Pharmacologic blockade of JAK1/JAK2 reduces GvHD and preserves the graft-versus-leukemia effect

scientific article

Pharmacologic blockade of JAK1/JAK2 reduces GvHD and preserves the graft-versus-leukemia effect is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2014PLoSO...9j9799C
P356DOI10.1371/JOURNAL.PONE.0109799
P932PMC publication ID4188578
P698PubMed publication ID25289677
P5875ResearchGate publication ID266625748

P50authorBader AlahmariQ57032058
Jaebok ChoiQ52430559
P2093author name stringMatthew Holt
John F DiPersio
Matthew L Cooper
Julie Ritchey
Lynne Collins
P2860cites workAn experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxinQ71881409
Interleukin-12 inhibits graft-versus-host disease through an Fas-mediated mechanism associated with alterations in donor T-cell activation and expansionQ74477786
Real-time imaging of ligand-induced IKK activation in intact cells and in living miceQ81045070
NCI First International Workshop on The Biology, Prevention, and Treatment of Relapse After Allogeneic Hematopoietic Stem Cell Transplantation: Report from the Committee on the Biology Underlying Recurrence of Malignant Disease following AllogeneicQ82884856
Activity of therapeutic JAK 1/2 blockade in graft-versus-host diseaseQ87635679
Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera.Q27851427
Interferon-γ: an overview of signals, mechanisms and functionsQ28207081
The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumorsQ33613105
CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasmsQ33944270
In vivo administration of hypomethylating agents mitigate graft-versus-host disease without sacrificing graft-versus-leukemia.Q33997187
Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasmsQ34021151
Constitutively active Stat5b in CD4+ T cells inhibits graft-versus-host disease lethality associated with increased regulatory T-cell potency and decreased T effector cell responsesQ34033872
The JAK/STAT signaling pathwayQ34305849
Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13Q34541778
Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progressionQ34755408
The JAK inhibitor AZD1480 regulates proliferation and immunity in Hodgkin lymphoma.Q35664956
IFNγR signaling mediates alloreactive T-cell trafficking and GVHDQ36395621
Comprehensive review of JAK inhibitors in myeloproliferative neoplasms.Q36776428
AZD1480: a phase I study of a novel JAK2 inhibitor in solid tumorsQ37038472
Myeloid-derived suppressor cells in breast cancerQ37172813
Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host diseaseQ37373067
New perspectives on the biology of acute GVHD.Q37641063
Recent patents in the discovery of small molecule inhibitors of JAK3.Q37733546
The role of JAK pathway dysregulation in the pathogenesis and treatment of acute myeloid leukemiaQ38064832
Selective JAK2 inhibition specifically decreases Hodgkin lymphoma and mediastinal large B-cell lymphoma growth in vitro and in vivoQ39017147
Kinetics of in vivo elimination of suicide gene-expressing T cells affects engraftment, graft-versus-host disease, and graft-versus-leukemia after allogeneic bone marrow transplantationQ40517810
Regulation of MHC class I and II gene transcription: differences and similaritiesQ42681956
High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARα expressionQ44443187
Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanismQ47745301
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectleukemiaQ29496
pharmacologyQ128406
P304page(s)e109799
P577publication date2014-10-07
P1433published inPLOS OneQ564954
P1476titlePharmacologic blockade of JAK1/JAK2 reduces GvHD and preserves the graft-versus-leukemia effect
P478volume9

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cites work (P2860)
Q49645938Application of proteomics to graft-versus-host disease: from biomarker discovery to potential clinical applications
Q99721339Association of donor IFNL4 genotype and non-relapse mortality after unrelated donor myeloablative haematopoietic stem-cell transplantation for acute leukaemia: a retrospective cohort study
Q52310616Baricitinib-induced blockade of interferon gamma receptor and interleukin-6 receptor for the prevention and treatment of graft-versus-host disease.
Q37522548Biology of chronic graft-vs-host disease: Immune mechanisms and progress in biomarker discovery.
Q37638846CML cells actively evade host immune surveillance through cytokine-mediated downregulation of MHC-II expression.
Q47114304Compassionate use of ruxolitinib in acute and chronic graft versus host disease refractory both to corticosteroids and extracorporeal photopheresis.
Q38786084Emerging drugs for graft-versus-host disease
Q37114440Immunological basis for treatment of graft versus host disease after liver transplant
Q91587430Mechanisms Underlying the Anti-inflammatory and Immunosuppressive Activity of Ruxolitinib
Q39002166Mechanistic approaches for the prevention and treatment of chronic GVHD.
Q49238507New and emerging therapies for acute and chronic graft versus host disease
Q39023963Novel targets in the treatment of chronic graft-versus-host disease
Q54186062Recipient and donor JAK2 46/1 haplotypes are associated with acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation.
Q91844259Resolution of secondary hemophagocytic lymphohistiocytosis after treatment with the JAK1/2 inhibitor ruxolitinib
Q26851417Risk of Infectious Complications in Hemato-Oncological Patients Treated with Kinase Inhibitors
Q96431807Risk of infections in patients with myeloproliferative neoplasms-a population-based cohort study of 8363 patients
Q92528596Roles of JAK2 in Aging, Inflammation, Hematopoiesis and Malignant Transformation
Q48231285Ruxolitinib as a promising treatment for corticosteroid-refractory graft-versus-host disease
Q64055485Ruxolitinib for Therapy of Graft-versus-Host Disease
Q50115590Ruxolitinib for the treatment of patients with steroid-refractory GVHD: an introduction to the REACH trials
Q91174334Ruxolitinib in refractory acute and chronic graft-versus-host disease: a multicenter survey study
Q92327065Ruxolitinib treatment for acute gastrointestinal graft-versus-host disease caused by donor-derived CD19-Chimeric antigen receptor T-Cell infusion in a patient with B-ALL relapsed after Allo-HSCT
Q49724160Ruxolitinib: a steroid sparing agent in chronic graft-versus-host disease
Q37302887Steroids Versus Steroids Plus Additional Agent in Frontline Treatment of Acute Graft-versus-Host Disease: A Systematic Review and Meta-Analysis of Randomized Trials
Q60938512Strategies for Enhancing and Preserving Anti-leukemia Effects Without Aggravating Graft-Versus-Host Disease
Q55060181T-Cell Manipulation Strategies to Prevent Graft-Versus-Host Disease in Haploidentical Stem Cell Transplantation.
Q52927960Targeting Aurora kinase A and JAK2 prevents GVHD while maintaining Treg and antitumor CTL function.
Q59800879Targeting IFNGR/IL6R or downstream JAK1/JAK2 to control GvHD
Q48139357Targeting JAK2 reduces GVHD and xenograft rejection through regulation of T cell differentiation.
Q92569958The Biological and Clinical Relevance of G Protein-Coupled Receptors to the Outcomes of Hematopoietic Stem Cell Transplantation: A Systematized Review
Q64257524The IL-12 Cytokine and Receptor Family in Graft-vs.-Host Disease
Q49384876The Role of Janus Kinase Signaling in Graft-Versus-Host Disease and Graft Versus Leukemia.

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