Ruxolitinib treatment for acute gastrointestinal graft-versus-host disease caused by donor-derived CD19-Chimeric antigen receptor T-Cell infusion in a patient with B-ALL relapsed after Allo-HSCT

scientific article published on 15 July 2019

Ruxolitinib treatment for acute gastrointestinal graft-versus-host disease caused by donor-derived CD19-Chimeric antigen receptor T-Cell infusion in a patient with B-ALL relapsed after Allo-HSCT is …
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scholarly articleQ13442814

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P356DOI10.1016/J.RETH.2019.06.006
P932PMC publication ID6646647
P698PubMed publication ID31367654

P2093author name stringHe Huang
Yingying Yang
Yongxian Hu
P2860cites workChimeric antigen receptor T cells for sustained remissions in leukemiaQ29617588
CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemiaQ29620607
Pharmacologic blockade of JAK1/JAK2 reduces GvHD and preserves the graft-versus-leukemia effectQ34301568
How I treat refractory acute GVHD.Q35828633
Allogeneic T Cells That Express an Anti-CD19 Chimeric Antigen Receptor Induce Remissions of B-Cell Malignancies That Progress After Allogeneic Hematopoietic Stem-Cell Transplantation Without Causing Graft-Versus-Host DiseaseQ35904666
Late mortality after allogeneic hematopoietic cell transplantation and functional status of long-term survivors: report from the Bone Marrow Transplant Survivor StudyQ36141716
Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: a multicenter surveyQ36862931
Donor-derived CD19-targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantationQ37390239
Mechanistic approaches for the prevention and treatment of chronic GVHD.Q39002166
Donor origin CAR T cells: graft versus malignancy effect without GVHD, a systematic reviewQ39106490
Donor-derived CD19-targeted T cell infusion induces minimal residual disease-negative remission in relapsed B-cell acute lymphoblastic leukaemia with no response to donor lymphocyte infusions after haploidentical haematopoietic stem cell transplantaQ47596812
Immunosuppression for 6-8 weeks after modified donor lymphocyte infusion reduced acute graft-versus-host disease without influencing graft-versus-leukemia effect in haploidentical transplant.Q51042672
Ruxolitinib in GvHD (RIG) study: a multicenter, randomized phase 2 trial to determine the response rate of Ruxolitinib and best available treatment (BAT) versus BAT in steroid-refractory acute graft-versus-host disease (aGvHD) (NCT02396628)Q59336540
Activity of therapeutic JAK 1/2 blockade in graft-versus-host diseaseQ87635679
P921main subjectruxolitinibQ7383611
P304page(s)139-142
P577publication date2019-07-15
P1433published inRegenerative TherapyQ50817062
P1476titleRuxolitinib treatment for acute gastrointestinal graft-versus-host disease caused by donor-derived CD19-Chimeric antigen receptor T-Cell infusion in a patient with B-ALL relapsed after Allo-HSCT
P478volume11

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