Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo

scientific article

Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI39503
P932PMC publication ID2798683
P698PubMed publication ID20038804

P50authorKoji EtoQ87047082
Hitoshi TakizawaQ38523964
Yohei MoritaQ41779368
P2093author name stringSatoshi Yamazaki
Kiyoshi Takatsu
Noriko Tamura
Satoshi Takaki
Hiromitsu Nakauchi
Ichiro Manabe
Naoya Takayama
Satoshi Nishimura
Shinya Goto
Atsushi Oda
Akira Sawaguchi
Hidekazu Nishikii
Sei Kakinuma
Satoshi Okamura
P2860cites workCoordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeletonQ24293554
Src kinase activation by direct interaction with the integrin β cytoplasmic domainQ24298960
PTP-1B is an essential positive regulator of platelet integrin signalingQ24317102
Newly identified genetic risk variants for celiac disease related to the immune responseQ24654340
Glycoprotein VI-dependent and -independent pathways of thrombus formation in vivoQ24669536
Signal-dependent translation of a regulatory protein, Bcl-3, in activated human plateletsQ24675173
The integrin beta tail is required and sufficient to regulate adhesion signaling to Rac1.Q44177176
Specification of the direction of adhesive signaling by the integrin beta cytoplasmic domainQ46171254
A new functional role of the fibrinogen RGD motif as the molecular switch that selectively triggers integrin alphaIIbbeta3-dependent RhoA activation during cell spreadingQ46546710
Identification of a fibrin-independent platelet contractile mechanism regulating primary hemostasis and thrombus growth.Q46725762
Tyrosine phosphorylation of the integrin beta 3 subunit regulates beta 3 cleavage by calpain.Q53602922
Enhanced engraftment of hematopoietic stem/progenitor cells by the transient inhibition of an adaptor protein, Lnk.Q53645271
Regional localization of Fyn in adult brain; studies with mice in which fyn gene was replaced by lacZQ72625240
Beta3 tyrosine phosphorylation in alphaIIbbeta3 (platelet membrane GP IIb-IIIa) outside-in integrin signalingQ74314932
Real-time in vivo imaging of platelets, tissue factor and fibrin during arterial thrombus formation in the mouseQ74817597
Rac GTPases differentially integrate signals regulating hematopoietic stem cell localizationQ80385968
Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient miceQ81813892
Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, LnkQ24675202
The adaptor molecule Lnk negatively regulates tumor necrosis factor-alpha-dependent VCAM-1 expression in endothelial cells through inhibition of the ERK1 and -2 pathwaysQ28236956
Integrins: dynamic scaffolds for adhesion and signaling in plateletsQ28267584
Growth and maturation of megakaryocytes is regulated by Lnk/Sh2b3 adaptor protein through crosstalk between cytokine- and integrin-mediated signalsQ28278879
Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transductionQ28287126
Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathwaysQ28306960
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarctionQ28308221
Thrombin-initiated platelet activation in vivo is vWF independent during thrombus formation in a laser injury modelQ28509120
Inhibition of plasminogen activator inhibitor-1: its mechanism and effectiveness on coagulation and fibrosisQ28579222
The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machineryQ28589476
ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists.Q30159628
In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissueQ30481061
The molecular adapter SLP-76 relays signals from platelet integrin alphaIIbbeta3 to the actin cytoskeleton.Q31673052
Eph kinases and ephrins support thrombus growth and stability by regulating integrin outside-in signaling in platelets.Q33895889
Integrins and Src: dynamic duo of adhesion signalingQ34432517
Cytokines regulate postnatal hematopoietic stem cell expansion: opposing roles of thrombopoietin and LNK.Q34958781
Platelets in atherothrombosisQ34986345
Adaptors as central mediators of signal transduction in immune cellsQ35055629
Integrin regulation of cell signalling and motility.Q35780436
Laminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVI.Q35848605
The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIb-IIIa) activationQ35868825
Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient miceQ36369746
Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesisQ36402414
In vivo thrombus formationQ36884296
Platelet integrin adhesive functions and signalingQ36909800
Novel therapeutic targets at the platelet vascular interface.Q37049864
Control of B cell production by the adaptor protein lnk. Definition Of a conserved family of signal-modulating proteinsQ37624302
Analysis of Fyn function in hemostasis and alphaIIbbeta3-integrin signalingQ39989355
Integrin cytoplasmic tyrosine motif is required for outside-in alphaIIbbeta3 signalling and platelet functionQ41700251
Involvement of Src kinases and PLCgamma2 in clot retractionQ42026902
Kinetic regulation of beta 3 integrin tyrosine phosphorylationQ44164527
P4510describes a project that usesImageJQ1659584
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)179-190
P577publication date2009-12-21
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleLnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo
P478volume120

Reverse relations

cites work (P2860)
Q56000938Determination of system level alterations in host transcriptome due to Zika virus (ZIKV) Infection in retinal pigment epithelium
Q53205345Dok-1 negatively regulates platelet integrin αIIbβ3 outside-in signalling and inhibits thrombosis in mice.
Q42582678Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets.
Q35694571Evaluation of targeting c-Src by the RGT-containing peptide as a novel antithrombotic strategy
Q33413336Expandable megakaryocyte cell lines enable clinically applicable generation of platelets from human induced pluripotent stem cells
Q38000164Factor XIII is a key molecule at the intersection of coagulation and fibrinolysis as well as inflammation and infection control
Q36194061Functional Effect of the Mutations Similar to the Cleavage during Platelet Activation at Integrin β3 Cytoplasmic Tail when Expressed in Mouse Platelets
Q42742651Gene transfer of the adaptor Lnk (SH2B3) prevents porcine endothelial cell activation and apoptosis: implication for xenograft's cytoprotection
Q37738343Genetics of atherothrombosis and thrombophilia
Q30537307Hierarchical organization in the hemostatic response and its relationship to the platelet-signaling network
Q27310713IL-1α induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs
Q89820694Imaging Platelet Processes and Function-Current and Emerging Approaches for Imaging in vitro and in vivo
Q64948132Impact of genetic polymorphisms on platelet function and response to anti platelet drugs.
Q30514057In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling
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Q35651764Integrin-αvβ3 regulates thrombopoietin-mediated maintenance of hematopoietic stem cells
Q35987858LNK (SH2B3) is a key regulator of integrin signaling in endothelial cells and targets α-parvin to control cell adhesion and migration.
Q40645397LNK/SH2B3 Loss of Function Promotes Atherosclerosis and Thrombosis
Q26770863Linkage between the mechanisms of thrombocytopenia and thrombopoiesis
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