis | Q33358404 | ||
| Low Mpl receptor expression in a pedigree with familial platelet disorder with predisposition to acute myelogenous leukemia and a novel AML1 mutation | Q33365223 | ||
| Deficiency in the Wiskott-Aldrich protein induces premature proplatelet formation and platelet production in the bone marrow compartment | Q33370471 | ||
| Decreased platelet expression of myosin regulatory light chain polypeptide (MYL9) and other genes with platelet dysfunction and CBFA2/RUNX1 mutation: insights from platelet expression profiling | Q33373057 | ||
| The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway | Q33374705 | ||
| A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the alphaIIbbeta3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia | Q33377699 | ||
| TPO-independent megakaryocytopoiesis. | Q33377875 | ||
| Mutation in beta1-tubulin correlates with macrothrombocytopenia in Cavalier King Charles Spaniels | Q33379541 | ||
| Human phenotypes associated with GATA-1 mutations | Q33381670 | ||
| Proplatelet formation in heterozygous Bernard-Soulier syndrome type Bolzano. | Q33382354 | ||
| Megakaryopoiesis | Q33390616 | ||
| Platelet formation | Q33390619 | ||
| Shaping of terminal megakaryocyte differentiation and proplatelet development by sphingosine-1-phosphate receptor S1P4 | Q33391203 | ||
| Developmental differences in megakaryocytopoiesis are associated with up-regulated TPO signaling through mTOR and elevated GATA-1 levels in neonatal megakaryocytes | Q33394052 | ||
| Dasatinib enhances megakaryocyte differentiation but inhibits platelet formation | Q33394424 | ||
| SCL-mediated regulation of the cell-cycle regulator p21 is critical for murine megakaryopoiesis | Q33395408 | ||
| Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets | Q33397149 | ||
| Blood platelet production and morphology | Q33399059 | ||
| Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function | Q33399439 | ||
| Compound inheritance of a low-frequency regulatory SNP and a rare null mutation in exon-junction complex subunit RBM8A causes TAR syndrome | Q33399905 | ||
| MKL1 and MKL2 play redundant and crucial roles in megakaryocyte maturation and platelet formation | Q33402409 | ||
| An analysis of megakaryocytopoiesis in the C3H mouse: an animal model whose megakaryocytes have 32N as the modal DNA class | Q33408969 | ||
| Abnormal platelet function, population, and survival-time in a boy with congenital absent radii and thrombocytopenia | Q33461195 | ||
| Platelet Adenine Nucleotide "Storage Pool Deficiency" In Thrombocytopenic Absent Radii Syndrome | Q33468560 | ||
| Storage Pool Disease of Platelets in an Infant with Thrombocytopenic Absent Radii (TAR) Syndrome Simulating Fanconi’s Anaemia | Q33486189 | ||
| Mice lacking transcription factor NF-E2 provide in vivo validation of the proplatelet model of thrombocytopoiesis and show a platelet production defect that is intrinsic to megakaryocytes | Q33503448 | ||
| Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice | Q33789872 | ||
| Genetic analysis of hierarchical regulation for Gata1 and NF-E2 p45 gene expression in megakaryopoiesis | Q33876985 | ||
| Proplatelet formation of megakaryocytes is triggered by autocrine-synthesized estradiol | Q33938189 | ||
| In vitro megakaryocyte differentiation and proplatelet formation in Ph-negative classical myeloproliferative neoplasms: distinct patterns in the different clinical phenotypes. | Q33941304 | ||
| Hierarchical differentiation of myeloid progenitors is encoded in the transcription factor network | Q33996801 | ||
| AML1 is overexpressed in patients with myeloproliferative neoplasms and mediates JAK2V617F-independent overexpression of NF-E2 | Q34022432 | ||
| GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis | Q34034571 | ||
| Transcription factor networks in erythroid cell and megakaryocyte development | Q35112203 | ||
| Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. | Q35134867 | ||
| Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification | Q35153770 | ||
| New gene functions in megakaryopoiesis and platelet formation | Q35909375 | ||
| Efficacy of vorinostat in a murine model of polycythemia vera | Q35909673 | ||
| Safety and efficacy of everolimus, a mTOR inhibitor, as single agent in a phase 1/2 study in patients with myelofibrosis. | Q36003480 | ||
| Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes | Q36313419 | ||
| Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death | Q36324970 | ||
| Distance preferences in the arrangement of binding motifs and hierarchical levels in organization of transcription regulatory information. | Q36372981 | ||
| Transendothelial migration of megakaryocytes in response to stromal cell-derived factor 1 (SDF-1) enhances platelet formation | Q36401529 | ||
| Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival | Q36776853 | ||
| Epigenetic inheritance of cell differentiation status | Q37140403 | ||
| AML1/RUNX1 works as a negative regulator of c-Mpl in hematopoietic stem cells | Q37142554 | ||
| Transcription factors mediate long-range enhancer-promoter interactions | Q37425505 | ||
| The mitogen-activated protein kinase signaling pathways: role in megakaryocyte differentiation | Q37623945 | ||
| Thrombocytogenesis by megakaryocyte; Interpretation by protoplatelet hypothesis | Q37874075 | ||
| Gene expression profiling in polycythaemia vera: overexpression of transcription factor NF-E2. | Q38328642 | ||
| Multiple oligomerization domains of KANK1-PDGFRβ are required for JAK2-independent hematopoietic cell proliferation and signaling via STAT5 and ERK. | Q38620874 | ||
| Functional characterization of the promoter region of the human EVI1 gene in acute myeloid leukemia: RUNX1 and ELK1 directly regulate its transcription. | Q39332914 | ||
| RUNX1-induced silencing of non-muscle myosin heavy chain IIB contributes to megakaryocyte polyploidization | Q39384298 | ||
| Induction of myeloproliferative disorder and myelofibrosis by thrombopoietin receptor W515 mutants is mediated by cytosolic tyrosine 112 of the receptor. | Q39765423 | ||
| The Evi1 proto-oncoprotein blocks endomitosis in megakaryocytes by inhibiting sustained cyclin-dependent kinase 2 catalytic activity. | Q40374742 | ||
| The megakaryocyte platelet system and vascular disease | Q40662541 | ||
| Consistent up-regulation of Stat3 Independently of Jak2 mutations in a new murine model of essential thrombocythemia | Q43213477 | ||
| Platelet formation is the consequence of caspase activation within megakaryocytes | Q44083637 | ||
| Caspase-12: a developmental link between G-protein-coupled receptors and integrin alphaIIbbeta3 activation | Q44826916 | ||
| Estrogen stimulates differentiation of megakaryocytes and modulates their expression of estrogen receptors alpha and beta | Q44860321 | ||
| P275 | copyright license | Creative Commons Attribution 2.5 Generic | Q18810333 |
| P433 | issue | 4 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | cell | Q7868 |
| transcription factor | Q407384 | ||
| blood platelet disease | Q2429620 | ||
| bone marrow cells | Q66004840 | ||
| hemic and immune systems | Q70202933 | ||
| P304 | page(s) | 593-604 | |
| P577 | publication date | 2013-04-01 | |
| P1433 | published in | Journal of Thrombosis and Haemostasis | Q6296004 |
| P1476 | title | Transcription factors in late megakaryopoiesis and related platelet disorders | |
| P478 | volume | 11 |
| Q33569847 | Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation |
| Q51109149 | Estrogen promotes megakaryocyte polyploidization via estrogen receptor beta-mediated transcription of GATA1. |
| Q38187494 | Ex vivo production of platelets from stem cells |
| Q33442207 | Germline ETV6 mutations and predisposition to hematological malignancies |
| Q33441057 | Hematopoietic transcription factor mutations: important players in inherited platelet defects. |
| Q35894555 | Identification of genomic aberrations in hemangioblastoma by droplet digital PCR and SNP microarray highlights novel candidate genes and pathways for pathogenesis |
| Q47913269 | Induced Pluripotent Stem Cell-Derived Megakaryocytes and Platelets for Disease Modeling and Future Clinical Applications |
| Q91644908 | Inherited Thrombocytopenia: Update on Genes and Genetic Variants Which may be Associated With Bleeding |
| Q33434192 | Inherited platelet dysfunction and hematopoietic transcription factor mutations |
| Q33431116 | Inherited thrombocytopenia: novel insights into megakaryocyte maturation, proplatelet formation and platelet lifespan |
| Q59384150 | Insights in Megakaryopoiesis and Platelet Biogenesis from Studies of Inherited Thrombocytopenias |
| Q27320898 | Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming |
| Q38929541 | MN1-Fli1 oncofusion transforms murine hematopoietic progenitor cells into acute megakaryoblastic leukemia cells. |
| Q59798399 | Nfe2 is dispensable for early but required for adult thrombocyte formation and function in zebrafish |
| Q58585823 | Partial reprogramming of heterologous cells by defined factors to generate megakaryocyte lineage-restricted biomolecules |
| Q47863498 | Pediatric Acute Megakaryoblastic Leukemia: Multitasking Fusion Proteins and Oncogenic Cooperations. |
| Q59355656 | Platelet Transcriptome Profiling in HIV and ATP-Binding Cassette Subfamily C Member 4 (ABCC4) as a Mediator of Platelet Activity |
| Q34294719 | Platelets and cancer: a casual or causal relationship: revisited. |
| Q41015953 | RUNX1 represses the erythroid gene expression program during megakaryocytic differentiation |
| Q29037128 | Regulation and function of the NFE2 transcription factor in hematopoietic and non-hematopoietic cells |
| Q35591443 | SCL/TAL1-mediated transcriptional network enhances megakaryocytic specification of human embryonic stem cells |
| Q33432515 | The effect of amifostine on differentiation of the human megakaryoblastic Dami cell line |
| Q41103573 | The gene expression signature of anagrelide provides an insight into its mechanism of action and uncovers new regulators of megakaryopoiesis |
| Q27321267 | Three-Dimensional Environment Sustains Hematopoietic Stem Cell Differentiation into Platelet-Producing Megakaryocytes |
| Q35931452 | Transcriptional Auto-Regulation of RUNX1 P1 Promoter |
| Q33418847 | X-linked thrombocytopenia with thalassemia displays bone marrow reticulin fibrosis and enhanced angiogenesis: comparisons with primary myelofibrosis |
| Q60918248 | microRNA-22 promotes megakaryocyte differentiation through repression of its target, |
| Q92739724 | β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis |
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