Synaptic vesicle recycling: steps and principles

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Synaptic vesicle recycling: steps and principles is …
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scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1002/EMBJ.201386357
P8608Fatcat IDrelease_lxpt33jtcfd7tfb7ejf3lm4ugi
P3181OpenCitations bibliographic resource ID1673635
P932PMC publication ID4194108
P698PubMed publication ID24596248
P5875ResearchGate publication ID260528574

P2093author name stringS. O. Rizzoli
P2860cites workLong-term relationships between synaptic tenacity, synaptic remodeling, and network activityQ21145818
Cholesterol binds to synaptophysin and is required for biogenesis of synaptic vesiclesQ22011017
The synaptic vesicle cycleQ24297813
The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursorsQ24307447
Structure, function and regulation of the vacuolar (H+)-ATPaseQ24323225
External push and internal pull forces recruit curvature-sensing N-BAR domain proteins to the plasma membraneQ24339419
Transport route for synaptobrevin via a novel pathway of insertion into the endoplasmic reticulum membraneQ24568369
Superresolution imaging of chemical synapses in the brainQ24599389
Synaptophysin, a major synaptic vesicle protein, is not essential for neurotransmitter releaseQ24601743
Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter releaseQ24611697
Counting the number of releasable synaptic vesicles in a presynaptic terminalQ24646074
Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREsQ24656954
Synaptic vesicle exocytosis captured by quick freezing and correlated with quantal transmitter releaseQ24682015
Activation of endosomal dynein motors by stepwise assembly of Rab7-RILP-p150Glued, ORP1L, and the receptor betalll spectrinQ24683555
RIM genes differentially contribute to organizing presynaptic release sitesQ26269874
RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zoneQ26269881
CSPα knockout causes neurodegeneration by impairing SNAP-25 functionQ26269887
Doc2 supports spontaneous synaptic transmission by a Ca(2+)-independent mechanismQ26269899
Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosisQ26269909
RIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13Q26269920
RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interactionQ26269921
Synaptophysin is targeted to similar microvesicles in CHO and PC12 cellsQ26269968
rab3 is a small GTP-binding protein exclusively localized to synaptic vesiclesQ26269982
Molecular machines governing exocytosis of synaptic vesiclesQ26849286
Membrane curvature and its generation by BAR proteinsQ27006768
GTPase networks in membrane trafficQ27015776
COPI budding within the Golgi stackQ27021670
A high precision survey of the molecular dynamics of mammalian clathrin-mediated endocytosisQ27322340
Ca2+ influx through distinct routes controls exocytosis and endocytosis at drosophila presynaptic terminalsQ44722207
The structural organization of the readily releasable pool of synaptic vesiclesQ44814913
The kinetics of synaptic vesicle pool depletion at CNS synaptic terminalsQ44815994
Developmental refinement of vesicle cycling at Schaffer collateral synapsesQ45210560
Vesicle endocytosis requires dynamin-dependent GTP hydrolysis at a fast CNS synapse.Q45214894
An isolated pool of vesicles recycles at rest and drives spontaneous neurotransmissionQ45274254
Super-resolution imaging prompts re-thinking of cell biology mechanisms: selected cases using stimulated emission depletion microscopyQ45348282
Synaptic PI(3,4,5)P3 is required for Syntaxin1A clustering and neurotransmitter releaseQ45399289
Calcium dependence of exo- and endocytotic coupling at a glutamatergic synapse.Q45916727
Synaptophysin is sorted from endocytotic markers in neuroendocrine PC12 cells but not transfected fibroblastsQ46169848
A targeting signal in VAMP regulating transport to synaptic vesiclesQ46365410
Clathrin-dependent and clathrin-independent retrieval of synaptic vesicles in retinal bipolar cellsQ46543788
Single synaptic vesicle tracking in individual hippocampal boutons at rest and during synaptic activity.Q46818707
Axonal translation of β-catenin regulates synaptic vesicle dynamics.Q36837251
Activity-dependent control of bulk endocytosis by protein dephosphorylation in central nerve terminalsQ36856219
Inactivation of clathrin heavy chain inhibits synaptic recycling but allows bulk membrane uptakeQ36860399
Roles of calmodulin and calmodulin-binding proteins in synaptic vesicle recycling during regulated exocytosis at submicromolar Ca2+ concentrationsQ36865269
SNARE proteins synaptobrevin, SNAP-25, and syntaxin are involved in rapid and slow endocytosis at synapsesQ36902034
The neurotransmitter cycle and quantal sizeQ36946152
Ca(2+) and calmodulin initiate all forms of endocytosis during depolarization at a nerve terminal.Q36951925
The SNARE proteins SNAP25 and synaptobrevin are involved in endocytosis at hippocampal synapsesQ36954387
SNARE function is not involved in early endosome dockingQ36992967
Mu2 adaptin facilitates but is not essential for synaptic vesicle recycling in Caenorhabditis elegansQ36993368
Most vesicles in a central nerve terminal participate in recyclingQ37010287
Alignment of synaptic vesicle macromolecules with the macromolecules in active zone material that direct vesicle dockingQ37033490
Reconstitution of the vital functions of Munc18 and Munc13 in neurotransmitter releaseQ37071048
UNC-13L, UNC-13S, and Tomosyn form a protein code for fast and slow neurotransmitter release in Caenorhabditis elegansQ37094524
Fos and Jun potentiate individual release sites and mobilize the reserve synaptic vesicle pool at the Drosophila larval motor synapse.Q37103741
Formation of Golgi-derived active zone precursor vesicles.Q37117339
Ultrafast endocytosis at Caenorhabditis elegans neuromuscular junctionsQ37145198
The synaptic vesicle cluster: a source of endocytic proteins during neurotransmitter releaseQ37149042
Proteasome inhibition triggers activity-dependent increase in the size of the recycling vesicle pool in cultured hippocampal neuronsQ37149682
Synaptic vesicle protein trafficking at the glutamate synapse.Q37160079
Influence of synaptic vesicle position on release probability and exocytotic fusion modeQ37180772
Mechanical tension contributes to clustering of neurotransmitter vesicles at presynaptic terminalsQ37268796
Position of UNC-13 in the active zone regulates synaptic vesicle release probability and release kineticsQ37290090
Think locally: control of ubiquitin-dependent protein degradation in neuronsQ37349687
A distributed set of interactions controls mu2 functionality in the role of AP-2 as a sorting adaptor in synaptic vesicle endocytosis.Q37432138
Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis.Q37464966
Rab3 dynamically controls protein composition at active zones.Q37484962
The little we know on the structure and machinery of V-ATPaseQ37485461
The balance between capture and dissociation of presynaptic proteins controls the spatial distribution of synapsesQ37503931
Ultrafast endocytosis at mouse hippocampal synapses.Q37642826
Intersectin 1: a versatile actor in the synaptic vesicle cycleQ37674793
Membrane protein clusters at nanoscale resolution: more than pretty picturesQ37739708
The synapsins: key actors of synapse function and plasticity.Q37741320
Rab7: Role of its protein interaction cascades in endo-lysosomal trafficQ37790159
Vesicular sterols are essential for synaptic vesicle cycling.Q42792578
Two-color far-field fluorescence nanoscopyQ42908511
Role of Drosophila Rab5 during endosomal trafficking at the synapse and evoked neurotransmitter releaseQ42917089
V-ATPase Membrane Sector Associates with Synaptobrevin to Modulate Neurotransmitter ReleaseQ42952232
Morphological correlates of functionally defined synaptic vesicle populationsQ43558103
Visualization of changes in presynaptic function during long-term synaptic plasticityQ43653565
Visualizing postendocytic traffic of synaptic vesicles at hippocampal synapsesQ43730142
A membrane marker leaves synaptic vesicles in milliseconds after exocytosis in retinal bipolar cellsQ44158659
Effects of 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one on synaptic vesicle cycling at the frog neuromuscular junction.Q44251927
The ubiquitin proteasome system acutely regulates presynaptic protein turnover and synaptic efficacyQ44461744
Auxilin-dynamin interactions link the uncoating ATPase chaperone machinery with vesicle formation.Q44468554
Synaptic vesicle mobility in mouse motor nerve terminals with and without synapsin.Q46852222
Constitutive sharing of recycling synaptic vesicles between presynaptic boutonsQ46931398
Fast synaptic fatigue in shibire mutants reveals a rapid requirement for dynamin in synaptic vesicle membrane traffickingQ47070147
Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle releaseQ47070593
Drosophila synaptotagmin I null mutants survive to early adulthoodQ47072128
Inactivity produces increases in neurotransmitter release and synapse sizeQ47198414
Development of tonic firing behavior in rat soleus muscleQ47928653
A complete genetic analysis of neuronal Rab3 function.Q47952687
Rapid and intermittent cotransport of slow component-b proteinsQ48232827
Comparing video-rate STED nanoscopy and confocal microscopy of living neuronsQ48242975
Kinetics of synaptic vesicle refilling with neurotransmitter glutamateQ48301483
Synaptic vesicles recycling spontaneously and during activity belong to the same vesicle poolQ48311376
Synaptosomes possess an exocytotic pool of glutamateQ48332236
Endocytic structures and synaptic vesicle recycling at a central synapse in awake ratsQ48378968
Actin has a molecular scaffolding, not propulsive, role in presynaptic functionQ48405526
Proteasome inhibition alleviates SNARE-dependent neurodegenerationQ48407910
Reliability and precision of the mouse calyx of Held synapseQ48416953
Comment on "The dynamic control of kiss-and-run and vesicular reuse probed with single nanoparticles".Q48456444
Dynamic control of synaptic vesicle replenishment and short-term plasticity by Ca(2+)-calmodulin-Munc13-1 signalingQ48461386
Single and multiple vesicle fusion induce different rates of endocytosis at a central synapseQ48592708
Rab3 superprimes synaptic vesicles for release: implications for short-term synaptic plasticity.Q48673213
Independent vesicle pools underlie different modes of release during neuronal development.Q48677274
Synapsin dispersion and reclustering during synaptic activityQ48726387
Post-transcriptional regulation of synaptic vesicle protein expression and the developmental control of synaptic vesicle formation.Q48757809
Site-specific phosphorylation of synapsin I by mitogen-activated protein kinase and Cdk5 and its effects on physiological functionsQ48939390
A small GTP-binding protein dissociates from synaptic vesicles during exocytosisQ50337421
Helical extension of the neuronal SNARE complex into the membraneQ27646399
Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitmentQ27678096
Functional rafts in cell membranesQ27860768
Rab proteins as membrane organizersQ27860861
Phosphoinositides in cell regulation and membrane dynamicsQ27861051
Synaptotagmin activates membrane fusion through a Ca2+-dependent trans interaction with phospholipidsQ27863371
Rab GTPases as coordinators of vesicle trafficQ28131746
Association of the kinesin motor KIF1A with the multimodular protein liprin-alphaQ28202542
The molecular motor toolbox for intracellular transportQ28211349
Vesicular proteins exocytosed and subsequently retrieved by compensatory endocytosis are nonidenticalQ28252426
Changes in muscle contractile properties and neural control during human muscular fatigueQ28259787
Video-rate far-field optical nanoscopy dissects synaptic vesicle movementQ28269663
Molecular anatomy of a trafficking organelleQ28274481
Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteinsQ28276992
Synaptic vesicles position complexin to block spontaneous fusionQ28284213
Alternative zippering as an on-off switch for SNARE-mediated fusionQ28307492
Recruitment of endophilin to clathrin-coated pit necks is required for efficient vesicle uncoating after fissionQ28505115
SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle releaseQ28505380
Snapin facilitates the synchronization of synaptic vesicle fusionQ28508747
Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphateQ28511509
Essential role of phosphoinositide metabolism in synaptic vesicle recyclingQ28511682
Synaptophysin regulates the kinetics of synaptic vesicle endocytosis in central neuronsQ28512527
Overlapping role of dynamin isoforms in synaptic vesicle endocytosisQ28513338
A function for the AP3 coat complex in synaptic vesicle formation from endosomesQ28567917
Stonin 2 is a major adaptor protein for clathrin-mediated synaptic vesicle retrievalQ28570743
The involvement of the small GTP-binding protein Rab5a in neuronal endocytosisQ28571235
Visualization of synaptic vesicle movement in intact synaptic boutons using fluorescence fluctuation spectroscopyQ28571700
Assembling the presynaptic active zone: a characterization of an active one precursor vesicleQ28571859
Molecular in situ topology of Aczonin/Piccolo and associated proteins at the mammalian neurotransmitter release siteQ28576284
Synaptic vesicle recycling at CNS snapses without AP-2Q28577663
Evidence for early endosome-like fusion of recently endocytosed synaptic vesiclesQ28579652
The V0 sector of the V-ATPase, synaptobrevin, and synaptophysin are associated on synaptic vesicles in a Triton X-100-resistant, freeze-thawing sensitive, complexQ28583592
SNARE protein recycling by αSNAP and βSNAP supports synaptic vesicle primingQ28589671
Kainate modulates presynaptic GABA release from two vesicle poolsQ33592144
Synapsins as regulators of neurotransmitter releaseQ33598970
Regulation of endosome fusion.Q33637955
Acute dynamin inhibition dissects synaptic vesicle recycling pathways that drive spontaneous and evoked neurotransmissionQ33661188
Preferred sites of exocytosis and endocytosis colocalize during high- but not lower-frequency stimulation in mouse motor nerve terminals.Q33693767
Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassemblyQ33697076
Mechanisms of synaptic vesicle recycling illuminated by fluorescent dyes.Q33785262
Synaptic vesicle biogenesisQ33804355
Cotrafficking of SV2 and synaptotagmin at the synapse.Q33835261
Activity-dependent bulk endocytosis and clathrin-dependent endocytosis replenish specific synaptic vesicle pools in central nerve terminalsQ33929652
Molecular determinants of presynaptic active zonesQ33941567
Activity-dependent augmentation of spontaneous neurotransmission during endoplasmic reticulum stressQ33942946
SNARE-complex disassembly by NSF follows synaptic-vesicle fusionQ33947145
Dynamin I phosphorylation by GSK3 controls activity-dependent bulk endocytosis of synaptic vesicles.Q33948657
Synaptic vesicle poolsQ33983958
SV2 acts via presynaptic calcium to regulate neurotransmitter release.Q34034957
A heterogeneous "resting" pool of synaptic vesicles that is dynamically interchanged across boutons in mammalian CNS synapsesQ34076862
A comprehensive comparison of transmembrane domains reveals organelle-specific propertiesQ34083658
Structure and dynamics of a two-helix SNARE complex in live cellsQ34087501
The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motorsQ34100590
Limited intermixing of synaptic vesicle components upon vesicle recyclingQ34104085
Safety factor at the neuromuscular junctionQ34199050
Three modes of synaptic vesicular recycling revealed by single-vesicle imagingQ34203451
Regulation of synaptic vesicle docking by different classes of macromolecules in active zone materialQ34206193
Depletion of vesicles from frog neuromuscular junctions by prolonged tetanic stimulationQ34207075
Evidence for recycling of synaptic vesicle membrane during transmitter release at the frog neuromuscular junctionQ34207383
Turnover of transmitter and synaptic vesicles at the frog neuromuscular junctionQ34207387
Membrane protein sequestering by ionic protein-lipid interactionsQ34226601
Endocytosis of synaptic vesicle membrane at the frog neuromuscular junctionQ34264377
The first five seconds in the life of a clathrin-coated pit.Q34292187
Single reconstituted neuronal SNARE complexes zipper in three distinct stagesQ34294781
Super-resolution imaging reveals the internal architecture of nano-sized syntaxin clustersQ34304810
Actin, spectrin, and associated proteins form a periodic cytoskeletal structure in axonsQ34317568
Probing vesicle dynamics in single hippocampal synapsesQ34351915
A new ticket for entry into budding vesicles-ubiquitinQ34365247
Protein-lipid interactions and phosphoinositide metabolism in membrane traffic: insights from vesicle recycling in nerve terminalsQ34374331
Rapid Ca2+-dependent decrease of protein ubiquitination at synapsesQ34388074
Impaired recycling of synaptic vesicles after acute perturbation of the presynaptic actin cytoskeletonQ34394543
The dephosphins: dephosphorylation by calcineurin triggers synaptic vesicle endocytosisQ34416249
Phosphatidylinositol-(4,5)-bisphosphate regulates sorting signal recognition by the clathrin-associated adaptor complex AP2.Q34421459
NCAM and vesicle cycling: the importance of good glue in the long run.Q34459742
Secretory vesicles are preferentially targeted to areas of low molecular SNARE densityQ34482442
STED microscopy reveals that synaptotagmin remains clustered after synaptic vesicle exocytosisQ34513459
Distinct endocytic pathways control the rate and extent of synaptic vesicle protein recyclingQ34568799
Clathrin-mediated endocytosis at synapsesQ34634168
Three-dimensional architecture of presynaptic terminal cytomatrix.Q34642485
Kiss-and-run, collapse and 'readily retrievable' vesiclesQ34654997
Single-molecule analysis of a molecular disassemblase reveals the mechanism of Hsc70-driven clathrin uncoatingQ34665652
Synaptic vesicles retain their identity through the endocytic cycleQ34746833
Protein quantification at the single vesicle level reveals that a subset of synaptic vesicle proteins are trafficked with high precisionQ34807735
Use-dependent AMPA receptor block reveals segregation of spontaneous and evoked glutamatergic neurotransmissionQ34911758
Spontaneous glutamate release is independent of calcium influx and tonically activated by the calcium-sensing receptorQ34989736
A synaptic vesicle-associated Ca2+ channel promotes endocytosis and couples exocytosis to endocytosis.Q35001595
Synaptic tetraspan vesicle membrane proteins are conserved but not needed for synaptogenesis and neuronal function in Caenorhabditis elegans.Q35039350
Physical and functional connection between auxilin and dynamin during endocytosisQ35040012
Signals involved in targeting membrane proteins to synaptic vesiclesQ35065820
SNARE motif-mediated sorting of synaptobrevin by the endocytic adaptors clathrin assembly lymphoid myeloid leukemia (CALM) and AP180 at synapsesQ35170795
Two synaptobrevin molecules are sufficient for vesicle fusion in central nervous system synapsesQ35180827
Why do worms need cholesterol?Q35190121
Synaptophysin is required for synaptobrevin retrieval during synaptic vesicle endocytosisQ35281762
The reserve pool of synaptic vesicles acts as a buffer for proteins involved in synaptic vesicle recyclingQ35344955
A small pool of vesicles maintains synaptic activity in vivoQ35345585
Regulation of vesicular neurotreansmitter transportersQ35546785
Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release.Q35562324
Ca²⁺ influx slows single synaptic vesicle endocytosisQ35605344
Loading and recycling of synaptic vesicles in the Torpedo electric organ and the vertebrate neuromuscular junctionQ35617857
Maintenance of transmitter release from neuromuscular junctions with different patterns of usage "in vivo".Q35700662
The role of extracellular calcium in exo- and endocytosis of synaptic vesicles at the frog motor nerve terminalsQ79135046
Synaptic vesicles interchange their membrane proteins with a large surface reservoir during recyclingQ79921374
Mobility of synaptic vesicles in different pools in resting and stimulated frog motor nerve terminalsQ80034619
The body temperature in rats on normal and deficient diets: Preliminary reportQ80327636
Synapsins contribute to the dynamic spatial organization of synaptic vesicles in an activity-dependent mannerQ84899754
Kinesin-1/Hsc70-dependent mechanism of slow axonal transport and its relation to fast axonal transportQ28594088
SNAREs--engines for membrane fusionQ29547230
Molecular mechanism and physiological functions of clathrin-mediated endocytosisQ29615660
Membrane curvature and mechanisms of dynamic cell membrane remodellingQ29617321
Membrane fusionQ29618140
Endophilin drives the fast mode of vesicle retrieval in a ribbon synapseQ30010485
Sorting in early endosomes reveals connections to docking- and fusion-associated factorsQ30047766
Endophilin functions as a membrane-bending molecule and is delivered to endocytic zones by exocytosis.Q30155977
Targeting of the synaptic vesicle protein synaptobrevin in the axon of cultured hippocampal neurons: evidence for two distinct sorting steps.Q30442138
Axonal membrane proteins are transported in distinct carriers: a two-color video microscopy study in cultured hippocampal neuronsQ30477482
Cell- and stimulus-dependent heterogeneity of synaptic vesicle endocytic recycling mechanisms revealed by studies of dynamin 1-null neuronsQ30483551
Differential requirements for clathrin in receptor-mediated endocytosis and maintenance of synaptic vesicle poolsQ30485732
Cytoskeletal requirements in axonal transport of slow component-bQ30486187
The dynamic control of kiss-and-run and vesicular reuse probed with single nanoparticlesQ30488206
Coordinated actions of actin and BAR proteins upstream of dynamin at endocytic clathrin-coated pitsQ30494265
Rapid structural alterations of the active zone lead to sustained changes in neurotransmitter release.Q30494986
Endosomal sorting of readily releasable synaptic vesiclesQ30497264
Single secretory granules of live cells recruit syntaxin-1 and synaptosomal associated protein 25 (SNAP-25) in large copy numbersQ30497544
Syntaxin clusters assemble reversibly at sites of secretory granules in live cellsQ30497547
Mechanistic logic underlying the axonal transport of cytosolic proteinsQ30500273
Actin-dependent rapid recruitment of reluctant synaptic vesicles into a fast-releasing vesicle poolQ30512960
Readily releasable pool of synaptic vesicles measured at single synaptic contactsQ30528334
Rapid feedback regulation of synaptic efficacy during high-frequency activity at the Drosophila larval neuromuscular junctionQ30540256
Glutamate induces the rapid formation of spine head protrusions in hippocampal slice culturesQ30856843
The architecture of active zone material at the frog's neuromuscular junctionQ30981051
Phosphoinositides in membrane traffic at the synapseQ32066953
Visualization of the dynamics of synaptic vesicle and plasma membrane proteins in living axonsQ32129557
Structure and function of neuromuscular junctions in the vastus lateralis of man. A motor point biopsy study of two groups of patientsQ33189587
Macromolecular-scale resolution in biological fluorescence microscopyQ33251616
3D reconstruction of high-resolution STED microscope imagesQ33338854
How does synaptotagmin trigger neurotransmitter release?Q33345212
Macromolecular connections of active zone material to docked synaptic vesicles and presynaptic membrane at neuromuscular junctions of mouseQ33410405
Evaluation of the heterogeneous reactivity of the syntaxin molecules on the inner leaflet of the plasma membraneQ33507761
Structural determinants of the reliability of synaptic transmission at the vertebrate neuromuscular junctionQ35700679
Reduced release probability prevents vesicle depletion and transmission failure at dynamin mutant synapsesQ35779287
Stick-and-diffuse and caged diffusion: a comparison of two models of synaptic vesicle dynamicsQ35781192
Neuropeptide delivery to synapses by long-range vesicle circulation and sporadic capture.Q35803998
Determinants of synaptobrevin regulation in membranesQ35810575
A membrane pool retrieved via endocytosis overshoot at nerve terminals: a study of its retrieval mechanism and roleQ35888943
Identification of CSPα clients reveals a role in dynamin 1 regulation.Q35893528
VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmissionQ35916627
Release probability of hippocampal glutamatergic terminals scales with the size of the active zone.Q36068532
Quantum dots provide an optical signal specific to full collapse fusion of synaptic vesiclesQ36140639
ER-to-Golgi transport: form and formation of vesicular and tubular carriers.Q36175436
Mechanisms of vertebrate synaptogenesisQ36196530
Structural changes after transmitter release at the frog neuromuscular junctionQ36208626
The cytoskeletal architecture of the presynaptic terminal and molecular structure of synapsin 1.Q36219796
Redistribution of synaptophysin and synapsin I during alpha-latrotoxin-induced release of neurotransmitter at the neuromuscular junctionQ36222565
The synaptic vesicle cycle: a single vesicle budding step involving clathrin and dynaminQ36237077
Minireview: recent developments in the regulation of glucose transporter-4 traffic: new signals, locations, and partnersQ36252775
ADP ribosylation factor 1 is required for synaptic vesicle budding in PC12 cells.Q36276374
Single-vesicle imaging reveals that synaptic vesicle exocytosis and endocytosis are coupled by a single stochastic modeQ36300120
Botulinum neurotoxin A blocks synaptic vesicle exocytosis but not endocytosis at the nerve terminalQ36313397
Colocalization of synapsin and actin during synaptic vesicle recyclingQ36381468
Differences in synaptic efficacy at neuromuscular junctions in frog twitch musclesQ36414984
RIM promotes calcium channel accumulation at active zones of the Drosophila neuromuscular junction.Q36450432
Quantitative fine-structural analysis of olfactory cortical synapsesQ36459259
RIM controls homeostatic plasticity through modulation of the readily-releasable vesicle poolQ36469214
Synaptic vesicle membrane proteins interact to form a multimeric complexQ36530918
Colocalization of synaptophysin with transferrin receptors: implications for synaptic vesicle biogenesisQ36532901
Vesicle formation at the plasma membrane and trans-Golgi network: the same but differentQ36594583
Compromised fidelity of endocytic synaptic vesicle protein sorting in the absence of stonin 2Q36598109
Protein sorting in the synaptic vesicle life cycleQ36639159
AP2 hemicomplexes contribute independently to synaptic vesicle endocytosisQ36666714
Sorting of synaptophysin into special vesicles in nonneuroendocrine epithelial cellsQ36709683
Emerging roles for ubiquitin and protein degradation in neuronal functionQ36747899
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.Q37811131
Protein scaffolds in the coupling of synaptic exocytosis and endocytosisQ37838259
Vesicular neurotransmitter transporter: bioenergetics and regulation of glutamate transportQ37879648
Structural insights into dynamin-mediated membrane fissionQ38051857
Perspectives on kiss-and-run: role in exocytosis, endocytosis, and neurotransmissionQ38067906
Presynaptic regulation of quantal size: K+/H+ exchange stimulates vesicular glutamate transportQ38592365
Estimates of quantal content during 'chemical potentiation' of transmitter releaseQ39284298
Synapsin I senses membrane curvature by an amphipathic lipid packing sensor motif.Q39430082
ELP3 controls active zone morphology by acetylating the ELKS family member BruchpilotQ39431404
Ca2+ induces clustering of membrane proteins in the plasma membrane via electrostatic interactionsQ39583577
Clathrin-mediated endocytosis is the dominant mechanism of vesicle retrieval at hippocampal synapses.Q39751968
A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosisQ39752213
KIF1Bbeta- and KIF1A-mediated axonal transport of presynaptic regulator Rab3 occurs in a GTP-dependent manner through DENN/MADD.Q39752721
Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosisQ39753923
Bassoon speeds vesicle reloading at a central excitatory synapse.Q39754011
Loss of skywalker reveals synaptic endosomes as sorting stations for synaptic vesicle proteinsQ39754179
RIM-binding protein, a central part of the active zone, is essential for neurotransmitter releaseQ39754475
Vesicle hypothesis of the release of quanta of acetylcholineQ40284776
Synaptophysin I controls the targeting of VAMP2/synaptobrevin II to synaptic vesicles.Q40286914
Stonin 2 is an AP-2-dependent endocytic sorting adaptor for synaptotagmin internalization and recyclingQ40320414
The SNARE motif is essential for the formation of syntaxin clusters in the plasma membraneQ40323730
Vti1a identifies a vesicle pool that preferentially recycles at rest and maintains spontaneous neurotransmissionQ40442647
Activity-dependent control of slow synaptic vesicle endocytosis by cyclin-dependent kinase 5.Q40803584
Newly synthesized synaptophysin is transported to synaptic-like microvesicles via constitutive secretory vesicles and the plasma membrane.Q41083206
Mice lacking synaptophysin reproduce and form typical synaptic vesiclesQ41264671
The movement of membranous organelles in axons. Electron microscopic identification of anterogradely and retrogradely transported organellesQ41264903
Clathrin dependence of synaptic-vesicle formation at the Drosophila neuromuscular junctionQ41334894
Motor-unit discharge rates in maximal voluntary contractions of three human musclesQ41590650
A v-SNARE participates in synaptic vesicle formation mediated by the AP3 adaptor complexQ41644775
Assembly of presynaptic active zones from cytoplasmic transport packetsQ41730812
A vesicle superpool spans multiple presynaptic terminals in hippocampal neurons.Q41786614
What is Rate-Limiting during Sustained Synaptic Activity: Vesicle Supply or the Availability of Release SitesQ41810022
CDK5 serves as a major control point in neurotransmitter release.Q41862687
SNARE proteins: one to fuse and three to keep the nascent fusion pore openQ41920045
Vesicular ATPase inserted into the plasma membrane of motor terminals by exocytosis alkalinizes cytosolic pH and facilitates endocytosisQ41957038
Axonal transport of synapsin I-like proteins in rabbit retinal ganglion cellsQ41964022
Two pathways of synaptic vesicle retrieval revealed by single-vesicle imagingQ41997492
A preferentially segregated recycling vesicle pool of limited size supports neurotransmission in native central synapsesQ42022259
Synaptic vesicle retrieval time is a cell-wide rather than individual-synapse property.Q42090946
The t-SNAREs syntaxin 1 and SNAP-25 are present on organelles that participate in synaptic vesicle recyclingQ42117532
High- and low-mobility stages in the synaptic vesicle cycleQ42125696
A general model of synaptic transmission and short-term plasticityQ42136692
Synaptic vesicle pools: an updateQ42140979
v-SNARE composition distinguishes synaptic vesicle pools.Q42142233
A role for the ubiquitin-proteasome system in activity-dependent presynaptic silencingQ42153361
Synaptobrevin N-terminally bound to syntaxin-SNAP-25 defines the primed vesicle state in regulated exocytosisQ42176873
Defect in synaptic vesicle precursor transport and neuronal cell death in KIF1A motor protein-deficient mice.Q42243086
Metabolic control of vesicular glutamate transport and release.Q42370957
The fate of synaptic vesicle components upon fusionQ42380550
Abnormal synaptic vesicle biogenesis in Drosophila synaptogyrin mutantsQ42429487
Optical quantal analysis of synaptic transmission in wild-type and rab3-mutant Drosophila motor axonsQ42484876
Use dependence of presynaptic tenacity.Q42497470
One SNARE complex is sufficient for membrane fusionQ42531466
A resting pool of vesicles is responsible for spontaneous vesicle fusion at the synapseQ42547280
Quantitative proteomics analysis of detergent-resistant membranes from chemical synapses: evidence for cholesterol as spatial organizer of synaptic vesicle cyclingQ42692486
Hair cell synaptic ribbons are essential for synchronous auditory signalling.Q50473698
Fast vesicle fusion in living cells requires at least three SNARE complexes.Q50541149
Anatomy and dynamics of a supramolecular membrane protein cluster.Q50668558
Intracellular transport of single-headed molecular motors KIF1A.Q50740212
The small GTPase Rab7 controls the endosomal trafficking and neuritogenic signaling of the nerve growth factor receptor TrkA.Q50747092
Fatigue of maintained voluntary muscle contraction in manQ51108545
The same synaptic vesicles drive active and spontaneous release.Q52712414
Effects of enhanced activity on synaptic transmission in mouse extensor digitorum longus muscleQ54298017
CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity.Q54397791
Real-time measurements of vesicle-SNARE recycling in synapses of the central nervous system.Q55033831
Neurotransmitter release: fusion or 'kiss-and-run'?Q55038012
Synaptotagmin-1 Docks Secretory Vesicles to Syntaxin-1/SNAP-25 Acceptor ComplexesQ56992446
A readily retrievable pool of synaptic vesiclesQ57949867
Endosomal Fusion upon SNARE Knockdown is Maintained by Residual SNARE Activity and Enhanced DockingQ57978902
Localization of Rab5 to synaptic vesicles identifies endosomal intermediate in synaptic vesicle recycling pathwayQ57979066
Syntaxin1A Lateral Diffusion Reveals Transient and Local SNARE InteractionsQ58052095
Topogenesis and sorting of synaptophysin: Synthesis of a synaptic vesicle protein from a gene transfected into nonneuroendocrine cellsQ58438839
Firing patterns of motor units in normal ratsQ59062044
A common origin of synaptic vesicles undergoing evoked and spontaneous fusionQ62089125
The absence of neuromuscular transmission failure in sustained maximal voluntary contractionsQ67247592
Influence of spinal cord transection on the presence and axonal transport of CGRP-, chromogranin A-, VIP-, synapsin I-, and synaptophysin-like immunoreactivities in rat motor nerveQ67465442
Muscle injury, cross-sectional area and fibre type distribution in mouse soleus after intermittent wheel-runningQ68589262
Muscle damage and repair in voluntarily running mice: strain and muscle differencesQ69419124
Contractile speed and EMG changes during fatigue of sustained maximal voluntary contractionsQ70154300
Monitoring of black widow spider venom (BWSV) induced exo- and endocytosis in living frog motor nerve terminals with FM1-43Q71014073
Axonal transport of synaptic vesicle proteins in the rat optic nerveQ73071990
Transmitter release differs at snake twitch and tonic endplates during potassium-induced nerve terminal depolarizationQ73145371
Endocytic vesicles move at the tips of actin tails in cultured mast cellsQ73177693
The contribution of postsynaptic folds to the safety factor for neuromuscular transmission in rat fast- and slow-twitch musclesQ73211955
Voluntary strength and fatigueQ73466180
Action, and spontaneous release, of acetylcholine at an inexcitable nerve-muscle junctionQ73689914
Synaptic vesicle pools at the frog neuromuscular junctionQ73744519
Cdk5/p25(nck5a) interaction with synaptic proteins in bovine brainQ73748003
Three-dimensional comparison of ultrastructural characteristics at depressing and facilitating synapses onto cerebellar Purkinje cellsQ74411621
Synaptic vesicle dynamics in rat fast and slow motor nerve terminalsQ74624725
Spontaneous electromyographic activity in adult rat soleus muscleQ74765936
Alterations in transmission, vesicle dynamics, and transmitter release machinery at NCAM-deficient neuromuscular junctionsQ77334872
Synaptic physiology and ultrastructure in comatose mutants define an in vivo role for NSF in neurotransmitter releaseQ77679760
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectcellQ7868
nervous systemQ9404
synaptic vesicle uncoatingQ21135065
synaptic vesicle budding from endosomeQ22291791
P304page(s)788-822
P577publication date2014-04-16
P1433published inThe EMBO JournalQ1278554
P1476titleSynaptic vesicle recycling: steps and principles
P478volume33

Reverse relations

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