Novel TPO receptor agonist TA-316 contributes to platelet biogenesis from human iPS cells

scientific article published on 28 February 2017

Novel TPO receptor agonist TA-316 contributes to platelet biogenesis from human iPS cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1182/BLOODADVANCES.2016000844
P932PMC publication ID5738977
P698PubMed publication ID29296963

P50authorKoji EtoQ87047082
P2093author name stringHiromitsu Nakauchi
Takanori Nakamura
Akira Sawaguchi
Sou Nakamura
Natsuki Abe
Ayako Aihara
Taito Nishino
Naoshi Sugimoto
Tomo Koike
P2860cites workPromotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietinQ24316187
Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonistQ33382190
Development of thrombopoietin receptor agonists for clinical use.Q33385506
Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cellsQ33392928
An image-based screen identifies a small molecule regulator of megakaryopoiesisQ33402801
Expandable megakaryocyte cell lines enable clinically applicable generation of platelets from human induced pluripotent stem cellsQ33413336
Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiationQ34320917
Diagnosis and management of refractoriness to platelet transfusionQ34494961
A novel nonpeptidyl human c-Mpl activator stimulates human megakaryopoiesis and thrombopoiesisQ34495411
Overview of blood components and their preparationQ34659748
Platelet transfusion - the art and science of compromiseQ37049262
Hematopoietic stem cell expansion: challenges and opportunities.Q38035450
Distinct routes of lineage development reshape the human blood hierarchy across ontogenyQ39745504
Aryl hydrocarbon receptor-dependent enrichment of a megakaryocytic precursor with a high potential to produce proplateletsQ41107641
Establishment and characterization of the thrombopoietin-dependent megakaryocytic cell line, UT-7/TPO.Q41196985
Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl.Q41457316
Establishment and characterization of an erythropoietin-dependent subline, UT-7/Epo, derived from human leukemia cell line, UT-7.Q41541963
Establishment and characterization of a human leukemic cell line with megakaryocytic features: dependency on granulocyte-macrophage colony-stimulating factor, interleukin 3, or erythropoietin for growth and survivalQ41704996
VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanismQ44043571
Autocrine-paracrine VEGF loops potentiate the maturation of megakaryocytic precursors through Flt1 receptor.Q44198511
Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cellsQ45155046
Basic fibroblast growth factor promotes the proliferation of human megakaryocyte progenitor cellsQ72827255
Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitorsQ81015137
P433issue7
P304page(s)468-476
P577publication date2017-02-28
P1476titleNovel TPO receptor agonist TA-316 contributes to platelet biogenesis from human iPS cells
P478volume1

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cites work (P2860)
Q58751503A β1-tubulin-based megakaryocyte maturation reporter system identifies novel drugs that promote platelet production
Q47382721Human NOTCH4 is a key target of RUNX1 in megakaryocytic differentiation
Q91556007Intrabone transplant provides full stemness of cord blood stem cells with fast hematopoietic recovery and low GVHD rate: results from a prospective study
Q90285682Thrombopoietin knock-in augments platelet generation from human embryonic stem cells

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