Programmable 3D silk bone marrow niche for platelet generation ex vivo and modeling of megakaryopoiesis pathologies.

scientific article

Programmable 3D silk bone marrow niche for platelet generation ex vivo and modeling of megakaryopoiesis pathologies. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1182/BLOOD-2014-08-595561
P932PMC publication ID4383799
P698PubMed publication ID25575540
P5875ResearchGate publication ID270706016

P50authorChiara E GhezziQ59688281
Lorenzo TozziQ59695411
Giovanna BruniQ60974262
David L. KaplanQ61761312
Cristian StaiiQ91790095
Elise SpeddenQ123152261
Alessandro MalaraQ56972265
Alessandra BalduiniQ56972276
Christian A Di BuduoQ57204120
Mauro MagnaniQ58970727
P2093author name stringYing Chen
Antonella Antonelli
Carla Sfara
Lindsay S Wray
Luigi De Marco
Daniel Smoot
P2860cites workIdentification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord bloodQ28269379
Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancerQ30476541
Myosin-II inhibition and soft 2D matrix maximize multinucleation and cellular projections typical of platelet-producing megakaryocytesQ30502470
Megakaryocytes contribute to the bone marrow-matrix environment by expressing fibronectin, type IV collagen, and lamininQ30583557
Modulation of in vitro angiogenesis in a three-dimensional spheroidal coculture model for bone tissue engineering.Q31135167
Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesisQ33358404
Expandable megakaryocyte cell lines enable clinically applicable generation of platelets from human induced pluripotent stem cellsQ33413336
Association of fibrin with the platelet cytoskeletonQ33477082
Adhesion and homing of blood-borne cells in bone marrow microvessels.Q33690165
Dynamic niches in the origination and differentiation of haematopoietic stem cellsQ33693938
The challenging world of cytopenias: distinguishing myelodysplastic syndromes from other disorders of marrow failureQ33829778
In vitro megakaryocyte differentiation and proplatelet formation in Ph-negative classical myeloproliferative neoplasms: distinct patterns in the different clinical phenotypes.Q33941304
Materials fabrication from Bombyx mori silk fibroinQ34220322
Shear enhances thrombopoiesis and formation of microparticles that induce megakaryocytic differentiation of stem cells.Q34293014
Autologous platelets as a source of proteins for healing and tissue regenerationQ61050227
Improved stability of 2,3-bisphosphoglycerate during storage of hexokinase-overloaded erythrocytesQ69773486
Dissecting clot retraction and platelet aggregation. Clot retraction does not require an intact fibrinogen gamma chain C terminusQ71058629
Human bone marrow microvascular endothelial cells support long-term proliferation and differentiation of myeloid and megakaryocytic progenitorsQ71789644
Circulating megakaryocytes and platelet release in the lungQ72592711
Ultrastructure of platelet formation by human megakaryocytes cultured with the Mpl ligandQ73260630
Suppression of hematopoietic activity in tenascin-C-deficient miceQ74576884
Basement membrane of mouse bone marrow sinusoids shows distinctive structure and proteoglycan composition: a high resolution ultrastructural studyQ74610091
Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitorsQ81015137
VEGFR1 stimulates a CXCR4-dependent translocation of megakaryocytes to the vascular niche, enhancing platelet production in miceQ84268501
Manipulation of oxygenation and flow-induced shear stress can increase the in vitro yield of platelets from cord bloodQ84857092
Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistanceQ85243285
Two differential flows in a bioreactor promoted platelet generation from human pluripotent stem cell-derived megakaryocytesQ86657049
Silk as a BiomaterialQ34988084
Gel spinning of silk tubes for tissue engineeringQ35502734
Three-dimensional system for the in vitro study of megakaryocytes and functional platelet production using silk-based vascular tubesQ35579676
Characterization of adhesive interactions between human endothelial cells and megakaryocytes.Q35610016
Linking hematopoiesis to endochondral skeletogenesis through analysis of mice transgenic for collagen X.Q35748002
Extracellular matrix structure and nano-mechanics determine megakaryocyte function.Q35794111
The bone marrow niche for haematopoietic stem cellsQ35887876
Matrix nanotopography as a regulator of cell functionQ35925306
RETRACTED: Stabilization of vaccines and antibiotics in silk and eliminating the cold chainQ36132649
Transendothelial migration of megakaryocytes in response to stromal cell-derived factor 1 (SDF-1) enhances platelet formationQ36401529
Expansion of engrafting human hematopoietic stem/progenitor cells in three-dimensional scaffolds with surface-immobilized fibronectin.Q36675920
Adhesion mechanisms in platelet functionQ36856340
Mimicking stem cell niches to increase stem cell expansionQ36979314
Functionalized silk biomaterials for wound healingQ37075364
Silk fibroin microtubes for blood vessel engineeringQ37226418
Distinct spatio-temporal Ca2+ signaling elicited by integrin alpha2beta1 and glycoprotein VI under flow.Q37372846
Challenges and promises for the development of donor-independent platelet transfusionsQ38074224
Physical influences of the extracellular environment on cell migrationQ38263780
VEGFR-3 is expressed on megakaryocyte precursors in the murine bone marrow and plays a regulatory role in megakaryopoiesisQ39314303
Modulation of perfusion and oxygenation by red blood cell oxygen affinity during acute anemiaQ41978412
Silk film biomaterials for cornea tissue engineeringQ42176794
Separation of in-vitro-derived megakaryocytes and platelets using spinning-membrane filtrationQ42662112
Scalable generation of universal platelets from human induced pluripotent stem cells.Q43010381
Stabilization and release of enzymes from silk filmsQ43135894
Prolonged continuous in vitro human platelet production using three-dimensional scaffoldsQ43136245
Distinct roles of ADP receptors in von Willebrand factor-mediated platelet signaling and activation under high flowQ45000365
A novel flow cytometry-based platelet aggregation assay.Q45792585
Megakaryocyte-matrix interaction within bone marrow: new roles for fibronectin and factor XIII-A.Q46501234
Bone marrow-on-a-chip replicates hematopoietic niche physiology in vitro.Q51516597
Engineered adipose tissue supplied by functional microvessels.Q51786337
Adhesive receptors, extracellular proteins and myosin IIA orchestrate proplatelet formation by human megakaryocytes.Q53457979
Dynamic Visualization of Thrombopoiesis Within Bone MarrowQ58450371
P433issue14
P407language of work or nameEnglishQ1860
P304page(s)2254-2264
P577publication date2015-01-09
P1433published inBloodQ885070
P1476titleProgrammable 3D silk bone marrow niche for platelet generation ex vivo and modeling of megakaryopoiesis pathologies
P478volume125

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cites work (P2860)
Q409656433D models of the hematopoietic stem cell niche under steady-state and active conditions.
Q41480921A new path to platelet production through matrix sensing.
Q42086488A paradigm shift in platelet transfusion therapy
Q47257067A uniform-shear rate microfluidic bioreactor for real-time study of proplatelet formation and rapidly-released platelets
Q33430809Abnormal proplatelet formation and emperipolesis in cultured human megakaryocytes from gray platelet syndrome patients
Q39350686Application of microfluidic devices in studies of thrombosis and hemostasis
Q52561904Biodegradable silk catheters for the delivery of therapeutics across anatomical repair sites.
Q55334386Ceramic Hollow Fibre Constructs for Continuous Perfusion and Cell Harvest from 3D Hematopoietic Organoids.
Q35692415Comparative analysis of human ex vivo-generated platelets vs megakaryocyte-generated platelets in mice: a cautionary tale
Q39252350Creating artificial lymphoid tissues to study immunity and hematological malignancies
Q49557978Current status of blood 'pharming': megakaryoctye transfusions as a source of platelets
Q42335815Eltrombopag, a potent stimulator of megakaryopoiesis.
Q35836174Embryonic stem cells as sources of donor-independent platelets
Q92219763Enabling Large-Scale Ex Vivo Production of Megakaryocytes from CD34+ Cells Using Gas-Permeable Surfaces
Q36919097Graphene Oxide promotes embryonic stem cell differentiation to haematopoietic lineage.
Q48589365Hematopoietic Niche - Exploring Biomimetic Cues to Improve the Functionality of Hematopoietic Stem/Progenitor Cells
Q90489529In vitro culture of murine megakaryocytes from fetal liver-derived hematopoietic stem cells
Q33443202In vitro generation of platelets: Where do we stand?
Q97533489In vitro platelet production for transfusion purposes: Where are we now?
Q90733820Induction of differentiation of human stem cells ex vivo: Toward large-scale platelet production
Q64080775Infused factor VIII-expressing platelets or megakaryocytes as a novel therapeutic strategy for hemophilia A
Q33432109Inherited thrombocytopenias-recent advances in clinical and molecular aspects
Q43109025Innovation in the field of thrombocytopenias: achievements since the beginning of the century and promises for the future.
Q27320898Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming
Q64934930Large-scale production of megakaryocytes in microcarrier-supported stirred suspension bioreactors.
Q27345351Microfluidic model of the platelet-generating organ: beyond bone marrow biomimetics
Q52721711Microvasculature-directed thrombopoiesis in a 3D in vitro marrow microenvironment.
Q47684382Modular flow chamber for engineering bone marrow architecture and function
Q57214406Multi-channel silk sponge mimicking bone marrow vascular niche for platelet production
Q48031372Multi-layered silk film coculture system for human corneal epithelial and stromal stem cells.
Q49196741Multifunctional Bioreactor System for Human Intestine Tissues
Q58574268Multiple membrane extrusion sites drive megakaryocyte migration into bone marrow blood vessels
Q92424711Multiscale engineering of immune cells and lymphoid organs
Q37101382Navigating the bone marrow niche: translational insights and cancer-driven dysfunction.
Q57167167On the Way to Platelet Production
Q57166306On the way to in vitro platelet production
Q28069839Pathophysiological Significance of Store-Operated Calcium Entry in Megakaryocyte Function: Opening New Paths for Understanding the Role of Calcium in Thrombopoiesis
Q33438649Platelet bioreactor: accelerated evolution of design and manufacture
Q40115861Platelet production from induced pluripotent stem cells
Q37215777Polyurethane scaffolds seeded with CD34(+) cells maintain early stem cells whilst also facilitating prolonged egress of haematopoietic progenitors.
Q33890308Presence of diabetes autoantigens in extracellular vesicles derived from human islets
Q33434705Rapamycin and bafilomycin A1 alter autophagy and megakaryopoiesis
Q38543301Regulation of the genetic code in megakaryocytes and platelets
Q33434519Revealing eltrombopag's promotion of human megakaryopoiesis through AKT/ERK-dependent pathway activation
Q26741792Stem Cells Applications in Regenerative Medicine and Disease Therapeutics
Q37355219Tense your megas! Structural rigidity is key
Q28830861The European Hematology Association Roadmap for European Hematology Research: a consensus document
Q50355706The Plant Hormone Abscisic Acid Is a Prosurvival Factor in Human and Murine Megakaryocytes
Q48106053The role of extracellular matrix stiffness in megakaryocyte and platelet development and function.
Q39117766The role of the extracellular matrix in primary myelofibrosis
Q40126127Thrombopoietin/TGF-β1 Loop Regulates Megakaryocyte Extracellular Matrix Component Synthesis.
Q36756232Tissue Engineering and Regenerative Medicine 2015: A Year in Review
Q33442786Towards the Manufacture of Megakaryocytes and Platelets for Clinical Application.
Q26770860Understanding platelet generation from megakaryocytes: implications for in vitro-derived platelets

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