Risk of Infectious Complications in Hemato-Oncological Patients Treated with Kinase Inhibitors

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Risk of Infectious Complications in Hemato-Oncological Patients Treated with Kinase Inhibitors is …
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scholarly articleQ13442814

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P356DOI10.4137/BMI.S22430
P932PMC publication ID4841329
P698PubMed publication ID27127405

P50authorDieter BuchheidtQ40279734
P2093author name stringWolf-Karsten Hofmann
Mark Reinwald
Tobias Boch
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The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemiaQ27266125
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Crizotinib versus chemotherapy in advanced ALK-positive lung cancer.Q27852316
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Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6): an open-label, randomised phase 3 trialQ27852787
Ceritinib in ALK-rearranged non-small-cell lung cancerQ27852989
Combined vemurafenib and cobimetinib in BRAF-mutated melanomaQ27853076
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First-line crizotinib versus chemotherapy in ALK-positive lung cancerQ27853101
Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomised, phase 3 trialsQ27853120
Ibrutinib in previously treated Waldenström's macroglobulinemia.Q27853148
Sunitinib versus interferon alfa in metastatic renal-cell carcinomaQ28282757
Idelalisib and rituximab in relapsed chronic lymphocytic leukemiaQ28306347
The tyrosine kinase Btk regulates the macrophage response to Listeria monocytogenes infectionQ28504622
Bruton's Tyrosine Kinase (BTK) and Vav1 contribute to Dectin1-dependent phagocytosis of Candida albicans in macrophagesQ28534361
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Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trialQ29618031
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Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trialQ29620127
Everolimus in postmenopausal hormone-receptor-positive advanced breast cancerQ29620676
Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemiaQ29620690
Reduced immunosuppressive properties of axitinib in comparison with other tyrosine kinase inhibitorsQ30317831
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Approval summary: imatinib mesylate in the treatment of metastatic and/or unresectable malignant gastrointestinal stromal tumorsQ33344650
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Axitinib versus sorafenib as first-line therapy in patients with metastatic renal-cell carcinoma: a randomised open-label phase 3 trialQ38160956
Regorafenib: a novel multitargeted tyrosine kinase inhibitor for colorectal cancer and gastrointestinal stromal tumorsQ38164667
Tofacitinib: The First Janus Kinase (JAK) inhibitor for the treatment of rheumatoid arthritisQ38167009
Protein kinase inhibitors in renal cell carcinoma.Q38170411
Bosutinib: a review of its use in patients with Philadelphia chromosome-positive chronic myelogenous leukemiaQ38178192
Safety and efficacy of addition of VEGFR and EGFR-family oral small-molecule tyrosine kinase inhibitors to cytotoxic chemotherapy in solid cancers: a systematic review and meta-analysis of randomized controlled trialsQ38195958
Epidemiology of infections in cancer patientsQ38202569
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Ponatinib: a review of its use in adults with chronic myeloid leukaemia or Philadelphia chromosome-positive acute lymphoblastic leukaemiaQ38210132
Everolimus for subependymal giant cell astrocytoma in patients with tuberous sclerosis complex: 2-year open-label extension of the randomised EXIST-1 studyQ38279723
Current treatment strategies for inhibiting mTOR in cancerQ38286529
BRAF and MEK inhibition in melanoma.Q38342905
FDA approval: ceritinib for the treatment of metastatic anaplastic lymphoma kinase-positive non-small cell lung cancer.Q38371186
Dasatinib 140 mg once daily versus 70 mg twice daily in patients with Ph-positive acute lymphoblastic leukemia who failed imatinib: Results from a phase 3 studyQ38375967
The kinase-inhibitor sorafenib inhibits multiple steps of the Hepatitis C Virus infectious cycle in vitro.Q38893121
JAK Inhibition Impairs NK Cell Function in Myeloproliferative NeoplasmsQ41127061
JAK1/2 inhibition impairs T cell function in vitro and in patients with myeloproliferative neoplasmsQ41138516
Pooled safety analysis of EGFR-TKI treatment for EGFR mutation-positive non-small cell lung cancerQ41370614
Complications of mammalian target of rapamycin inhibitor anticancer treatment among patients with tuberous sclerosis complex are common and occasionally life-threateningQ41463007
Everolimus-based immunosuppressive regimens in lung transplant recipients: impact on CMV infectionQ41636433
Reactivation of chronic hepatitis B infection related to imatinib mesylate therapyQ41892625
Nilotinib hampers the proliferation and function of CD8+ T lymphocytes through inhibition of T cell receptor signallingQ41963473
Renal function, efficacy, and safety of sirolimus and mycophenolate mofetil after short-term calcineurin inhibitor-based quadruple therapy in de novo renal transplant patients: one-year analysis of a randomized multicenter trialQ42171624
X-linked agammaglobulinemia: report on a United States registry of 201 patientsQ64377617
Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritisQ84751886
Activity of therapeutic JAK 1/2 blockade in graft-versus-host diseaseQ87635679
TemsirolimusQ87733399
Axitinib for renal cell carcinomaQ94699157
Activity and tolerability of nilotinib: a retrospective multicenter analysis of chronic myeloid leukemia patients who are imatinib resistant or intolerantQ33390350
Dasatinib: a review of its use in the treatment of chronic myeloid leukaemia and Philadelphia chromosome-positive acute lymphoblastic leukaemia.Q33397085
Dasatinib or imatinib in newly diagnosed chronic-phase chronic myeloid leukemia: 2-year follow-up from a randomized phase 3 trial (DASISION).Q33398716
JAK inhibition with ruxolitinib versus best available therapy for myelofibrosisQ33399977
Fluorouracil, leucovorin, and irinotecan plus either sunitinib or placebo in metastatic colorectal cancer: a randomized, phase III trialQ33405554
Pazopanib versus sunitinib in metastatic renal-cell carcinomaQ33409916
Three-year efficacy, safety, and survival findings from COMFORT-II, a phase 3 study comparing ruxolitinib with best available therapy for myelofibrosisQ33411211
Idelalisib, a selective inhibitor of phosphatidylinositol 3-kinase-δ, as therapy for previously treated indolent non-Hodgkin lymphomaQ33413834
Salvage therapy with everolimus reduces the severity of treatment-refractory chronic GVHD without impairing disease control: a dual center retrospective analysisQ33416874
Ruxolitinib: a review of its use in patients with myelofibrosisQ33419865
Ruxolitinib versus standard therapy for the treatment of polycythemia vera.Q33420037
Chemotherapy With or Without Maintenance Sunitinib for Untreated Extensive-Stage Small-Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Phase II Study-CALGB 30504 (Alliance).Q33420821
Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: a phase II study from the European organisation for research and treatment of cancer-soft tissue and bone sarcoma group (EORTC stuQ33447149
PI3Kδ inhibition by idelalisib in patients with relapsed indolent lymphomaQ33690142
Targeted therapies in hematology and their impact on patient care: chronic and acute myeloid leukemiaQ33903030
Rituximab maintenance treatment of relapsed/resistant follicular non-Hodgkin's lymphoma: long-term outcome of the EORTC 20981 phase III randomized intergroup studyQ33990849
Inhibitory effects of the JAK inhibitor CP690,550 on human CD4(+) T lymphocyte cytokine productionQ34007875
Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110δ, for relapsed/refractory chronic lymphocytic leukemiaQ34009003
β-Arrestin 2 negatively regulates Toll-like receptor 4 (TLR4)-triggered inflammatory signaling via targeting p38 MAPK and interleukin 10.Q34044736
Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemiaQ34052075
Sunitinib malate for the treatment of pancreatic neuroendocrine tumorsQ34163515
Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemiaQ34183674
Safety and activity of ibrutinib plus rituximab for patients with high-risk chronic lymphocytic leukaemia: a single-arm, phase 2 studyQ34240404
Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): a phase 2b/3 randomised trialQ34263959
Pharmacologic blockade of JAK1/JAK2 reduces GvHD and preserves the graft-versus-leukemia effectQ34301568
Combination of temsirolimus (CCI-779) with chemoradiation in newly diagnosed glioblastoma multiforme (GBM) (NCCTG trial N027D) is associated with increased infectious risksQ34316147
A randomised, double-blind phase III study of pazopanib in patients with advanced and/or metastatic renal cell carcinoma: final overall survival results and safety update.Q34322740
An opportunistic infection associated with ruxolitinib, a novel janus kinase 1,2 inhibitorQ34343220
Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiencyQ34380652
Crizotinib in advanced, chemoresistant anaplastic lymphoma kinase-positive lymphoma patientsQ34401878
Sorafenib: targeting multiple tyrosine kinases in cancerQ34416659
Disseminated tuberculosis in a patient treated with a JAK2 selective inhibitor: a case report.Q34434935
The risk of infections in hematologic patients treated with rituximab is not influenced by cumulative rituximab dosage - a single center experienceQ34486116
Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemiaQ34620246
Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial.Q34633525
Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trialQ34638316
Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trialQ34645665
A phase 1 study of the PI3Kδ inhibitor idelalisib in patients with relapsed/refractory mantle cell lymphoma (MCL).Q34663617
Safety of bosutinib versus imatinib in the phase 3 BELA trial in newly diagnosed chronic phase chronic myeloid leukemiaQ35008618
Randomized, placebo-controlled, phase III trial of sunitinib plus prednisone versus prednisone alone in progressive, metastatic, castration-resistant prostate cancer.Q35063446
A phase I/II study of the Janus kinase (JAK)1 and 2 inhibitor ruxolitinib in patients with relapsed or refractory acute myeloid leukemiaQ35132525
Ibrutinib treatment ameliorates murine chronic graft-versus-host diseaseQ35140097
Identification of a role for the PI3K/AKT/mTOR signaling pathway in innate immune cellsQ35144129
Three-year follow-up of treatment-naïve and previously treated patients with CLL and SLL receiving single-agent ibrutinibQ35450520
Higher Risk of Infections with PI3K-AKT-mTOR Pathway Inhibitors in Patients with Advanced Solid Tumors on Phase I Clinical Trials.Q35462692
Corticosteroids augment BRAF inhibitor vemurafenib induced lymphopenia and risk of infectionQ35515704
Final report of a phase II study of imatinib mesylate with hyper-CVAD for the front-line treatment of adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemiaQ35571035
A systematic review of the efficacy and safety experience reported for sorafenib in advanced renal cell carcinoma (RCC) in the post-approval settingQ35591889
Differential influence of vemurafenib and dabrafenib on patients' lymphocytes despite similar clinical efficacy in melanomaQ35611909
Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral responseQ35889249
Randomized phase III placebo-controlled trial of letrozole plus oral temsirolimus as first-line endocrine therapy in postmenopausal women with locally advanced or metastatic breast cancer.Q36494245
Hepatitis B reactivation in chronic myeloid leukemia patients receiving tyrosine kinase inhibitorQ36654518
Risk of infections in renal cell carcinoma (RCC) and non-RCC patients treated with mammalian target of rapamycin inhibitorsQ36959193
Imatinib mesylate-related fatal acute hepatic failure in a patient with chronic myeloid leukaemia and chronic hepatitis B infectionQ37117640
Epidermal growth factor receptor-mediated innate immune responses and their roles in airway diseases.Q37283112
Chronic myeloid leukemia patient manifesting fatal hepatitis B virus reactivation during treatment with imatinib rescued by liver transplantation: case report and literature reviewQ37566301
Vascular endothelial growth factor pathway-targeted therapy as initial systemic treatment of patients with renal cancer.Q37627806
Clinical responses to vemurafenib in patients with metastatic papillary thyroid cancer harboring BRAF(V600E) mutationQ37667684
Noninfectious pneumonitis after everolimus therapy for advanced renal cell carcinomaQ37701147
Epidemiology and Management of Infectious Complications of Contemporary Management of Chronic LeukemiasQ37779328
Management of adverse events associated with the use of everolimus in patients with advanced renal cell carcinoma.Q37863795
Posterior reversible encephalopathy syndrome induced by anti-VEGF agents.Q37957052
Everolimus plus octreotide long-acting repeatable for the treatment of advanced neuroendocrine tumours associated with carcinoid syndrome (RADIANT-2): a randomised, placebo-controlled, phase 3 studyQ37961390
Characteristics of, and risk factors for, infections in patients with cancer treated with dasatinib and a brief review of other complicationsQ37977471
A comprehensive review of everolimus clinical reports: a new mammalian target of rapamycin inhibitorQ38044248
The JAK-STAT pathway and hematopoietic stem cells from the JAK2 V617F perspectiveQ38140890
Incidence of Pneumocystis jiroveci pneumonia among groups at risk in HIV-negative patientsQ42204004
Hepatitis B viral reactivation secondary to imatinib treatment in a patient with gastrointestinal stromal tumorQ42208983
Pneumocystis jiroveci pneumonia in patients receiving dasatinib treatmentQ42212297
Effects of tofacitinib on lymphocytes in rheumatoid arthritis: relation to efficacy and infectious adverse events.Q42232321
Low incidence rate of opportunistic and viral infections during imatinib treatment in chronic myeloid leukemia patients in early and late chronic phaseQ42276725
An open-label, multicenter, randomized, phase II study of pazopanib in combination with pemetrexed in first-line treatment of patients with advanced-stage non-small-cell lung cancerQ42635935
Safety and efficacy of tofacitinib, an oral janus kinase inhibitor, for the treatment of rheumatoid arthritis in open-label, longterm extension studiesQ42651946
Immunoprofiling of patients with chronic myeloid leukemia at diagnosis and during tyrosine kinase inhibitor therapyQ42956257
Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study.Q43056663
Phase I/II study of sunitinib malate in Japanese patients with gastrointestinal stromal tumor after failure of prior treatment with imatinib mesylateQ43281012
The JAK-inhibitor ruxolitinib impairs dendritic cell function in vitro and in vivoQ43451422
Early mortality after diagnosis of multiple myeloma: analysis of patients entered onto the United kingdom Medical Research Council trials between 1980 and 2002--Medical Research Council Adult Leukaemia Working PartyQ43472495
Rapid response to vemurafenib in a heavily pretreated patient with hairy cell leukemia and a BRAF mutationQ43539481
Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factorQ43873032
Development of Varicella-Zoster virus infection in patients with chronic myelogenous leukemia treated with imatinib mesylate.Q44358941
Progressive multifocal leukoencephalopathy associated with ruxolitinibQ44509111
Analysis of infections and all-cause mortality in phase II, phase III, and long-term extension studies of tofacitinib in patients with rheumatoid arthritisQ44518151
Parvovirus B19 acute infection and a reactivation of cytomegalovirus and herpesvirus 6 in a chronic myeloid leukemia patient during treatment with dasatinib (BMS-354825).Q44630703
Bilateral toxoplasmosis retinitis associated with ruxolitinibQ44909357
Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent mannerQ45168860
A double-blind, randomised, placebo-controlled phase III intergroup study of gefitinib in patients with advanced NSCLC, non-progressing after first line platinum-based chemotherapy (EORTC 08021/ILCP 01/03).Q45272587
Sorafenib inhibits activation of human peripheral blood T cells by targeting LCK phosphorylationQ45340125
Reactivation of hepatitis B virus infection following ruxolitinib treatment in a patient with myelofibrosis.Q45350105
Fatal hepatitis B virus reactivation in a chronic myeloid leukemia patient during imatinib mesylate treatmentQ45422025
Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: a randomised phase 3 trialQ45842857
Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis.Q45930884
Epidermal growth factor receptor and HER2-neu mRNA expression in non-small cell lung cancer Is correlated with survival.Q46004116
Sorafenib for treatment of renal cell carcinoma: Final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial.Q46006772
MAPK-independent impairment of T-cell responses by the multikinase inhibitor sorafenibQ46135183
Dasatinib exerts an immunosuppressive effect on CD8+ T cells specific for viral and leukemia antigensQ46488793
Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disordersQ46513376
Toll-like receptor signaling is impaired in dendritic cells from patients with X-linked agammaglobulinemiaQ46756876
Phase III trial of sunitinib in combination with capecitabine versus capecitabine monotherapy for the treatment of patients with pretreated metastatic breast cancerQ46757183
High complete remission rate and promising outcome by combination of imatinib and chemotherapy for newly diagnosed BCR-ABL-positive acute lymphoblastic leukemia: a phase II study by the Japan Adult Leukemia Study GroupQ46847866
Imatinib impairs the proliferation and function of CD4+CD25+ regulatory T cells in a dose-dependent manner.Q46969850
Sorafenib in combination with intensive chemotherapy in elderly patients with acute myeloid leukemia: results from a randomized, placebo-controlled trialQ47903403
Tyrosine kinase inhibitors impair B-cell immune responses in CML through off-target inhibition of kinases important for cell signalingQ49291505
Btk is a positive regulator in the TREM-1/DAP12 signaling pathway.Q50335863
The effect of sunitinib on immune subsets in metastatic clear cell renal cancer.Q50537326
Pazopanib plus weekly paclitaxel versus weekly paclitaxel alone for platinum-resistant or platinum-refractory advanced ovarian cancer (MITO 11): a randomised, open-label, phase 2 trial.Q50564383
Pneumocystis jirovecii pneumonia under everolimus in two patients with metastatic pancreatic neuroendocrine tumors.Q51704257
Ruxolitinib is a potent immunosuppressive compound: is it time for anti-infective prophylaxis?Q54393708
Safety and efficacy of everolimus with exemestane vs. exemestane alone in elderly patients with HER2-negative, hormone receptor-positive breast cancer in BOLERO-2.Q54394851
Nilotinib vs imatinib in patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase: ENESTnd 3-year follow-up.Q54504324
Randomized phase 2b trial of tofacitinib (CP-690,550) in de novo kidney transplant patients: efficacy, renal function and safety at 1 year.Q54505605
Different immunoprofiles in patients with chronic myeloid leukemia treated with imatinib, nilotinib or dasatinib.Q54539122
The JAK inhibitor tofacitinib regulates synovitis through inhibition of interferon-γ and interleukin-17 production by human CD4+ T cells.Q54544974
Drug evaluation: Nilotinib - a novel Bcr-Abl tyrosine kinase inhibitor for the treatment of chronic myelocytic leukemia and beyond.Q55044207
Phase III study of sorafenib after transarterial chemoembolisation in Japanese and Korean patients with unresectable hepatocellular carcinomaQ57214428
Gastrointestinal stromal tumours: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-upQ57570640
P433issueSuppl 3
P407language of work or nameEnglishQ1860
P304page(s)55-68
P577publication date2015-01-01
P1433published inBiomarker InsightsQ4915072
P1476titleRisk of Infectious Complications in Hemato-Oncological Patients Treated with Kinase Inhibitors
P478volume10

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cites work (P2860)
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